The DOI matches its Crossref record; 89 of the 91 references it cites were found in a registry or an index.
Alcohol and drugs in epilepsy: Pathophysiology, presentation, possibilities, and prevention
Abstract
Summary: The potentially serious outcomes from ingestion of and dependence on toxins make this an important topic for epileptologists. We must be aware of the potential for harm from compounds that may be freely available, yet patients may try to conceal their use. Problematic compounds may cause seizures either acutely or on withdrawal: Their use may reduce effectiveness of antiepileptic drugs, or may simply promote and enhance chaotic lifestyles. Any or all of these factors may worsen seizure control or even directly cause seizures. This article highlights the pathophysiology behind provoked seizures, provides clues to diagnosis, and then outlines the steps that clinicians should take to reduce the deleterious effects of toxic compounds.
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“In addition, alcohol use may affect the clinical course of pre‐existing epilepsy either by changes in anti‐epileptic drug pharmacokinetics or by non‐compliance with prescribed medication 236, 237.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [237]
Citations
Cites
Extent of illicit drug use and dependence, and their contribution to the global burden of disease
Degenhardt, L. J., & Hall, W. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61138-0 · Cited by 1,354
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A., Azad, S. C., Cascio, M. G., Gutiérrez, S. O., van der Stelt, M., et al. (2003) · Science · doi:10.1126/science.1088208 · Cited by 1,208
Temkin, N. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.28900.x · Cited by 501
Mayo-Smith, M. F. (1997) · JAMA · doi:10.1001/jama.278.2.144 · Cited by 434
Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo
Jones, N. A., Hill, A. J., Smith, I., Bevan, S. A., Williams, C. M., Whalley, B. J., & Stephens, G. J. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.159145 · Cited by 353
Current Research on Opioid Receptor Function
Feng, Y., He, X., Yang, Y., Chao, D., Lazarus, L. H., & Xia, Y. (2012) · Current Drug Targets · doi:10.2174/138945012799201612 · Cited by 330
CDT, GGT, and AST As Markers of Alcohol Use: The WHO/ISBRA Collaborative Project
Conigrave, K. M., Degenhardt, L. J., Whitfield, J. B., Saunders, J. B., Helander, A., Tabakoff, B., & on behalf of the WHO/ISBRA Study Group (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02542.x · Cited by 281
Ethanol opens G-protein-activated inwardly rectifying K+ channels
Kobayashi, T., Ikeda, K., Kojima, H., Niki, H., Yano, R., Yoshioka, T., & Kumanishi, T. (1999) · Nature Neuroscience · doi:10.1038/16019 · Cited by 259
Seizures in Alcohol-Dependent Patients
Hillbom, M., Pieninkeroinen, I., & Leone, M. A. (2003) · CNS Drugs · doi:10.2165/00023210-200317140-00002 · Cited by 243
Bayard, M. M., McIntyre, J., Hill, K. R., & Woodside, J. R. (2000) · CRC Press eBooks · doi:10.1201/9781420036961-14 · Cited by 232
Research works printed but not linked: 2
- 10.1001/jama.1997.03550020076042 · DOI · Paper page
- Scottish Executive Health Department, 2002, Plan for action on alcohol problems
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Items 101–105 of 105
Additional file 1 of Epilepsy and other seizure disorders in acute psychiatric inpatients
Nakken, E. I., Grinde, F., Vaaler, A., Drange, O. K., Brodtkorb, E., & Sæther, S. G. (2021) · Figshare · doi:10.6084/m9.figshare.17210235
Szałwińska, K., Cyuńczyk, M., Kochanowicz, J., & Witkowska, A. M. (2021) · Figshare · doi:10.6084/m9.figshare.14880533
Dynamique de l’excitabilité corticale dans l’épilepsie-absence et intégration sensorielle
Williams, M. (2018) · theses.fr (ABES) · doi:10.70675/f3f16401z6809z4b94z8a26z7ab6e7bd4a9f
Dasara, M., Dono, F., Evangelista, G., Quintieri, P., Cipollone, S., Liviello, D., Ferrante, R., & Sensi, S. L. (2026) · BMC Neurology · doi:10.1186/s12883-026-04936-z
Pegg, E., Sen, A., Vadlamudi, L., Voinescu, P. E., Bui, E., Puntambekar, P., Krishnaiengar, S., Zarroli, K. A., Anagnostis, P. G., Bosdou, J. Κ., et al. (2026) · Maturitas · doi:10.1016/j.maturitas.2026.109134
Metadata
- Authors
- Leach, J. P., Mohanraj, R., & Borland, W.
- Affiliations
- Southern General Hospital (GB)
- Salford Royal Hospital (GB)
- Gartnavel General Hospital (GB)
- Corresponding author
- Leach, John Paul
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2012-09
- Volume
- 53
- Issue
- s4
- Pages
- 48-57
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1553610755
- Cited by
- 105
- References
- 91
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 21 · 2020: 11 · 2019: 4 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 2 · 2012: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- alcohol, drugs, epilepsy, provoked seizures, substance use, withdrawal seizures, antiepileptic drug interactions, seizure control, pathophysiology, prevention, diagnosis
- MeSH terms
- Alcohol Drinking, Ethanol, Alcoholism, Benzodiazepines, Marijuana Abuse, Central Nervous System Depressants, Epilepsy, gamma-Aminobutyric Acid, Heroin Dependence, Humans, Ketamine, Seizures, Substance-Related Disorders, Amphetamine-Related Disorders, Cocaine-Related Disorders, Alcohol Withdrawal Seizures
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