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Cited by 567

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Brain Gray and White Matter Volume Loss Accelerates with Aging in Chronic Alcoholics: A Quantitative MRI Study

Pfefferbaum, Adolf, Lim, Kelvin O., Zipursky, Robert B., Mathalon, Daniel H., Rosenbloom, Margaret J., Lane, Barton, Ha, Chung Nim, Sullivan, Edith V.·1992·Alcoholism: Clinical and Experimental Research
DOI 10.1111/j.1530-0277.1992.tb00702.x
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Abstract

Magnetic resonance imaging (MRI) was used to study in vivo the brains of 49 patients with chronic alcoholism, 3 to 4 weeks postwithdrawal, and 43 normal healthy controls, all right‐handed male veterans between the ages of 23 and 70 years. MRI scans were analyzed using semi‐automated procedure, which allowed the subcortical regions to be segmented into cerebrospinal fluid (CSF) and brain tissue and the cortical regions to be segmented into CSF, gray matter, and white matter. An age regression model was used to examine the effects of alcohol on brain structure, over and above that expected from the normal aging process. The alcoholics exhibited decreased tissue and increased CSF after correcting for aging. In the cortex, there was significant loss of both gray matter and white matter volume. In this sample of alcoholics, no particular cortical region was preferentially affected or spared. Furthermore, brain tissue volume loss increased with advanced age in the alcoholics. In this group of alcoholics there was no relationship between length of illness and age, i.e., the younger alcoholics had as heavy alcohol use histories as did the older alcoholics. Thus, the increased brain tissue loss with advanced age is interpreted as evidence for age‐related increase in brain vulnerability to chronic alcohol abuse.

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Crossref · 10.1111/j.1530-0277.1992.tb00702.x

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Metadata

Authors
Pfefferbaum, A., Lim, K. O., Zipursky, R. B., Mathalon, D. H., Rosenbloom, M. J., Lane, B., Ha, C. N., & Sullivan, E. V.
Venue
Alcoholism: Clinical and Experimental Research
Publisher
Wiley
Published
1992-12
Volume
16
Issue
6
Pages
1078-1089
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
DOI
10.1111/j.1530-0277.1992.tb00702.x
OpenAlex
W2089692573
Cited by
567
References
41
FWCI
8.96
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Brain Gray and White Matter Volume Loss Accelerates with Aging in Chronic Alcoholics: A Quantitative MRI Study. https://app.cochat.ai/papers/10.1111/j.1530-0277.1992.tb00702.x
The paper
Pfefferbaum, A., Lim, K. O., Zipursky, R. B., Mathalon, D. H., Rosenbloom, M. J., Lane, B., Ha, C. N., & Sullivan, E. V. (1992). Brain Gray and White Matter Volume Loss Accelerates with Aging in Chronic Alcoholics: A Quantitative MRI Study. Alcoholism: Clinical and Experimental Research. https://doi.org/10.1111/j.1530-0277.1992.tb00702.x

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.