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Cited by 70Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesGenetic Associations and Epidemiology

Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians

Enoch, Mary‐Anne, Waheed, Juwaria F., Harris, Claudia R., Albaugh, Bernard, Goldman, David·2006·Alcoholism Clinical and Experimental Research
DOI 10.1111/j.1530-0277.2006.00045.x
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Abstract

BACKGROUND: Alcoholism and heavy smoking are highly comorbid and are cotransmitted in the general U.S. population; however little is known about comorbidity in American Indians. The catechol-O-methyltransferase (COMT) functional polymorphism, Val158Met, has been associated with alcoholism in Caucasians. The aims of our study were firstly to investigate patterns of alcohol and tobacco consumption and comorbidity between alcoholism and smoking in Plains American Indians and secondly to determine the influence, including sexual dimorphic effects, of COMT Val158Met and COMT haplotypes, on these behaviors. METHODS: Diagnostic and Statistical Manual-III-R lifetime diagnoses were assigned to 342 community-ascertained Plains American Indians (201 women, 141 men). Lifetime drinking and smoking histories were obtained. Five COMT loci, including Val158Met, were genotyped. Haplotype-based analyses identified 1 block with 3 common haplotypes; 2 included Val158, and 1 had the Met158 allele. RESULTS: The alcoholics drank heavily (12+/-8 drinks/drinking day) but episodically (max 10+/-8 d/mo). Although 62% of male alcoholics and 40% of female alcoholics were smokers (> or =10 cigarettes/d), only 12% of alcoholic men and 8% of alcoholic women smoked heavily (>20/d). In women, the COMT Val158 allele frequency was maximal in alcoholic smokers (0.85), decreasing to 0.74 in nonalcoholic smokers, 0.67 in alcoholic nonsmokers, and 0.64 in nonalcoholic nonsmokers (chi2 = 11.1, 3 df, p = 0.011). Women showed a main effect of Val158 on smoking (p=0.003). Both male and female alcoholics were more likely to have at least 1 Val158 allele compared with nonalcoholics (0.95 vs 0.88, p < 0.05). Approximately 30% of all participants were long-term, nonaddicted light, social smokers (3.6+/-1.7 cigarettes/d); they had the same Val158Met frequencies as nonsmokers. Haplotype analyses supported the Val158Met findings; however, only 1 of the 2 Val158 haplotypes was implicated. CONCLUSIONS: Plains Indians have different smoking and drinking patterns and considerably less comorbidity between alcoholism and heavy smoking compared with the general U.S. population. Our COMT Val158Met results suggest that there may be both sex differences in the genetic origins of alcoholism and smoking in this population and overlap in genetic vulnerability to both addictions in women.

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  • Some data suggest alcoholic sub-phenotypes may associate with specific COMT diplotypes.

    “some data suggest that alcoholic sub-phenotypes may associate with specific COMT diplotypes (Enoch et al., 2006; Kweon et al., 2005; Tiihonen et al., 1999; Wang et al., 2001).”

    From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Enoch et al., 2006

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Authors
Enoch, M., Waheed, J. F., Harris, C. R., Albaugh, B., & Goldman, D.
Affiliations
  • National Institutes of Health (US)
  • Weatherford (United States) (US)
Corresponding author
Enoch, Mary‐Anne
ORCID
Goldman, David
Venue
Alcoholism Clinical and Experimental Research
Publisher
Wiley
Published
2006-02-13
Volume
30
Issue
3
Pages
399-406
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
DOI
10.1111/j.1530-0277.2006.00045.x
OpenAlex
W2023640651
Cited by
70
References
47
Citations by year
2024: 1 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 4 · 2013: 6 · 2012: 8
FWCI
2.91
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
alcoholism, smoking, COMT Val158Met, catechol-O-methyltransferase, sex differences, alcohol consumption patterns, tobacco use, genetic susceptibility, social smoking, Native American health disparities, smoking cessation
MeSH terms
Adult, Alcoholism, Catechol O-Methyltransferase, Female, Genotype, Haplotypes, Humans, Indians, North American, Male, Polymorphism, Genetic, Psychiatric Status Rating Scales, Sex Characteristics, Smoking, Polymorphism, Single Nucleotide, Phosphodiesterase I

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