Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholism
Abstract
Catechol-O-methyltransferase (COMT) is a key modulator of dopaminergic and noradrenergic neurotransmission. There is a functional polymorphism of the COMT gene, Val108Met in the soluble form of the enzyme (Val158Met in the membrane-bound form). Involvement of the dopaminergic systems in alcoholism has been suggested in mice and humans. We examined associations between this polymorphism and alcoholism in 175 Japanese alcoholics and 354 age- and gender-matched Japanese controls. No significant difference in the allelic distributions in alcoholics and controls and no significant associations between antisocial behaviors in alcoholics and this polymorphism were observed. Therefore, the COMT gene is not likely to play a significant role in alcoholism.
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Studies linking COMT to alcoholism are equivocal.
“Studies linking COMT to alcoholism are equivocal (Ishiguro et al., 1999; Kauhanen et al., 2000; Kim et al., 2006; Samochowiec et al., 2006; Sery et al., 2006).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Ishiguro et al., 1999
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Bilder, R. M., Volavka, J., Lachman, H. M., & Grace, A. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300542 · Cited by 769 · see citing works
Impulsivity, frontal lobes and risk for addiction
Crews, F. T., & Boettiger, C. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.018 · Cited by 679 · see citing works
“Studies linking COMT to alcoholism are equivocal (Ishiguro et al., 1999; Kauhanen et al., 2000; Kim et al., 2006; Samochowiec et al., 2006; Sery et al., 2006).”
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- Authors
- lshiguro, H., Shibuya, T. H., Toru, M., Saito, T., & Arinami, T.
- Affiliations
- University of Tsukuba (JP)
- Sapporo Medical University (JP)
- Tokyo Medical and Dental University (JP)
- ORCID
- Saito, T.
- Venue
- Psychiatric Genetics
- Published
- 1999-09
- Volume
- 9
- Issue
- 3
- Pages
- 135-138
- ISSN
- 0955-8829 (ISSN-L)
- OpenAlex
- W2017526555
- Cited by
- 52
- References
- 0
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- catechol-O-methyltransferase, COMT gene, COMT Val158Met polymorphism, alcoholism, genetic association, dopamine signaling, noradrenergic neurotransmission, antisocial behavior, Japanese population
- MeSH terms
- Adult, Aged, Alcoholism, Animals, Catechol O-Methyltransferase, Female, Humans, Japan, Male, Middle Aged, Polymorphism, Genetic, Reference Values, Substance Withdrawal Syndrome, Age of Onset, Amino Acid Substitution, Alcohol-Related Disorders, Asian People, Mice
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