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Alcohol in Moderation, Cardioprotection, and Neuroprotection: Epidemiological Considerations and Mechanistic Studies
Open accessAbstract
In contrast to many years of important research and clinical attention to the pathological effects of alcohol (ethanol) abuse, the past several decades have seen the publication of a number of peer‐reviewed studies indicating the beneficial effects of light‐moderate, nonbinge consumption of varied alcoholic beverages, as well as experimental demonstrations that moderate alcohol exposure can initiate typically cytoprotective mechanisms. A considerable body of epidemiology associates moderate alcohol consumption with significantly reduced risks of coronary heart disease and, albeit currently a less robust relationship, cerebrovascular (ischemic) stroke. Experimental studies with experimental rodent models and cultures (cardiac myocytes, endothelial cells) indicate that moderate alcohol exposure can promote anti‐inflammatory processes involving adenosine receptors, protein kinase C (PKC), nitric oxide synthase, heat shock proteins, and others which could underlie cardioprotection. Also, brain functional comparisons between older moderate alcohol consumers and nondrinkers have received more recent epidemiological study. In over half of nearly 45 reports since the early 1990s, significantly reduced risks of cognitive loss or dementia in moderate, nonbinge consumers of alcohol (wine, beer, liquor) have been observed, whereas increased risk has been seen only in a few studies. Physiological explanations for the apparent CNS benefits of moderate consumption have invoked alcohol’s cardiovascular and/or hematological effects, but there is also experimental evidence that moderate alcohol levels can exert direct “neuroprotective” actions—pertinent are several studies in vivo and rat brain organotypic cultures, in which antecedent or preconditioning exposure to moderate alcohol neuroprotects against ischemia, endotoxin, β‐amyloid, a toxic protein intimately associated with Alzheimer’s, or gp120, the neuroinflammatory HIV‐1 envelope protein. The alcohol‐dependent neuroprotected state appears linked to activation of signal transduction processes potentially involving reactive oxygen species, several key protein kinases, and increased heat shock proteins. Thus to a certain extent, moderate alcohol exposure appears to trigger analogous mild stress‐associated, anti‐inflammatory mechanisms in the heart, vasculature, and brain that tend to promote cellular survival pathways.
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“a protective effect of light to moderate drinking has some biological plausibility 212, but evidence on this is inconsistent.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [212]
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Cited by
Sorted by citations
The relationship between different dimensions of alcohol use and the burden of disease—an update
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The relation between different dimensions of alcohol consumption and burden of disease: an overview
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Natural products as a source of Alzheimer's drug leads
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Neuroinflammation, Neurodegeneration, and Depression
Hurley, L. L., & Tizabi, Y. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9348-1 · Cited by 268
“Epidemiological studies show trends that light to moderate drinkers have reduced risk of dementia and cognitive decline in comparison to non-drinkers (reviewed Collins et al. 2009).”
BackgroundResveratrol in cardiovascular health and disease
Petrovski, G., Gurusamy, N., & Das, D. K. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05843.x · Cited by 232
Self-citationEthanol and Cognition: Indirect Effects, Neurotoxicity and Neuroprotection: A Review
Brust, J. C. M. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041540 · Cited by 240
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BackgroundMitochondrial aldehyde dehydrogenase and cardiac diseases
Chen, C., Sun, L., & Mochly‐Rosen, D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq192 · Cited by 207
Moderate alcohol consumption and cognitive risk
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Self-citationUp-Regulation of MicroRNAs in Brain of Human Alcoholics
Lewohl, J. M., Núnez, Y. O., Dodd, P. R., Tiwari, G. R., Harris, R. A., & Mayfield, R. D. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01544.x · Cited by 196
“Interestingly, there is growing body of evidence describing a neuroprotective role for moderate alcohol drinking that significantly reduces the risk of either cognitive decline or dementia, including Alzheimer’s disease (Collins et al., 2009).”
BackgroundStetler, R. A., Leak, R. K., Gan, Y., Li, P., Zhang, F., Hu, X., Zheng, J., Chen, J., Zigmond, M. J., & Gao, Y. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.005 · Cited by 191
Alcohol consumption and cognitive decline in early old age
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The Role of Phytochemicals in the Treatment and Prevention of Dementia
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Resveratrol and Alzheimer’s Disease: Mechanistic Insights
Ahmed, T., Javed, S., Javed, S., Tariq, A., Šamec, D., Tejada, S., Nabavi, S. F., Braidy, N., & Nabavi, S. M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9839-9 · Cited by 183
“SIRT1 is even activated by orally administration of resveratrol [100, 101], and this is in agreement with the reports that moderate consumption of red wine has neuroprotective effects; a major constituent of red wine is resveratrol, and the neuroprotective effect exerted by red wine consumption is due to antioxidative…”
BackgroundGoetzel, R. Z., Pei, X., Tabrizi, M. J., Henke, R. M., Kowlessar, N. M., Nelson, C. F., & Metz, R. D. (2012) · Health Affairs · doi:10.1377/hlthaff.2011.0819 · Cited by 183
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Postural Instability in Parkinson’s Disease: A Review
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InfluentialSelf-citationMedicinal Plants and Dementia Therapy: Herbal Hopes for Brain Aging?
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“Longitudinal and cohort studies (19 studies over a 10 yr period) and 25 cross-sectional or case-control studies show over half of the risk factors for cognitive decline or dementia were lower in moderate consumers of alcohol compared with abstainers [147].”
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“Lactate plays a crucial role in injury and disease, and some researchers have suggested the consumption of alcohol in moderation, though not a viable treatment option due to its risk of addiction, since it is the greatest possible source of lactate from our daily diet [108].”
BackgroundDiet and Kidney Disease in High-Risk Individuals With Type 2 Diabetes Mellitus
Dunkler, D. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.9051 · Cited by 144
Alcohol and Cognition in the Elderly: A Review
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Alcohol Consumption, Blood Pressure, and the Risk of Stroke
Hillbom, M., Saloheimo, P., & Juvela, S. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0194-y · Cited by 133
“However, several other biologic effects of alcohol have been suggested to contribute to the decreased incidence of IS in moderate drinkers, including elevated HDL cholesterol, lowered fibrinogen levels, impaired primary hemostasis, better endothelial function, and some anti-inflammatory actions of alcohol [11].”
BackgroundMetabolic links between diabetes and Alzheimer’s disease
Maher, P. A., & Schubert, D. R. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.18 · Cited by 122
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Klatsky, A. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.12.019 · Cited by 103
Costanzo, S., Castelnuovo, A. F. D., Donati, M. B., Iacoviello, L., & de Gaetano, G. (2010) · Circulation · doi:10.1161/circulationaha.109.865840 · Cited by 103
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Nutritional Risk Factors, Microbiota and Parkinson’s Disease: What Is the Current Evidence?
Boulos, C., Yaghi, N., El Hayeck, R., Heraoui, G. N., & Fakhoury-Sayegh, N. (2019) · Nutrients · doi:10.3390/nu11081896 · Cited by 109
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Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors
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The Good, the Bad, and the Ugly with Alcohol Use and Abuse on the Heart
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“It also decreases low-density lipoprotein (LDL) oxidation and platelet aggregation (Collins et al., 2009; El-Mas et al., 2011; Krenz and Korthuis, 2012).”
InfluentialVetrano, D., Landi, F., Buyser, S. D. D., Carfì, A., Zuccalà, G., Petrovic, M., Volpato, S., Cherubini, A., Corsonello, A., Bernabei, R., et al. (2014) · European journal of internal medicine · doi:10.1016/j.ejim.2013.08.709 · Cited by 76
“Physical performance,measuredwith the speed of gait, has previously been associated to LOS and other relevant outcomes in geriatric patients admitted to acute care services and in the community [29-40].”
BackgroundPositive and Negative Effects of Alcohol and Nicotine and Their Interactions: A Mechanistic Review
Hurley, L. L., Taylor, R. E., & Tizabi, Y. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9275-6 · Cited by 83
Alcohol and cardiovascular diseases
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Pretreatment Alcohol Drinking Goals are Associated with Treatment Outcomes
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“However, alcohol is unique from other drugs of abuse because it can be consumed legally, it bears large cultural significance, and it may, in small and controlled quantities, even yield health benefits (Collins et al., 2009; Nova et al., 2012).”
BackgroundAlcohol Consumption and Cardiovascular Risk: Mechanisms of Action and Epidemiologic Perspectives
Castelnuovo, A. F. D., Costanzo, S., di Giuseppe, R., de Gaetano, G., & Iacoviello, L. (2009) · Future Cardiology · doi:10.2217/fca.09.36 · Cited by 76
“Epidemiologic evidence In spite of the fact that the healthy effect of moderate intake of alcohol is by now well accepted [75,76], important issues remain to be discussed regarding the relationship between alcohol and CVD.”
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“While many studies have indicated that modest daily intake of alcohol may have health benefits (Collins et al. 2009, for review), excessive alcohol consumption is known to result in a variety of serious health problems, including alcoholic liver disease (Mutlu et al. 2009; Mutlu et al. 2012),…”
BackgroundAlcoholic and Cocaine-Associated Cardiomyopathies
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“Despite the fact that the healthy effect of moderate intake of alcohol is by now well accepted [12, 41]; important issues remain to be discussed about the relationship between alcohol and CVD, including the possible effect of confounding, the differences in types of alcoholic beverages, the optimal amount of alcohol i…”
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Reas, E. T., Laughlin, G. A., Kritz‐Silverstein, D. C., Barrett-Connor, E. L., & McEvoy, L. K. (2016) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2016.89 · Cited by 59
Alcohol intake and brain structure in a multiethnic elderly cohort
Gu, Y., Scarmeas, N., Short, E. E., Luchsinger, J. A., DeCarli, C. S., Stern, Y., Manly, J. J., Schupf, N., Mayeux, R. P., & Brickman, A. M. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.08.004 · Cited by 58
“The mechanism for the potential beneficial effect of light-to-moderate alcohol intake on TBV is unknown, but it might be due to alcohol’s functions on reduction of inflammation; reduction of low-density lipoprotein and increase of high-density lipoprotein; reduction of insulin resistance and increase in insulin sensit…”
Collins, M. A., Neafsey, E. J., Wang, K., Achille, N. J., Mitchell, R. M., & Sivaswamy, S. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8138-0 · Cited by 59
“Preconditioning-dependent protection by alcohol (ethanol) against ischemic insult of the heart is supported by a range of studies [5, 6], such that the phenomenon is considered a likely component of cardioprotection in moderate alcohol consumers [7].”
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“This protection appears linked to signal transduction activation processes potentially involving ROS, several key protein kinases, and increased heat shock proteins [112].”
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“However, a moderate alcohol intake may be protective of cochlear blood flow [61], promoting cytoprotective and anti-inflammatory mechanisms that strengthen cellular survival pathways, and directly enhance neuroprotective mechanisms that preserve hearing [62].”
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Relationship of Wine Consumption with Alzheimer’s Disease
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“reported a J-shaped relationship between alcohol intake and cognitive decline in patients with mild cognitive impairment, and showed that high consumption of alcoholic beverages as well as complete abstention increase the risk of dementia, and that light–moderate alcohol drinking may be associated with a decreased ris…”
BackgroundHajj, E. C. E., Hajj, M. C. E., Voloshenyuk, T. G., Mouton, A. J., Khoutorova, E., Molina, P. E., Gilpin, N. W., & Gardner, J. D. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12239 · Cited by 52
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“that RSV in particular acts on estrogen receptor beta which has a major function in the cognitive processes, so by binding of RSV to estrogen receptor beta, this results in improvement of cognitive impairment which results from AD [10].”
BackgroundDiet and Neurocognition: Review of Evidence and Methodological Considerations
Smith, P. J., & Blumenthal, J. A. (2010) · Current Aging Science · doi:10.2174/1874609811003010057 · Cited by 50
“Despite these positive findings and plausible physiological mechanisms , the available evidence must be interpreted cautiously due to potential sampling bias and differences across observational studies [82, 86, 87].”
BackgroundSong, B., Akbar, M. D., Jo, I., Hardwick, J. P., & Abdelmegeed, M. A. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.002 · Cited by 51
Geng, X., Fu, P., Ji, X., Peng, C., Fredrickson, V. L., Sy, C. A., Meng, R., Ling, F., Du, H., Tan, X., et al. (2013) · Stroke · doi:10.1161/strokeaha.111.000315 · Cited by 48
“Epidemiological studies have suggested a role for ethanol as a potential neuroprotectant in stroke.(18,19) We previously demonstrated that 1.”
BackgroundRetractedAlcohol intake and brain white matter in middle aged men: microscopic and macroscopic differences
McEvoy, L. K., Fennema-Notestine, C., Elman, J. A., Eyler, L. T., Franz, C. E., Hagler, D. J., Hatton, S. N., Lyons, M. J., Panizzon, M. S., Dale, A. M., et al. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.02.006 · Cited by 41
“properties (Collins et al., 2009; Crews and Nixon, 2009); however, CRP levels did not differ across groups.”
InfluentialSliwowska, J. H., Barker, J. M., Barha, C. K., Lan, N., Weinberg, J., & Galea, L. A. M. (2010) · Stress · doi:10.3109/10253890903531582 · Cited by 46
“Interestingly, a number of studies examining effects of alcohol consumption in adulthood have shown that alcohol in moderation (not, more than 2 drinks/day) may have cardioprotective and neuroprotective effects (Collins et al. 2009).”
BackgroundAlcohol consumption, drinking patterns, and cognitive function in older Eastern European adults
Horvat, P., Richards, M., Kubínová, R., Pająk, A., Malyutina, S. K., Shishkin, S. V., Pikhart, H., Peasey, A., Marmot, M. G., Singh‐Manoux, A., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000001164 · Cited by 46
“Most observational studies report moderate drinking to be beneficial for cognitive function in mid- to later life(2) with anti-inflammatory effects postulated among the underlying mechanisms.(25) Consistent with this, we observed significantly better cognitive scores in moderate drinkers than low-level drinkers in wom…”
BackgroundAlcohol as a risk factor for hearing loss: A systematic review and meta-analysis
Qian, P., Zhao, Z., Liu, S., Xin, J., Liu, Y., Hao, Y., Wang, Y., & Yang, L. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280641 · Cited by 40
“However, moderate alcohol intake may be protective against cochlear blood flow [58], promoting cytoprotection, and directly enhancing neuroprotective mechanisms that preserve hearing [59].”
BackgroundMetabolic determinants of white matter hyperintensity burden in patients with ischemic stroke
Cloonan, L. K., Fitzpatrick, K. M., Kanakis, A. S., Furie, K. L., Rosand, J. M., & Rost, N. S. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.02.052 · Cited by 40
“Alcohol has a known effect on the endothelium, which can be either protective [33,34]or detrimental [35,36].”
BackgroundAlcohol and wine in relation to cancer and other diseases
Giacosa, A., Adam‐Blondon, A., Baer-Sinnott, S., Barale, R., Bavaresco, L., Gaspero, G. D., Dugo, L., Ellison, R. C., Gerbi, V., Gifford, D., et al. (2011) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e32834761d3 · Cited by 40
“, 2004) as well as neuroprotection (Collins et al., 2009) and may increase longevity of life (Farchi et al.”
BackgroundThe factors contributing to cognitive dysfunction in type 2 diabetic patients
Xia, S.-S., Xia, W.-L., Huang, J., Zou, H., Tao, J., & Yang, Y. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2019.12.113 · Cited by 43
“Moderate drinking has potential benefits for cognitive performance, Alzheimer’s disease and other dementias, with unknown mechanisms (30,31).”
BackgroundHarmful and beneficial relationships between alcohol consumption and subclinical atherosclerosis
Kim, M. K., Shin, J., Kweon, S., Shin, D. H., Lee, Y.-H., Chun, B., & Choi, B. Y. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.02.004 · Cited by 40
Evidence triangulation in health research
Gutierrez, S., Glymour, M. M., & Smith, G. D. (2025) · European Journal of Epidemiology · doi:10.1007/s10654-024-01194-6 · Cited by 52
“Much of this debate stems from earlier research studies suggesting a potential beneficial effect of light-to-moderate alcohol consumption (compared to no alcohol consumption) on cardiovascular disease, a known risk factor for dementia [51, 52].”
Prospective study of alcohol consumption and self-reported hearing loss in women
Curhan, S. G., Eavey, R. D., Wang, M., Stampfer, M. J., & Curhan, G. C. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.10.001 · Cited by 39
“Alcohol intake may protect cochlear blood flow (Seidman, Quirk, & Shirwany, 1999), promote cytoprotective and anti-inflammatory mechanisms that strengthen cellular survival pathways, and directly enhance neuroprotective mechanisms that preserve hearing (Collins et al., 2009).”
BackgroundEarly changes to oxidative stress levels following exposure to formaldehyde in ICR mice
Matsuoka, T., Takaki, A., Ohtaki, H., & Shioda, S. (2010) · The Journal of Toxicological Sciences · doi:10.2131/jts.35.721 · Cited by 38
“Other studies have shown that increased stress responses result in the protection of host organs and tissues from lethal stress- es (Collins et al., 2009; Pong, 2004; Zhao, 2007).”
BackgroundThe role of microglia in ischemic preconditioning
McDonough, A., & Weinstein, J. R. (2019) · Glia · doi:10.1002/glia.23695 · Cited by 39
“Rapid preconditioning has been best described in response to anesthetics such as isoflurane (de Klaver, Manning, Palmer, & Rich, 2002) as well as solvents such as dimethyl sulfoxide (Nakamuta et al., 2001) and ethanol (reviewed in Collins et al. (2009)).”
BackgroundFathi, R., Nasiri, K., Akbari, A., گلزار, ف. ا. ک., & Farajtabar, Z. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117958 · Cited by 38
Dose-Related Influence of Chronic Alcohol Consumption on Cerebral Ischemia/Reperfusion Injury
Zhao, H., Mayhan, W. G., Arrick, D. M., Xiong, W., & Sun, H. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01461.x · Cited by 41
“N IH -PA Author M anuscript N IH -PA Author M anuscript Kaste, 1983), whereas light-moderate consumption of alcohol reduces the morbidity of ischemic stroke (Collins et al., 2009; Gill et al., 1986).”
BackgroundMasuo, Y., Imai, T., Shibato, J., Hirano, M., Jones, O. A. H., Maguire, M. L., Satoh, K., Kikuchi, S., & Rakwal, R. (2009) · Electrophoresis · doi:10.1002/elps.200900045 · Cited by 38
Voluptuary habits and clinical subtypes of Parkinson's disease: The FRAGAMP case–control study
Nicoletti, A. S. Q., Pugliese, P., Nicoletti, G., Arabia, G., Annesi, G., Mari, M. D., Lamberti, P., Grasso, L., Marconi, R., Epifanio, A., et al. (2010) · Movement Disorders · doi:10.1002/mds.23297 · Cited by 38
“The alcohol-dependent neuroprotected state appears linked to activation of signal transduction processes potentially involving reactive oxygen species, several key protein kinases, and increased heat shock proteins.(24)”
BackgroundEthanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage
Bate, C., & Williams, A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.030 · Cited by 38
“Since some epidemiological studies suggest that the moderate consumption of alcohol protects against the development of AD (Collins et al., 2009; Mukamal et al., 2003; Stampfer et al., 2005) the effects of ethanol on cultured neurons were examined.”
Use of Out-of-Hospital Ethanol Administration to Improve Outcome in Mass Methanol Outbreaks
Zakharov, S., Pelclová, D., Urban, P., Navrátil, T., Nurieva, O., Kotikova, K., Diblík, P., Kurcová, I., Běláček, J., Komarc, M., et al. (2016) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2016.01.010 · Cited by 35
Drinking Patterns of Older Adults with Chronic Medical Conditions
Ryan, M., Merrick, E. L., Hodgkin, D., Horgan, C. M., Garnick, D. W., Panas, L., Ritter, G. A., Blow, F. C., & Saitz, R. (2013) · Journal of General Internal Medicine · doi:10.1007/s11606-013-2409-1 · Cited by 33
Physicochemical Properties and Antioxidant Activity of Portuguese Craft Beers and Raw Materials
Silva, S., Oliveira, A. I., Cruz, A., Oliveira, R. F., Almeida, R., & Pinho, C. (2022) · Molecules · doi:10.3390/molecules27228007 · Cited by 32
Chronic depression as a model disease for cerebral aging
Bewernick, B. H., & Schlaepfer, T. E. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/bbewernick · Cited by 31
Toxic Effects of Low Alcohol and Nicotine Combinations in SH-SY5Y Cells are Apoptotically Mediated
Ramlochansingh, C., Taylor, R. E., & Tizabi, Y. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9239-x · Cited by 32
“Recent evidence indicates that at a low or moderate level, consumption of alcohol may have a variety of health benefits including cardiovascular and/or neuroprotection (Collins et al. 2009).”
Associated factors of white matter hyperintensity volume: a machine-learning approach
Grosu, S., Rospleszcz, S., Hartmann, F., Habes, M., Bamberg, F., Schlett, C. L., Galiè, F., Lorbeer, R., Auweter, S., Selder, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81883-4 · Cited by 32
Wang, T., Chou, D. Y.-T., Ding, J. Y., Fredrickson, V. L., Peng, C., Schafer, S., Guthikonda, M., Kreipke, C. W., Rafols, J. A., & Ding, Y. (2012) · Journal of neurosurgery · doi:10.3171/2012.8.jns12736 · Cited by 31
Qi, S., Liu, Y. U., Hao, L.-Y., Guan, Q.-H., Gu, Y.-H., Zhang, J., Yan, H. M., Wang, M., & Zhang, G.-Y. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.018 · Cited by 29
Nutraceutical strategies for ameliorating the toxic effects of alcohol
McCarty, M. F. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2012.12.040 · Cited by 29
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Activation of Cardiac Fibroblasts by Ethanol Is Blocked by TGF ‐β Inhibition
Law, B. A., & Carver, W. E. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12111 · Cited by 28
“Though light to moderate use of alcohol has been shown to be cardioprotective, chronic consumption results in detrimental damage to most organs including the heart (Collins et al., 2009).”
BackgroundCasañas‐Sánchez, V., Pérez, J. A. P., Quinto‐Alemany, D., & Díaz, M. L. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00312 · Cited by 29
“…HSP70) upon ROS generation, and that HSP-dependent protection is intimately associated to selective protein kinase C (PKCα and PKCδ) and FAK (focal adhesion kinase) activation, NOS (nitric oxide synthase), the focal adhesion complex, and stabilization of the cytoskeleton (Collins et al., 2009).”
BackgroundKok, E., Karppinen, T. T., Luoto, T. M., Alafuzoff, I. I., & Karhunen, P. J. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13102 · Cited by 27
Alcohol Consumption and Risk of All-Cause and Cardiovascular Disease Mortality in Men
Howie, E. K., Sui, X., Lee, D.-C., Hooker, S. P., Hébert, J. R., & Blair, S. N. (2011) · Journal of Aging Research · doi:10.4061/2011/805062 · Cited by 27
“Several hypotheses exist for the mechanism of this protective effect including increased exposure to antioxidants, improved lipid profiles, reduced insulin resistance, decreased blood coagulation, and modified inflammation pathways [11, 12].”
Godfrey, J., Jeanguenin, L., Castro, N., Olney, J. J., Dudley, J., Pipkin, J. A., Walls, S. M., Wang, W., Herr, D. R., Harris, G. L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139012 · Cited by 27
“The relationship between ethanol consumption and adverse cardiovascular and neurological outcomes exhibits a J-shaped or Ushaped curve, with light to moderate drinking associated with decreased risk compared to abstinence, while high levels of alcohol consumption confer increased risk [3,34,38].”
BackgroundXie, J. R., Tian, X., He, S., Wei, Y., Peng, B., & Wu, Z. (2018) · Molecules · doi:10.3390/molecules23061239 · Cited by 27
“Previous studies have shown that light to moderate alcohol consumption can exert a series of protective effects [1].”
BackgroundWu, W. (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000521 · Cited by 26
The role of sphingolipids in psychoactive drug use and addiction
Kalinichenko, L. S., Gulbins, E., Kornhuber, J., & Müller, C. P. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1840-1 · Cited by 26
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“Some experimental studies further suggest that ethanol may directly affect brain structure [41,42].”
Peana, A. T., Bassareo, V., & Acquas, E. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00051-9 · Cited by 25
Acute administration of ethanol reduces apoptosis following ischemic stroke in rats
Fu, P., Peng, C., Ding, J. Y., Asmaro, K. P., Sullivan, J. M., Guthikonda, M., & Ding, Y. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.02.011 · Cited by 25
“Recent studies have uncovered a surprising correlation between alcohol and neuroprotection (Collins et al., 2009; Salim et al., 2009; Tien et al., 2006).”
BackgroundA Virtue Analysis of Recreational Marijuana Use
Sullivan, E., & Austriaco, N. P. G. (2016) · The Linacre Quarterly · doi:10.1080/00243639.2015.1125083 · Cited by 24
Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3
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“Moderate to low EtOH (two drinks for men and one for women) may reduce stress and increase feelings of well-being with some beneficial effects on cardiovascular and neuronal systems (Collins et al. 2008, 2010; Tizabi et al. 2018).”
Metadata
- Authors
- Collins, M. A., Neafsey, E. J., Mukamal, K. J., Gray, M. O., Parks, D. A., Das, D. K., & Korthuis, R. J.
- Affiliations
- San Francisco General Hospital (US)
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2009-01-22
- Volume
- 33
- Issue
- 2
- Pages
- 206-219
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC2908373
- OpenAlex
- W2111348890
- Cited by
- 235
- References
- 128
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 7 · 2020: 9 · 2019: 16 · 2018: 9 · 2017: 13 · 2016: 14 · 2015: 11 · 2014: 17 · 2013: 24 · 2012: 16
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01aa011723-03)
- National Institute on Alcohol Abuse and Alcoholism (R01AA013568, AA 11135, AA014945, R01AA011135, R01AA014945, AA013568, AA 13361, AA 011723, F31AA013361)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK043785)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- moderate drinking, cardioprotection, neuroprotection, coronary artery disease, ischemic stroke, dementia, cognitive decline, anti-inflammatory mechanism, adenosine receptors, protein kinase C, nitric oxide synthase, heat shock proteins, cerebral ischemia, amyloid-beta, gp120, reactive oxygen species, signal transduction
- MeSH terms
- Resveratrol, Alcohol Drinking, Ethanol, Animals, Antioxidants, Cardiotonic Agents, Cardiovascular Diseases, Central Nervous System Depressants, Dementia, Humans, Nitric Oxide, Protein Kinase C, Stilbenes, Neuroprotective Agents
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