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Altered White Matter Integrity in Adolescent Binge Drinkers
Open accessAbstract
Background: White matter integrity has been found to be compromised in adult alcoholics, but it is unclear when in the course of alcohol exposure white matter abnormalities become apparent. This study assessed microstructural white matter integrity among adolescent binge drinkers with no history of an alcohol use disorder. Methods: We used diffusion tensor imaging to examine fractional anisotropy (FA), a measure of directional coherence of white matter tracts, among teens with ( n = 14) and without ( n = 14) histories of binge drinking but no history of alcohol use disorder, matched on age, gender, and education. Results: Binge drinkers had lower FA than controls in 18 white matter areas (clusters ≥27 contiguous voxels, each with p < 0.01) throughout the brain, including the corpus callosum, superior longitudinal fasciculus, corona radiata, internal and external capsules, and commissural, limbic, brainstem, and cortical projection fibers, while exhibiting no areas of higher FA. Among binge drinkers, lower FA in 6 of these regions was linked to significantly greater lifetime hangover symptoms and/or higher estimated peak blood alcohol concentrations. Conclusions: Binge drinking adolescents demonstrated widespread reductions of FA in major white matter pathways. Although preliminary, these results could indicate that infrequent exposure to large doses of alcohol during youth may compromise white matter fiber coherence.
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“Two independent research groups found that binge-drinking adolescents—compared to controls—had lower FA (Badsberg Jensen & Pakkenberg, 1993; McQueeny et al., 2009).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as McQueeny et al., 2009
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“Two independent research groups found that binge-drinking adolescents—compared to controls—had lower FA (Badsberg Jensen & Pakkenberg, 1993; McQueeny et al., 2009).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as McQueeny et al., 2009
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Metadata
- Authors
- McQueeny, T., Schweinsburg, B. C., Schweinsburg, A. D., Jacobus, J., Bava, S., Frank, L. R., & Tapert, S. F.
- Affiliations
- San Diego State University (US)
- Corresponding author
- Tapert, Susan F.
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2009-06-22
- Volume
- 33
- Issue
- 7
- Pages
- 1278-1285
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC2825379
- OpenAlex
- W2060375736
- Cited by
- 266
- References
- 63
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 10 · 2021: 12 · 2020: 15 · 2019: 16 · 2018: 17 · 2017: 15 · 2016: 12 · 2015: 26 · 2014: 30 · 2013: 36 · 2012: 16
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01 AA13419, R01AA013419)
- National Institute of Mental Health (R01MH064729, R01 MH64729)
- National Institute on Drug Abuse (R01DA021182)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- adolescent binge drinking, white matter integrity, fractional anisotropy, alcohol exposure, corpus callosum, superior longitudinal fasciculus, corona radiata, internal capsule, external capsule, peak blood alcohol concentration, diffusion tensor imaging
- MeSH terms
- Adolescent, Age Factors, Ethanol, Brain, Female, Humans, Male, Nerve Fibers, Myelinated, Diffusion Magnetic Resonance Imaging, Young Adult
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