Structural maturation of neural pathways in children and adolescents: in vivo study
Abstract
Structural maturation of fiber tracts in the human brain, including an increase in the diameter and myelination of axons, may play a role in cognitive development during childhood and adolescence. A computational analysis of structural magnetic resonance images obtained in 111 children and adolescents revealed age-related increases in white matter density in fiber tracts constituting putative corticospinal and frontotemporal pathways. The maturation of the corticospinal tract was bilateral, whereas that of the frontotemporal pathway was found predominantly in the left (speech-dominant) hemisphere. These findings provide evidence for a gradual maturation, during late childhood and adolescence, of fiber pathways presumably supporting motor and speech functions.
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White matter volume increase is linear during the second decade of life, decelerating into adulthood.
“By many accounts, this increase is linear during the second decade of life, decelerating into adulthood (Giedd et al., 1999; Ostby et al., 2009; Paus et al., 1999).”
From The social brain in adolescence: evidence from functional magnetic resonance imaging and behavioural studies (2011) · cites this paper as Paus et al., 1999
White matter volume and density increase across the brain.
“Secondly, white matter volume and density increase across the brain.”
From The social brain in adolescence: evidence from functional magnetic resonance imaging and behavioural studies (2011) · cites this paper as Paus et al., 1999
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- Authors
- Paus, T., Zijdenbos, A., Worsley, K., Collins, D. L., Blumenthal, J., Giedd, J. N., Rapoport, J. L., & Evans, A. C.
- Affiliations
- Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.
- Montreal Neurological Institute and Hospital (CA)
- National Institutes of Health (US)
- Venue
- Science
- Published
- 1999-03-19
- Volume
- 283
- Issue
- 5409
- Pages
- 1908-1911
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089127919
- Cited by
- 1,322
- References
- 42
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 15 · 2023: 40 · 2022: 26 · 2021: 30 · 2020: 39 · 2019: 28 · 2018: 42 · 2017: 46 · 2016: 63 · 2015: 58 · 2014: 55 · 2013: 96 · 2012: 56
- FWCI
- 35.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- white matter maturation, corticospinal tract, fiber tracts, myelination, axon diameter, cognitive development, children, adolescents, hemispheric lateralization, motor function, structural MRI
- MeSH terms
- Adolescent, Aging, Axons, Brain, Brain Mapping, Child, Child, Preschool, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Motor Skills, Myelin Sheath, Nerve Fibers, Neural Conduction, Neural Pathways, Synaptic Transmission, Regression Analysis, Speech, Spinal Cord, Temporal Lobe
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