Cited by 1,322Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesNeural and Behavioral Psychology Studies

Structural maturation of neural pathways in children and adolescents: in vivo study

Paus, Tomáš, Zijdenbos, Alex, Worsley, Keith, Collins, D. Louis, Blumenthal, Jonathan, Giedd, Jay N., Rapoport, Judith L., Evans, Alan C.·1999·Science

Abstract

Structural maturation of fiber tracts in the human brain, including an increase in the diameter and myelination of axons, may play a role in cognitive development during childhood and adolescence. A computational analysis of structural magnetic resonance images obtained in 111 children and adolescents revealed age-related increases in white matter density in fiber tracts constituting putative corticospinal and frontotemporal pathways. The maturation of the corticospinal tract was bilateral, whereas that of the frontotemporal pathway was found predominantly in the left (speech-dominant) hemisphere. These findings provide evidence for a gradual maturation, during late childhood and adolescence, of fiber pathways presumably supporting motor and speech functions.

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Crossref · 10.1126/science.283.5409.1908

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Authors
Paus, T., Zijdenbos, A., Worsley, K., Collins, D. L., Blumenthal, J., Giedd, J. N., Rapoport, J. L., & Evans, A. C.
Affiliations
  • Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.
  • Montreal Neurological Institute and Hospital (CA)
  • National Institutes of Health (US)
Venue
Science
Published
1999-03-19
Volume
283
Issue
5409
Pages
1908-1911
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2089127919
Cited by
1,322
References
42
Citations by year
2026: 11 · 2025: 21 · 2024: 15 · 2023: 40 · 2022: 26 · 2021: 30 · 2020: 39 · 2019: 28 · 2018: 42 · 2017: 46 · 2016: 63 · 2015: 58 · 2014: 55 · 2013: 96 · 2012: 56
FWCI
35.70
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
white matter maturation, corticospinal tract, fiber tracts, myelination, axon diameter, cognitive development, children, adolescents, hemispheric lateralization, motor function, structural MRI
MeSH terms
Adolescent, Aging, Axons, Brain, Brain Mapping, Child, Child, Preschool, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Motor Skills, Myelin Sheath, Nerve Fibers, Neural Conduction, Neural Pathways, Synaptic Transmission, Regression Analysis, Speech, Spinal Cord, Temporal Lobe

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