The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Anemia Is Associated with Disability and Decreased Physical Performance and Muscle Strength in the Elderly
Abstract
Objectives: To examine the association between anemia and disability, physical performance, and muscle strength in older persons. Design: Cross‐sectional. Setting: Community‐dwelling older persons in the Chianti area in Italy. Participants: A total of 1,156 persons aged 65 and older participating in the InChianti Study (“Invecchiare in Chianti,” i.e., Aging in the Chianti Area). Measurements: Anemia was defined according to World Health Organization criteria as a hemoglobin concentration below 12 g/dL in women and below 13 g/dL in men. Disability in six basic and eight instrumental activities of daily living was assessed. Physical performance was assessed using the short physical performance battery (4‐m walk, balance, and chair stands), which yields a summary performance score ranging from 0 to 12 (high). Muscle strength was determined using knee extensor and handgrip strength assessments. Results: Overall, 11.1% of the men and 11.5% of the women had anemia. After adjustment for age, sex, body mass index, Mini‐Mental State Examination score, creatinine level, and presence of various comorbid conditions, anemic persons had more disabilities (1.71 vs 1.04, P =.002) and poorer performance (8.8 vs 9.6, P =.003) than persons without anemia. Anemic persons also had significantly lower knee extensor strength (14.1 vs 15.2 kg, P =.02) and lower handgrip strength (25.3 vs 27.1 kg, P =.04) than persons without anemia. Further adjustment for inflammatory markers (interleukin‐6, C‐reactive protein, tumor necrosis factor‐α) did not change these associations. Conclusion: Anemia is associated with disability, poorer physical performance, and lower muscle strength. Further research should explore whether treating anemia has a beneficial effect on the functional status of older persons.
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Self-citationLower-extremity function in persons over the age of 70 years as a predictor of subsequent disability
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HIF-1α is essential for myeloid cell-mediated inflammation
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Self-citationSerum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency
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Serum IL‐6 Level and the Development of Disability in Older Persons
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Self-citationFerrucci, L., Penninx, B. W. J. H., Volpato, S., Harris, T. B., Bandeen‐Roche, K., Balfour, J., Leveille, S. G., Fried, L. P., & Md, J. M. G. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50605.x · Cited by 618
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Anemia at older age: etiologies, clinical implications, and management
Stauder, R., Valent, P., & Theurl, I. (2018) · Blood · doi:10.1182/blood-2017-07-746446 · Cited by 479
Impact of anemia on hospitalization and mortality in older adults
Culleton, B. F., Manns, B. J., Zhang, J., Tonelli, M., Klarenbach, S., & Hemmelgarn, B. R. (2006) · Blood · doi:10.1182/blood-2005-10-4308 · Cited by 455
Inflammatory Markers and Incident Mobility Limitation in the Elderly
Penninx, B. W. J. H., Kritchevsky, S. B., Newman, A. B., Nicklas, B. J., Simonsick, E. M., Rubin, S., Nevitt, M., Visser, M., Harris, T., & Pahor, M. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52308.x · Cited by 326
Self-citationCesari, M., Fielding, R. A., Pahor, M., Goodpaster, B., Hellerstein, M., Van Kan, G. A., Anker, S. D., Rutkove, S., Vrijbloed, J. W., Isaac, M., et al. (2012) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-012-0078-2 · Cited by 285
Self-citationEndocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221
Metadata
- Authors
- Penninx, B. W. J. H., Pahor, M., Cesari, M., Corsi, A. M., Woodman, R. C., Bandinelli, S., Guralnik, J. M., & Ferrucci, L.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2004-04-14
- Volume
- 52
- Issue
- 5
- Pages
- 719-724
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1809229150
- Cited by
- 566
- References
- 30
- FWCI
- 11.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Penninx, B. W. J. H., Pahor, M., Cesari, M., Corsi, A. M., Woodman, R. C., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2004). Anemia Is Associated with Disability and Decreased Physical Performance and Muscle Strength in the Elderly. Journal of the American Geriatrics Society. https://doi.org/10.1111/j.1532-5415.2004.52208.x
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