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Cited by 249Balance, Gait, and Falls PreventionFrailty in Older AdultsNutrition and Health in Aging

The DOI matches its Crossref record; 26 of the 28 references it cites were found in a registry or an index.

Knee Extension Strength Cutpoints for Maintaining Mobility

Manini, Todd M., Visser, Marjolein, Won‐Park, Seok, Patel, Kushang V., Strotmeyer, Elsa S., Chen, Hepei, Goodpaster, Bret, De Rekeneire, Nathalie, Newman, Anne B., Simonsick, Eleanor M., Kritchevsky, Stephen B., Ryder, Kathy, Schwartz, Ann V., Harris, Tamara B.·2007·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.2007.01087.x
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Abstract

OBJECTIVES: To identify levels of knee extensor strength that are associated with high and low risk of incident severe mobility limitation (SML) in initially well‐functioning older adults. DESIGN: Prospective cohort study. SETTING: University clinic center. PARTICIPANTS: One thousand three hundred fifty‐five men and 1,429 women (aged 73.6±2.85) who reported no mobility limitation. MEASUREMENTS: Unilateral knee extensor isokinetic strength of participants was obtained. Participants were followed over a median of 5.90 years for the onset of SML, defined as two consecutive reports of a lot of difficulty or inability to walk one‐quarter of a mile or climb 10 steps. Deciles of knee extension strength relative to body weight were evaluated to identify cutpoints most predictive of incident SML. Cutpoints were then compared with prevalence of having slow gait speed (<1.22 m/s) and mortality. RESULTS: Two sex‐specific knee extension strength cutpoints were found. High and low risk of SML corresponded to less than 1.13 newton‐meters (Nm)/kg (1st decile) and more than 1.71 Nm/kg (6th decile) in men and less than 1.01 Nm/kg (3rd decile) and more than 1.34 Nm/kg (7th decile) in women, respectively. Moderate risk was defined as being between the low‐ and high‐risk cutpoints. Individuals with knee extension strength in the high‐ and moderate‐risk categories were more likely to have a gait speed less than 1.22 m/s (hazard ratio (HR)=7.00, 95% confidence interval (CI)=5.47–8.96 and HR=2.14 7.00, 95% CI=1.73–2.64, respectively) and had a higher risk of death (HR=1.77, 95% CI=1.41–2.23 and HR=1.51, 95% CI=1.24–1.84, respectively) than individuals in the low‐risk category. Adjustment for demographic factors, health behaviors, and medical conditions did not alter these associations. CONCLUSION: Knee extensor strength cutpoints provide objective markers to identify initially well‐functioning older adults at high and low risk of future mobility limitation.

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Research works printed but not linked: 5

  1. Harris T., 1997, Muscle mass and strength, Relation to function in population studies, 127, 1004s
  2. Newman AB, 2003, Strength and muscle quality in a well‐functioning cohort of older adults, The Health, Aging and Body Composition Study, 51, 323
  3. Guralnik JM, 2000, Lower extremity function and subsequent disability, Consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery, 55, M221
  4. 1994, The National Bicycling and Walking Study: Transportation Choices for a Changing America (Report No. FHWA‐PD‐94‐023)
  5. Ainsworth BE, 1993, Compendium of physical activities, classification of energy costs of human physical activities, 25, 71

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Metadata

Authors
Manini, T. M., Visser, M., Won‐Park, S., Patel, K. V., Strotmeyer, E. S., Chen, H., Goodpaster, B., De Rekeneire, N., Newman, A. B., Simonsick, E. M., Kritchevsky, S. B., Ryder, K., Schwartz, A. V., & Harris, T. B.
Affiliations
Centers for Disease Control and Prevention (US)
ORCID
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2007-03
Volume
55
Issue
3
Pages
451-457
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.2007.01087.x
OpenAlex
W1601971225
Semantic Scholar
2464fd9793a31786efdce2a735b538f76989efdb
Cited by
249
References
28
Citations by year
2026: 9 · 2025: 6 · 2024: 16 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 21 · 2019: 20 · 2018: 11 · 2017: 12 · 2016: 19 · 2015: 19 · 2014: 11 · 2013: 11 · 2012: 21
FWCI
23.28
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
  • VU Research Portal (publishedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (N01‐AG‐6–2101, N01AG62106, N01-AG-62103)
Topics
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords
quadriceps strength, isokinetic strength, mobility limitations, older adults, walking speed, mortality, sex differences, risk prediction, muscle strength
MeSH terms
Aged, Body Weight, Exercise Test, Female, Follow-Up Studies, Gait, Humans, Isometric Contraction, Knee, Male, Prospective Studies, Sex Factors, United States, Cohort Studies, Risk Assessment, Mobility Limitation, Muscle Strength

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