PHYSICAL ACTIVITY AS AN INDEX OF HEART ATTACK RISK IN COLLEGE ALUMNI1

PAFFENBARGER, RALPH S.; WING, ALVIN L.; HYDE, ROBERT T.

doi:10.1093/oxfordjournals.aje.a112608

Cited by 1,980Physical Activity and HealthCardiovascular Health and Risk FactorsCardiovascular Effects of Exercise

PHYSICAL ACTIVITY AS AN INDEX OF HEART ATTACK RISK IN COLLEGE ALUMNI1

PAFFENBARGER, RALPH S., WING, ALVIN L., HYDE, ROBERT T.·1978·American Journal of Epidemiology

DOI 10.1093/oxfordjournals.aje.a112608

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Abstract

Risk of first heart attack was found to be related inversely to energy expenditure reported by 16,936 Harvard male alumni, aged 35-74 years, of whom 572 experienced heart attacks in 117,680 person-years of followup. Stairs climbed, blocks walked, strenuous sports played, and a composite physical activity index all opposed risk. Men with index below 2000 kilocalories per week were at 64% higher risk than classmates with higher index. Adult exercise was independent of other influences on heart attack risk, and peak exertion as strenuous sports play enhanced the effect of total energy expenditure. Notably, alumni physical activity supplanted student athleticism assessed in college 16-50 years earlier. If it is postulated that varsity athlete status implies selective cardiovascular fitness, such selection alone is insufficient to explain lower heart attack risk in later adult years. Ex-varsity athletes retained lower risk only if they maintained a high physical activity index as alumni.

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People who exercise regularly have a lower baseline risk of myocardial infarction.
“People who exercise regularly not only have a lower base-line risk of myocardial infarction, but as demonstrated by this study, they also have a lower relative risk that an infarction will be triggered by heavy physical exertion.”
From Triggering of Acute Myocardial Infarction by Heavy Physical Exertion -- Protection against Triggering by Regular Exertion (1993) · cites this paper as [28]
Regular exercise is associated with a reduction in the long-term risk of coronary events.
“numerous studies5,24-31 have found that regular exercise is associated with a reduction in the long-term risk of coronary events.”
From Triggering of Acute Myocardial Infarction by Heavy Physical Exertion -- Protection against Triggering by Regular Exertion (1993) · cites this paper as [28]

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Authors: PAFFENBARGER, R. S., WING, A. L., & HYDE, R. T.
Affiliations: Harvard University (US)
Corresponding author: PAFFENBARGER, RALPH S.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1978-09
Volume: 108
Issue: 3
Pages: 161-175
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/oxfordjournals.aje.a112608
OpenAlex: W2147078612
Cited by: 1,980
References: 0
Citations by year: 2026: 10 · 2025: 22 · 2024: 30 · 2023: 23 · 2022: 24 · 2021: 36 · 2020: 40 · 2019: 40 · 2018: 55 · 2017: 56 · 2016: 40 · 2015: 50 · 2014: 49 · 2013: 56 · 2012: 54
FWCI: 17.01
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords: physical activity, myocardial infarction risk, myocardial infarction, energy expenditure, university alumni, varsity athletes, cardiorespiratory fitness, cardiovascular disease prevention
MeSH terms: Adult, Aged, Connecticut, Coronary Disease, Physical Exertion, Humans, Male, Middle Aged, Obesity, Physical Fitness, Retrospective Studies, Risk, Smoking, Sports

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PHYSICAL ACTIVITY AS AN INDEX OF HEART ATTACK RISK IN COLLEGE ALUMNI1

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