Effect of Testosterone Treatment on Bone Mineral Density in Men Over 65 Years of Age
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Estradiol has powerful effects on gonadotropin release in men.
“It is well known from experimental evidence and from clinical observations that estradiol has powerful effects on gonadotropin release in men.”
From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [32]
Modulation of plasma estradiol levels within the male physiological range is associated with strong effects on plasma levels of LH through an effect at the level of the pituitary gland.
“Modulation of plasma estradiol levels within the male physiological range is associated with strong effects on plasma levels of LH through an effect at the level of the pituitary gland [32].”
From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [32]
Effects of testosterone on bone are detectable already after 6 months and continue at least for 3 years.
“Effects on bone are detectable already after 6 months while continuing at least for 3 years.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [25]
In studies of testosterone administration up to 36 months, bone mineral density increases over that period, and it is unclear whether maximum effects are attained after 36 months.
“From studies analyzing the effects of testosterone administration over as long as 36 months (25, 26) an increase was observed over that time period and it did not become clear whether the maximum effects of testosterone improving bone mineral have been attained after 36 months.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [25]
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Corona, G., Rastrelli, G., Forti, G., & Maggi, M. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02200.x · Cited by 124 · see citing works
Cui, Y., Zong, H., Yan, H., & Zhang, Y. (2014) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2013.60 · Cited by 123 · see citing works
Hoyos, C. M., Killick, R., Yee, B. J., Grunstein, R. R., & Liu, P. Y. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04413.x · Cited by 118 · see citing works
Chen, J., Lin, P., Tsai, Y.-R., Yang, Y.-C., & Kang, H. (2019) · Cells · doi:10.3390/cells8111318 · Cited by 122 · see citing works
Snyder, P. J., Peachey, H., Berlin, J. A., Rader, D. J., Usher, D. C., Loh, L., Hannoush, P., Dlewati, A., Holmes, J. H., Santanna, J., et al. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00813-0 · Cited by 116 · see citing works
Self-citationThe Role of Testosterone in the Elderly: What Do We Know?
Barone, B., Napolitano, L., Abate, M., Cirillo, L., Reccia, P., Passaro, F., Turco, C., Morra, S., Mastrangelo, F., Scarpato, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073535 · Cited by 120 · see citing works
Ringe, J. D., Faber, H., & Dorst, A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.7988 · Cited by 125 · see citing works
von Eckardstein, S., Noé, G., Brache, V., Nieschlag, E., Croxatto, H. B., Alvarez, F., Moo-Young, A. J., Sivin, I., Kumar, N., Small, M., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-022043 · Cited by 114 · see citing works
Why Is Androgen Replacement in Males Controversial?
Cunningham, G. R., & Toma, S. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0266 · Cited by 111 · see citing works
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Determinants of bone density in healthy older men with low testosterone levels
Kenny, A. M., Prestwood, K. M., Marcello, K. M., & Raisz, L. G. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.9.m492 · Cited by 111 · see citing works
- Authors
- Snyder, P. J.
- Corresponding author
- Snyder, P. J.
- ORCID
- Snyder, P. J.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1999-06-01
- Volume
- 84
- Issue
- 6
- Pages
- 1966-1972
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W4237287004
- Cited by
- 460
- References
- 0
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 11 · 2021: 11 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 14 · 2015: 7 · 2014: 20 · 2013: 20 · 2012: 15
- FWCI
- 16.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- testosterone replacement therapy, bone mineral density, older men, osteoporosis, androgen deficiency
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