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Atrial Fibrillation and Risk of Dementia: A Prospective Cohort Study
Open accessAbstract
OBJECTIVES: To determine whether atrial fibrillation (AF) is associated with risk of incident dementia or Alzheimer's disease (AD), beyond its effect on stroke. DESIGN: Prospective cohort study. SETTING: An integrated healthcare delivery system. PARTICIPANTS: A population‐based sample of 3,045 community‐dwelling adults aged 65 and older without dementia or clinical stroke followed from 1994 to 2008. MEASUREMENTS: AF was identified from health plan electronic data using International Classification of Diseases, Ninth Revision , codes from inpatient and outpatient encounters. Covariates came from self‐report, study measures, and health plan data. Participants were screened every 2 years using the Cognitive Abilities Screening Instrument (range 0–100), with detailed neuropsychological and clinical assessment of those scoring less than 86. A multidisciplinary consensus committee determined diagnoses of all‐cause dementia and possible or probable AD using standard research criteria. RESULTS: AF was present in 132 (4.3%) participants at baseline and was diagnosed in 370 (12.2%) more over a mean of 6.8 years of follow‐up; 572 participants (18.8%) developed dementia (449 with AD). The adjusted hazard ratio associated with AF was 1.38 (95% confidence interval (CI)=1.10–1.73) for all‐cause dementia and 1.50 (95% CI=1.16–1.94) for possible or probable AD. Results were similar for participants with and without clinically recognized stroke during follow‐up and in sensitivity analyses examining only probable AD. CONCLUSION: AF is associated with higher risk of developing AD and dementia. Future studies should examine whether specific treatments, including optimal anticoagulation, can decrease this risk.
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“Women generally have reduced ventricular wall thickness and smaller left atria and ventricles compared with men.138–141”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [140]
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Additional file 2 of Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Nakase, T., Tatewaki, Y., Thyreau, B., Odagiri, H., Tomita, N., Yamamoto, S., Takano, Y., Muranaka, M., & Taki, Y. (2023) · Figshare · doi:10.6084/m9.figshare.22602130
Additional file 4 of Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Nakase, T., Tatewaki, Y., Thyreau, B., Odagiri, H., Tomita, N., Yamamoto, S., Takano, Y., Muranaka, M., & Taki, Y. (2023) · Figshare · doi:10.6084/m9.figshare.22602136
Additional file 3 of Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Nakase, T., Tatewaki, Y., Thyreau, B., Odagiri, H., Tomita, N., Yamamoto, S., Takano, Y., Muranaka, M., & Taki, Y. (2023) · Figshare · doi:10.6084/m9.figshare.22602133
Additional file 5 of Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Nakase, T., Tatewaki, Y., Thyreau, B., Odagiri, H., Tomita, N., Yamamoto, S., Takano, Y., Muranaka, M., & Taki, Y. (2023) · Figshare · doi:10.6084/m9.figshare.22602139
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Metadata
- Authors
- Dublin, S., Anderson, M. L., Haneuse, S. J., Heckbert, S. R., Crane, P. K., Breitner, J. C. S., McCormick, W., Bowen, J. D., Teri, L., McCurry, S. M., & Larson, E. B.
- Affiliations
- Kaiser Permanente Washington Health Research Institute (US)
- Harvard University (US)
- ORCID
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2011-08
- Volume
- 59
- Issue
- 8
- Pages
- 1369-1375
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- PMC
- PMC3289545
- OpenAlex
- W1560082628
- Cited by
- 168
- References
- 37
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 13 · 2019: 19 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 15 · 2013: 8 · 2012: 14
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (U01AG006781, K23AG028954)
- National Heart, Lung, and Blood Institute (R01HL068986)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- atrial fibrillation, dementia, Alzheimer's disease, incident dementia risk, stroke, older adults, anticoagulation, cognitive decline
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrial Fibrillation, Cross-Sectional Studies, Female, Health Surveys, Humans, Male, Prospective Studies, Risk Factors, Washington, Cohort Studies, Incidence, Stroke
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