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Cited by 260

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

New‐Onset Heart Failure After Permanent Right Ventricular Apical Pacing in Patients with Acquired High‐Grade Atrioventricular Block and Normal Left Ventricular Function

ZHANG, XUE‐HUA, CHEN, HUA, SIU, CHUNG‐WAH, YIU, KAI‐HANG, CHAN, WING‐SZE, LEE, KATHY L., CHAN, HON‐WAH, LEE, STEPHEN W., FU, GUO‐SHENG, LAU, CHU‐PAK, TSE, HUNG‐FAT·2008·Journal of Cardiovascular Electrophysiology
DOI 10.1111/j.1540-8167.2007.01014.x
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Abstract

Introduction: Emerging data have suggested that right ventricular (RV) apical pacing results in progressive left ventricular (LV) dysfunction and contributes to the development of heart failure (HF). This study aimed to investigate the prevalence and clinical predictors for the development of new‐onset HF after long‐term RV apical pacing in patients with acquired atrioventricular (AV) block who require permanent pacing. Methods: We studied the clinical outcomes after long‐term RV apical pacing for acquired AV block in 304 patients without a prior history of HF. All patients had >90% ventricular pacing as determined by device diagnostic data. Results: After a median follow‐up of 7.8 years, 79 patients (26.0%) developed new‐onset HF after RV apical pacing. Univariate Cox‐regression analysis revealed that older age at the time of pacemaker implantation (P < 0.001), the presence of coronary artery disease (CAD) (P < 0.001) or atrial fibrillation (P = 0.03), VVI pacemaker (P < 0.001), wider paced QRS duration (P < 0.001), and new‐onset myocardial infarction (P < 0.001) were predictors for HF. Multivariate analysis revealed that older age at implantation (Hazard ratio [HR] 1.06, 95% confidential interval [CI] 1.04–1.09, P < 0.001), CAD (HR 1.98, 95% CI 1.12–3.50, P < 0.05), and a wider paced QRS duration (HR 1.27 for each 10 ms increment, 95% CI 1.11–1.45, P = 0.001) were independent predictors of HF. Furthermore, cardiovascular mortality was significantly increased in those with HF (36.7% vs. 2.7%, P < 0.001). Conclusions: After a median follow‐up of 7.8 years, permanent RV apical pacing was associated with HF in 26% of patients. Elderly age at the time of implant, a wider paced QRS duration and the presence of CAD independently predicted new‐onset HF. More importantly, HF after RV apical pacing was associated with a higher cardiovascular mortality.

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Metadata

Authors
ZHANG, X., CHEN, H., SIU, C., YIU, K., CHAN, W., LEE, K. L., CHAN, H., LEE, S. W., FU, G., LAU, C., & TSE, H.
Venue
Journal of Cardiovascular Electrophysiology
Publisher
Wiley
Published
2007-11-14
Volume
19
Issue
2
Pages
136-141
ISSN
  • 1045-3873 (ISSN-L)
  • 1540-8167
DOI
10.1111/j.1540-8167.2007.01014.x
OpenAlex
W2025769511
Cited by
260
References
33
FWCI
7.56
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: New‐Onset Heart Failure After Permanent Right Ventricular Apical Pacing in Patients with Acquired High‐Grade Atrioventricular Block and Normal Left Ventricular Function. https://app.cochat.ai/papers/10.1111/j.1540-8167.2007.01014.x
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ZHANG, X., CHEN, H., SIU, C., YIU, K., CHAN, W., LEE, K. L., CHAN, H., LEE, S. W., FU, G., LAU, C., & TSE, H. (2008). New‐Onset Heart Failure After Permanent Right Ventricular Apical Pacing in Patients with Acquired High‐Grade Atrioventricular Block and Normal Left Ventricular Function. Journal of Cardiovascular Electrophysiology. https://doi.org/10.1111/j.1540-8167.2007.01014.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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