Cerebral White Matter Lesions in Patients with Crohn’s Disease
Abstract
BACKGROUND: To investigate the incidence, characteristics, and predisposing factors for cerebral white matter lesions in patients with Crohn's disease. METHODS: We retrospectively evaluated the incidence and characteristics of cerebral T2 white matter abnormalities in 54 patients with Crohn's disease and compared to 100 age-matched controls. We also investigated potential co-morbidities known to be associated with white matter abnormalities in Crohn's patients with normal and abnormal Magnetic Resonance Imaging (MRI). RESULTS: Seventy-two percent of patients with Crohn's disease had T2 white matter abnormalities, as compared with 34% of the age-matched controls (P < .001). Lesion severity and size were not significantly different between the two groups; however, periventricular distribution and fulfillment of the Barkhof MRI criteria were overrepresented in Crohn's population. History of hypertension, diabetes, and migraine; gender, duration of disease and prior exposure to anti-tumor necrosis factor were not significantly different between Crohn's patients with and without white matter abnormalities; however, patients with lesions were significantly older than those without. CONCLUSIONS: Patients with Crohn's disease have a higher incidence of white matter T2 hyperintensities as compared with controls. Age was the only significant factor for the abnormalities within Crohn's group. White matter T2 hyperintensities are likely another extra-intestinal manifestation of Crohn's disease.
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White matter alterations have been observed in IBD patients compared to controls in a small number of studies on nervous system imaging in patients with IBD.
“white matter alterations have also been observed in IBD patients compared to controls in a small number of studies on nervous system imaging in patients with IBD.”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [97]
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- Authors
- Chen, M., Lee, G., Kwong, L. N., Lamont, S., & Chaves, C.
- Affiliations
- Lahey Hospital and Medical Center (US)
- Corresponding author
- Chaves, Claudia
- ORCID
- Kwong, Lawrence N.
- Venue
- Journal of Neuroimaging
- Publisher
- Wiley
- Published
- 2010-11-17
- Volume
- 22
- Issue
- 1
- Pages
- 38-41
- ISSN
- 1051-2284 (ISSN-L)
- 1552-6569
- OpenAlex
- W2137454855
- Cited by
- 34
- References
- 14
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Keywords
- Crohn's disease, cerebral white matter lesions, T2 hyperintensity, Barkhof criteria, periventricular lesions, extraintestinal manifestations, age as risk factor, hypertension, migraine, diabetes mellitus, anti-TNF therapy
- MeSH terms
- Crohn Disease, Female, Humans, Magnetic Resonance Imaging, Male, Massachusetts, Middle Aged, Nerve Fibers, Myelinated, Neuromuscular Diseases, Risk Factors, Sensitivity and Specificity, Reproducibility of Results, Comorbidity, Prevalence, Risk Assessment
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