Evolution of the carboxylate Jen transporters in fungi.
Open accessAbstract
Synteny analysis is combined with sequence similarity and motif identification to trace the evolution of the putative monocarboxylate (lactate/pyruvate) transporters Jen1p and the dicarboxylate (succinate/fumarate/malate) transporters Jen2p in Hemiascomycetes yeasts and Euascomycetes fungi. It is concluded that a precursor form of Jen1p, named here preJen1p, arose by the duplication of an ancestral Jen2p, during the speciation of Yarrowia lipolytica, which was transferred into a new syntenic context. The Jen1p transporters differentiated from preJen1p in Kluyveromyces lactis, before the Whole Genome Duplication (WGD), and are conserved as a single copy in the Saccharomyces species. In contrast, the ancestral Jen2p was definitively lost just prior to the WGD and is absent in Saccharomyces.
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JEN1 homologues are absent from the C. glabrata genome.
“However, JEN1 homologues are absent from the C. glabrata genome (Lodi et al., 2007).”
From Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate (2015) · cites this paper as Lodi et al., 2007
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Transport of carboxylic acids in yeasts.
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Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate
Mota, S., Alves, R., Carneiro, C., Silva, S., Brown, A. J., Istel, F., Kuchler, K., Sampaio, P., Casal, M., Henriques, M., et al. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00919 · Cited by 49 · see citing works
- Authors
- Lodi, T., Diffels, J., Goffeau, A., & Baret, P. V.
- Affiliations
- University of Parma (IT)
- UCLouvain (BE)
- Corresponding author
- Lodi, Tiziana
- Venue
- FEMS Yeast Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08
- Volume
- 7
- Issue
- 5
- Pages
- 646-656
- ISSN
- 1567-1356 (ISSN-L)
- 1567-1364
- OpenAlex
- W2043823785
- Cited by
- 25
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Yeast Research (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Funders
- Università degli Studi di Parma
- Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- monocarboxylate transporters, dicarboxylate transporter, lactate transport, pyruvate transport, succinate transport, malate transport, gene duplication, whole-genome duplication, synteny, Yarrowia lipolytica, Kluyveromyces lactis, Saccharomyces, transporter evolution
- MeSH terms
- Amino Acid Sequence, Ascomycota, Fungal Proteins, Molecular Sequence Data, Phylogeny, Evolution, Molecular, Synteny, Monocarboxylic Acid Transporters, Symporters
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