Transport of carboxylic acids in yeasts.

Casal, Margarida; Paiva, Sandra; Queirós, Odília; Soares-Silva, Isabel

doi:10.1111/j.1574-6976.2008.00128.x

Cited by 185Fungal and yeast genetics researchMicrobial Metabolic Engineering and BioproductionDrug Transport and Resistance Mechanisms

Transport of carboxylic acids in yeasts.

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Casal, Margarida, Paiva, Sandra, Queirós, Odília, Soares-Silva, Isabel·2008·FEMS Microbiology Reviews

DOI 10.1111/j.1574-6976.2008.00128.x

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Abstract

Carboxylic acid transporters form a heterogeneous group of proteins, presenting diverse mechanisms of action and regulation, and belonging to several different families. Multiple physiological and genetic studies in several organisms, from yeast to mammals, have allowed the identification of various genes coding for carboxylate transporters. Detailed understanding of the metabolism and transport of these nutrients has become more important than ever, both from a fundamental and from an applied point of view. Under a biotechnological perspective, the increasing economic value of these compounds has boosted this field of research considerably. Here we review the current knowledge on yeast carboxylate transporters, at the biochemical and molecular level, focusing also on recent biotechnological developments.

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The enrichment of carboxylic acid metabolism and cell redox homeostasis implicates a potential link between drug resistance and mitochondrial function.
“Gene Ontology term analysis revealed the enrichment of carboxylic acid metabolism and cell redox homeostasis in R1 (Fig. 1e), implicating a potential link between drug resistance and mitochondrial function, the main cellular location of carboxylic acid metabolism22.”
From Candida auris skin tropism and antifungal resistance are mediated by carbonic anhydrase Nce103 (2025) · cites this paper as [22]
The section on mitochondrial carboxylate transporters describes carriers for Krebs-cycle intermediates, supporting a connection between mitochondria and carboxylic acid metabolism. It does not establish that mitochondria are the main cellular location of all carboxylic acid metabolism. The Gene Ontology enrichment and proposed drug-resistance link are the citing authors’ inference, not findings attributed to this source. (LLM, conf=0.82)
Experimental — accuracy not yet measured
At pH 5.0, the charged anionic form (CH3COO-) acts as a nutrient rather than the undissociated acid (CH3COOH) conferring a weak acid stress.
“We examined growth at pH 5.0, a value above the pKa of the acid, where the charged anionic form (CH3COO-) acts as a nutrient rather than the undissociated acid (CH3COOH) conferring a weak acid stress (Casal et al., 2008; Stratford et al., 2013).”
From Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate (2015) · cites this paper as Casal et al., 2008

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Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata
Chew, S. Y., Ho, K. L., Cheah, Y. K., Ng, T. S., Sandai, D., Brown, A. J. P., & Than, L. T. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-39117-1 · Cited by 49 · see citing works
Candida auris skin tropism and antifungal resistance are mediated by carbonic anhydrase Nce103
Phan-Canh, T., Coman, C., Lackner, M., Troppmair, N., Müller, C., Cerbu, D., Seiser, S., Penninger, P., Tsymala, I., Khunweeraphong, N., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02189-z · Cited by 16 · see citing works
“1e), implicating a potential link between drug resistance and mitochondrial function, the main cellular location of carboxylic acid metabolism 22 .”
Phylogenomics of a Saccharomyces cerevisiae cocoa strain reveals adaptation to a West African fermented food population
Díaz-Muñoz, C., Verce, M., De Vuyst, L., & Weckx, S. (2022) · iScience · doi:10.1016/j.isci.2022.105309 · Cited by 10 · see citing works

Authors: Casal, M., Paiva, S., Queirós, O., & Soares-Silva, I.
Affiliations: University of Minho (PT)
Corresponding author: Casal, Margarida
ORCID: Casal, Margarida
Paiva, Sandra
Queirós, Odília
Venue: FEMS Microbiology Reviews
Publisher: Oxford University Press (OUP)
Published: 2008-11
Volume: 32
Issue: 6
Pages: 974-994
ISSN: 0168-6445 (ISSN-L)
1574-6976
DOI: 10.1111/j.1574-6976.2008.00128.x
OpenAlex: W2006651212
Cited by: 185
References: 167
Citations by year: 2026: 11 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 12 · 2021: 25 · 2020: 13 · 2019: 17 · 2018: 6 · 2017: 15 · 2016: 4 · 2015: 12 · 2014: 10 · 2013: 8 · 2012: 7
FWCI: 0.49
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: FEMS Microbiology Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Food and Drug Administration
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: yeast, transporters, transporter regulation, biotechnology, carboxylic acid metabolism
MeSH terms: Amino Acid Sequence, Biological Transport, Carboxylic Acids, Citric Acid Cycle, Fungal Proteins, Molecular Sequence Data, Phylogeny, Yeasts, Gene Expression Regulation, Fungal, Sequence Alignment, Membrane Transport Proteins

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Transport of carboxylic acids in yeasts.

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