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Cited by 220Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsGastroesophageal reflux and treatments

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Effect of Amitryptiline on Symptoms, Sleep, and Visceral Perception in Patients With Functional Dyspepsia

Mertz, H, Fass, R, Kodner, A, Yan-Go, F, Fullerton, S, Mayer, E A·1998·American Journal of Gastroenterology
DOI 10.1111/j.1572-0241.1998.00160.x
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Abstract

Objective Tricyclic antidepressants in low doses are widely used in the therapy of patients with functional gastrointestinal disorders, yet the mechanism(s) of action of these drugs in these disorders is not known. In the current study, we sought to determine in a group of patients with functional dyspepsia and associated poor sleep how amitryptiline affects digestive symptoms, perceptual responses to gastric distension, and subjective and objective measures of sleep. Methods Patients were randomized to 4 wk of amitryptiline 50 mg taken at bedtime versus placebo. There was a 3-wk washout phase, followed by a cross-over to the alternate treatment. Perceptual sensitivity to gastric distention and sleep EEG were recorded at the end of each treatment period. Diaries of symptoms were maintained throughout. Results Seven of seven patients reported significantly less severe gastrointestinal symptoms after 4 wk on amitryptiline compared to placebo. Five of seven patients had evidence for altered perception of gastric balloon distension during placebo. However, the subjective symptom improvement on amitryptiline was not associated with a normalization of the perceptual responses to gastric distension. Baseline sleep dysfunction in the form of reduced sleep efficiency, increased arousal, or abnormal amounts of REM sleep was found in all seven patients. Amitryptiline significantly reduced absolute and relative amounts of REM sleep, but had no effect on sleep parameters related to nonreg…

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Crossref · 10.1111/j.1572-0241.1998.00160.x

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2 of 2 references verified0 citation errors · 0 not checkable

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  • Amitriptyline (50mg) was associated with poorer sleep efficiency for patients with functional dyspepsia, compared to placebo.

    “In another study (Mertz et al., 1998), amitriptyline (50mg) was associated with poorer sleep efficiency for patients with functional dyspepsia, compared to placebo.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Mertz et al., 1998

  • Amitriptyline (50mg) reduced REM sleep in gastroenterology patients, compared to placebo.

    “(Mertz et al., 1998) found that amitriptyline (50mg) reduced REM sleep in gastroenterology patients, compared to placebo, while (Carette et al., 1995) demonstrated fewer changes in REM sleep parameters in fibromyalgia patients (dosage, 25mg).”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Mertz et al., 1998

Citations

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Metadata

Authors
Mertz, H., Fass, R., Kodner, A., Yan-Go, F., Fullerton, S., & Mayer, E. A.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Mertz, H
ORCID
Venue
American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-02
Volume
93
Issue
2
Pages
160-165
ISSN
0002-9270 (ISSN-L)
DOI
10.1111/j.1572-0241.1998.00160.x
OpenAlex
W1975230079
Cited by
220
References
2
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 10 · 2013: 11 · 2012: 10
FWCI
8.81
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK040919, P30DK041301)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
amitriptyline, functional dyspepsia, tricyclic antidepressants, sleep, REM sleep, gastric distension, visceral sensation, visceral sensitivity, sleep efficiency, arousal, gastrointestinal symptoms, functional gastrointestinal disorders
MeSH terms
Adult, Aged, Amitriptyline, Antidepressive Agents, Tricyclic, Dilatation, Double-Blind Method, Dyspepsia, Female, Humans, Male, Middle Aged, Perception, Sleep, Stomach

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