Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity
Abstract
Abstract Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The present study confirms that B. lactis HN019 reduces intestinal transit.
“The present study confirms these observations.”
B. lactis HN019 reduces intestinal transit in a placebo-controlled dose-ranging study.
“The used B. lactis strain, HN019, has recently been shown to reduce intestinal transit in a placebo controlled dose ranging study [15,29].”
Cites
Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605 · see citing works
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
Bombardier, C., Laine, L., Reicin, A. S., Shapiro, D., Burgos‐Vargas, R., Davis, B. R., Day, R. O., Ferraz, M. B., Hawkey, C. J., Hochberg, M. C., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011233432103 · Cited by 4,014 · see citing works
Silverstein, F. E., Faich, G. A., Goldstein, J. L., Simon, L. S., Pincus, T., Whelton, A., Makuch, R., Eisen, G. M., Agrawal, N. M., Stenson, W. F., et al. (2000) · JAMA · doi:10.1001/jama.284.10.1247 · Cited by 3,144 · see citing works
Bacteriocins: Developing innate immunity for food
Cotter, P. D., Hill, C., & Ross, R. P. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1273 · Cited by 2,380 · see citing works
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221 · see citing works
Probiotics, prebiotics, and synbiotics—approaching a definition
Schrezenmeir, J., & de Vrese, M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.361s · Cited by 1,519 · see citing works
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475 · see citing works
Hla, T., & Neilson, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7384 · Cited by 1,465 · see citing works
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
Self-citationIngelman‐Sundberg, M. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500285 · Cited by 1,111 · see citing works
Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing
Walsh, B. T., Seidman, S. N., Sysko, R., & Gould, M. (2002) · JAMA · doi:10.1001/jama.287.14.1840 · Cited by 1,109 · see citing works
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024 · see citing works
Pharmacological profile of antidepressants and related compounds at human monoamine transporters
Tatsumi, M., Groshan, K., Blakely, R. D., & Richelson, E. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01393-9 · Cited by 939 · see citing works
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920 · see citing works
Ramamoorthy, S., Bauman, A. L., Moore, K. R., Han, H. J., Yang‐Feng, T. L., Chang, A. S., Ganapathy, V., & Blakely, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2542 · Cited by 880 · see citing works
Rachmilewitz, D., Katakura, K., Karmeli, F., Hayashi, T., Reinus, C., Rudensky, B., Akira, S., Takeda, K., Lee, J., Takabayashi, K., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.019 · Cited by 859 · see citing works
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833 · see citing works
Cloning and expression of a functional serotonin transporter from rat brain
Blakely, R., Berson, H. E., Fremeau, R. T., Caron, M. G., Peek, M. M., Prince, H. K., & Bradley, C. C. (1991) · Nature · doi:10.1038/354066a0 · Cited by 831 · see citing works
Whorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00734.x · Cited by 799 · see citing works
Self-citationEradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome
Pimentel, M., Chow, E. J., & Lin, H. C. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03368.x · Cited by 780 · see citing works
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764 · see citing works
Coates, M. D., Mahoney, C. R., Linden, D. R., Sampson, J. E., Chen, J. C., Blaszyk, H., Crowell, M. D., Sharkey, K. A., Gershon, M. D., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.013 · Cited by 761 · see citing works
From magic bullets to designed multiple ligands
Morphy, R., Kay, C., & Ranković, Z. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03163-0 · Cited by 731 · see citing works
Pharmacogenomics and Individualized Drug Therapy
Eichelbaum, M. F., Ingelman‐Sundberg, M., & Evans, W. E. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104724 · Cited by 719 · see citing works
Schnitzer, T. J., Burmester, G. R., Mysler, E., Hochberg, M. C., Doherty, M., Ehrsam, E., Gitton, X., Krammer, G., Mellein, B., Matchaba, P. T., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16893-1 · Cited by 697 · see citing works
COX-1 and COX-2 tissue expression: implications and predictions.
Lj, C. (1997) · PubMed · Cited by 679 · see citing works
Nobaek, S., Johansson, M.-L., Molin, G., Ahrné, S., & Jeppsson, B. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02015.x · Cited by 653 · see citing works
Resta-Lenert, S., & Barrett, K. E. (2003) · Gut · doi:10.1136/gut.52.7.988 · Cited by 642 · see citing works
Dinan, T. G., Quigley, E. M. M., Ahmed, S. M. M., Scully, P., O’Brien, S., O’Mahony, L., O’Mahony, S., Shanahan, F., & Keeling, P. W. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.033 · Cited by 636 · see citing works
Self-citationCloning of a Serotonin Transporter Affected by Antidepressants
Hoffman, B. J., Mezey, É., & Brownstein, M. (1991) · Science · doi:10.1126/science.1948036 · Cited by 614 · see citing works
Tolerance for Rectosigmoid Distention in Irritable Bowel Syndrome
Whitehead, W. E., Holtkötter, B., Enck, P., Hoelzl, R., Holmes, K. D., Anthony, J. C., Shabsin, H. S., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90332-u · Cited by 592 · see citing works
Dunlop, S. P., Jenkins, D., Neal, K. R., & Spiller, R. C. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.028 · Cited by 583 · see citing works
Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia
Tack, J. F., Caenepeel, P., Fischler, B., Piessevaux, H. H., & Janssens, J. (2001) · Gastroenterology · doi:10.1053/gast.2001.27180 · Cited by 568 · see citing works
Self-citationCamilleri, M., Northcutt, A. R., Kong, S., Dukes, G. E., McSorley, D., & Mangel, A. W. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02033-x · Cited by 551 · see citing works
(2011) · Springer eBooks · doi:10.1007/springerreference_44317 · Cited by 549 · see citing works
Regional cerebral activity in normal and pathological perception of visceral pain
Silverman, D. H. S., Munakata, J., Ennes, H. S., Mandelkern, M. A., Hoh, C. K., & Mayer, E. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70220-8 · Cited by 546 · see citing works
Gershon, M. D. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02180.x · Cited by 521 · see citing works
Non-Steroidal Anti-Inflammatory Drugs
Hart, F. D., & HUSKISSON, E. C. (1984) · Drugs · doi:10.2165/00003495-198427030-00004 · Cited by 508 · see citing works
Niedzielin, K., Kordecki, H., & Birkenfeld, B. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200110000-00004 · Cited by 506 · see citing works
Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo
Karalis, K. P., Sano, H., Redwine, J. M., LISTWAK, S. J., Wilder, R. L., & Chrousos, G. P. (1991) · Science · doi:10.1126/science.1925600 · Cited by 482 · see citing works
Increased mast cells in the irritable bowel syndrome
O’Sullivan, Clayton, Breslin, Harman, Bountra, Mclaren, & O’Morain (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00221.x · Cited by 480 · see citing works
Abnormal colonic fermentation in irritable bowel syndrome
King, T. S., Elia, M., & Hunter, J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02146-1 · Cited by 473 · see citing works
Bouin, M., Plourde, V., Boivin, M., Riberdy, M., Lupien, F., Laganière, M., Verrier, P., & Poitras, P. (2002) · Gastroenterology · doi:10.1053/gast.2002.33601 · Cited by 470 · see citing works
Kim, H. J., Camilleri, M., Mckinzie, S., Lempke, M. B., Burton, D. D., Thomforde, G. M., & Zinsmeister, A. R. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01543.x · Cited by 468 · see citing works
Review article: roles played by 5‐hydroxytryptamine in the physiology of the bowel
Gershon, M. D. (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00002.x-i2 · Cited by 465 · see citing works
McCarthy, J., O’Mahony, L., O’Callaghan, L., Sheil, B., Vaughan, E. E., Fitzsimons, N., Fitzgibbon, J., O’Sullivan, G. C., Kiely, B., Collins, J. K., et al. (2003) · Gut · doi:10.1136/gut.52.7.975 · Cited by 462 · see citing works
Tobey, N. A., Carson, J., Alkiek, R. A., & Orlando, R. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8898633 · Cited by 461 · see citing works
de Lima, A. D., Bloom, F. E., & Morrison, J. H. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902740211 · Cited by 459 · see citing works
Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M. (2006) · Gut · doi:10.1136/gut.2005.066100 · Cited by 448 · see citing works
Serotonin Transporter: Gene, Genetic Disorders, and Pharmacogenetics
Murphy, D. L. (2004) · Molecular Interventions · doi:10.1124/mi.4.2.8 · Cited by 444 · see citing works
American Gastroenterological Association Technical Review on the Evaluation of Dyspepsia
Talley, N. J., Vakil, N. B., & Moayyedi, P. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.09.020 · Cited by 436 · see citing works
Self-citationChen, N., Reith, M. E. A., & Quick, M. W. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1064-5 · Cited by 411 · see citing works
Castagliuolo, I., Riegler, M. F., Valenick, L. V., LaMont, J. T., & Pothoulakis, C. (1999) · Infection and Immunity · doi:10.1128/iai.67.1.302-307.1999 · Cited by 408 · see citing works
Meta‐analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome
Poynard, T., Regimbeau, C., & Benhamou, Y. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.00937.x · Cited by 405 · see citing works
Kim, H. J., Vazquez Roque, M. I., Camilleri, M., Stephens, D., Burton, D. D., Baxter, K., Thomforde, G., & Zinsmeister, A. R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00695.x · Cited by 400 · see citing works
Singh, G. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.14.1530 · Cited by 400 · see citing works
Corticotrophin-releasing factor receptors: from molecular biology to drug design
Chalmers, D. T., Lovenberg, T. W., Grigoriadis, D. E., Behan, D. P., & Souza, E. B. D. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)81594-x · Cited by 398 · see citing works
Abnormal sensory perception in patients with esophageal chest pain
Richter, J. E., Barish, C. F., & Castell, D. O. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90685-2 · Cited by 397 · see citing works
Chen, J. C., Li, Z., Pan, H., Murphy, D. L., Tamir, H., Koepsell, H., & Gershon, M. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06348.2001 · Cited by 397 · see citing works
Jonker, J., & Schinkel, A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.053298 · Cited by 393 · see citing works
Pharmacologic Treatment of the Irritable Bowel Syndrome
Jailwala, J., Imperiale, T. F., & Kroenke, K. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-2-200007180-00013 · Cited by 374 · see citing works
KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., & KORPELA, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02579.x · Cited by 361 · see citing works
Atkinson, W., Lockhart, S., Whorwell, P. J., Keevil, B., & Houghton, L. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.09.031 · Cited by 355 · see citing works
Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome
Dunlop, S. P., Coleman, N. S., Blackshaw, E., Perkins, A. C., Singh, G., Marsden, C. A., & Spiller, R. E. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00726-8 · Cited by 355 · see citing works
Spiller, R. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00324-x · Cited by 353 · see citing works
Low-Dose Trazodone for Symptomatic Patients With Esophageal Contraction Abnormalities
Clouse, R. E., Lustman, P. J., Eckert, T. C., Ferney, D. M., & Griffith, L. S. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90979-6 · Cited by 353 · see citing works
Larkai, E., Smith, J. L., Lidsky, M. D., & Graham, D. (1987) · PubMed · Cited by 350 · see citing works
Grider, J. R., Foxx–Orenstein, A. E., & Jin, J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70203-3 · Cited by 349 · see citing works
Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract
Wade, P., Chen, J., Jaffe, B. M., Kassem, I., Blakely, R., & Gershon, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02352.1996 · Cited by 328 · see citing works
de León, J., Susce, M. T., Pan, R.-M., Fairchild, M., Koch, W. H., & Wedlund, P. J. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0103 · Cited by 319 · see citing works
Koepsell, H., Schmitt, B. M., & Gorboulev, V. (2003) · Springer eBooks · doi:10.1007/s10254-003-0017-x · Cited by 318 · see citing works
DNA from probiotic bacteria modulates murine and human epithelial and immune function
Jijon, H. B., Backer, J., Díaz, H., Yeung, H. P., Thiel, D., McKaigney, C. J., Simone, C. D., & Madsen, K. L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.003 · Cited by 318 · see citing works
Marshall, J. K., Thabane, M., Garg, A. X., Clark, W., Meddings, J., Collins, S. M., & for the WEL Investigators (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02284.x · Cited by 292 · see citing works
Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis
Linden, D. R., Chen, J.-X., Gershon, M. D., Sharkey, K. A., & Mawe, G. M. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00488.2002 · Cited by 291 · see citing works
Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome
Lembo, T., Munakata, J., Mertz, H., Niazi, N., Kodner, A., Nikas, V., & Mayer, E. A. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90809-5 · Cited by 290 · see citing works
Tack, J. F., Broekaert, D., Fischler, B., Oudenhove, L. V., Gevers, A. M., & Janssens, J. (2006) · Gut · doi:10.1136/gut.2005.077503 · Cited by 289 · see citing works
Self-citationSingh, G. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440130066007 · Cited by 286 · see citing works
10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*
Dalén, P., Dahl, M., Ruiz, M. L. B., Nordin, J., & Bertilsson, L. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90040-6 · Cited by 285 · see citing works
Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome
Camilleri, M., Atanasova, E. A., Carlson, P. J., Ahmad, U. S., Kim, H. J., Viramontes, B. E., McKinzie, S., & Urrutia, R. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.34780 · Cited by 285 · see citing works
Review article: exploring the link between Helicobacter pylori and gastric cancer
Kuipers, E. J. (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00002.x · Cited by 284 · see citing works
Stress‐induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells
Gué, M., Rio-Lacheze, C. D., Eutamène, H., Théodorou, V., Fioramonti, J., & Bueno, L. P. (1997) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1997.d01-63.x · Cited by 282 · see citing works
Self-citationGonsalkorale, W. M., Perrey, C., Pravica, V, Whorwell, P. J., & Hutchinson, I. V. (2003) · Gut · doi:10.1136/gut.52.1.91 · Cited by 273 · see citing works
Bausserman, M., & Michail, S. K. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.05.015 · Cited by 272 · see citing works
Evidence for exacerbation of irritable bowel syndrome during menses
Whitehead, W. E., Cheskin, L. J., Heller, B. R., Robinson, J. C., Crowell, M. D., Benjamin, C., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91079-l · Cited by 262 · see citing works
Yeo, A., Boyd, P., Lumsden, S., Saunders, T., Handley, A., Stubbins, M., Knaggs, A., Asquith, S., Taylor, I., Bahari, B., et al. (2004) · Gut · doi:10.1136/gut.2003.035451 · Cited by 260 · see citing works
(1982) · PubMed · Cited by 251 · see citing works
Castagliuolo, I., LaMont, J. T., Qiu, B., Fleming, S. M., Bhaskar, K. R., Nikulásson, S. Þ., Kornetsky, C. H., & Pothoulakis, C. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.5.g884 · Cited by 251 · see citing works
Sen, S., Mullan, M. M., Parker, T. J., Woolner, J. T., Tarry, S. A., & Hunter, J. O. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020597001460 · Cited by 245 · see citing works
OʼSullivan, M. (2000) · Digestive and Liver Disease · doi:10.1016/s1590-8658(00)80021-3 · Cited by 245 · see citing works
Kamiya, T., Wang, L., Forsythe, P., Goettsche, G., Mao, Y., Wang, Y., Tougas, G., & Bienenstock, J. (2006) · Gut · doi:10.1136/gut.2005.070987 · Cited by 242 · see citing works
Gastric wall tension determines perception of gastric distention
Distrutti, E., Azpiroz, F., Soldevilla, A., & Malagelada, J. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70006-5 · Cited by 238 · see citing works
Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome
Delvaux, M., Louvel, D., Mamet, J. ‐., Campos‐Oriola, R., & Frexinos, J. (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00375.x · Cited by 236 · see citing works
Regulation of 5-HT release from enterochromaffin cells
Racké, K., Reimann, A., Schwörer, H., & Kilbinger, H. J. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00075-7 · Cited by 230 · see citing works
Adverse Reactions of Selective Serotonin Reuptake Inhibitors
Spigset, O. (1999) · Drug Safety · doi:10.2165/00002018-199920030-00007 · Cited by 225 · see citing works
Mertz, H., Fass, R., Kodner, A., Yan‐Go, F. L., Fullerton, S. C., & Mayer, E. A. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00160.x · Cited by 220 · see citing works
Efficacy of alosetron in irritable bowel syndrome: a meta‐analysis of randomized controlled trials
Cremonini, F., Delgado‐Aros, S., & Camilleri, M. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00389.x · Cited by 219 · see citing works
Intestinal microecology and quality of life in irritable bowel syndrome patients
Si, J.-M. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i12.1802 · Cited by 218 · see citing works
Crofford, L. J., Sano, H., Karalis, K. P., Friedman, T. C., Epps, H. R., Remmers, E. F., Mathern, P., Chrousos, G. P., & Wilder, R. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.3.1587 · Cited by 216 · see citing works
G-protein β3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia 1 ☆
Holtmann, G., Siffert, W., Haag, S., Mueller, N., Langkafel, M., Senf, W., Zotz, R. B., & Talley, N. J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.006 · Cited by 213 · see citing works
Self-citationCoelho, A.-M., Vergnolle, N., Guiard, B. P., Fioramonti, J., & Bueno, L. P. (2002) · Gastroenterology · doi:10.1053/gast.2002.32387 · Cited by 212 · see citing works
Self-citationActivation of Intrinsic Afferent Pathways in Submucosal Ganglia of the Guinea Pig Small Intestine
Pan, H., & Gershon, M. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03295.2000 · Cited by 211 · see citing works
GORARD, D. A., LIBBY, G. W., & FARTHING, M. J. G. (1994) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1994.tb00273.x · Cited by 211 · see citing works
Mawe, G. M., Branchek, T. A., & Gershon, M. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9799 · Cited by 205 · see citing works
Review article: intestinal serotonin signalling in irritable bowel syndrome
Mawe, G. M., Coates, M. D., & Moses, P. L. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02858.x · Cited by 205 · see citing works
Propulsion in Guinea Pig Colon Induced by 5-Hydroxytryptamine (HT) via 5-HT4 and 5-HT3 Receptors
Jin, J., Foxx–Orenstein, A. E., & Grider, J. R. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37929-7 · Cited by 203 · see citing works
Willert, R. P., Woolf, C. J., Hobson, A. R., Delaney, C. M., Thompson, D. G., & Aziz, Q. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.047 · Cited by 202 · see citing works
Grider, J. R., Kuemmerle, J. F., & Jin, J. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.270.5.g778 · Cited by 196 · see citing works
Kamm, M. A., Müller-Lissner, S. A., Talley, N. J., Tack, J. F., Boeckxstaens, G. E., Minushkin, O. N., Калинин, А. А., Dzieniszewski, J., van der Haeck, P. W. E., Fordham, F., et al. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40749.x · Cited by 193 · see citing works
Self-citationNIV, E., NAFTALI, T., HALLAK, R., & VAISMAN, N. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.06.001 · Cited by 191 · see citing works
Quartero, A. O., Meiniche-Schmidt, V., Muris, J., Rubin, G., & de Wit, N. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003460.pub2 · Cited by 190 · see citing works
Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats
Takeuchi, K., Ueki, S., & Okabe, S. (1986) · Digestive Diseases and Sciences · doi:10.1007/bf01300266 · Cited by 190 · see citing works
Foxx-Orenstein, A., Jf, K., & Grider, J. R. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8898642 · Cited by 190 · see citing works
Brigidi, P., Vitali, B., Swennen, E., Bazzocchi, G., & Matteuzzi, D. (2001) · Research in Microbiology · doi:10.1016/s0923-2508(01)01254-2 · Cited by 188 · see citing works
Sheil, B., McCarthy, J., O’Mahony, L., Bennett, M. W., Ryan, P., Fitzgibbon, J. J., Kiely, B., Collins, J. K., & Shanahan, F. (2004) · Gut · doi:10.1136/gut.2003.027789 · Cited by 187 · see citing works
Prior, A., & Read, N. W. (1993) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1993.tb00087.x · Cited by 182 · see citing works
Vahedi, H., Merat, S., RASHIDIOON, A., Ghoddoosi, A. R., & Malekzadeh, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02566.x · Cited by 181 · see citing works
Coulie, B., Szarka, L., Camilleri, M., Burton, D., Mckinzie, S., Stambler, N., & Cedarbaum, J. (2000) · Gastroenterology · doi:10.1053/gast.2000.8553 · Cited by 178 · see citing works
The treatment of functional dyspepsia with red pepper
Bortolotti, M., Coccia, G., Grossi, G., & Miglioli, M. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01280.x · Cited by 178 · see citing works
Serotoninergic neuroenteric modulators
Talley, N. J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07103-3 · Cited by 178 · see citing works
Self-citationAdrenergic modulation of human colonic motor and sensory function
Bharucha, A. E., Camilleri, M., Zinsmeister, A. R., & Hanson, R. B. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.5.g997 · Cited by 177 · see citing works
The role of nerve growth factor in a model of visceral inflammation
Dmitrieva, N., Shelton, D., Rice, A. S. C., & McMahon, S. B. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00575-1 · Cited by 174 · see citing works
Ait-Belgnaoui, A., Bradesi, S., Fioramonti, J., Theodorou, V., & Bueno, L. (2005) · Pain · doi:10.1016/j.pain.2004.10.002 · Cited by 171 · see citing works
Self-citationBarreau, F., Cartier, C., Ferrier, L., Fioramonti, J., & Bueno, L. P. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.019 · Cited by 171 · see citing works
Self-citationKim, H. J., Camilleri, M., Carlson, P., Cremonini, F., Ferber, I., Stephens, D., Mckinzie, S., Zinsmeister, A., & Urrutia, R. (2004) · Gut · doi:10.1136/gut.2003.030882 · Cited by 168 · see citing works
Tack, J. F., Müller-Lissner, S., Bytzer, P., Corinaldesi, R., Chang, L., Viegas, A., Schnekenbuehl, S., Dunger-Baldauf, C., & Rueegg, P. (2005) · Gut · doi:10.1136/gut.2005.070789 · Cited by 168 · see citing works
Self-citationRaybould, H. E., Glatzle, J., Robin, C., Meyer, J. H., Phan, T., Wong, H., & Sternini, C. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00292.2001 · Cited by 164 · see citing works
Delvaux, M. M., Louvel, D., Lagier, E., Scherrer, B., Abitbol, J., & Frexinos, J. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70226-x · Cited by 158 · see citing works
Pharmacology of serotonin: what a clinician should know
Ponti, F. D. (2004) · Gut · doi:10.1136/gut.2003.035568 · Cited by 158 · see citing works
Expression of 5-HT3 receptors in the rat gastrointestinal tract
Glatzle, J., Sternini, C., Robin, C., Zittel, T. T., Wong, H. C., Reeve, J. R., & Raybould, H. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.34245 · Cited by 156 · see citing works
Enhanced perception of physiological intestinal motility in the irritable bowel syndrome
Kellow, J. E., Eckersley, G. M., & Jones, M. P. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90400-f · Cited by 156 · see citing works
Dapoigny, M. C., Abitbol, J., & Fraitag, B. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02209014 · Cited by 155 · see citing works
Visceral perception in irritable bowel syndrome
Zighelboim, J., Talley, N. J., Phillips, S. F., Harmsen, W. S., & Zinsmeister, A. R. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02064986 · Cited by 152 · see citing works
Self-citationPonti, F. D., & Tonini, M. (2001) · Drugs · doi:10.2165/00003495-200161030-00001 · Cited by 147 · see citing works
Serotonin Transporter Gene Polymorphism in Irritable Bowel Syndrome
Pata, C., Erdal, E. M., Derici, E., Yazar, A., Kanık, A., & Ulu, O. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05841.x · Cited by 146 · see citing works
Modeling of Corticosteroid Pharmacogenomics in Rat Liver Using Gene Microarrays
Jin, J. Y., Almon, R. R., DuBois, D. C., & Jusko, W. J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.053256 · Cited by 144 · see citing works
Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist Alosetron
Berman, S. M., Chang, L., Suyenobu, B., Derbyshire, S. W., Stains, J., FitzGerald, L., Mandelkern, M., Hamm, L., Vogt, B., Naliboff, B. D., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.35990 · Cited by 139 · see citing works
Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis
O'Hara, J. R., Ho, W., Linden, D. R., Mawe, G. M., & Sharkey, K. A. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00090.2004 · Cited by 139 · see citing works
Broekaert, D., Fischler, B., Sifrim, D. A., Janssens, J., & Tack, J. F. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02772.x · Cited by 134 · see citing works
Self-citationSerotonin transporter function and expression are reduced in mice with TNBS‐induced colitis
Linden, D. R., Foley, K. F., Mcquoid, C., Simpson, J., Sharkey, K. A., & Mawe, G. M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00673.x · Cited by 134 · see citing works
Suttorp, N., Hippenstiel, S., Fuhrmann, M., Krull, M., & Podzuweit, T. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.270.3.c778 · Cited by 133 · see citing works
HALPERN, G. M., Prindiville, T. P., Blankenburg, M., Hsia, T., & Gershwin, M. E. (1996) · PubMed · Cited by 131 · see citing works
Lee, K. J., Kim, J., & Cho, S. W. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02685.x · Cited by 130 · see citing works
Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention
Tack, J. F., Caenepeel, P., Corsetti, M., & Janssens, J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.07.005 · Cited by 129 · see citing works
Self-citationCoffin, B., Farmachidi, J.-P., Rueegg, P. C., Bastie, A., & Bouhassira, D. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01449.x · Cited by 125 · see citing works
The 5‐HT4 receptor agonist, tegaserod, is a potent 5‐HT2B receptor antagonist in vitro and in vivo
Beattie, D. T., Smith, J. A. M., Marquess, D. G., et al. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705929 · Cited by 121 · see citing works
Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review
Hojo, M., Miwa, H., Yokoyama, T., Ohkusa, T., Nagahara, A., Kawabe, M., Asaoka, D., Izumi, Y., & Sato, N. (2005) · Journal of Gastroenterology · doi:10.1007/s00535-005-1687-8 · Cited by 120 · see citing works
Mayer, E. A., Berman, S. M., Derbyshire, S. W. G., Suyenobu, B. Y., Chang, L., Fitzgerald, L., Mandelkern, M. A., Hamm, L. R., Vogt, B. A., & Naliboff, B. D. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01287.x · Cited by 117 · see citing works
5‐HT2B receptors play a key role in mediating the excitatory effects of 5‐HT in human colon in vitro
Borman, R. A., Tilford, N. S., Harmer, D. W., et al. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704571 · Cited by 117 · see citing works
Serretti, A., Benedetti, F., Zanardi, R., & Smeraldi, E. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.013 · Cited by 116 · see citing works
Tack, J. F., Broekaert, D., Coulie, B. J., Fischler, B., & Janssens, J. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01469.x · Cited by 115 · see citing works
Self-citationPlasticity in serotonin control mechanisms in the gut
Gershon, M. D. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.07.005 · Cited by 111 · see citing works
Talley, N. J., ZANTEN, S. V. V., Saez, L. R., Dukes, G. E., Perschy, T. L., Heath, M., Kleoudis, C. S., & Mangel, A. W. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.00941.x · Cited by 110 · see citing works
Self-citationTSUCHIYA, J., BARRETO, R., OKURA, R., KAWAKITA, S., FESCE, E., & MAROTTA, F. (2004) · Chinese Journal of Digestive Diseases · doi:10.1111/j.1443-9573.2004.00176.x · Cited by 108 · see citing works
A Study of Candidate Genotypes Associated with Dyspepsia in a U.S. Community
Camilleri, C. E., Carlson, P. J., Camilleri, M., Castillo, E. J., Locke, G. R., Geno, D. M., Stephens, D. A., Zinsmeister, A. R., & Urrutia, R. A. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00481.x · Cited by 107 · see citing works
Gorard, S. A. C., Libby, G., & Farthing, M. J. G. (1994) · Gut · doi:10.1136/gut.35.4.496 · Cited by 107 · see citing works
III. Visceral afferent pathways: a source of new therapeutic targets for abdominal pain
Bueno, L. P., Fioramonti, J., & Villar, R. G. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.5.g670 · Cited by 105 · see citing works
Self-citationCremonini, F., Camilleri, M., McKinzie, S., Carlson, P., Camilleri, C. E., Burton, D. D., Thomforde, G. M., Urrutia, R. A., & Zinsmeister, A. R. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41081.x · Cited by 103 · see citing works
Delvaux, M. M., Beck, A., Jacob, J., Bouzamondo, H., Weber, F. T., & Frexinos, J. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01922.x · Cited by 102 · see citing works
Tegaserod for the treatment of irritable bowel syndrome
Evans, B., Clark, W., Moore, D., & Whorwell, P. J. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003960.pub2 · Cited by 97 · see citing works
Role of prostaglandins in regulating gastric motility
Sanders, K. M. (1984) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1984.247.2.g117 · Cited by 97 · see citing works
Goldberg, P. A., Kamm, M. A., Setti-Carraro, P., van der Sijp, J. R. M., & Roth, C. (2009) · Digestion · doi:10.1159/000201377 · Cited by 95 · see citing works
Influence of tegaserod on proximal gastric tone and on the perception of gastric distension
Tack, J. F., Vos, R. D., Janssens, J., Salter, J., Jauffret, S., & Vandeplassche, G. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01775.x · Cited by 92 · see citing works
Self-citationPost-infectious irritable bowel syndrome
Spiller, R. E., & Campbell, E. (2005) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000194792.36466.5c · Cited by 92 · see citing works
Role of nerve growth factor in the trinitrobenzene sulfonic acid-induced colonic hypersensitivity
Delafoy, L., Raymond, F., Doherty, A. M., Eschalier, A., & Diop, L. (2003) · Pain · doi:10.1016/s0304-3959(03)00266-5 · Cited by 91 · see citing works
Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human
Lecci, A., Capriati, A., Altamura, M., & Maggi, C. A. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.014 · Cited by 91 · see citing works
Effects of the somatostatin analogue octreotide on rectal afferent nerves in humans
Plourde, V., Lembo, T., Shui, Z., Parker, J., Mertz, H., Taché, Y., Sytnik, B., & Mayer, E. A. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.265.4.g742 · Cited by 91 · see citing works
5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons
Meuser, T., Pietruck, C., Gabriel, A., et al. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02011-8 · Cited by 90 · see citing works
Evidence for 5‐HT7 receptors mediating relaxation of human colonic circular smooth muscle
Prins, N. H., Briejer, M. R., Bergen, P. J. E. V., et al. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702762 · Cited by 90 · see citing works
Camilleri, M., Kim, D.-Y., McKinzie, S., Kim, H. J., Thomforde, G. M., Burton, D. D., Low, P. A., & Zinsmeister, A. R. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1053/cgh.2003.50019 · Cited by 90 · see citing works
Schikowski, A., Thewissen, M., Mathis, C., Ross, H., & Enck, P. (2002) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2002.00328.x · Cited by 88 · see citing works
5-HT7 Receptors Modulate Peristalsis and Accommodation in the Guinea Pig Ileum
Tonini, M., Vicini, R., Cervio, E., Ponti, F. D., GIORGIO, R. D., Barbara, G., Stanghellini, V., Dellabianca, A., & Sternini, C. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.08.005 · Cited by 86 · see citing works
Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum
Carter, D., Champney, M. S., Hwang, B., et al. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00195-q · Cited by 86 · see citing works
Evolution of Visceral Sensitivity in Patients with Irritable Bowel Syndrome
Poitras, P., Riberdy, M., Plourde, V., Boivin, M., & Verrier, P. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1014729125428 · Cited by 85 · see citing works
Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans
Chial, H. J., Camilleri, M., Ferber, I. J., Delgado-Aros, S., Burton, D. D., McKinzie, S., & Zinsmeister, A. R. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70038-x · Cited by 84 · see citing works
Liu, M., Rayport, S., Jiang, Y., Murphy, D. L., & Gershon, M. D. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00203.2002 · Cited by 83 · see citing works
Randich, A., Ren, K., & Gebhart, G. F. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.64.4.1115 · Cited by 82 · see citing works
Zhou, X., & Galligan, J. J. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)34967-5 · Cited by 81 · see citing works
Holtmann, G., Gschossmann, J., Neufang-Hüber, J., Gerken, G., & Talley, N. J. (2000) · Gut · doi:10.1136/gut.47.3.332 · Cited by 80 · see citing works
Self-citationCerebral responses evoked by electrical stimulation of the esophagus in normal subjects
Frieling, T., Enck, P., & WIENBECK, M. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90087-5 · Cited by 77 · see citing works
Rodriguez-Stanley, S., Zubaidi, S. M., Proskin, H. M., Kralstein, J. R., Shetzline, M. A., & Miner, P. B. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.01.014 · Cited by 75 · see citing works
Verne, G. N., Sen, A., & Price, D. D. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.02.009 · Cited by 74 · see citing works
Influence of acute serotonin reuptake inhibition on colonic sensorimotor function in man
Tack, J. F., Broekaert, D., Corsetti, M., Fischler, B., & Janssens, J. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02724.x · Cited by 73 · see citing works
Self-citationLawrence, A. J., Krstew, E., Dautzenberg, F. M., & Rühmann, A. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704783 · Cited by 73 · see citing works
Monro, R. L., Bornstein, J. C., & Bertrand, P. P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.006 · Cited by 73 · see citing works
Gastrointestinal Motor Disturbances in Functional Dyspepsia
Malagelada, J. R. (1991) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529109109534 · Cited by 73 · see citing works
Ueki, S., Takeuchi, K., & Okabe, S. (1988) · Digestive Diseases and Sciences · doi:10.1007/bf01535735 · Cited by 72 · see citing works
A somatostatin analogue inhibits afferent pathways mediating perception of rectal distention
Hasler, W. L., Soudan, H. C., & Owyang, C. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90347-f · Cited by 71 · see citing works
A prospective study characterizing full-length hepatitis B virus genomes during acute exacerbation
Liu, C., Chen, P., Lai, M., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50003 · Cited by 71 · see citing works
Genes and the Response to Drugs
Caraco, Y. (2004) · New England Journal of Medicine · doi:10.1056/nejme048278 · Cited by 71 · see citing works
Julia, V., Su, X., Buéno, L., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70015-6 · Cited by 71 · see citing works
Maubach, K. A., & Grundy, D. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.277ad.x · Cited by 70 · see citing works
Ondansetron reduces nausea induced by gastroduodenal stimulation without changing gastric motility
Feinle, C., & Read, N. W. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.4.g591 · Cited by 70 · see citing works
Physiological Genomics of Antidepressant Targets: Keeping the Periphery in Mind
Blakely, R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08319.2001 · Cited by 69 · see citing works
Olivier, B., Soudijn, W., & van Wijngaarden, I. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8391-7_3 · Cited by 69 · see citing works
An Open-Label Trial of Theophylline for Functional Chest Pain
Rao, S. S. C., Mudipalli, R. S., Mujica, V. R., et al. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1021017524660 · Cited by 68 · see citing works
Stichtenoth, D. O., Marhauer, V., Tsikas, D., et al. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00676.x · Cited by 68 · see citing works
Nitric oxide released by lactobacillus farciminis improvesTNBS‐induced colitis in rats
Lamine, F., Fioramonti, J., Bueno, L. P., Nepveu, F., Cauquil, E., Lobysheva, I. I., Eutamène, H., & Théodorou, V. (2004) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310007152 · Cited by 68 · see citing works
Self-citationSensitization of visceral afferents to bradykinin in rat jejunum in vitro
Brunsden, A. M., & Grundy, D. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00517.x · Cited by 66 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
Dimidi, E., Christodoulides, S., Fragkos, K. C., Scott, S. M., & Whelan, K. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.089151 · Cited by 316 · see citing works
Prebiotics and probiotics; modifying and mining the microbiota
Quigley, E. M. M. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.01.004 · Cited by 238 · see citing works
Magro, D. O., de Oliveira, L. M. R., Bernasconi, I., de Souza Ruela, M., Credidio, L., Barcelos, I. K., Leal, R. F., Ayrizono, M. D. L. S., Fagundes, J. J., Teixeira, L. D. B., et al. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-75 · Cited by 105 · see citing works
Quigley, E. M. M. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.009 · Cited by 67 · see citing works
Self-citationSchmulson, M., & Chang, L. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04637.x · Cited by 70 · see citing works
Quigley, E. M. M. (2007) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2007.07.012 · Cited by 67 · see citing works
Self-citationRecent developments in the therapy of irritable bowel syndrome
Saad, R. J., & Chey, W. D. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.2.117 · Cited by 21 · see citing works
- Authors
- Bueno, L., De Ponti, F., Fried, M., Kullak‐ublick, G. A., Kwiatek, M. A., Pohl, D., Quigley, E. M. M., Tack, J., & Talley, N. J.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- University Hospital Zurich (CH)
- University College Cork (IE)
- KU Leuven (BE)
- Mayo Clinic (US)
- Corresponding author
- Bueno, L.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2007-01
- Volume
- 19
- Issue
- s1
- Pages
- 89-119
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2032490947
- Cited by
- 64
- References
- 268
- Citations by year
- 2026: 1 · 2023: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- visceral hypersensitivity, functional gastrointestinal disorders, pharmacotherapy, probiotics, pharmacogenomics, drug development
- MeSH terms
- Animals, Gastrointestinal Diseases, Humans, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Pain Threshold, Visceral Afferents, Serotonin Agents, Probiotics, Gastrointestinal Tract, Cyclooxygenase 2 Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review