Cited by 64Gastrointestinal motility and disordersPain Mechanisms and TreatmentsPsychosomatic Disorders and Their Treatments

Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity

Bueno, L., De Ponti, F., Fried, M., Kullak‐ublick, G. A., Kwiatek, M. A., Pohl, D., Quigley, E. M. M., Tack, J. +1 more·2007·Neurogastroenterology & Motility

Abstract

Abstract Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.

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Crossref · 10.1111/j.1365-2982.2006.00876.x

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Authors
Bueno, L., De Ponti, F., Fried, M., Kullak‐ublick, G. A., Kwiatek, M. A., Pohl, D., Quigley, E. M. M., Tack, J., & Talley, N. J.
Affiliations
  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
  • University Hospital Zurich (CH)
  • University College Cork (IE)
  • KU Leuven (BE)
  • Mayo Clinic (US)
Corresponding author
Bueno, L.
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2007-01
Volume
19
Issue
s1
Pages
89-119
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
OpenAlex
W2032490947
Cited by
64
References
268
Citations by year
2026: 1 · 2023: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 2
FWCI
1.41
Type
journal article
Language
en
Open access
closed
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
visceral hypersensitivity, functional gastrointestinal disorders, pharmacotherapy, probiotics, pharmacogenomics, drug development
MeSH terms
Animals, Gastrointestinal Diseases, Humans, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Pain Threshold, Visceral Afferents, Serotonin Agents, Probiotics, Gastrointestinal Tract, Cyclooxygenase 2 Inhibitors

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