The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.
Impact of fatigue on the quality of life of patients with primary biliary cirrhosis
Abstract
OBJECTIVE: Fatigue is a frustrating symptom frequently reported by patients with primary biliary cirrhosis (PBC), but it is still poorly understood and not well evaluated. Our aim was to determine its importance and its impact on the quality of life and mental health status of patients with PBC. METHODS: Patients with PBC (103 women and 13 men with a mean age of 52.6 yr) completed self-report questionnaires to evaluate the impact of fatigue on their quality of life (Fatigue Impact Scale, FIS), the perception of their own mental health (Symptom Check list-90-R, SCL), and depression (Beck Depression Inventory, BDI). A cohort of age-matched healthy blood donors served as controls. RESULTS: Fatigue was present in 99 patients (85.3%) and was the worst or one of the worst symptoms in about half of them. In PBC patients, the mean FIS and SCL indexes were significantly increased, compared to healthy controls (1.49 +/- 1.11 vs 0.6 +/- 0.6 and 0.72 +/- 0.55 vs 0.36 +/- 0.35, respectively). Unexpectedly, 52 patients (44.8%) could be classified as having depression (BDI score > 10). Significant correlations were found between the FIS and SCL indexes, between the FIS index and the BDI score, as well as between the BDI score and the SCL index. Finally, fatigue was not related to the disease severity parameters, that is, clinical, biochemical, metabolic, and pathological. CONCLUSIONS: Fatigue is a frequent and disabling complaint that impairs the quality of life of PBC patients and their perception of their own mental health, which may be associated with an unexpected depressive condition. In addition, the FIS questionnaire can be considered as a useful tool to assess fatigue in PBC patients and may be used in the evaluation of specific treatments aimed at reducing this complaint in such patients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although fatigue is not specific to PBC, it is frequently reported by patients (over 50%) and when severe, as it is in 20% of patients, is a significant cause of QoL impairment.12 171 205–208”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [207]
In the citing paper
“While examining the effect of fatigue on quality of life in patients with primary biliary cholangitis, Huet and colleagues found self-reported DEP to be ~45%.[24]”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [24]
Citations
Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
Measuring the Functional Impact of Fatigue: Initial Validation of the Fatigue Impact Scale
Fisk, J. D., Ritvo, P. G., Ross, L., Haase, D. A., Marrie, T. J., & Schlech, W. F. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/18.supplement_1.s79 · Cited by 1,546
The impact of fatigue on patients with multiple sclerosis
Fisk, J. D., Pontefract, A., Ritvo, P. G., Archibald, C. J., & Murray, T. J. (1994) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100048691 · Cited by 1,025 · cited 4×
“Determining how a patient’s quality of life may be affected by his or her fatigue and assessing his or her present experience of fatigue are essential to understanding the overall impact of the disease on the patient’s general health status (11).”
BackgroundResultInfluentialPrognosis in primary biliary cirrhosis: Model for decision making
Dickson, R. E., Grambsch, P. M., Fleming, T. R., Fisher, L. D., & Langworthy, A. (1989) · Hepatology · doi:10.1002/hep.1840100102 · Cited by 816 · cited 1×
“Epidemiological data, liver biochemistry, and Mayo risk score (13) were collected at the latest visit, as well as the pathological stage at diagnosis (14).”
BackgroundStaging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)
Ludwig, J., Dickson, E. R., & McDonald, G. S. A. (1978) · Virchows Archiv A Pathological Anatomy and Histology · doi:10.1007/bf00432479 · Cited by 753
The measurement of fatigue: a new instrument
Schwartz, J. E., Jandorf, L., & Krupp, L. B. (1993) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(93)90104-n · Cited by 562
Chronic Fatigue in Primary Care
Kroenke, K. (1988) · JAMA · doi:10.1001/jama.260.7.929 · Cited by 558
Case-Finding Instruments for Depression in Primary Care Settings
Mulrow, C. D., Williams, J. W., Gerety, M. B., Ramirez, G., Montiel, O. M., & Kerber, C. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-12-199506150-00004 · Cited by 456
Fatigue in primary care: Prevalence, psychiatric comorbidity, illness behavior, and outcome
Cathébras, P. J., Robbins, J. M., Kirmayer, L. J., & Hayton, B. C. (1992) · Journal of General Internal Medicine · doi:10.1007/bf02598083 · Cited by 240
Fatigue in primary biliary cirrhosis
Cauch-Dudek, K., Abbey, S., Stewart, D. E., & Heathcote, E. J. (1998) · Gut · doi:10.1136/gut.43.5.705 · Cited by 237
Research works printed but not linked: 6
- Jones E.A., 1995, Hepatology, 22, 1606
- Kroenke K., 1998, JAMA, 260, 929, 10.1001/jama.1988.03410070057028 · DOI
- Morrison J.D., 1980, J Fam Pract, 10, 795
- Sugarman J.R., 1984, J Fam Pract, 19, 643
- Derogatis L., 1994, SCL-90-R, administration, scoring, and procedure manual
- Swain M.G., 1995, Hepatology, 22, 1560
Cited by
Sorted by citations
Items 201–262 of 262
Etiology and prevalence of fatigue in chronic liver disease: clinical view
Salama, Z. A., Darweesh, S. K., Shehab, H. M., & Abd-Elhameed, M. A. (2016) · The Egyptian Journal of Internal Medicine · doi:10.4103/1110-7782.193892 · Cited by 5
Determining the nature and impact of fatigue after liver transplantation
Talwalkar, J. A. (2006) · Liver Transplantation · doi:10.1002/lt.20781 · Cited by 4
Clinical Impact of Depression in Cirrhosis
Serigado, J. M., Barboza, K. C., Marcus, P., & Sigal, S. H. (2018) · Current Hepatology Reports · doi:10.1007/s11901-018-0386-x · Cited by 4
Talwalkar, J. A., & Lindor, K. D. (2006) · Elsevier eBooks · doi:10.1016/b978-1-4160-3258-8.50046-2 · Cited by 4
Assessment of Fatigue in Adults with Disabilities
Kalapatapu, R. K., & Cristian, A. (2009) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2008.12.001 · Cited by 3
Shiba, S., 柿崎, 暁., Sato, K., 武, 市., Tojima, H., 大輔, 神., Naganuma, A., Hosonuma, K., 正敏, 柳., Matsuzaki, Y., et al. (2007) · Kanzo · doi:10.2957/kanzo.48.256 · Cited by 3
Relatedness theory as a framework for the treatment of fatigued women
Patusky, K. L. (2002) · Archives of Psychiatric Nursing · doi:10.1053/apnu.2002.36235 · Cited by 3
Methodological Issues and the Measurement of Fatigue in Primary Biliary Cirrhosis * #
Revicki, D. A. (2005) · Hepatology · doi:10.1002/hep.20789 · Cited by 3
Meyer, F., Rischmüller, K., Wiese, M. L., Sautter, L. F., Esau, S., Müller, J., Ehlers, L., Metges, C. C., Kropp, P. A., Garbe, L., et al. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.11.005 · Cited by 2
Sebode, M., Bantel, H., Baumann, U., Bufler, P., Demir, M., Dold, L., Keitel, V., Klein, R., Kremer, A. E., Jansen, P. L., et al. (2026) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2769-2475 · Cited by 2
Untas, A., Goffette, C., Flahault, C., Vioulac, C., Chazouillères, O., Soret, P., Belkacem, K. B., Gaouar, F., Bernard, N., Rousseau, A., et al. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003639 · Cited by 3
Practical management of primary biliary cholangitis
Parés, A. R. (2021) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2021.8219/2021 · Cited by 2
Tanaka, A., Leung, P. S. C., Bowlus, C. L., & Gershwin, M. E. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_22 · Cited by 2
Diagnostic value of anti-gp210 antibodies in primary biliary cirrhosis: a case-based review
Valour, F., Durupt, S., Khenifer, S., & Durieu, I. (2013) · BMJ Case Reports · doi:10.1136/bcr-2013-009803 · Cited by 2
Quality of Life and Physical Activity after Liver Transplantation. Literature Review.
Stępień–Słodkowska, M., Niewiadomska, M., & Kotarska, K. (2017) · Central European Journal of Sport Sciences and Medicine · doi:10.18276/cej.2017.1-06 · Cited by 2
Zamor, P. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-33628-8_10 · Cited by 2
Sclair, S. N., & Levy, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-37591-7.00042-2 · Cited by 2
Jorgensen, R. A. (2010) · University of Minnesota Digital Conservancy (University of Minnesota) · Cited by 2
Measuring fatigue in medically unwell and distressed patients
Prince, M. I., & Jones, D. E. (2001) · Current Opinion in Psychiatry · doi:10.1097/00001504-200111000-00017 · Cited by 3
Levy, C., Carrion, A. F., & Mayo, M. J. (2017) · Wiley eBooks · doi:10.1002/9781119251316.ch21 · Cited by 2
Health related quality of life in patients with primary biliary cholangitis
Yassin, F. A., Abiyev, A., Ergin, M., Ekmen, N., & İbi̇ş, M. (2022) · Journal of Clinical Medicine of Kazakhstan · doi:10.23950/jcmk/12292 · Cited by 1
Zhao, C., Zang, B., Liu, Q., Liu, B., Yao, Y., Li, H., Yang, Y., & Liu, B. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1444473 · Cited by 1
Sheptulina, A. F., Golubeva, J. A., Kiselev, A. R., & Drapkina, O. M. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i10.110848 · Cited by 2
Sharafkhaneh, A., Velamuri, S., Melendez, J. A., Akhtar, F., & Hirshkowitz, M. (2013) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2013.04.002 · Cited by 1
Kalaitzakis, E. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.06.012 · Cited by 1
Raszeja‐Wyszomirska, J. (2017) · International Journal of Clinical and Experimental Medical Sciences · doi:10.11648/j.ijcems.20170304.11 · Cited by 1
PARKINSON'S DISEASE ACCOMPANIED BY PRIMARY BILIARY CIRRHOSIS: A CASE REPORT
Tehrani, M. R. H., & Poursadeghfard, M. (2020) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000471 · Cited by 1
Portosystemic Shunt Associated with Severe Episodic Weakness
Wessmann, A., Volk, H. A., Shelton, G. D., Chandler, K., BAINES, S. J., & Cappello, R. (2006) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2006.tb01827.x · Cited by 1
Tanaka, A., Takahashi, H., Nezu, S., Ueno, Y., Kikuchi, K., Shibuya, A., Ohira, H., Zeniya, M., Montali, L., Invernizzi, P., et al. (2009) · Kanzo · doi:10.2957/kanzo.50.51 · Cited by 1
Josefsson, A., Fu, M. L. X., Bjornsson, E. S., Castedal, M., & Kalaitzakis, E. (2015) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000292 · Cited by 1
Tanaka, A., & Gershwin, M. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00058-0 · Cited by 2
Health Status Assessment and Economic Analyses in Cirrhosis and Portal Hypertension
Talwalkar, J. A., & Kim, W. R. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-885-4_28
Fatigue vid kronisk leversjukdom
Palmbring, B., & Johansson, S. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Approach to the Patient with Cholestasis and Jaundice
Dancygier, H., & Rogart, J. N. (2009) · Springer eBooks · doi:10.1007/978-3-540-93842-2_52
Patient Selection and Indications for Liver Transplantation
Brown, K., & Kazimi, M. (2014) · doi:10.1002/9781118873434.ch29 · Cited by 3
Lloyd, G. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543975.018
Psychosomatische Aspekte chronischer Lebererkrankungen
Häuser, W. (2007) · Springer eBooks · doi:10.1007/978-3-211-69159-5_19
Treatment of fatigue in Hepatogastroenterology: fact or fiction?
Piche, T., Huet, P., & Tran, A. (2005) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(05)82129-3
Self-citationJosefsson, A. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Liver Transplantation for Primary Biliary Cirrhosis
Talwalkar, J. A., Kim, W. R., & Dickson, E. R. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-0118-2.50017-3
Pathophysiological Basis of Pruritus and Fatigue in Cholestasis
Swain, M. G. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9034-1_21
Carey, E. J., & Levy, C. (2018) · Clinics in Liver Disease · doi:10.1016/s1089-3261(18)30044-8
Cancer Immunotherapy: Friend or Foe of Mental Health?
Saghazadeh, A., & Rezaei, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-64550-6_16
Diseases of the Liver: Primary Biliary Cholangitis
Phillips, P. K., & Said, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-25626-5_7
Psychological, Cognitive, and Laboratory Characteristics of End-Stage Liver Disease Patients
Mirgoziev, M., Baghernezhad, M., Malek‐Hosseini, S. A., Rezaee, M., Ansarinia, Z., Gholami, S., & Nikeghbalian, S. (2020) · Hepatitis Monthly · doi:10.5812/hepatmon.96433
Психологічні особливості пацієнтів з хронічною неінфекційною гепатологічною патологією
Skurat, K. (2019) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.26766/pmgp.v4i4.248
Cholangitis and cholangiodysplasia
(2006) · Springer eBooks · doi:10.1007/3-540-28977-1_32
Kuntz, E., & Kuntz, H.-D. (2002) · Springer eBooks · doi:10.1007/978-3-662-04680-7_32
Newton, J. L., & Jones, D. E. J. (2010) · Occupational Medicine · doi:10.1093/occmed/kqq169
Abe, K., Fujita, M., Hayashi, M., Takahashi, A., & Ohira, H. (2020) · doi:10.21203/rs.3.rs-26504/v1
Challenges for diagnosis and treatment of primary biliary cholangitis
Tanaka, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85389-7.00007-7
Skat-Rørdam, P. A., Eliasson, J., Kjær, M. S., Jeppesen, P. B., & Ytting, H. (2023) · Minerva Gastroenterology · doi:10.23736/s2724-5985.23.03206-0
Weltzsch, J. P., Sebode, M., & Hartl, J. (2023) · Die Gastroenterologie · doi:10.1007/s11377-023-00725-z
Khakoo, N. S., & Levy, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23947-2.00039-4
Staufer, K. (2024) · Springer eBooks · doi:10.1007/978-3-662-68436-8_14
Du, Q., Han, Y., & Pan, P. (2025) · Medicine · doi:10.1097/md.0000000000044731
Fatigue in Cholestatic Liver Disease: A Review of Mechanisms and Non-Pharmacological Management
Isley, S., Johnson, E., Swain, M. G., & Tandon, P. (2025) · Current Hepatology Reports · doi:10.1007/s11901-025-00706-6
Canivet, C. M. (2019) · theses.fr (ABES) · doi:10.70675/d03174c8z45cez439ezba77z41b6ed9403b3
Kumar, S., Shamseddine, N., Yang, H., Zhang, S., Chen, J., & Kowdley, K. V. (2026) · Journal of Comparative Effectiveness Research · doi:10.57264/cer-2025-0179
Saruhan, M. A., Oyman, F., Dertsiz, B., Saruhan, K., & Adalı, G. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15207967
A Propósito de um Caso de Cirrose Hepática.
de Carvalho, R. M. V. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/zd97-7767
Metadata
- Authors
- Huet, P.-M., Deslauriers, J., Tran, A., Faucher, C., & Charbonneau, J.
- Affiliations
- Hôpital Saint-Luc (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- ORCID
- Tran, Albert
- Venue
- The American Journal of Gastroenterology
- Published
- 2000-03
- Volume
- 95
- Issue
- 3
- Pages
- 760-767
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W1988292608
- Cited by
- 262
- References
- 24
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 12 · 2019: 7 · 2018: 15 · 2017: 9 · 2016: 4 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 5
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- primary biliary cirrhosis, fatigue, quality of life, depression, mental health, Fatigue Impact Scale, SCL-90-R, Beck Depression Inventory, symptom burden, disease severity
- MeSH terms
- Adult, Aged, Depression, Fatigue, Female, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Personality Inventory, Quality of Life, Sick Role, Sickness Impact Profile
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
