The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.
Impact of fatigue on the quality of life of patients with primary biliary cirrhosis
Abstract
OBJECTIVE: Fatigue is a frustrating symptom frequently reported by patients with primary biliary cirrhosis (PBC), but it is still poorly understood and not well evaluated. Our aim was to determine its importance and its impact on the quality of life and mental health status of patients with PBC. METHODS: Patients with PBC (103 women and 13 men with a mean age of 52.6 yr) completed self-report questionnaires to evaluate the impact of fatigue on their quality of life (Fatigue Impact Scale, FIS), the perception of their own mental health (Symptom Check list-90-R, SCL), and depression (Beck Depression Inventory, BDI). A cohort of age-matched healthy blood donors served as controls. RESULTS: Fatigue was present in 99 patients (85.3%) and was the worst or one of the worst symptoms in about half of them. In PBC patients, the mean FIS and SCL indexes were significantly increased, compared to healthy controls (1.49 +/- 1.11 vs 0.6 +/- 0.6 and 0.72 +/- 0.55 vs 0.36 +/- 0.35, respectively). Unexpectedly, 52 patients (44.8%) could be classified as having depression (BDI score > 10). Significant correlations were found between the FIS and SCL indexes, between the FIS index and the BDI score, as well as between the BDI score and the SCL index. Finally, fatigue was not related to the disease severity parameters, that is, clinical, biochemical, metabolic, and pathological. CONCLUSIONS: Fatigue is a frequent and disabling complaint that impairs the quality of life of PBC patients and their perception of their own mental health, which may be associated with an unexpected depressive condition. In addition, the FIS questionnaire can be considered as a useful tool to assess fatigue in PBC patients and may be used in the evaluation of specific treatments aimed at reducing this complaint in such patients.
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“Although fatigue is not specific to PBC, it is frequently reported by patients (over 50%) and when severe, as it is in 20% of patients, is a significant cause of QoL impairment.12 171 205–208”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [207]
In the citing paper
“While examining the effect of fatigue on quality of life in patients with primary biliary cholangitis, Huet and colleagues found self-reported DEP to be ~45%.[24]”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [24]
Citations
Cites
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“Determining how a patient’s quality of life may be affected by his or her fatigue and assessing his or her present experience of fatigue are essential to understanding the overall impact of the disease on the patient’s general health status (11).”
BackgroundResultInfluentialPrognosis in primary biliary cirrhosis: Model for decision making
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“Epidemiological data, liver biochemistry, and Mayo risk score (13) were collected at the latest visit, as well as the pathological stage at diagnosis (14).”
BackgroundStaging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)
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Cited by
Sorted by citations
Hirschfield, G. M., Beuers, U., Corpechot, C., Invernizzi, P., Jones, D., Marzioni, M., & Schramm, C. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.03.022 · Cited by 1,480
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Heathcote, J. (2000) · Hepatology · doi:10.1053/he.2000.5984 · Cited by 412
Hirschfield, G. M., Dyson, J. K., Alexander, G. J. M., Chapman, M. H., Collier, J., Hübscher, S., Patanwala, I., Pereira, S. P., Thain, C., Thorburn, D., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315259 · Cited by 362
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Metadata
- Authors
- Huet, P.-M., Deslauriers, J., Tran, A., Faucher, C., & Charbonneau, J.
- Affiliations
- Hôpital Saint-Luc (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- ORCID
- Tran, Albert
- Venue
- The American Journal of Gastroenterology
- Published
- 2000-03
- Volume
- 95
- Issue
- 3
- Pages
- 760-767
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W1988292608
- Cited by
- 262
- References
- 24
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 12 · 2019: 7 · 2018: 15 · 2017: 9 · 2016: 4 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 5
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- primary biliary cirrhosis, fatigue, quality of life, depression, mental health, Fatigue Impact Scale, SCL-90-R, Beck Depression Inventory, symptom burden, disease severity
- MeSH terms
- Adult, Aged, Depression, Fatigue, Female, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Personality Inventory, Quality of Life, Sick Role, Sickness Impact Profile
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