Fatigue in primary biliary cirrhosis

Cauch-Dudek, K; Abbey, S; Stewart, D E; Heathcote, E J

doi:10.1136/gut.43.5.705

Cited by 237Liver Diseases and ImmunityFibromyalgia and Chronic Fatigue Syndrome ResearchLiver Disease Diagnosis and Treatment

Fatigue in primary biliary cirrhosis

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Cauch-Dudek, K, Abbey, S, Stewart, D E, Heathcote, E J·1998·Gut

DOI 10.1136/gut.43.5.705PMC PMC1727314

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Abstract

Background—Fatigue is a frequent and debilitating symptom in patients with primary biliary cirrhosis (PBC). Aims—To study fatigue in relation to sleep, depression, and liver disease severity. Methods—Patients with PBC completed validated self report questionnaires measuring fatigue, sleep quality, depression, and functional capacity. Verbally reported fatigue and observer rated measure of depression and ursodeoxycholic acid (UDCA) use were recorded. Liver biochemistry and tests to rule out metabolic causes of fatigue were performed. Results—Mean age of the 88 patients enrolled was 57 years; 86% were female and mean duration of disease was 6.6 years. Median bilirubin was 13 μmol/l (mean 18.6). Verbally reported fatigue (for more than six months) was present in 60 patients (68%). The self rated Fatigue Severity Score (FSS) correlated well with verbally reported fatigue (p=0.0001). The FSS did not correlate with age, duration of disease, serum bilirubin, Mayo Risk Score, or UDCA use, but correlation was seen with sleep quality. Fatigued patients had more sleep problems and higher depression scores than non-fatigued patients. Self rated depression was present in 28% (17/60) of fatigued compared with 4% (1/28) of non-fatigued patients. Conclusions—Long term fatigue affected 68% of the patients with PBC but it was not related to the severity of their liver disease. Poor sleep quality and depression were commonly associated with fatigue.

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Fatigue is not specific to PBC, is frequently reported by patients (over 50%) and when severe (20%) is a significant cause of QoL impairment.
“Although fatigue is not specific to PBC, it is frequently reported by patients (over 50%) and when severe, as it is in 20% of patients, is a significant cause of QoL impairment.12 171 205–208”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [206]

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Authors: Cauch-Dudek, K., Abbey, S., Stewart, D. E., & Heathcote, E. J.
Affiliations: aDepartment of Medicine, bDepartment of Psychiatry, Toronto Hospital, University of Toronto, Canada
University of Toronto (CA)
ORCID: Abbey, S
Venue: Gut
Publisher: BMJ
Published: 1998-11-01
Volume: 43
Issue: 5
Pages: 705-710
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.43.5.705
PMC: PMC1727314
OpenAlex: W2031912248
Cited by: 237
References: 42
Citations by year: 2026: 4 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 11 · 2017: 7 · 2016: 5 · 2015: 9 · 2014: 3 · 2013: 5 · 2012: 9
FWCI: 4.51
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords: primary biliary cirrhosis, fatigue, sleep quality, depression, liver disease severity, Fatigue Severity Scale, ursodeoxycholic acid, functional capacity, Mayo risk score, bilirubin
MeSH terms: Adult, Aged, Aged, 80 and over, Cognition Disorders, Depressive Disorder, Fatigue, Female, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Surveys and Questionnaires, Self Disclosure, Sleep Wake Disorders

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Fatigue in primary biliary cirrhosis

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