Domperidone: Review of Pharmacology and Clinical Applications in Gastroenterology
Abstract
Domperidone is a dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine. Unlike metoclopramide, it does not cause any adverse neurological symptoms as it has minimal penetration through the blood-brain barrier. It thus provides an excellent safety profile for long-term administration orally in the recommended doses. Domperidone is widely used in many countries and can now be officially prescribed to patients in the United States by an investigational new drug application for the treatment of gastroparesis and any condition causing chronic nausea and vomiting. In view of this additional clinical exposure of domperidone to a new generation of gastroenterologists and other specialists, the purpose of this timely review is to revisit the pharmacology, clinical application, and safety profile of this beneficial medication.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Domperidone and Erythromycin require careful cardiac monitoring.
“whereas Domperidone and Erythromycin require careful cardiac monitoring [3, 14, 123].”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [123]
Cites
Abell, T. L., Bernstein, V. K., Cutts, T., Farrugia, G., Forster, J., Hasler, W. L., Mccallum, R. W., Olden, K. W., Parkman, H. P., Parrish, C. R., et al. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00760.x · Cited by 361 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Review article: metoclopramide and tardive dyskinesia
RAO, A. S., & CAMILLERI, M. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04189.x · Cited by 316 · see citing works
Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments
Poirier, A.-A., Aubé, B., Côté, M., Morin, N., Di Paolo, T., & Soulet, D. (2016) · Parkinson s Disease · doi:10.1155/2016/6762528 · Cited by 130 · see citing works
A Systematic Review of the Efficacy of Domperidone for the Treatment of Diabetic Gastroparesis
Sugumar, A., Singh, A., & Pasricha, P. J. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.02.065 · Cited by 102 · see citing works
Domperidone-induced tardive dyskinesia and withdrawal psychosis in an elderly woman with dementia
Roy-Desruisseaux, J., Landry, J., Bocti, C., Tessier, D., Hottin, P., & Trudel, J.-F. (2011) · Annals of Pharmacotherapy · doi:10.1345/aph.1q214 · Cited by 32 · see citing works
Diabetic gastroparesis: pathophysiology and impact on insulin timing choices
Galeano, F., Tumminia, A., Oteri, V., Le Moli, R., Piticchio, T., Scilletta, S., Di Marco, M., Di Pino, A., & Frasca, F. (2026) · Endocrine · doi:10.1007/s12020-026-04693-6
“…is limited to 12 weeks due to extrapyramidal and tardive dyskinesia risk [3, 14, 120, 121], (although an intranasal formulation of metoclopramide was designed to help alleviate symptoms [64, 122]), whereas Domperi-done and Erythromycin require careful cardiac monitoring [3, 14, 123].”
- Authors
- Reddymasu, S. C., Soykan, I., & McCallum, R. W.
- Affiliations
- University of Kansas Medical Center (US)
- Corresponding author
- McCallum, Richard W.
- ORCID
- McCallum, Richard W.
- Venue
- The American Journal of Gastroenterology
- Published
- 2007-09
- Volume
- 102
- Issue
- 9
- Pages
- 2036-2045
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2068241878
- Cited by
- 304
- References
- 1
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 26 · 2023: 20 · 2022: 20 · 2021: 10 · 2020: 19 · 2019: 14 · 2018: 22 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 19 · 2013: 22 · 2012: 14
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- domperidone, antiemetics, prokinetic agents, chemoreceptor trigger zone, gastroparesis, blood-brain barrier penetration, drug safety, pharmacology
- MeSH terms
- Antiemetics, Domperidone, Gastrointestinal Diseases, Humans, Nausea, Vomiting, Dopamine Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
