A Systematic Review of the Efficacy of Domperidone for the Treatment of Diabetic Gastroparesis
Open accessAbstract
Background & aims Despite being widely used in more than 20 countries for the treatment of diabetic gastroparesis for several decades, domperidone is approved only on an investigational basis in the United States. However, because its use is increasing, it is important for gastroenterologists in this country to understand its effectiveness in this condition. The literature on this subject varies considerably with respect to the methods and outcome measures, making a meta-analysis unfeasible.Methods Our objective was to systematically analyze studies of the efficacy of domperidone in diabetic gastroparesis, with a focus on their methodologic and scientific merit. Information from 28 trials (11 full articles and 17 abstracts) from 1981 to 2007 was analyzed.Results The average study quality score was 8.3 out of a possible 15 and the total sample size equaled 1016. Overall, 64% of the studies showed significant efficacy of domperidone on the improvement of symptoms. Sixty percent of the studies showed an efficacy in gastric emptying and 67% of the studies proved the drug effective in reducing hospital admissions.Conclusions Overall, our assessment is that there is level 3 evidence for the efficacy of domperidone in diabetic gastroparesis, leading to a grade C recommendation for its use in this condition. These results need to be interpreted very cautiously because of significant methodologic limitations of these studies, including the fact that most positive studies lacked a control arm. It is clear that larger and better-designed studies are needed to further validate the use of this drug in diabetic gastroparesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Domperidone has much less blood-brain barrier penetration than metoclopramide; it is used worldwide but not FDA-approved because of unconvincing efficacy data, though it has a good safety profile.
“Domperidone, another D2-antagonist, has much less penetration through the blood-brain barrier when compared to metoclopramide. In use throughout the world, it has not been approved by the FDA, because of unconvincing efficacy data, although it possesses a good safety profile [61].”
From Gastrointestinal symptoms in postural tachycardia syndrome: a systematic review (2018) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582 · see citing works
Current methods of the U.S. Preventive Services Task Force
Harris, R., Helfand, M., Woolf, S. H., Lohr, K. N., Mulrow, C. D., Teutsch, S. M., & Atkins, D. C. (2001) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(01)00261-6 · Cited by 1,720 · see citing works
Koch, K. L., Stern, R. M., Stewart, W. R., & Vasey, M. W. (1989) · PubMed · Cited by 324 · see citing works
Domperidone: Review of Pharmacology and Clinical Applications in Gastroenterology
Reddymasu, S. C., Soykan, I., & McCallum, R. W. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01255.x · Cited by 304 · see citing works
Patterson, D., Abell, T., Rothstein, R., Koch, K., & Barnett, J. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.00456.x · Cited by 266 · see citing works
Domperidone: A Peripherally Acting Dopamine 2 -Receptor Antagonist
Barone, J. A. (1999) · Annals of Pharmacotherapy · doi:10.1345/aph.18003 · Cited by 260 · see citing works
Gastric emptying in patients with diabetes mellitus.
Loo, F. D., Palmer, D., Soergel, K., Kalbfleisch, J., & Wood, C. M. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80019-0 · Cited by 254 · see citing works
Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy
Horowitz, M., Harding, P. E., Chatterton, B. E., Collins, P., & Shearman, D. J. C. (1985) · Digestive Diseases and Sciences · doi:10.1007/bf01318363 · Cited by 233 · see citing works
Silvers, D., Kipnes, M., Broadstone, V., Patterson, D., Quigley, E. M., McCallum, R., Leidy, N., Farup, C., Liu, Y., & Joslyn, A. (1998) · Clinical Therapeutics · doi:10.1016/s0149-2918(98)80054-4 · Cited by 152 · see citing works
Patterson, D. (1999) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(98)00337-2 · Cited by 152 · see citing works
Soykan, İ., Sarosiek, I., & McCallum, R. W. (1997) · PubMed · Cited by 119 · see citing works
Vittal, H., Farrugia, G., Gomez, G., & Pasricha, P. J. (2007) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0838 · Cited by 109 · see citing works
Self-citationThe role of prolactin and growth hormone in breast cancer
Wennbo, H., & Törnell, J. (2000) · Oncogene · doi:10.1038/sj.onc.1203349 · Cited by 107 · see citing works
Dhir, R., & Richter, J. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200403000-00008 · Cited by 88 · see citing works
Domperidone is more effective than cisapride in children with diabetic gastroparesis
Franzese, A., Borrelli, O., Corrado, G., Rea, P., Nardo, G. D., Grandinetti, A., Dito, L., & Cucchiara, S. (2002) · Alimentary Pharmacology and Therapeutics · doi:10.1046/j.1365-2036.2002.01240.x · Cited by 77 · see citing works
Insulin Administration Enhances Growth of the β-Cell Mass in Streptozotocin-Treated Newborn Rats
Movassat, J., Saulnier, C., & Portha, B. (1997) · Diabetes · doi:10.2337/diab.46.9.1445 · Cited by 75 · see citing works
Current Concepts in Diabetic Gastroparesis
Smith, D. S., & Ferris, C. D. (2003) · Drugs · doi:10.2165/00003495-200363130-00002 · Cited by 68 · see citing works
Making a case for domperidone in the treatment of gastrointestinal motility disorders
AHMAD, N., KEITHFERRIS, J., GOODEN, E., & Abell, T. L. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.07.004 · Cited by 68 · see citing works
An evidence-based approach to gastroenterology therapy
Schoenfeld, P., Cook, D., Hamilton, F. A., Laine, L., Morgan, D. J., & Peterson, W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70439-1 · Cited by 57 · see citing works
Domperidone versus metoclopramide in the treatment of diabetic gastroparesis
Dumitraşcu, D., & Weinbeck, M. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01721.x · Cited by 50 · see citing works
Diabetic gastroparesis: treatment with domperidone--a double-blind, placebo-controlled trial.
Heer, M., Müller-Duysing, W., Benes, I., Weitzel, M., Pirovino, M., Altorfer, J., & Schmid, M. K. (1983) · Digestion · doi:10.1159/000198955 · Cited by 43 · see citing works
Nagler, J., & Miskovitz, P. F. (1981) · PubMed · Cited by 38 · see citing works
Management of Idiopathic, Diabetic and Miscellaneous Gastroparesis with Cisapride
Champion, M. C. (1989) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528909091230 · Cited by 25 · see citing works
Treatment of Diabetic Gastroparesis with Oral Domperidone
Watts, G. F., Armitage, M., Sinclair, J., & Hill, R. (1985) · Diabetic Medicine · doi:10.1111/j.1464-5491.1985.tb00689.x · Cited by 25 · see citing works
Does combination prokinetic therapy benefit patients with refractory diabetic gastroparesis?
Lehmann, K., & Patterson, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)26858-8 · Cited by 4 · see citing works
Increase in Mammographic Breast Density Associated with the Use of Domperidone
Harvey, J. A., Cowan, J. H., & LoRusso, A. P. (2004) · The Breast Journal · doi:10.1111/j.1075-122x.2004.21441.x · Cited by 3 · see citing works
(1995) · Gastroenterology · doi:10.1016/0016-5085(95)22804-7 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 12
- Barone JA. Domperidone: a peripherally acting dopamine2-recep- tor antagonist. Ann Pharmacother 1999;33:429 -440.
- Braun AP. Domperidone in the treatment of symptoms of delayed gastric emptying in diabetic patients. Adv Ther 1989;6:51-62.
- Kozarek R. Domperidone for symptomatic management of dia- betic gastroparesis in metoclopramide treatment failures. Adv Ther 1990;7:61-68.
- Bingaman S, Koch K. Long-term domperidone treatment for symptoms of gastroparesis in diabetic patients. Diabetes 1997; 46:1204.
- Miller M, Patterson D. Natural history of diabetic gastroparesis treated with cisapride or domperidone. Am J Gastroenterol 1991; 86:1316 -1316.
- Patterson DJ, Botoman VA, Kozarek RA, et al. Domperidone is effective long-term treatment for diabetic gastroparesis. Gastro- enterology 1991;100:A137.
- Patterson D, Koch K, Abell T, et al. A multicenter placebo-con- trolled study of domperidone in diabetic gastroparesis. Gastro- enterology 1993;104:A564.
- Patterson D, Meldrum N, Kozarek RM. Long-term efficacy of domperidone in patients with diabetes and symptoms of gastro- paresis. Diabetes 1997;46:490.
- Koch KL, Bingaman S, Stern RM. Withdrawal study of domperi- done vs placebo in diabetic patients: effect on upper gastroin- testinal symptoms and gastric myoelectrical activity. Gastroen- terology 1995;108:A630.
- Abell TL, Rashed H, Cutts T, et al. Autonomic function is a determinant of quality of life improvement in response to domp- eridone therapy. Diabetes 1997;46:1445.
- Champion MC, Braaten J, Gulenchyn K. Domperidone compared to cisapride in the management of gastroparesis. Am J Gastro- enterol 1991;86:1309.
- Champion MC, Gulenchyn K, O'Leary T, et al. Domperidone im- proves symptoms and solid phase gastric emptying in diabetic gastroparesis. Am J Gastroenterol 1987;82:975.
Cited by
Sorted by citations
11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes—2019
American Diabetes Association (2018) · Diabetes Care · doi:10.2337/dc19-s011 · Cited by 402 · see citing works
11. Microvascular Complications and Foot Care: <i>Standards of Medical Care in Diabetes—2021</i>
American Diabetes Association (2021) · Diabetes Care · doi:10.2337/dc21-s011 · Cited by 395 · see citing works
11. Microvascular Complications and Foot Care: <i>Standards of Medical Care in Diabetes−2020</i>
American Diabetes Association (2020) · Diabetes Care · doi:10.2337/dc20-s011 · Cited by 460 · see citing works
Gastric emptying and glycaemia in health and diabetes mellitus
Phillips, L. K., Deane, A. M., Jones, K. L., Rayner, C. K., & Horowitz, M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.202 · Cited by 273 · see citing works
12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes—2024
ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Gibbons, C. H., Giurini, J. M., Hilliard, M. E., Johnson, E. L., et al. (2023) · Diabetes Care · doi:10.2337/dc24-s012 · Cited by 245 · see citing works
12. Retinopathy, Neuropathy, and Foot Care: <i>Standards of Medical Care in Diabetes—2022</i>
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s012 · Cited by 177 · see citing works
12. Retinopathy, Neuropathy, and Foot Care: <i>Standards of Care in Diabetes—2023</i>
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Gibbons, C. H., Giurini, J. M., Hilliard, M. E., et al. (2023) · Diabetes Care · doi:10.2337/dc23-s012 · Cited by 169 · see citing works
Kobori, T., Onishi, Y., Yoshida, Y., Tahara, T., Kikuchi, T., Kubota, T., Iwamoto, M., Sawada, T., Kobayashi, R., Fujiwara, H., et al. (2023) · Journal of Diabetes Investigation · doi:10.1111/jdi.14005 · Cited by 144 · see citing works
Dyspepsia: Organic Versus Functional
Oustamanolakis, P., & Tack, J. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318241b335 · Cited by 146 · see citing works
Outcomes and Factors Associated With Reduced Symptoms in Patients With Gastroparesis
Pasricha, P. J., Yates, K. P., Nguyen, L., Clarke, J., Abell, T. L., Farrugia, G., Hasler, W. L., Koch, K. L., Snape, W. J., McCallum, R. W., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.008 · Cited by 143 · see citing works
Self-citationGastroparesis: pathogenesis, diagnosis and management
Hasler, W. L. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.116 · Cited by 126 · see citing works
Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives
Stevens, J. E., Jones, K. L., Rayner, C. K., & Horowitz, M. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2013.795948 · Cited by 87 · see citing works
Leelakanok, N., Holcombe, A. L., & Schweizer, M. L. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0360-0 · Cited by 84 · see citing works
Gastroparesis: Approach, Diagnostic Evaluation, and Management
Tang, D. M., & Friedenberg, F. K. (2011) · Disease-a-Month · doi:10.1016/j.disamonth.2010.12.007 · Cited by 84 · see citing works
A Systematic Review on Intrapyloric Botulinum Toxin Injection for Gastroparesis
Bai, Y., Xu, M., Yang, X., Xu, C., Gao, J., Zou, D., & Li, Z. (2009) · Digestion · doi:10.1159/000235917 · Cited by 83 · see citing works
Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine
Doggrell, S. A., & Hancox, J. C. (2013) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.851193 · Cited by 70 · see citing works
Functional dyspepsia and gastroparesis: one disease or two
Lacy, B. E. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.104 · Cited by 66 · see citing works
Schey, R., Saadi, M., Midani, D., Roberts, A., Parupalli, R., & Parkman, H. P. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4272-5 · Cited by 64 · see citing works
Cardiovascular safety of prokinetic agents: A focus on drug‐induced arrhythmias
Giudicessi, J. R., Ackerman, M. J., & Camilleri, M. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13302 · Cited by 66 · see citing works
Gastrointestinal and Hepatic Disease in Systemic Sclerosis
Frech, T., & Mar, D. A. (2017) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2017.09.002 · Cited by 57 · see citing works
Diagnostic yield of small bowel capsule endoscopy depends on the small bowel transit time
Westerhof, J. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i13.1502 · Cited by 56 · see citing works
Hu, B., Ye, H., Sun, C., Zhang, Y., Lao, Z.-G., Wu, F., Liu, Z., Huang, L., Qu, C., Xian, L., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0784-1 · Cited by 56 · see citing works
Gastrointestinal symptoms in postural tachycardia syndrome: a systematic review
Mehr, S. E., Barbul, A., & Shibao, C. A. (2018) · Clinical Autonomic Research · doi:10.1007/s10286-018-0519-x · Cited by 55 · see citing works
Hondeghem, L. M. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31827afd0d · Cited by 55 · see citing works
Gastroparesis: Medical and Therapeutic Advances
Navas, C. M., Patel, N. K., & Lacy, B. E. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4679-7 · Cited by 52 · see citing works
Acupuncture for symptomatic gastroparesis
Kim, K. H., Lee, M. S., Choi, T., & Kim, T. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009676.pub2 · Cited by 47 · see citing works
Hasler, W. L. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328358d619 · Cited by 40 · see citing works
Gastroparesis: Concepts, Controversies, and Challenges
Bielefeldt, K. (2012) · Scientifica · doi:10.6064/2012/424802 · Cited by 40 · see citing works
Luttikhold, J., de Ruijter, F. M., van Norren, K., Diamant, M., Witkamp, R. F., van Leeuwen, P. A. M., & Vermeulen, M. A. R. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12421 · Cited by 39 · see citing works
Gastro-oesophageal reflux disease and non-asthma lung disease
Morehead, R. S. (2009) · European Respiratory Review · doi:10.1183/09059180.00002509 · Cited by 39 · see citing works
Systemic sclerosis—challenges for clinical practice
McMahan, Z. H., & Hummers, L. K. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.191 · Cited by 39 · see citing works
Zheng, T., & Camilleri, M. (2021) · PubMed Central · Cited by 37 · see citing works
Gastrointestinal motility disorders in children.
Ambartsumyan, L., & Rodriguez, L. (2014) · Europe PMC (PubMed Central) · Cited by 38 · see citing works
Diabetic gastroparesis: current challenges and future prospects
Avalos, D. J., Sarosiek, I., Loganathan, P., & McCallum, R. W. (2018) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s131650 · Cited by 38 · see citing works
Sanger, G. J., & Andrews, P. L. R. (2023) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17466 · Cited by 38 · see citing works
Novel insights into the pathogenic impact of diabetes on the gastrointestinal tract
Portincasa, P., Bonfrate, L., Wang, D. Q., Frühbeck, G., Garruti, G., & Ciaula, A. D. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13846 · Cited by 37 · see citing works
Gastric motor and sensory function
Tack, J. F. (2009) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328331b5ad · Cited by 36 · see citing works
Effect of Chronic Domperidone Use on QT Interval
Field, J. S., Wasilewski, M. A., Bhuta, R. V., Malik, Z. A., Cooper, J. M., Parkman, H. P., & Schey, R. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001183 · Cited by 32 · see citing works
Sarosiek, I., Natta, M. L. V., Parkman, H. P., Abell, T. L., Koch, K. L., Kuo, B., Shulman, R. J., Farrugia, G., Grover, M., Hamilton, F. A., et al. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.05.063 · Cited by 31 · see citing works
Self-citationBroad, J., Góralczyk, A., Mannur, K. R., Dukes, G. E., & Sanger, G. J. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12338 · Cited by 29 · see citing works
Pharmacologic Treatment for Pediatric Gastroparesis: A Review of the Literature
Tillman, E. M., Smetana, K. S., Bantu, L., & Buckley, M. G. (2016) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-21.2.120 · Cited by 29 · see citing works
Association Between Symptoms, Quality of Life, and Gastric Emptying in Dyspeptic Patients
Wuestenberghs, F., Juge, M., Melchior, C., Desprez, C., Leroi, A., & Gourcerol, G. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19060 · Cited by 28 · see citing works
Diabetic gastroparesis: Therapeutic options
Alam, U., Asghar, O., & Malik, R. A. (2010) · Diabetes Therapy · doi:10.1007/s13300-010-0010-8 · Cited by 26 · see citing works
The Role of Dopamine in Repurposing Drugs for Oncology
Moura, C. V., & Vale, N. (2023) · Biomedicines · doi:10.3390/biomedicines11071917 · Cited by 22 · see citing works
Management and prevention of delayed gastric emptying after pancreaticoduodenectomy
Kim, Y. (2012) · Korean Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.14701/kjhbps.2012.16.1.1 · Cited by 21 · see citing works
Westerhof, J., Weersma, R. K., Hoedemaker, R. A., & Koornstra, J. J. (2014) · BMC Gastroenterology · doi:10.1186/1471-230x-14-162 · Cited by 19 · see citing works
Neural networks involved in nausea in adult humans: A systematic review
Varangot‐Reille, C., Sanger, G. J., Andrews, P. L. R., Herranz‐Gómez, A., Suso‐Martí, L., de la Nava, J., & Cuenca‐Martínez, F. (2022) · Autonomic Neuroscience · doi:10.1016/j.autneu.2022.103059 · Cited by 19 · see citing works
Approach to the Patient with Nausea and Vomiting
Hasler, W. L. (2015) · Wiley eBooks · doi:10.1002/9781118512074.ch38 · Cited by 16 · see citing works
Pharmacologic treatments for gastroparesis
Camilleri, M., & Jencks, K. J. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2024.100019 · Cited by 14 · see citing works
Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula
Duvoisin, G., & Krishnan, U. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00076 · Cited by 14 · see citing works
Lee, A. A., & Hasler, W. L. (2017) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-017-0146-y · Cited by 12 · see citing works
Emerging drugs for the treatment of gastroparesis
Hasler, W. L. (2014) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2014.899353 · Cited by 12 · see citing works
Adverse Effects of Domperidone: Prolonged QuesT for Knowledge?
Bashashati, M., Sarosiek, I., Siddiqui, T., & McCallum, R. W. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4333-9 · Cited by 12 · see citing works
Lee, A. A. (2013) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-013-2254-x · Cited by 10 · see citing works
Vitton, V., D’Journo, X. B., Reynaud‐Gaubert, M., Barthet, M. A., & Gonzalez, J. (2021) · Clinical Transplantation · doi:10.1111/ctr.14434 · Cited by 8 · see citing works
Kanji, S., Stevenson, A., & Hutton, B. (2014) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v67i4.1378 · Cited by 8 · see citing works
Domperidone prolongs oral to duodenal transit time in video capsule endoscopy
McFarlane, M. J., Liu, B., & Nwokolo, C. U. (2017) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-017-2399-8 · Cited by 8 · see citing works
Zhang, Y.-X., Zhang, Y.-J., Miao, R., Fang, X.-Y., Wei, J., Wei, Y., Lin, J.-R., & Tian, J.-X. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i3.313 · Cited by 5 · see citing works
Mukker, J. K., Dukes, G. E., Tolkoff, M., Wang, L., Almansa, C., Huh, S. Y., Nishihara, M., Ramsden, D., & Chen, C. (2022) · Clinical and Translational Science · doi:10.1111/cts.13274 · Cited by 7 · see citing works
Gastrointestinal Manifestations of Diabetes
Bharucha, A. E., & Camilleri, M. (2016) · doi:10.1002/9781118924853.ch50 · Cited by 7 · see citing works
Nagarwala, J., Dev, S., & Markin, A. (2016) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2015.12.005 · Cited by 5 · see citing works
Current and future treatment management strategies for gastroparesis
Loganathan, P., Gajendran, M., & McCallum, R. W. (2019) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2019.1617694 · Cited by 4 · see citing works
Diagnóstico y tratamiento actual de la gastroparesia: una revisión sistemática de la literatura
Barrera, V. M., Aponte, D. M., Ortíz, R. G. P., & Quiroga, J. E. O. (2020) · Revista Colombiana de Gastroenterología · doi:10.22516/25007440.561 · Cited by 5 · see citing works
Saboo, B., Mulwani, N., Petare, A. U., Veligandla, K. C., Pinto, C. S., Mane, A., Rathod, R., & KOTAK, B. P. (2023) · Drugs in Context · doi:10.7573/dic.2022-10-3 · Cited by 4 · see citing works
Diagnostik und Therapie gastrointestinaler Funktionsstörungen bei Diabetes mellitus
Keller, J. (2013) · Der Diabetologe · doi:10.1007/s11428-013-1066-7 · Cited by 4 · see citing works
Acupuncture for symptomatic gastroparesis
Kim, K. H., Lee, M. S., Choi, T., Kim, T., & Ernst, E. K. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009676 · Cited by 4 · see citing works
Gastric schwannoma with post-surgical gastroparesis: a case report and literature review
Miao, G., De, Z., Li, J., Deng, Y., Gu, X., & Feng, T. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2024.1496074 · Cited by 3 · see citing works
Moura, C., Gouveia, M. J., & Vale, N. (2025) · Life · doi:10.3390/life15071097 · Cited by 3 · see citing works
Ghrelin Agonists as Emerging Prokinetic Agents
Tack, J. F., & Corsetti, M. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.08.032 · Cited by 3 · see citing works
Gastrointestinal motor disorders: treatment with prokinetics
Ахмедов, В. А. (2022) · Russian Medical Inquiry · doi:10.32364/2587-6821-2022-6-5-252-258 · Cited by 3 · see citing works
Suryani, D., Bahtiar, A., & Andrajati, R. (2017) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2017.v10s5.23109 · Cited by 3 · see citing works
Blandizzi, C., & Scarpignato, C. (2011) · Side effects of drugs annual · doi:10.1016/b978-0-444-53741-6.00036-2 · Cited by 3 · see citing works
Gastroenterologische Probleme bei diabetischer Neuropathie
Keller, J. (2008) · Der Diabetologe · doi:10.1007/s11428-008-0260-5 · Cited by 2 · see citing works
Pharmacological Causes and Treatments of Nausea and Vomiting
Hasler, W. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-34076-0_9 · Cited by 2 · see citing works
Lang, J., Reed, E., Fisher, M., & McKay, G. (2012) · Practical Diabetes · doi:10.1002/pdi.1728 · Cited by 2 · see citing works
Diabetic gastroparesis: Therapeutic options
Alam, U., Asghar, O., & Malik, R. A. (2010) · Diabetes Therapy · doi:10.1007/s13300-010-002-82010 · Cited by 2 · see citing works
Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives
Har, A. F., & Croffie, J. M. B. (2016) · Springer eBooks · doi:10.1007/978-3-319-43268-7_44 · Cited by 2 · see citing works
Varvoglis, D. N., & Farrell, T. M. (2022) · Journal of Laparoendoscopic & Advanced Surgical Techniques · doi:10.1089/lap.2022.0342 · Cited by 2 · see citing works
Mosli, M. H., Al-Judaibi, B., & Almadi, M. A. (2014) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.141683 · Cited by 1 · see citing works
Arya, D. K., Pèrié, L., Mohanta, G. C., Mishra, R., Kumar, Y., Picot, C. R., & Verma, N. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119218 · Cited by 2 · see citing works
Diabetic Gastroparesis in Evolution
Eubanks, A., Jehu, D. A., Obineme, C. G., & Sharma, A. (2026) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002381 · Cited by 1 · see citing works
Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives
Har, A. F., & Croffie, J. M. B. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-709-9_41 · Cited by 1 · see citing works
Alteraciones motoras gástricas
Luè, A., & Biarge, F. S. (2012) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0304-5412(12)70267-6 · Cited by 1 · see citing works
Malagelada, J., & Malagelada, C. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6189-2.00014-7 · Cited by 1 · see citing works
Kuzemko-Baranowska, D., Rymarz, E., Prystupa, A., Dzida, G. J., & Mosiewicz, J. (2017) · Journal of Pre-Clinical and Clinical Research · doi:10.26444/jpccr/75140 · Cited by 1 · see citing works
Camilleri, M., & Parkman, H. P. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.215 · Cited by 1 · see citing works
Gastrointestinal Manifestations of Diabetes
Bharucha, A. E., & Camilleri, M. (2010) · doi:10.1002/9781444324808.ch46 · Cited by 1 · see citing works
Upper Gastrointestinal Manifestations of Diabetes
Camilleri, M. (2021) · Wiley eBooks · doi:10.1002/9781119603207.ch22 · Cited by 1 · see citing works
Sanger, G. J., & Andrews, P. L. R. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.01.043 · Cited by 1 · see citing works
Gastrointestinal Manifestations of Diabetes
Camilleri, M., & Bharucha, A. E. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch55 · Cited by 1 · see citing works
Clinical studies of glucose variability and hypoglycemia in adult patients with type 1 diabetes
Bragd, J. (2011) · Figshare
Diagnosis & dietary intervention in patients with diabetic gastroparesis
Olausson, E. A. (2013)
Russian Federation (2014) · CyberLeninK (CyberLeninka)
Small Bowel Obstruction, Cyclic Vomiting, and Gastroparesis
Nagarwala, J., Dev, S., & Markin, A. (2016)
Ghorpade, V. S., Mali, K. K., Dias, R. J., & Havaldar, V. D. (2017) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.51.4s.87
Corrales, P. J. P., & Meneses, A. L. (2012) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0304-5412(12)70421-3
Parkman, H. P., & Talley, N. J. (2016) · doi:10.1002/9781119127437.ch21
Zheng, T., & Camilleri, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-13911-6.00033-5
Management of failed pyloric drainage procedures in patients with gastroparesis
Awad, M. M. (2025) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2025.102231
- Authors
- Sugumar, A., Singh, A., & Pasricha, P. J.
- Affiliations
- Mayo Clinic (US)
- The University of Texas Medical Branch at Galveston (US)
- Stanford Medicine (US)
- Corresponding author
- Pasricha, Pankaj Jay
- ORCID
- Pasricha, Pankaj Jay
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 6
- Issue
- 7
- Pages
- 726-733
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2069589846
- Cited by
- 102
- References
- 28
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 1 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 13
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- domperidone, diabetic gastroparesis, drug efficacy, gastric emptying, symptom improvement, hospitalization, study quality, level of evidence
- MeSH terms
- Clinical Trials as Topic, Domperidone, Humans, United States, Treatment Outcome, Gastroparesis, Diabetes Complications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
