The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The Gut Microbiota Predispose to the Pathophysiology of Acute Postradiotherapy Diarrhea
Abstract
INTRODUCTION: Severe diarrhea may complicate pelvic radiotherapy and force interruption of treatment. As there is no current clinical or experimental information on the role of the gut microbiota in this pathogenesis, we conducted a pilot observational study on the fecal microbiota in patients receiving pelvic radiotherapy. METHODS: The study involved 10 patients who underwent 5 wk of radiotherapy for abdominal tumors and 5 controls. Four fecal samples were collected from each individual: before, during, at the end, and 2 wk after treatment. Following the amplification of the bacterial 16S rRNA gene from the samples, DNA fingerprinting and cloning-sequencing techniques were used to determine their microbial profile and composition, respectively. RESULTS: Six patients suffered acute postradiotherapy diarrhea and 4 did not. In patients without diarrhea, as well as in healthy volunteers, microbial diversity was stable over a period of 7 wk. However, patients exhibiting diarrhea showed a progressive modification in their microbial diversity. A radical drop in similarity index was observed at the end (P= 0.026) and still 2 wk after radiotherapy (P= 0.014). Interestingly, cluster analysis of the microbial profile in the first sample (S1) (collected before radiotherapy) displayed a dendogram where patients that presented diarrhea clustered separately from those that did not develop diarrhea after radiotherapy. Moreover, sequence analysis of dominant bacteria in the S1 sample confirmed differences between the diarrhea and nondiarrhea groups. DISCUSSION: In this set of patients, susceptibility or protection against diarrhea after radiotherapy could be linked to different initial microbial colonization.
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“CRT has also been shown to alter overall richness and diversity of the gut microbiome in cancer patients20,21.”
From Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation (2021) · cites this paper as [21]
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Gouveia, L., Serpa, J., & Mendes, C. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12166-0_3
Modifications iatrogènes du microbiote intestinal : impact de la chimiothérapie
Montassier, E. (2014)
Metadata
- Authors
- Manichanh, C., Varela, E., Martinez, C., Antolin, M., Llopis, M., Dor, J., Giralt, J., Guarner, F., & Malagelada, J.-R.
- Affiliations
- Vall d'Hebron Hospital Universitari (ES)
- Institut National de la Recherche Agronomique (FR)
- Corresponding author
- Manichanh, Chaysavanh
- Venue
- The American Journal of Gastroenterology
- Published
- 2008-07
- Volume
- 103
- Issue
- 7
- Pages
- 1754-1761
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2078326955
- Cited by
- 201
- References
- 26
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 16 · 2023: 22 · 2022: 25 · 2021: 18 · 2020: 21 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 6 · 2013: 8 · 2012: 4
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, pelvic radiotherapy, fecal microbiota composition, microbial diversity, 16S rRNA gene sequencing, bacterial colonization, abdominal tumors, radiation toxicity
- MeSH terms
- Abdominal Neoplasms, Aged, Diarrhea, DNA, Bacterial, Feces, Female, Gene Amplification, Humans, Intestines, Male, Middle Aged, Pelvis, Radiotherapy
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