Impact of Pelvic Radiotherapy on Gut Microbiota of Gynecological Cancer Patients Revealed by Massive Pyrosequencing
Open accessAbstract
Although pelvic irradiation is effective for the treatment of various cancer types, many patients who receive radiotherapy experience serious complications. Gut microbial dysbiosis was hypothesized to be related to the occurrence of radiation-induced complications in cancer patients. Given the lack of clinical or experimental data on the impact of radiation on gut microbiota, a prospective observational study of gut microbiota was performed in gynecological cancer patients receiving pelvic radiotherapy. In the current study, the overall composition and alteration of gut microbiota in cancer patients receiving radiation were investigated by 454 pyrosequencing. Gut microbial composition showed significant differences (P < 0.001) between cancer patients and healthy individuals. The numbers of species-level taxa were severely reduced after radiotherapy (P < 0.045), and the abundance of each community largely changed. In particular, the phyla Firmicutes and Fusobacterium were significantly decreased by 10% and increased by 3% after radiation therapy, respectively. In addition, overall gut microbial composition was gradually remolded after the full treatment course of pelvic radiotherapy. In this set of cancer patients, dysbiosis of the gut microbiota was linked to health status, and the gut microbiota was influenced by pelvic radiotherapy. Although further studies are needed to elucidate the relationship between dysbiosis and complications induced by pelvic radiotherapy, the current study may offer insights into the treatment of cancer patients suffering from complications after radiation therapy.
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- Authors
- Nam, Y.-D., Kim, H. J., Seo, J.-G., Kang, S. W., & Bae, J.-W.
- Affiliations
- Kyung Hee University (KR)
- Seoul National University (KR)
- Cell Biotech (South Korea) (KR)
- Corresponding author
- Kang, Seung Wan
- Bae, Jin-Woo
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-12-18
- Volume
- 8
- Issue
- 12
- Pages
- e82659
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3867375
- OpenAlex
- W2066853142
- Cited by
- 230
- References
- 46
- Citations by year
- 2026: 8 · 2025: 24 · 2024: 26 · 2023: 33 · 2022: 23 · 2021: 30 · 2020: 31 · 2019: 18 · 2018: 14 · 2017: 8 · 2016: 5 · 2015: 5 · 2014: 3
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Research Foundation
- National Research Foundation of Korea (2011-0028854)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- pelvic radiotherapy, gut microbiota, gynecologic cancer, dysbiosis, radiation complications, Firmicutes, Fusobacterium, microbial community composition, health status
- MeSH terms
- Adult, Female, Genital Neoplasms, Female, Humans, Middle Aged, RNA, Ribosomal, 16S, Gastrointestinal Tract, Microbiota
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