Cited by 203Bacterial Identification and Susceptibility TestingAntimicrobial Resistance in StaphylococcusGenetic diversity and population structure

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Tracing isolates of bacterial species by multilocus variable number of tandem repeat analysis (MLVA)

Open access

Van Belkum, Alex·2007·FEMS Immunology & Medical Microbiology

DOI 10.1111/j.1574-695x.2006.00173.x

Open this paper in CoChat — free account Open PDF

Abstract

All bacterial genomes contain multiple loci of repetitive DNA. Repeat unit sizes and repeat sequences may vary when multiple loci are considered for different isolates of an individual microbial species. Moreover, it has been documented on many occasions that the number of repeat units per locus is a strain-defining parameter. Consequently, there is isolate-specificity in the number of repeats per locus when different strains of a given bacterial species are compared. The experimental assessment of this variability for a number of different loci has been called 'multilocus variable number of tandem repeat analysis' (MLVA). The approach can be supported or extended by locus-specific DNA sequencing for establishing mutations in the individual repeat units, which usually enhances the resolution of the approach considerably. Essentially, MLVA with or without supportive sequencing has been developed for all of the medically relevant bacterial species and can be used effectively for tracing outbreaks or other forms of bacterial dissemination. MLVA is a modern, timely and versatile bacterial typing methodology.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1574-695x.2006.00173.x

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd
Fleischmann, R. D., Adams, M. D., White, O. R., Clayton, R. A., Kirkness, E. F., Kerlavage, A. R., Bult, C. J., Tomb, J.-F., Dougherty, B. A., Merrick, J. M., et al. (1995) · Science · doi:10.1126/science.7542800 · Cited by 5,731
Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology
van Embden, J. D., Cave, M. D., Crawford, J. T., Dale, J. W., Eisenach, K. D., Gicquel, B., Hermans, P. W. M., Martı́n, C., McAdam, R. A., & Shinnick, T. M. (1993) · Journal of Clinical Microbiology · doi:10.1128/jcm.31.2.406-409.1993 · Cited by 2,341
Identification of genes that are associated with DNA repeats in prokaryotes
Jansen, R., Embden, J. D. A. V., Gaastra, W., & Schouls, L. M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02839.x · Cited by 1,802
Typing of Methicillin-Resistant Staphylococcus aureus in a University Hospital Setting by Using Novel Software for spa Repeat Determination and Database Management
Harmsen, D., Claus, H., Witte, W., Rothgänger, J., Claus, H., Turnwald, D., & Vogel, U. F. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.12.5442-5448.2003 · Cited by 1,567
Yersinia pestis , the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
Achtman, M., Zurth, K., Morelli, G., Torrea, G., Guiyoule, A., & Carniel, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14043 · Cited by 1,126
Evaluation of Protein A Gene Polymorphic Region DNA Sequencing for Typing ofStaphylococcus aureusStrains
Shopsin, B., Gómez, M. J., Montgomery, S. O., Smith, D. H., Waddington, M. G., Dodge, D. E., Bost, D. A., Riehman, M., Naidich, S., & Kreiswirth, B. N. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.11.3556-3563.1999 · Cited by 984
Phase and Antigenic Variation in Bacteria
van der Woude, M. W., & Bäumler, A. J. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.3.581-611.2004 · Cited by 766
Short-sequence DNA repeats in prokaryotic genomes
van Belkum, A., Scherer, S., van Alphen, L., & Verbrugh, H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.275-293.1998 · Cited by 737
Investigation of Bioterrorism-Related Anthrax, United States, 2001: Epidemiologic Findings
Jernigan, D. B., Raghunathan, P. L., Bell, B. P., Brechner, R. J., Bresnitz, E. A., Butler, J. C., Cetron, M. S., Cohen, M. J., Doyle, T. J., Fischer, M., et al. (2002) · Emerging infectious diseases · doi:10.3201/eid0810.020353 · Cited by 708
Genetic diversity in the Mycobacterium tuberculosis complex based on variable numbers of tandem DNA repeats
Frothingham, R., & Meeker-O’Connell, W. A. (1998) · Microbiology · doi:10.1099/00221287-144-5-1189 · Cited by 600

Show all 66 references

Sorted by citations

Items 101–200 of 203

Contrasting genetic diversity and structure among Malagasy Ralstonia pseudosolanacearum phylotype I populations inferred from an optimized Multilocus Variable Number of Tandem Repeat Analysis scheme
Rasoamanana, H., Ravelomanantsoa, S., Yahiaoui, N., Dianzinga, N. T., Rébert, E., Gauche, M. M., Pécrix, Y., Costet, L., Rieux, A., Prior, P., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0242846 · Cited by 13
“It has been widely used in medical microbiology [8] to trace the origin of epidemics or the spread of virulent or antibiotic-resistant variants.”
Background
Repeat-based subtyping and grouping of Staphylococcus aureus from human infections and bovine mastitis using the R-domain of the clumping factor A gene
Said, K. B., Ramotar, K., Zhu, G., & Zhao, X. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2008.09.004 · Cited by 12
The discovery, function and development of the variable number tandem repeats in differentMycobacteriumspecies
Sun, Z., Li, W., Xu, S., & Huang, H. (2015) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2015.1022506 · Cited by 11
Single Nucleotide Polymorphism Genotyping and Distribution of Coxiella burnetii Strains from Field Samples in Belgium
Pozzo, F. D., Renaville, B., Martinelle, L., Renaville, R., Thys, C., Smeets, F., Kirschvink, N. A., Grégoire, F., Delooz, L., Czaplicki, G., et al. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.02799-15 · Cited by 11
Genotyping of Coxiella burnetii from Cattle by Multispacer Sequence Typing and Multiple Locus Variable Number of Tandem Repeat Analysis in the Republic of Korea
Truong, A., Youn, S. Y., Yoo, M.-S., Lim, J., Yoon, S., & Cho, Y. S. (2022) · Genes · doi:10.3390/genes13111927 · Cited by 10
Multilocus variable-number tandem-repeat analysis for subtypingSalmonella entericaserovar Gallinarum
Kang, M., Kwon, Y. K., Oh, J. Y., Call, D. R., An, B.-K., Song, E.-A., Kim, J. Y., Shin, E.-G., Kim, M. J., Kwon, J. H., et al. (2011) · Avian Pathology · doi:10.1080/03079457.2011.613915 · Cited by 10
Molecular epidemiology of meningococci: Application of DNA sequence typing
Vogel, U. F. (2010) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2010.04.017 · Cited by 10
Molecular Strain Typing and Characterisation of Toxigenic Clostridium difficile
Dingle, T. C., & MacCannell, D. (2015) · Methods in microbiology · doi:10.1016/bs.mim.2015.07.001 · Cited by 10
Evolution of Variable Number Tandem Repeats and Its Relationship with Genomic Diversity in Salmonella Typhimurium
Fu, S., Octavia, S., Wang, Q., Tanaka, M. M., Tay, C. Y., Sintchenko, V., & Lan, R. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02002 · Cited by 10
“Keywords: S. Typhimurium, SNP, VNTR, directional mutability, epidemiological typing INTRODUCTION All bacterial genomes contain repetitive DNA in multiple loci called variable-number tandemrepeat (VNTR) (van Belkum, 2007).”
Background
Effective application of multiple locus variable number of tandem repeats analysis to tracing Staphylococcus aureus in food-processing environment
Rešková, Z., Koreňová, J., & Kuchta, T. (2013) · Letters in Applied Microbiology · doi:10.1111/lam.12200 · Cited by 10
“In this study, we used multiple locus variable number of tandem repeats analysis (MLVA), which is a bacterial genotyping method of moderate complexity with a good discrimination reported with various clinically important bacteria (van Belkum 2007).”
Method
Characterization ofBrachyspira hyodysenteriaeisolates from Italy by multilocus sequence typing and multiple locus variable number tandem repeat analysis
Gasparrini, S., Alborali, G. L., Pitozzi, A., Guarneri, F., Giacomini, E., Baldo, V., Scali, F., Lazzaro, M., & Boniotti, M. B. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13492 · Cited by 9
The Klebsiella pheV tRNA locus: a hotspot for integration of alien genomic islands
van Aartsen, J. J. (2008) · Bioscience Horizons The International Journal of Student Research · doi:10.1093/biohorizons/hzn006 · Cited by 9
“Alternatively, these repeats may serve as a novel target for enhanced Klebsiella molecular typing.(46) The data presented here contributes to the complex and evolving story of bacterial genome plasticity and clearly places Klebsiella among the growing list of bacteria exhibiting a high degree of intra species genome d…”
Background
The New LM-PCR/Shifter Method for the Genotyping of Microorganisms Based on the Use of a Class IIS Restriction Enzyme and Ligation-Mediated PCR
Krawczyk, B. (2011) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1104.04019 · Cited by 9
“Other strategies that are currently being investigated for their epidemiological usefulness are the variable number of tandem repeat (VNTR), or multiple locus variable multilocus tandem repeat (MLVA) analyses [9, 16].”
Background
The Microbe: The Basics of Structure, Morphology, and Physiology as They Relate to Microbial Characterization and Attribution
Jackman, J. (2011) · Springer eBooks · doi:10.1007/978-1-60327-219-3_2 · Cited by 9
Selection of optimal combinations of loci by the Optimal Combination Finder computer program from a group of variable number tandem repeat loci for use in Staphylococcus aureus food poisoning case investigations
Wang, X., Huang, B., Blair, B., Eglezos, S., & Bates, J. R. (2012) · Journal of Medical Microbiology · doi:10.1099/jmm.0.040287-0 · Cited by 9
“MLVA is regarded as a well-recognized typing method (Lindstedt, 2005; van Belkum, 2007).”
Method
Draft Genome Sequences of Two Xanthomonas euvesicatoria Strains from the Balkan Peninsula
Vancheva, T., Lefeuvre, P., Bogatzevska, N., Moncheva, P., & Koebnik, R. (2015) · Genome Announcements · doi:10.1128/genomea.01528-14 · Cited by 9
“In order to develop new molecular markers for epidemiological surveillance, such as variablenumber tandem repeats (VNTR) (7), we sequenced the genomes of two strains from the Balkan Peninsula.”
Background
Detection of Xanthomonas axonopodis pv. manihotis, the causal agent of cassava bacterial blight diseases in cassava (Manihot esculenta) in Ghana by polymerase chain reaction
Abdulai, M., Basım, H., Basım, E., Baki, D., & Öztürk, N. (2017) · European Journal of Plant Pathology · doi:10.1007/s10658-017-1297-3 · Cited by 9
“…developed and used for Xam population studies, among such techniques is the use of VNTR loci which has a discriminating power to detect and reveal polymorphisms in the tandem repeat sequence in a given target genome, which could not be detected by other molecular genetic markers (Van Belkum 2007).”
Method
Evaluation of Neisseria gonorrhoeae Multiple-Locus Variable-Number Tandem-Repeat Analysis, N. gonorrhoeae Multiantigen Sequence Typing, and Full-Length porB Gene Sequence Analysis for Molecular Epidemiological Typing
Heymans, R., Golparian, D., Bruisten, S. M., Schouls, L. M., & Unemo, M. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.05386-11 · Cited by 8
Multiple-Locus Variable-Number Tandem Repeat Analysis Scheme for Non-O157 Shiga Toxin-Producing Escherichia coli: Focus on Serogroups O103, O121, O145, O165, and O91
Izumiya, H., Lee, K., Ishijima, N., Iyoda, S., & Ohnishi, M. (2020) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2020.095 · Cited by 8
PCR melting profile as a tool for outbreak studies of Salmonella enterica in chickens
Żaczek, A., Wojtasik, A., Izdebski, R., Górecka, E., Wójcik, E. A., Nowak, T. Ł., Kwieciński, P., & Dziadek, J. (2015) · BMC Veterinary Research · doi:10.1186/s12917-015-0451-4 · Cited by 8
Current Situation of Antimicrobial Resistance and Genetic Differences inStenotrophomonas maltophiliaComplex Isolates by Multilocus Variable Number of Tandem Repeat Analysis
Rhee, J.-Y., Song, J., & Ko, K. S. (2016) · Infection and Chemotherapy · doi:10.3947/ic.2016.48.4.285 · Cited by 8
Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism for Brucella abortus
Li, X., Kang, Y., Lin, L., Jia, E.-H., Piao, D., Jiang, H. B., Zhang, C., He, J. H., Chang, Y., Guo, X., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00917 · Cited by 7
Phenotypic and genetic analyses of 111 clinical and environmental O1, O139, and non-O1/O139Vibrio choleraestrains from different geographical areas
Sellek, R. E., Niemcewicz, M., Olsen, J. S., Bassy, O., Lorenzo, P., MARTÍ, L., Roszkowiak, A., Kocik, J., & Ramos, J. C. C. (2011) · Epidemiology and Infection · doi:10.1017/s0950268811002147 · Cited by 7
TracingStaphylococcus aureusin small and medium-sized food-processing factories on the basis of molecular sub-species typing
Koreňová, J., Rešková, Z., Véghová, A., & Kuchta, T. (2014) · International Journal of Environmental Health Research · doi:10.1080/09603123.2014.958135 · Cited by 7
Development of multiple-locus variable-number tandem-repeat analysis for rapid genotyping of Ehrlichia ruminantium and its application to infected Amblyomma variegatum collected in heartwater endemic areas in Uganda
Nakao, R., Morrison, L. J., ZHOU, L., Magona, J. W., Jongejan, F., & Sugimoto, C. (2011) · Parasitology · doi:10.1017/s003118201100165x · Cited by 7
“Multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) is a prominent typing tool which has been successfully applied to genotyping of a variety of bacterial species (Lindstedt, 2005; van Belkum, 2007).”
Method
Coxiella burnetii: Emerging threats, molecular insights, and advances in diagnosis and control measures
Mohammadi, M. R., Moradkasani, S., Latifian, M., & Esmaeili, S. (2025) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2025.107213 · Cited by 6
Accurately assembling nanopore sequencing data of highly pathogenic bacteria
Thomas, C., Brangsch, H., Galeone, V., Hölzer, M., Marz, M., & Linde, J. (2025) · BMC Genomics · doi:10.1186/s12864-025-11793-6 · Cited by 6
Multiplex polymerase chain reaction typing scheme based on Escherichia coli O157:H7 Sakai prophage (Sp)-associated genes
Tóth, I., Bagyinszky, E., & Sváb, D. (2022) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2022.04.015 · Cited by 6
Genotyping of Bifidobacterium longum subsp. longum strains by multilocus variable number of tandem repeat analysis
Matamoros, S., Savard, P., & Roy, D. (2011) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2011.10.005 · Cited by 6
Development of a Multiple-Locus Variable-Number Tandem-Repeat Typing Scheme for Genetic Fingerprinting of Burkholderia cenocepacia and Application to Nationwide Epidemiological Analysis
Segonds, C., Thouverez, M., Barthe, A., Bossuet‐Greif, N., Tisseyre, L., Plésiat, P., Vergnaud, G., Chabanon, G., & Pourcel, C. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.02473-14 · Cited by 6
Nucleic acid sequencing for characterizing infectious and/or novel agents in complex samples
Detter, J. C., Johnson, S. L., Bishop‐Lilly, K. A., Chain, P., Gibbons, H. S., Minogue, T. D., Sozhamannan, S., Gieson, E. J. V., & Resnick, I. G. (2014) · Elsevier eBooks · doi:10.1533/9780857099167.1.3 · Cited by 6
A new inclusive MLVA assay to investigate genetic variability of Xylella fastidiosa with a specific focus on the Apulian outbreak in Italy
Mazzaglia, A., Rahi, Y. J., Taratufolo, M. C., Tatì, M., Turco, S., Ciarroni, S., Tagliavento, V., Valentini, F., D'ONGHIA, A. M., & Balestra, G. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-68072-5 · Cited by 6
Strain typing and antimicrobial susceptibility of Salmonella enterica Albany isolates from duck farms in South Korea
Han, M., Chae, M. H., Lee, S., No, K., & Han, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27402 · Cited by 5
Bacillus anthracis and other Bacillus species
Cote, C. K., Heffron, J. D., Bailey, S. O., Welkos, S. L., & Bozue, J. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-818619-0.00084-8 · Cited by 5
Variable Number of Tandem Repeats (VNTR) analysis of Flavobacterium psychrophilum from salmonids in Chile and Norway
Apablaza, P., Brevik, Ø. J., Mjøs, S. A., Valdebenito, S., Ilardi, P., Battaglia, J., Dalsgaard, I., & Nylund, A. (2015) · BMC Veterinary Research · doi:10.1186/s12917-015-0469-7 · Cited by 5
Molecular Methods for Bacterial Strain Typing
Shokoohizadeh, L. (2016) · Medical Laboratory Journal · doi:10.18869/acadpub.mlj.10.2.1 · Cited by 5
Genome Sequences of Three Brucella canis Strains Isolated from Humans and a Dog
Viana, M. V. C., Wattam, A. R., Batra, D. G., Boisvert, S., Brettin, T. S., Frace, M. A., Xia, F., Azevedo, V., Tiller, R. V., & Hoffmaster, A. R. (2017) · Genome Announcements · doi:10.1128/genomea.01688-16 · Cited by 5
Forensic public health
Khan, A. S., Amara, P. S., & Morse, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815379-6.00008-8 · Cited by 5
Newer Methods for Bacterial Strain Typing
van Belkum, A. (2008) · Clinical Microbiology Newsletter · doi:10.1016/j.clinmicnews.2008.04.001 · Cited by 5
Dynamic of Mutational Events in Variable Number Tandem Repeats ofEscherichia coliO157:H7
Bustamante, A. V., Sanso, A. M., Segura, D. O., Parma, A. E., & Lucchesi, P. M. A. (2013) · BioMed Research International · doi:10.1155/2013/390354 · Cited by 5
Cronobacter sakazakii, a New Threat: Characteristic, Molecular Epidemiology and Virulence Factors
Mashoufi, A., Hashemi, M. B., Ghazvini, K., Ghayour‐Mobarhan, M., & Afshari, A. (2017) · Annual Research & Review in Biology · doi:10.9734/arrb/2017/37657 · Cited by 5
Evaluation of genetic diversity among aquatic and fecal isolates of Escherichia coli using multilocus variable number of tandem repeat analysis
Khare, N., Kaushik, M., Kumar, S., & Gulati, P. (2020) · 3 Biotech · doi:10.1007/s13205-020-2066-0 · Cited by 4
“Conventional typing methods such as serotyping, biochemical typing and antibiogram-based typing of bacterial species have been used extensively (van Belkum 2007).”
Method
Evaluation and Selection of Multilocus Variable-Number Tandem-Repeat Analysis Primers for Genotyping Brucella abortus Biovar 1 Isolated from Human Patients
Lee, S., Hwang, K. J., Park, M., Hwang, S. D., Chai, H.-Y., Chu, H., & Park, S. (2013) · Osong Public Health and Research Perspectives · doi:10.1016/j.phrp.2013.09.005 · Cited by 4
Repeat-based Sequence Typing of Carnobacterium maltaromaticum
Rahman, A., Kheir, S. M. E., Back, A., Mangavel, C., Revol‐Junelles, A., & Borges, F. (2016) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.03.003 · Cited by 4
Comparison of Multilocus Variable-Number Tandem-Repeat Analysis with Multilocus Sequence Typing and Pulsed-Field Gel Electrophoresis for Enterococcus faecalis
Sadowy, E., Sieńko, A., & Hryniewicz, W. (2011) · Polish Journal of Microbiology · doi:10.33073/pjm-2011-048 · Cited by 4
“…variation of number of repeats present in bacterial genomes and thus also provides an unambiguous, portable identification of an isolate (van Belkum, 2007). e aim of this study was to evaluate the discriminatory power and typability of MLVA using an extensive collection of isolates…”
An SIMD Algorithm for Wraparound Tandem Alignment
Loving, J., Scaduto, J. P., & Benson, G. (2017) · Lecture notes in computer science · doi:10.1007/978-3-319-59575-7_13 · Cited by 4
Molecular Subtyping Methods forListeria monocytogenes
Lomonaco, S., & Nucera, D. M. (2014) · doi:10.1002/9781118278666.ch13 · Cited by 4
Conservation and Evolution of Microsatellites in Vertebrate Genomes
Buschiazzo, E. (2008) · UC Research Repository (University of Canterbury) · doi:10.26021/8100 · Cited by 4
Genomic Analysis ofSalmonella entericaSerovar Typhimurium Definitive Phage Type 104
Izumiya, H., Terajima, J., Yamamoto, S., Ohnishi, M., Watanabe, H., Akemi, K. A. I., Kurazono, T., Taguchi, M., Asai, T., Akiba, M., et al. (2013) · Emerging infectious diseases · doi:10.3201/eid1905.121395 · Cited by 3
Molecular typing of cytotoxin-producing Klebsiella oxytoca isolates by 16S-23S internal transcribed spacer PCR
Dallal, M. M. S., Validi, M., Douraghi, M., & Bakhshi, B. (2019) · New Microbes and New Infections · doi:10.1016/j.nmni.2019.100545 · Cited by 3
“length polymorphism [11], multilocus sequence typing (MLST) [12] and multilocus variable number tandem repeat analysis (MLVA) [13].”
MethodInfluential
Guidelines for characterizing LAB, bifidobacteria and related genera for taxonomic purposes
Mattarelli, P., Biavati, B., Hammes, W. P., & Holzapfel, W. H. (2014) · doi:10.1002/9781118655252.app1 · Cited by 3
Foodborne Yersinia : Identification and Molecular Epidemiology of Isolates from Human Infections
Hallanvuo, S. (2009) · Työväentutkimus Vuosikirja · Cited by 3
Molecular characterisation of Coxiella burnetii dairy cattle strains in Estonia
Neare, K., Tummeleht, L., Jinnerot, T., Lassen, B., & Viltrop, A. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1568226 · Cited by 2
Real-time polymerase chain reaction followed by fast sequencing allows rapid genotyping of microbial pathogens
Wahab, T., Ankarklev, J., Lebbad, M., Glavas, S., Svärd, S. G., & Palm, D. (2010) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2010.524661 · Cited by 2
Characterization and evaluation of tandem repeats for the identification of Geobacillus
Krilavičiūtė, A., & Kuisienė, N. (2013) · Open Life Sciences · doi:10.2478/s11535-013-0168-3 · Cited by 2
Finding an optimal loci combination of variable number tandem repeats using genetic algorithms
Ang, K. L., Tan, S. C., Ong, C. S., & Ngeow, Y. F. (2015) · International Symposium on Technology Management and Emerging Technologies (ISTMET) · doi:10.1109/istmet.2015.7359009 · Cited by 2
Forensic Public Health
Khan, A. S., & Pesik, N. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-382006-8.00015-3 · Cited by 2
Staphylococcus epidermidis, Clonality and Accessory Gene Regulator Diversity in Clinical Isolates
Peerayeh, S. N., Behmanesh, M., & Moghadas, A. J. (2018) · Archives of Clinical Infectious Diseases · doi:10.5812/archcid.62833 · Cited by 2
Molecular Epidemiological Analysis of Enterohemorrhagic Escherichia coli
Izumiya, H. (2019) · Japanese Journal of Food Microbiology · doi:10.5803/jsfm.36.10 · Cited by 2
Haemophilus influenzae
Gilsdorf, J. R. (2009) · Springer eBooks · doi:10.1007/978-0-387-09843-2_17 · Cited by 2
Draft Genome Sequences of Two Xanthomonas vesicatoria Strains from the Balkan Peninsula
Vancheva, T., Bogatzevska, N., Moncheva, P., Lefeuvre, P., & Koebnik, R. (2015) · Genome Announcements · doi:10.1128/genomea.01558-14 · Cited by 2
Detecting and Tracking Emerging Pathogenic and Spoilage Bacteria from Farm to Fork
Duffy, G. (2009) · Springer eBooks · doi:10.1007/978-0-387-89026-5_17 · Cited by 2
“A sub-typing method targeting these repeats, multiple-locus VNTR analysis (MLVA), has emerged as a powerful tool for characterisation of bacterial pathogens ( Van Belkum, 2007 ).”
Method
GENOMIC DIVERSITY OF THE CLOSTRIDIUM PERFRINGENS ISOLATES FROM HEALTHY AND ENTEROTOXEMIA AFFECTED LIVESTOCK USING MLVA METHOD
Hayati, M., Tadayon, K., Tahamtan, Y., Manavian, M., Paradise, A., Sadeghzadeh, S., & Shahriari, R. (2025) · Archives of Veterinary Medicine · doi:10.46784/e-avm.v18i2.475 · Cited by 1
MLVA typing of Brucella canis isolated from dogs in Gyeongbuk province, Korea
Kim, S.-G., Sohn, J. H., Jang, Y.-S., & Kim, S.-Y. (2012) · Korean Journal of Veterinary Service · doi:10.7853/kjvs.2012.35.4.275 · Cited by 1
Genotyping of Brucella abortus isolated from cattle in Gyeongbuk province by MLVA
Kim, S.-G., Kim, Y.-H., Lee, H.-Y., Choi, J.-H., & Choi, S. (2011) · Korean Journal of Veterinary Service · doi:10.7853/kjvs.2011.34.3.227 · Cited by 1
“세균의 분류 방법은 고전적으로 생물형, 혈청형, 파지형, 약제내성형 등의 방법이 있으나, 최근 들어 분자생물학의 발전과 더불어 분자유전학적 방법에 의한 유전형 및 분자형 등의 방법이 많이 이용되고 있으나 어떤 형태의 균 분류방법을 이용하든 높은 감 별력과 반복된 실험에서 동일한 결과를 얻을 수 있는 재현성이 반드시 수반되어야 올바른 방법이라 할 수 있다(van Belkum, 2007).”
Influential
A new genotyping scheme based on MLVA for inter-laboratory surveillance of Streptococcus pyogenes
Imperi, M., Pittiglio, V., D’Avenio, G., Gherardi, G., Ciammaruconi, A., Lista, F. R., Pourcel, C., Baldassarri, L., & Creti, R. (2016) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2016.06.010 · Cited by 1
Microbial Forensics: Bioterrorism and Biocrime
Eom, Y. (2018) · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · doi:10.15616/bsl.2018.24.2.55 · Cited by 1
“이런 특정 패턴을 분석해서 어떤 균종을 확정 동정하게 된다 (van Belkum, 2007).”
MLVA typing of Haemophilus influenzae isolated from two Iranian university hospitals.
Nejati, F., Fateh, A., Nojoumi, S. A., Rahbar, M., Behrouzi, A., Vaziri, F., & Siadat, S. D. (2018) · Europe PMC (PubMed Central) · Cited by 1
MERCAT: Visualising molecular epidemiology data combining genetic markers and drug resistance profiles
Aandahl, Z., Bhatia, S., Vaudagnotto, N., Street, A. G., Francis, A. R., & Tanaka, M. M. (2019) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2019.104043 · Cited by 1
Implementation of whole genome sequencing for bacteria genotyping
Artyszuk, D., & Wołkowicz, T. (2018) · Postępy Mikrobiologii - Advancements of Microbiology · doi:10.21307/pm-2018.57.2.179 · Cited by 1
Standardization of automated multi-locus variable number tandem repeats analysis for Methicillin-resistant Staphylococcus aureus typing isolated from invasive infections in paraguayan pediatric population
Florentín, M., Salinas, C., Acuña, P., Rodríguez, F., & Guillén, R. (2020) · Revista de salud publica del Paraguay · doi:10.18004/rspp.2020.diciembre.30 · Cited by 1
Molecular Analysis of Pathogenic Bacteria and Their Toxins
Logue, C. M., & Nolan, L. K. (2009) · Springer eBooks · doi:10.1007/978-0-387-89026-5_18 · Cited by 1
Molecular Technologies for the Detection and Characterisation of Food‐Borne Pathogens
Duffy, G. (2017) · doi:10.1002/9781119105916.ch7 · Cited by 1
Emerging methods for foodborne bacterial subtyping
Pagotto, F., & Reid, A. (2011) · Elsevier eBooks · doi:10.1533/9780857090508.2.181
Biologische Kriegsführung und Bioterrorismus
Clark, D. P., & Pazdernik, N. J. (2009) · Spektrum Akademischer Verlag eBooks · doi:10.1007/978-3-8274-2189-0_23
Analysis of Contamination Sources of Staphylococcus aureus Related to Perilla Leaves Using Multi-Locus Variable Number of Tandem Repeat Analysis (MLVA)
Kim, S.-R., Shim, W., Han, N. R., & Chung, D. (2014) · Journal of Food Hygiene and Safety · doi:10.13103/jfhs.2014.29.4.278
Epidemiology of Yersinia enterocolitica on pig farms
Virtanen, S. (2014) · Työväentutkimus Vuosikirja
The Genetic Composition and Diversity of Francisella tularensis
Larsson, P. (2007) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Tipagem molecular e caracterização do potencial patogênico de linhagens de Yersinia enterocolitica biotipo 1A de origens diversas
Campioni, F. (2009) · doi:10.11606/d.60.2009.tde-03112009-133931
Identificación de regiones hipervariables de bacterias patógenas mediante herramientas bioinformáticas. Aplicación en el genotipado bacteriano
Bautista, M. J. (2012) · Repositorio Abierto (Universidad Internacional de Andalucía)
Identification of biological threat agents in the environment and its challenge
Blatný, J., Fykse, E. M., Olsen, J. S., Skogan, G., & Aarskaug, T. (2008)
Tipagem molecular e análise da diversidade genética de linhagens de Salmonella Enteritidis isoladas de humanos, alimentos e frangos no Brasil
Campioni, F. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2013.tde-27112013-095252
Gedruckt mit Genehmigung des Fachbereichs Veterinärmedizin der Freien Universität Berlin
Brunnberg, L., Staufenbiel, R., Zessin, K.-H., & Fries, R. (2009)
Mutations in lysX as the new and reliable markers for tuberculosis Beijing and modern Beijing strains
Zhao, L., Xiao, T., Sun, Q., Liu, H., Zhao, X.-Q., Jiang, Y., Li, G., Zeng, C.-Y., & Wan, K. (2015) · Tuberculosis · doi:10.1016/j.tube.2015.12.006
Utvikling og testing av Multiple-locus variable-number (MLVA) tandem repeat analysemetode for Shigella sp.
Rawal, M. (2007) · NORA - Norwegian Open Research Archives
Caracterização molecular de linhagens de Salmonella Typhimurium isoladas de humanos, alimentos, animais e ambiente no Brasil
Almeida, F. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2016.tde-02052016-104855
65. Investigation of Foodborne Illness Outbreaks
Hammond, R. M., Melka, D. C., & Tompkins, B. J. (2013) · American Public Health Association eBooks · doi:10.2105/mbef.0222.070
Comparative genomics of selected species of gram-negative bacteria.
Ren, C.-P. (2010) · University of Birmingham Institutional Research Archive (University of Birmingham)
MICROBIAL FORENSICS AND COMPUTATIONAL BIOLOGY
Khan, N. T. (2017) · Journal of Research in Health Science · doi:10.26739/2523-1243/-2017-2-2-1
Monophasic Salmonella Typhimurium in Australian pigs
Weaver, T. J. (2017) · Minerva Access (University of Melbourne)
Qualitätssicherung der Hygiene und Hygienemanagement
(2016) · Elsevier eBooks · doi:10.1016/b978-3-437-22312-9.00008-1
Laboratory evaluation of intoxications: toxins and drugs
Dugăeşescu, M., & Andrei-Bitere, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-824472-2.00014-2
Development of strain specific simple sequence repeats and assessment of genetic diversity in Erwinia amylovora from marker selection to phylogenetic analysis
Ham, H., Lee, Y. H., Moh, S. H., & Cho, W. K. (2025) · Scientific Reports · doi:10.1038/s41598-025-15530-7
Repetitive Sequences in the Anthrax Pathogen Genome—Use in Molecular Epidemiology and Influence on the Structure of Encoded Proteins
Goncharova, Y. O., & Timofeev, V. S. (2025) · Russian Journal of Genetics · doi:10.1134/s1022795425700735
A new tandem repeat-based genotyping scheme for the global surveillance of Xanthomonas citri pv. mangiferaeindicae, an understudied bacterial pathogen of major importance to mango and cashew production
Boyer, K., Zombré, C. T., Payan, L., Wonni, I., & Pruvost, O. (2025) · PLoS ONE · doi:10.1371/journal.pone.0336768
Genetic background and impact of Staphylococcus aureus in a cross-border region
Nulens, E. (2010) · doi:10.26481/dis.20101209en
Function of TALE1Xam in cassava bacterial blight : a transcriptomic approach
Muñoz‐Bodnar, A. (2013) · theses.fr (ABES) · doi:10.70675/c301d6e6z9fd4z440dzb939z26241c010f83
Génotypage à haut niveau de résolution des xanthomonades phytopathogènes à l’aide de marqueurs de type CRISPR et VNTR : de la preuve de principe à l’application
Poulin, L. (2014) · theses.fr (ABES) · doi:10.70675/181c39b7z7e09z477fz8848za3f165da7da8
Coxiella burnetii : de la culture aux manifestations cliniques
Eldin, C. (2017) · doi:10.70675/6dd3c81dz542dz45f5zb3cbz2a3f7dcfff52
Pantoea spp : a new bacterial threat to rice production in sub-Saharan Africa
Kini, K. (2018) · doi:10.70675/1d9fa062z6b6az453fza215zabea6902d8d0

Authors: Van Belkum, A.
Venue: FEMS Immunology & Medical Microbiology
Publisher: Oxford University Press (OUP)
Published: 2007-02
Volume: 49
Issue: 1
Pages: 22-27
ISSN: 0928-8244 (ISSN-L)
1574-695X
DOI: 10.1111/j.1574-695x.2006.00173.x
OpenAlex: W2085293610
Cited by: 203
References: 66
Citations by year: 2026: 1 · 2025: 8 · 2024: 4 · 2022: 3 · 2021: 1 · 2020: 8 · 2019: 9 · 2018: 8 · 2017: 11 · 2016: 11 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 14
FWCI: 1.43
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: FEMS Immunology & Medical Microbiology (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics: Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Keywords: MLVA, strain typing, bacterial genotyping, repetitive DNA, outbreak source tracing, bacterial dissemination
MeSH terms: Bacillus anthracis, Bacteria, DNA, Bacterial, Humans, Mycobacterium tuberculosis, Staphylococcus aureus, Genome, Bacterial, Minisatellite Repeats, Bioterrorism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tracing isolates of bacterial species by multilocus variable number of tandem repeat analysis (MLVA)

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks