Preterm and term neonates transplacentally acquire IgG antibodies specific to LPS from Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa
Open accessAbstract
High incidences of Gram-negative bacteria are found in neonatal nosocomial infections. Our aim was to investigate placental transmission of immunoglobulin G (IgG) reactive with lipopolysaccharide from Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli O111, O6 and O26. The total and lipopolysaccharide-specific IgM and IgG were determined in 11 maternal/umbilical-cord sera aged ≤33 weeks (GI); 21 aged >33 and <37 weeks (GII); and 32 term newborns (GIII). The total and lipopolysaccharide-specific IgM concentrations were equivalent in maternal sera. The total IgG concentrations were equivalent in maternal and newborn sera, with the exception of GIII newborns as compared with their mothers (P<0.0001) and with neonates from GI and GII (P<0.05). Lipopolysaccharide-specific IgG concentrations were lower in GI neonates than in their mothers (P<0.01) and lower in GII (P<0.05). Lower lipopolysaccharide-specific IgG levels were observed among neonates only for O111 in GI (P<0.05) and for O26 and Pseudomonas in GII, both as compared with GIII (P<0.05). The anti-lipopolysaccharide IgG transfer ratios were lower in GI (except for O26) and in GII (except for Klebsiella and O111) as compared with GIII (P<0.05). Our results suggest that the greater susceptibility to infections in preterm infants is influenced (besides the humoral response) by factors intrinsic and extrinsic to the condition of prematurity.
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At term, fetal IgG levels vary but usually exceed maternal levels by 20-30%.
“At term, fetal levels vary, however, usually exceed maternal levels by 20–30% (64, 125, 126).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [126]
The Discussion reports that median total IgG in term newborns was exactly 20% higher than in their mothers. This supports the lower end of the claimed range, but the paper does not establish that levels usually exceed maternal levels by 20–30%. (LLM, conf=0.85)
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IgG placental transfer in healthy and pathological pregnancies
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“At term, fetal levels vary, however, usually exceed maternal levels by 20–30% (64, 125, 126).”
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Self-citation
- Authors
- Silveira Lessa, A. L., Krebs, V. L. J., Brasil, T. B., Pontes, G. N., Carneiro-Sampaio, M., & Palmeira, P.
- Affiliations
- Universidade de São Paulo (BR)
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-07
- Volume
- 62
- Issue
- 2
- Pages
- 236-243
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W1775863721
- Cited by
- 33
- References
- 40
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 4 · 2012: 1
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Immunology & Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- transplacental IgG transfer, preterm infants, term infants, Klebsiella pneumoniae, Escherichia coli O111, Escherichia coli O26, Pseudomonas aeruginosa, neonatal nosocomial infection, IgM
- MeSH terms
- Adolescent, Adult, Antibodies, Bacterial, Escherichia coli, Female, Humans, Immunoglobulin G, Immunoglobulin M, Immunity, Maternally-Acquired, Infant, Newborn, Klebsiella pneumoniae, Lipopolysaccharides, Pseudomonas aeruginosa, Premature Birth, Young Adult
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