Placental Transfer of IgG Antibodies Specific to Klebsiella and Pseudomonas LPS and to Group B Streptococcus in Twin Pregnancies
Open accessAbstract
Group B Streptococcus (GBS), Klebsiella spp. and Pseudomonas spp. are important aetiological agents of neonatal infections in Brazil. There is a lack of data in the literature regarding the specific transport of immunoglobulin G (IgG) against these pathogens in multiple pregnancies. Maternal (n = 55) and umbilical cord (n = 110) blood samples were prospectively collected at birth from 55 twin pregnancies. The factors associated with cord levels and transfer ratios of IgG against GBS, Klebsiella and Pseudomonas were examined. The IgG umbilical cord serum levels specific to GBS, Klebsiella LPS and Pseudomonas LPS were significantly associated with maternal‐specific IgG concentrations and the presence of diabetes. The anti‐Klebsiella IgG cord serum concentrations were also related to birthweight and the presence of hypertension. The transfer ratios against GBS and Pseudomonas LPS were associated with maternal‐specific IgG concentrations. The transfer ratios for GBS and Pseudomonas LPS were associated with gestational age at delivery and the presence of diabetes, respectively. None of the examined parameters were related to Klebsiella LPS transfer ratios. We conclude that in twin pregnancies, specific maternal IgG serum concentrations and diabetes were the parameters associated with umbilical cord serum IgG concentrations reactive with the three pathogens investigated. All the other parameters investigated showed different associations with neonatal‐specific IgG levels according to the antigen studied. There was no uniformity of the investigated parameters regarding association with placental IgG transfer ratios against the GBS, Pseudomonas LPS and Klebsiella LPS.
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More recent studies demonstrate negative correlations between maternal IgG levels and placental transfer ratios for both total and antigen-specific IgG.
“Furthermore, a number of more recent studies have demonstrated negative correlations between maternal IgG levels and placental transfer ratios for both total and antigen-specific IgG (96–98).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [98]
The Discussion (page unavailable) reports a negative association between maternal antigen-specific IgG concentrations and transfer ratios for anti-GBS and anti-Pseudomonas antibodies in twin pregnancies. It does not report a negative correlation for total IgG, so this source supports only the antigen-specific part of the cited sentence. (LLM, conf=0.88)
Experimental — accuracy not yet measuredOne study found that pregnancy-induced hypertension was associated with increased transfer of IgG against Klebsiella spp.
“One study has examined the effect of pregnancy-induced hypertension on IgG transfer and, interestingly, found that hypertension was associated was increased transfer of IgG against Klebsiella spp. (98).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [98]
The Discussion reports that hypertension was positively associated with umbilical-cord IgG levels against Klebsiella spp. But the Stepwise multivariate analysis says no investigated parameter was associated with the anti-Klebsiella IgG transfer ratio. The claim therefore treats higher cord levels as evidence of increased transfer, which this study did not find. (LLM, conf=0.90)
Experimental — accuracy not yet measuredStach et al. and França et al. demonstrated an increased rate of IgG transfer in hyperglycemic mothers.
“Stach et al. (98) demonstrated an increased rate of IgG transfer in hyperglycemic mothers for all antigens they studied (GBS, Klebsiella LPS, and Pseudomonas LPS), as did França et al. (114).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [98]
The Discussion reports a positive correlation between maternal diabetes and cord-serum IgG levels for all three antigens, as well as the Pseudomonas transfer ratio. The Stepwise multivariate analysis does not show an increased transfer ratio for GBS or Klebsiella LPS in mothers with diabetes; it reports no association between the examined parameters and the Klebsiella transfer ratio. Page numbers were not supplied. (LLM, conf=0.90)
Experimental — accuracy not yet measuredMaternal antibody levels play a role in determining transfer efficiency.
“It is well established that maternal antibody levels play a role in determining transfer efficiency.”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [98]
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- Authors
- Stach, S. C. L., Brizot, M. L., Liao, A. W., Palmeira, P., Francisco, R. P. V., Carneiro‐Sampaio, M. M. S., & Zugaib, M.
- Affiliations
- Universidade de São Paulo (BR)
- Department of Obstetrics and Gynecology São Paulo University Medical School Sao Paulo Brazil
- Department of Pediatrics São Paulo University Medical School Sao Paulo Brazil
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 2015-01-20
- Volume
- 81
- Issue
- 2
- Pages
- 135-141
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W1987012652
- Cited by
- 19
- References
- 27
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2017: 2
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Scandinavian Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- São Paulo Research Foundation (2011/13587-4)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Keywords
- twin pregnancy, Streptococcus agalactiae, Klebsiella, Pseudomonas, neonatal infection, maternal IgG, umbilical cord blood, diabetes in pregnancy, birth weight, hypertension, gestational age
- MeSH terms
- Antibodies, Bacterial, Birth Weight, Female, Fetal Blood, Gestational Age, Humans, Immunoglobulin G, Immunity, Maternally-Acquired, Infant, Newborn, Klebsiella, Lipopolysaccharides, Male, Maternal-Fetal Exchange, Placenta, Pregnancy, Prospective Studies, Pseudomonas, Streptococcus agalactiae, Multivariate Analysis, Pregnancy, Twin
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