The effect of desferrioxamine on the growth of Staphylococcus aureus, Yersinia enterocolitica and Streptococcus faecalis in human serum: Uptake of desferrioxamine-bound iron
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Growth of Staphylococcus aureus and Yersinia enterocolitica in human serum was enhanced by addition of excess iron or of the iron-chelating drug desferrioxamine, but neither had any effect on the growth of Streptococcus faecalis. Desferrioxamine could remove iron slowly from transferrin under physiological conditions, and desferrioxamine-bound iron was taken up by S. aureus and Y. enterocolitica but not by Strep. faecalis. The results suggest that patients with iron overload undergoing chelation therapy with desferrioxamine may have an increased risk of bacterial infection.
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S. aureus can use the hydroxymate-type siderophore desferrioxamine as an iron source.
“Brock and Ng demonstrated that S. aureus is capable of utilizing the hydroxymate-type siderophore desferrioxamine as an iron source [61].”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [61]
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- Authors
- Brock, J. H., & Ng, J.
- Affiliations
- Western Infirmary (GB)
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-11
- Volume
- 20
- Issue
- 3
- Pages
- 439-442
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- OpenAlex
- W2071856223
- Cited by
- 57
- References
- 14
- Citations by year
- 2026: 4 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2012: 1
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Microbiology Letters (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- deferoxamine, iron chelation therapy, iron overload, Staphylococcus aureus, Yersinia enterocolitica, Enterococcus faecalis, transferrin, iron absorption
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