Analysis of the proteome of Mycobacterium tuberculosis in silico

Tekaia, F.; Gordon, S.V.; Garnier, T.; Brosch, R.; Barrell, B.G.; Cole, S.T.

doi:10.1054/tuld.1999.0220

Cited by 311Tuberculosis Research and EpidemiologyGenomics and Phylogenetic StudiesBacterial Genetics and Biotechnology

Analysis of the proteome of Mycobacterium tuberculosis in silico

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Tekaia, F., Gordon, S.V., Garnier, T., Brosch, R., Barrell, B.G., Cole, S.T.·1999·Tubercle and Lung Disease

DOI 10.1054/tuld.1999.0220

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Abstract

Novel bioinformatics routines have been used to provide a more detailed definition of the proteome of Mycobacterium tuberculosis H37Rv. Over half of the current proteins result from gene duplication or domain shuffling events while one-sixth show no similarity to polypeptides described in other organisms. Prominent among the genes that appear to have been duplicated on numerous occasions are those involved in fatty acid metabolism, regulation of gene expression, and the unusually glycine-rich PE and PPE proteins. Protein similarity analysis, coupled with inspection of the genetic neighbourhood, was used to explore possible functional relatedness. This uncovered four large mce operons whose proteins may mediate initial interactions between the tubercle bacillus and host cells, together with a cluster of genes that might encode components of a structure required for secretion of ESAT-6 like proteins. Close linkage of the mmpL genes, encoding large membrane proteins, with those required for fatty acid metabolism suggests involvement in lipid transport. Compared to free-living bacteria, M. tuberculosis has a significantly smaller transport protein repertoire and this may reflect its intracellular lifestyle.

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ESX/T7S systems were first discovered almost 20 years ago during in silico analyses of the genome sequence and proteome of M. tuberculosis H37Rv.
“which were first discovered almost 20 years ago during in silico analyses of the genome sequence and the proteome of Mycobacterium tuberculosis H37Rv (17,18).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [18]
Five ESX systems are encoded in the genome of M. tuberculosis, and this is the highest number found in mycobacteria so far; other mycobacterial species show fewer systems (e.g., M. marinum four, M. abscessus three).
“Five ESX systems are encoded in the genome of M. tuberculosis (16,18), and this number is the highest found in mycobacteria so far; other mycobacterial species show fewer systems (e.g., Mycobacterium marinum shows four systems and Mycobacterium abscessus shows three systems) (21,22).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [18]

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© 1999 Harcourt Publishers Ltd Article no. tuld.1999.0220 Analysis of the proteome of
Tekaia, F., Gordon, S. V., Garnier, T., Brosch, R., Barrell, B. G., & Cole, S. T. (2013)
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RESEARCH ARTICLE Open Access Comparison of membrane proteins of Mycobacterium
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Authors: Tekaia, F., Gordon, S. V., Garnier, T., Brosch, R., Barrell, B. G., & Cole, S. T.
Affiliations: Institut Pasteur (FR)
Wellcome Sanger Institute (GB)
ORCID: Tekaia, F.
Gordon, S.V.
Brosch, R.
Cole, S.T.
Venue: Tubercle and Lung Disease
Publisher: Elsevier BV
Published: 1999-12
Volume: 79
Issue: 6
Pages: 329-342
ISSN: 0962-8479 (ISSN-L)
DOI: 10.1054/tuld.1999.0220
OpenAlex: W2076379808
Cited by: 311
References: 59
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 13 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 15 · 2014: 17 · 2013: 15 · 2012: 18
FWCI: 11.60
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Tubercle and Lung Disease (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, proteome, gene duplication, domain shuffling, fatty acid metabolism, gene expression regulation, host-pathogen interaction, lipid transport, membrane transporters, intracellular lifestyle
MeSH terms: Bacterial Proteins, Fatty Acids, Genes, Bacterial, Mycobacterium tuberculosis, Operon, Computational Biology, Genes, Duplicate, Proteome, Amino Acid Motifs

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Analysis of the proteome of Mycobacterium tuberculosis in silico

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