Cited by 454Lipid Membrane Structure and BehaviorCaveolin-1 and cellular processesSphingolipid Metabolism and Signaling

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Membranes: a meeting point for lipids, proteins and therapies

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Escribá, Pablo V., González‐Ros, José M., Goñi, Félix M., Kinnunen, Paavo K. J., Vigh, Lászlo, Sánchez‐Magraner, Lissete, Fernández, Asia M., Busquets, Xavier, Horváth, Ibolya, Barceló‐Coblijn, Gwendolyn·2008·Journal of Cellular and Molecular Medicine

DOI 10.1111/j.1582-4934.2008.00281.xPMC PMC4401130

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Abstract

Membranes constitute a meeting point for lipids and proteins. Not only do they define the entity of cells and cytosolic organelles but they also display a wide variety of important functions previously ascribed to the activity of proteins alone. Indeed, lipids have commonly been considered a mere support for the transient or permanent association of membrane proteins, while acting as a selective cell/organelle barrier. However, mounting evidence demonstrates that lipids themselves regulate the location and activity of many membrane proteins, as well as defining membrane microdomains that serve as spatio-temporal platforms for interacting signalling proteins. Membrane lipids are crucial in the fission and fusion of lipid bilayers and they also act as sensors to control environmental or physiological conditions. Lipids and lipid structures participate directly as messengers or regulators of signal transduction. Moreover, their alteration has been associated with the development of numerous diseases. Proteins can interact with membranes through lipid co-/post-translational modifications, and electrostatic and hydrophobic interactions, van der Waals forces and hydrogen bonding are all involved in the associations among membrane proteins and lipids. The present study reviews these interactions from the molecular and biomedical point of view, and the effects of their modulation on the physiological activity of cells, the aetiology of human diseases and the design of clinical drugs. In fact, the influence of lipids on protein function is reflected in the possibility to use these molecular species as targets for therapies against cancer, obesity, neurodegenerative disorders, cardiovascular pathologies and other diseases, using a new approach called membrane-lipid therapy.

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Authors: Escribá, P. V., González‐Ros, J. M., Goñi, F. M., Kinnunen, P. K. J., Vigh, L., Sánchez‐Magraner, L., Fernández, A. M., Busquets, X., Horváth, I., & Barceló‐Coblijn, G.
Affiliations: Research Institute of Health Sciences (ES)
University of the Basque Country (ES)
University of Helsinki (FI)
HUN-REN Szegedi Biológiai Kutatóközpont (HU)
Corresponding author: Escribá, Pablo V.
Goñi, Félix M.
Kinnunen, Paavo K. J.
Barceló‐Coblijn, Gwendolyn
ORCID: Escribá, Pablo V.
Goñi, Félix M.
Kinnunen, Paavo K. J.
Sánchez‐Magraner, Lissete
Busquets, Xavier
Horváth, Ibolya
Barceló‐Coblijn, Gwendolyn
Venue: Journal of Cellular and Molecular Medicine
Publisher: Wiley
Published: 2008-05-21
Volume: 12
Issue: 3
Pages: 829-875
ISSN: 1582-1838 (ISSN-L)
1582-4934
DOI: 10.1111/j.1582-4934.2008.00281.x
PMC: PMC4401130
OpenAlex: W2008091140
Cited by: 454
References: 347
Citations by year: 2026: 22 · 2025: 39 · 2024: 22 · 2023: 35 · 2022: 35 · 2021: 29 · 2020: 30 · 2019: 32 · 2018: 33 · 2017: 23 · 2016: 24 · 2015: 34 · 2014: 17 · 2013: 22 · 2012: 18
FWCI: 1.00
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Cellular and Molecular Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords: membrane lipids, membrane proteins, protein-lipid interactions, lipid rafts, signal transduction, lipid sensing, cancer therapy, obesity, neurodegenerative diseases, cardiovascular disease
MeSH terms: Animals, Drug Therapy, Humans, Membrane Lipids, Membrane Proteins, Models, Biological, Molecular Structure

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Membranes: a meeting point for lipids, proteins and therapies

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