An aPPARent functional consequence in skeletal muscle physiology via peroxisome proliferator-activated receptors

SATELLITE CELL OF SKELETAL MUSCLE FIBERS

Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683 · see citing works

Fiber Types in Mammalian Skeletal Muscles

Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022 · see citing works

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217 · see citing works

Satellite Cells and the Muscle Stem Cell Niche

Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166 · see citing works

PPARγ signaling and metabolism: the good, the bad and the future

Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016 · see citing works

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,960 · see citing works

Ageing as a Risk Factor for Disease

Niccoli, T., & Partridge, L. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.024 · Cited by 1,831 · see citing works

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766 · see citing works

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

(2006) · The Lancet · doi:10.1016/s0140-6736(06)69420-8 · Cited by 1,706 · see citing works

Transcriptional paradigms in mammalian mitochondrial biogenesis and function

Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666 · see citing works

PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,659 · see citing works

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561 · see citing works

The Many Faces of PPARγ

Lehrke, M., & Lazar, M. A. (2005) · Cell · doi:10.1016/j.cell.2005.11.026 · Cited by 1,452 · see citing works

Stem Cell Function, Self-Renewal, and Behavioral Heterogeneity of Cells from the Adult Muscle Satellite Cell Niche

Collins, C. A., Olsen, I., Zammit, P. S., Heslop, L., Petrie, A., Partridge, T. A., & Morgan, J. E. (2005) · Cell · doi:10.1016/j.cell.2005.05.010 · Cited by 1,445 · see citing works

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

Haemmerle, G., Lass, A., Zimmermann, R., Gorkiewicz, G., Meyer, C., Rozman, J., Heldmaier, G., Maier, R., Theussl, C., Eder, S., et al. (2006) · Science · doi:10.1126/science.1123965 · Cited by 1,375 · see citing works

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

Barroso, I., Gurnell, M., Crowley, V. E. F., Agostini, M., Schwabe, J. W., Soos, M. A., Maslen, G. L., Williams, T. D. M., Lewis, H., Schafer, A. J., et al. (1999) · Nature · doi:10.1038/47254 · Cited by 1,368 · see citing works

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

Deeb, S. S., Fajas, L., Nemoto, M., Pihlajamäki, J., Mykkänen, L., Kuusisto, J., Laakso, M., Fujimoto, W., & Auwerx, J. (1998) · Nature Genetics · doi:10.1038/3099 · Cited by 1,319 · see citing works

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267 · see citing works

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264 · see citing works

AMPK and PPARδ Agonists Are Exercise Mimetics

Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222 · see citing works

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

Grygiel‐Górniak, B. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-17 · Cited by 1,205 · see citing works

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194 · see citing works

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

Lluis Fajas, A., Auboeuf, D., Raspé, E., Schoonjans, K., Lefebvre, A., Saladin, R., Najib, J., Laville, M., Fruchart, J., Deeb, S. S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18779 · Cited by 1,188 · see citing works

Regulation of Muscle Fiber Type and Running Endurance by PPARδ

Wang, Y.-X., Zhang, C.-L., Yu, R. T., Cho, H. K., Nelson, M. C., Bayuga-Ocampo, C. R., Ham, J., Kang, H., & Evans, R. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020294 · Cited by 1,089 · see citing works

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily

Hwa, V., Oh, Y., & Rosenfeld, R. G. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.6.0382 · Cited by 1,076 · see citing works

Muscle Injuries

Järvinen, T. A. H., Järvinen, T. L. N., Kääriäinen, M., Kalimo, H., & Järvinen, M. (2005) · The American Journal of Sports Medicine · doi:10.1177/0363546505274714 · Cited by 1,069 · see citing works

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

He, W., Barak, Y., Hevener, A. L., Olson, P., Liao, D., Le, J., Nelson, M. C., Ong, E. S., Olefsky, J. M., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536828100 · Cited by 978 · see citing works

Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

Nolan, J. J., Ludvik, B. H., Beerdsen, P., Joyce, M., & Olefsky, J. M. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411033311803 · Cited by 925 · see citing works

Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?

Muñoz‐Cánoves, P., Scheele, C., Pedersen, B. K., & Serrano, A. L. (2013) · The FEBS Journal · doi:10.1111/febs.12338 · Cited by 774 · see citing works

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767 · see citing works

The randle cycle revisited: a new head for an old hat.

Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743 · see citing works

An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle

Handschin, C., Rhee, J., Lin, J., Tarr, P. T., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232352100 · Cited by 729 · see citing works

Muscle injuries and repair: current trends in research.

Huard, J., Li, Y., & Fu, F. H. (2002) · Journal of Bone and Joint Surgery. American volume · doi:10.2106/00004623-200205000-00022 · Cited by 688 · see citing works

Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors

Schug, T. T., Berry, D. C., Shaw, N. S., Travis, S. N., & Noy, N. (2007) · Cell · doi:10.1016/j.cell.2007.02.050 · Cited by 680 · see citing works

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 670 · see citing works

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

Folmes, C. D. L., Dzeja, P. P., Nelson, T. J., & Terzic, A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.10.002 · Cited by 664 · see citing works

Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.

Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1113 · Cited by 643 · see citing works

Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila

Grönke, S., Mildner, A., Fellert, S., Tennagels, N., Petry, S., Müller, G. A., Jäckle, H., & Kühnlein, R. P. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.04.003 · Cited by 621 · see citing works

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

Chavez, J. A., Knotts, T. A., Wang, L.-P., Li, G., Dobrowsky, R. T., Florant, G. L., & Summers, S. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212307200 · Cited by 617 · see citing works

A Ceramide-Centric View of Insulin Resistance

Chavez, J. A., & Summers, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.002 · Cited by 617 · see citing works

Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms

Al-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.007 · Cited by 614 · see citing works

Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43

Hong, Y.-H., Nishimura, Y., Hishikawa, D., Tsuzuki, H., Miyahara, H., Gotoh, C., Choi, K.-C., Feng, D. D., Chen, C., Lee, H.-G., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0545 · Cited by 613 · see citing works

Muscle injuries and repair: current trends in research.

Huard, J., Li, Y., & Fu, F. H. (2002) · PubMed · Cited by 604 · see citing works

Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects

Boden, G., Lebed, B., Schatz, M., Homko, C., & Lemieux, S. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1612 · Cited by 597 · see citing works

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate

Schmitz-Peiffer, C., Craig, D. L., & Biden, T. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24202 · Cited by 592 · see citing works

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

Yoon, M. J., Lee, G. Y., Chung, J.-J., Ahn, Y. H., Hong, S. H., & Kim, J. B. (2006) · Diabetes · doi:10.2337/db05-1322 · Cited by 546 · see citing works

Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

Ristow, M., Müller‐Wieland, D., Pfeiffer, A. F. H., Krone, W., & Kahn, C. R. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810013391403 · Cited by 544 · see citing works

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

Xu, H. E., Lambert, M. H., Montana, V. G., Plunket, K. D., Moore, L. B., Collins, J. L., Oplinger, J. A., Kliewer, S. A., Gampe, R. T., McKee, D. D., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241410198 · Cited by 541 · see citing works

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

Hancock, C. R., Han, D.-H., Chen, M., Terada, S., Yasuda, T., Wright, D. C., & Holloszy, J. O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802057105 · Cited by 538 · see citing works

Peroxisome proliferator‐activated receptor δ controls muscle development and oxydative capability

Luquet, S., Lopez‐Soriano, J., Holst, D., Fredenrich, A., Melki, J., Rassoulzadegan, M., & Grimaldi, P. A. (2003) · The FASEB Journal · doi:10.1096/fj.03-0269fje · Cited by 509 · see citing works

Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and γ-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus

Wolfrum, C., Borrmann, C. M., Börchers, T., & Spener, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051619898 · Cited by 503 · see citing works

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Knobloch, M., Braun, S., Zurkirchen, L., Schoultz, C., Zamboni, N., Araúzo-Bravo, M., Kovacs, W. J., Karalay, Ö., Suter, U., Machado, R. A. C., et al. (2012) · Nature · doi:10.1038/nature11689 · Cited by 503 · see citing works

Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription

Tan, N.-S., Shaw, N. S., Vinckenbosch, N., Liu, P., Yasmin, R., Desvergne, B., Wahli, W., & Noy, N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5114-5127.2002 · Cited by 499 · see citing works

Strength and muscle mass loss with aging process. Age and strength loss

Keller, K., & Engelhardt, M. M. (2019) · Muscles Ligaments and Tendons Journal · doi:10.32098/mltj.04.2013.17 · Cited by 499 · see citing works

PPARδ regulates glucose metabolism and insulin sensitivity

Lee, C., Olson, P., Hevener, A. L., Mehl, I. R., Chong, L.-W., Olefsky, J. M., Gonzalez, F. J., Ham, J., Kang, H., Peters, J. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511253103 · Cited by 495 · see citing works

Diacylglycerol-mediated insulin resistance

Erion, D. M., & Shulman, G. I. (2010) · Nature Medicine · doi:10.1038/nm0410-400 · Cited by 493 · see citing works

Muscle-specific Pparg deletion causes insulin resistance

Hevener, A. L., He, W., Barak, Y., Le, J., Bandyopadhyay, G. K., Olson, P., Wilkes, J. J., Evans, R. M., & Olefsky, J. M. (2003) · Nature Medicine · doi:10.1038/nm956 · Cited by 492 · see citing works

Peroxisome proliferator-activated receptors: insight into multiple cellular functions

Escher, P., & Wahli, W. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00231-6 · Cited by 491 · see citing works

The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man

Thiebaud, D., Jacot, E., Defronzo, R. A., Maeder, E., Jequier, E., & Felber, J.-P. (1982) · Diabetes · doi:10.2337/diacare.31.11.957 · Cited by 489 · see citing works

Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly

Verdijk, L. B., Koopman, R., Schaart, G., Meijer, K., Savelberg, H. H. C. M., & van Loon, L. J. C. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00278.2006 · Cited by 489 · see citing works

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily

Hwa, V. (1999) · Endocrine Reviews · doi:10.1210/er.20.6.761 · Cited by 466 · see citing works

Membranes: A meeting point for lipids, proteins and therapies

Escribá, P. V., González‐Ros, J. M., Goñi, F. M., Kinnunen, P. K. J., Vigh, L., Sánchez‐Magraner, L., Fernández, A. M., Busquets, X., Horváth, I., & Barceló‐Coblijn, G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00281.x · Cited by 454 · see citing works

Satellite cells attract monocytes and use macrophages as a support to escape apoptosis and enhance muscle growth

Chazaud, B., Sonnet, C., Lafuste, P., Bassez, G., Rimaniol, A., Poron, F., Authier, F., Dreyfus, P. A., & Gherardi, R. K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212046 · Cited by 452 · see citing works

Endurance Training in Humans Leads to Fiber Type-Specific Increases in Levels of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 and Peroxisome Proliferator-Activated Receptor-α in Skeletal Muscle

Russell, A. P., Feilchenfeldt, J. W., Schreiber, S., Praz, M., Crettenand, A., Gobelet, C., Meier, C. A., Bell, D., Kralli, A., Giacobino, J., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2874 · Cited by 451 · see citing works

Ceramide: second messenger or modulator of membrane structure and dynamics?

BLITTERSWIJK, W. J. V., van der Luit, A. H., Veldman, R. J., Verheij, M., & Borst, J. G. (2003) · Biochemical Journal · doi:10.1042/bj20021528 · Cited by 436 · see citing works

Skeletal muscle fiber quality in older men and women

Frontera, W. R., Suh, D., Krivickas, L. S., HUGHES, V. A., Goldstein, R., & Roubenoff, R. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c611 · Cited by 424 · see citing works

Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

Norris, A. W., Chen, L., Fisher, S. J., Szanto, I., Ristow, M., Jozsi, A. C., Hirshman, M. F., Rosen, E. D., Goodyear, L. J., Gonzalez, F. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17305 · Cited by 417 · see citing works

Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

Miles, P. D. G., Barak, Y., He, W., Evans, R. M., & Olefsky, J. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8538 · Cited by 400 · see citing works

Fatty Acid Homeostasis and Induction of Lipid Regulatory Genes in Skeletal Muscles of Peroxisome Proliferator-activated Receptor (PPAR) α Knock-out Mice

Muoio, D. M., MacLean, P. S., Lang, D. B., Li, S., Houmard, J. A., Way, J. M., Winegar, D. A., Corton, J. C., Dohm, G. L., & Kraus, W. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203997200 · Cited by 398 · see citing works

Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

Vavvas, D., Apazidis, A., Saha, A. K., Gamble, J., Patel, A., Kemp, B. E., Witters, L. A., & Ruderman, N. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13255 · Cited by 395 · see citing works

The transcriptional coactivator PGC-1β drives the formation of oxidative type IIX fibers in skeletal muscle.

Arany, Z., Lebrasseur, N., Morris, C., Smith, E., Yang, W., Ma, Y., Chin, S., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2006.12.003 · Cited by 370 · see citing works

PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

Schuler, M. J., Ali, F., Chambon, C., Duteil, D., Bornert, J., Tardivel, A., Desvergne, B., Wahli, W., Chambon, P., & METZGER, D. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.003 · Cited by 368 · see citing works

Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt

Kuo, Y.-C., Huang, K.-Y., Yang, C.-H., Yang, Y.-S., Lee, W.-Y., & Chiang, C.-W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709585200 · Cited by 367 · see citing works

Tissue-specific Functions in the Fatty Acid-binding Protein Family

Storch, J., & THUMSER, A. E. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.135210 · Cited by 363 · see citing works

The metabolic syndrome: role of skeletal muscle metabolism.

Stump, C. S., Henriksen, E. J., Wei, Y., & Sowers, J. R. (2006) · Annals of Medicine · doi:10.1080/07853890600888413 · Cited by 362 · see citing works

Peroxisome proliferator-activated receptor structures: Ligand specificity, molecular switch and interactions with regulators

Zoete, V., Grosdidier, A., & Michielin, O. A. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.01.007 · Cited by 361 · see citing works

Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance

Liu, L., Zhang, Y., Chen, N., Shi, X., Tsang, B., & Yu, Y.-H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30565 · Cited by 356 · see citing works

Strength and muscle mass loss with aging process. Age and strength loss.

Keller, K., & Engelhardt, M. (2013) · Europe PMC (PubMed Central) · Cited by 340 · see citing works

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

Ceddia, R. B., Somwar, R., Maida, A., Fang, X., Bikopoulos, G. J., & Sweeney, G. (2004) · Diabetologia · doi:10.1007/s00125-004-1609-y · Cited by 340 · see citing works

A quick look at biochemistry: Carbohydrate metabolism

Dashty, M. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.04.027 · Cited by 332 · see citing works

The metabolic regulation of aging

Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works

OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization

Wolins, N. E., Quaynor, B. K., Skinner, J. R., Tzekov, A., Croce, M. A., Gropler, M. C., Varma, V., Yao‐Borengasser, A., Rasouli, N., Kern, P. A., et al. (2006) · Diabetes · doi:10.2337/db06-0399 · Cited by 324 · see citing works

Peripheral arterial disease in diabetes—a review

Jude, E., Eleftheriadou, I., & Tentolouris, N. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02866.x · Cited by 321 · see citing works

Fatty acid metabolism in adipose tissue, muscle and liver in health and disease

Frayn, K. N., Arner, P., & Yki‐Järvinen, H. (2006) · Essays in Biochemistry · doi:10.1042/bse0420089 · Cited by 316 · see citing works

Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

Dobbins, R. L., Szczepaniak, L. S., Bentley, B., Esser, V., Myhill, J., & McGarry, J. D. (2001) · Diabetes · doi:10.2337/diabetes.50.1.123 · Cited by 315 · see citing works

Aging of skeletal muscle fibers

Miljkovic, N., Lim, J.-Y., Miljkovic, I., & Frontera, W. R. (2015) · Annals of Rehabilitation Medicine · doi:10.5535/arm.2015.39.2.155 · Cited by 309 · cited 2× · see citing works

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

Divakaruni, A. S., Wiley, S. E., Rogers, G. W., Andreyev, A. Y., Petrosyan, S., Loviscach, M., Wall, E. A., Yadava, N., Heuck, A. P., Ferrick, D. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303360110 · Cited by 308 · see citing works

Skeletal muscle regeneration is modulated by inflammation

Yang, W.-J., & Hu, P. (2018) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2018.01.002 · Cited by 303 · see citing works

Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues

LeBrasseur, N. K., Kelly, M., Tsao, T.-S., Farmer, S. R., Saha, A. K., Ruderman, N. B., & Tomas, E. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00453.2005 · Cited by 276 · see citing works

Live strong and prosper: the importance of skeletal muscle strength for healthy ageing

McLeod, M., Breen, L., Hamilton, D. L., & Philp, A. (2016) · Biogerontology · doi:10.1007/s10522-015-9631-7 · Cited by 274 · see citing works

A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

Finck, B. N., Bernal-Mizrachi, C., Han, D. H., Coleman, T., Sambandam, N., LaRiviere, L. L., Holloszy, J. O., Semenkovich, C. F., & Kelly, D. P. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.006 · Cited by 270 · see citing works

Gut microbiota, immune development and function

Bengmark, S. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.002 · Cited by 264 · see citing works

Thiazolidinediones and Heart Failure

Singh, S., Loke, Y. K., & Furberg, C. D. (2007) · Diabetes Care · doi:10.2337/dc07-0141 · Cited by 262 · see citing works

PPARs and ERRs: molecular mediators of mitochondrial metabolism

Fan, W., & Evans, R. M. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.11.002 · Cited by 253 · see citing works

Differential response of macrophage subpopulations to soleus muscle reloading after rat hindlimb suspension

St Pierre, B. A., & Tidball, J. G. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.1.290 · Cited by 251 · cited 1× · see citing works

Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle

Koonen, D. P. Y., Glatz, J. F. C., Bonen, A., & Luiken, J. J. F. P. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.08.018 · Cited by 238 · see citing works

Insulin resistance: a contributing factor to age-related muscle mass loss?

Guillet, C., & Boirie‌, Y. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(05)73648-x · Cited by 237 · see citing works

LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues

Dalen, K. T., Dahl, T. B., Holter, E., Arntsen, B. M., Londos, C., Sztalryd, C., & Nebb, H. I. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.11.011 · Cited by 236 · see citing works

Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages

Latroche, C., Weiss‐Gayet, M., Muller, L., Gitiaux, C., Leblanc, P., Liot, S., Larbi, S. B., Abou-Khalil, R., Verger, N., Bardot, P., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.027 · Cited by 234 · see citing works

The Insulin Receptor and Its Cellular Targets1

Kido, Y., Nakae, J., & Accili, D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7306 · Cited by 223 · see citing works

Fibrates Suppress Bile Acid Synthesis via Peroxisome Proliferator–Activated Receptor-α–Mediated Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Expression

Post, S. M., Duez, H., Gervois, P. P., Staels, B., Kuipers, F., & Princen, H. M. G. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1101.098228 · Cited by 219 · see citing works

Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development

Abbott, B. D. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.10.001 · Cited by 218 · see citing works

Exercise‐Induced Capillary Growth in Human Skeletal Muscle and the Dynamics of VEGF

Høier, B., & Hellsten, Y. (2014) · Microcirculation · doi:10.1111/micc.12117 · Cited by 215 · see citing works

Regulation of Skeletal Muscle Physiology and Metabolism by Peroxisome Proliferator-Activated Receptor δ

Ehrenborg, E., & Krook, A. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001560 · Cited by 213 · see citing works

Myopathy and rhabdomyolysis with lipid-lowering drugs

Hodel, C. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(02)00010-3 · Cited by 213 · see citing works

Isometric and dynamic endurance as a function of age and skeletal muscle characteristics

Larsson, L., & Karlsson, J. (1978) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1978.tb06259.x · Cited by 211 · see citing works

Skeletal muscle insulin resistance: roles of fatty acid metabolism and exercise

Turcotte, L. P., & Fisher, J. S. (2008) · Physical Therapy · doi:10.2522/ptj.20080018 · Cited by 209 · see citing works

Impaired Long-Chain Fatty Acid Utilization by Cardiac Myocytes Isolated From Mice Lacking the Heart-Type Fatty Acid Binding Protein Gene

Schaap, F. G., Binas, B., Danneberg, H., Vusse, G. J., & Glatz, J. F. C. (1999) · Circulation Research · doi:10.1161/01.res.85.4.329 · Cited by 208 · see citing works

Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids

Kersten, S., Lichtenstein, L., Steenbergen, E., Mudde, K., Hendriks, H., Hesselink, M. K. C., Schrauwen, P., & Müller, M. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.182147 · Cited by 206 · see citing works

Human Muscle Fiber Type–Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes

Albers, P. H., Pedersen, A. J. T., Birk, J. B., Steenberg, D. E., Vind, B. F., Baba, O., Nøhr, J., Højlund, K., & Wojtaszewski, J. F. P. (2014) · Diabetes · doi:10.2337/db14-0590 · Cited by 204 · see citing works

All muscle satellite cells are equal, but are some more equal than others?

Zammit, P. S. (2008) · Journal of Cell Science · doi:10.1242/jcs.019661 · Cited by 201 · see citing works

Age-Related Changes in Motor Cortical Properties and Voluntary Activation of Skeletal Muscle

Clark, B. C., & Taylor, J. L. (2011) · Current Aging Science · doi:10.2174/1874609811104030192 · Cited by 201 · see citing works

Impaired Activation of AMP-Kinase and Fatty Acid Oxidation by Globular Adiponectin in Cultured Human Skeletal Muscle of Obese Type 2 Diabetics

Chen, M. B., McAinch, A. J., Macaulay, S. L., Castelli, L. A., O’Brien, P. E., Dixon, J. B., Cameron‐Smith, D., Kemp, B. E., & Steinberg, G. R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1980 · Cited by 200 · see citing works

PPARδ Promotes Running Endurance by Preserving Glucose

Fan, W., Waizenegger, W., Lin, C. S., Sorrentino, V., He, M.-X., Wall, C. E., Li, H., Liddle, C., Yu, R. T., Atkins, A. R., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.006 · Cited by 198 · see citing works

Greater Transport Efficiencies of the Membrane Fatty Acid Transporters FAT/CD36 and FATP4 Compared with FABPpm and FATP1 and Differential Effects on Fatty Acid Esterification and Oxidation in Rat Skeletal Muscle

Nickerson, J. G., Alkhateeb, H. H., Benton, C. R., Lally, J., Nickerson, J., Han, X.-X., Wilson, M. H., Jain, S. S., Snook, L. A., Glatz, J. F. C., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004788 · Cited by 197 · see citing works

Activation of Malonyl-CoA Decarboxylase in Rat Skeletal Muscle by Contraction and the AMP-activated Protein Kinase Activator 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside

Saha, A. K., Schwarsin, A. J., Roduit, R., Massé, F., Kaushik, V. K., Tornheim, K., Prentki, M., & Ruderman, N. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000291200 · Cited by 194 · see citing works

From fat to FAT (CD36/SR-B2): Understanding the regulation of cellular fatty acid uptake

Glatz, J. F. C., & Luiken, J. J. F. P. (2016) · Biochimie · doi:10.1016/j.biochi.2016.12.007 · Cited by 194 · see citing works

Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: Inhibition of fatty acid transport

Harmon, C. M., Luce, P., Beth, A. H., & Abumrad, N. A. (1991) · The Journal of Membrane Biology · doi:10.1007/bf01951559 · Cited by 192 · see citing works

Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

Wagner, K., & Wagner, N. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.12.001 · Cited by 191 · see citing works

The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin

Shalev, A., Siegrist-Kaiser, C. A., Yen, P. M., Wahli, W., Burger, A., Chin, W. W., & Meier, C. A. (1996) · Endocrinology · doi:10.1210/endo.137.10.8828512 · Cited by 187 · see citing works

Lipid metabolism in the elderly

Toth, M., & Tchernof, A. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601033 · Cited by 187 · see citing works

Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration

Varga, T., Mounier, R., Patsalos, A., Gogolák, P., Peloquin, M., Horváth, A., Pap, A., Dániel, B., Nagy, G., Pintye, É., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.016 · Cited by 187 · see citing works

Beneficial Effects of Fenofibrate to Improve Endothelial Dysfunction and Raise Adiponectin Levels in Patients With Primary Hypertriglyceridemia

Koh, K. K., Han, S. H., Quon, M. J., Ahn, J. Y., & Shin, E. K. (2005) · Diabetes Care · doi:10.2337/diacare.28.6.1419 · Cited by 182 · see citing works

The Role of PPAR α Activation in Liver and Muscle

Burri, L., Thoresen, G. H., & Berge, R. K. (2010) · PPAR Research · doi:10.1155/2010/542359 · Cited by 159 · see citing works

Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4

Foley, K. P., Boguslavsky, S., & Klip, A. (2011) · Biochemistry · doi:10.1021/bi2000356 · Cited by 156 · see citing works

MBX-8025, A Novel Peroxisome Proliferator Receptor-δ Agonist: Lipid and Other Metabolic Effects in Dyslipidemic Overweight Patients Treated with and without Atorvastatin

Bays, H. E., Schwartz, S. L., Littlejohn, T. W., Kerzner, B., Krauss, R. M., Karpf, D. B., Choi, Y., Wang, X., Naim, S., & Roberts, B. K. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1061 · Cited by 151 · see citing works

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers-van Gogh, I., Schaart, G., Jeppesen, J., Kneppers, A., Mensink, M., Voshol, P. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400889111 · Cited by 150 · see citing works

Peroxisome Proliferator-activated Receptor α (PPARα) Turnover by the Ubiquitin-Proteasome System Controls the Ligand-induced Expression Level of Its Target Genes

Blanquart, C., Barbier, O., Fruchart, J., Staels, B., & Glineur, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110598200 · Cited by 150 · see citing works

Skeletal muscle capillary function: contemporary observations and novel hypotheses

Poole, D. C., Copp, S. W., Ferguson, S. K., & Musch, T. I. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.073874 · Cited by 147 · see citing works

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice

Huijsman, E., van de Par, C., Economou, C., van der Poel, C., Lynch, G. S., Schoiswohl, G., Haemmerle, G., Zechner, R., & Watt, M. J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2009 · Cited by 145 · see citing works

Continuous Nucleocytoplasmic Shuttling Underlies Transcriptional Activation of PPARγ by FABP4

Ayers, S. D., Nedrow, K. L., Gillilan, R. E., & Noy, N. (2007) · Biochemistry · doi:10.1021/bi700047a · Cited by 144 · see citing works

PPARδ Agonism Activates Fatty Acid Oxidation via PGC-1α but Does Not Increase Mitochondrial Gene Expression and Function

Kleiner, S., Nguyen-Tran, V., Baré, O., Huang, X., Spiegelman, B., & Wu, Z. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008797 · Cited by 143 · see citing works

Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function

Watt, M. J., & Hoy, A. J. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00561.2011 · Cited by 142 · see citing works

Gut microbiota can transfer fiber characteristics and lipid metabolic profiles of skeletal muscle from pigs to germ-free mice

Yan, H., Diao, H., Xiao, Y., Li, W., Yu, B., He, J., Yu, J., Zheng, P., Mao, X., Luo, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep31786 · Cited by 138 · see citing works

Rosiglitazone Improves Downstream Insulin Receptor Signaling in Type 2 Diabetic Patients

Miyazaki, Y., He, H., Mandarino, L. J., & DeFronzo, R. A. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1943 · Cited by 136 · see citing works

Skeletal Muscle Microvasculature: A Highly Dynamic Lifeline

Latroche, C., Gitiaux, C., Chrétien, F. C., Desguerre, I., Mounier, R., & Chazaud, B. (2015) · Physiology · doi:10.1152/physiol.00026.2015 · Cited by 135 · see citing works

Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor β/δ (FABP5-PPARβ/δ) Signaling Pathway

Armstrong, E. H., Goswami, D., Griffin, P. R., Noy, N., & Ortlund, E. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.514646 · Cited by 135 · see citing works

PPAR-gamma gene expression is elevated in skeletal muscle of obese and type II diabetic subjects

Park, K. S., Ciaraldi, T. P., Abrams-Carter, L., Mudaliar, S. R. D., Nikoulina, S. E., & Henry, R. R. (1997) · Diabetes · doi:10.2337/diab.46.7.1230 · Cited by 128 · see citing works

Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110β Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects

Kim, Y., Ciaraldi, T. P., Kong, A. P. S., Kim, D. S., Chu, N. V., Mohideen, P., Mudaliar, S. R. D., Henry, R. R., & Kahn, B. B. (2002) · Diabetes · doi:10.2337/diabetes.51.2.443 · Cited by 127 · see citing works

Thiazolidinediones and associated risk of bladder cancer: a systematic review and meta‐analysis

Turner, R. M., Kwok, C. S., Chen‐Turner, C., Maduakor, C. A., Singh, S., & Loke, Y. K. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12306 · Cited by 126 · see citing works

CD36-dependent Regulation of Muscle FoxO1 and PDK4 in the PPARδ/β-mediated Adaptation to Metabolic Stress

Nahlé, Z., Hsieh, M., Pietka, T., Coburn, C. T., Grimaldi, P. A., Zhang, M. Q., Das, D., & Abumrad, N. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706478200 · Cited by 122 · cited 1× · see citing works

Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione

Chen, Z., Vigueira, P. A., Chambers, K. T., Hall, A. M., Mitra, M. S., Qi, N., McDonald, W. G., Colca, J. R., Kletzien, R. F., & Finck, B. N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363960 · Cited by 121 · see citing works

PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle

Hondares, E., Pineda-Torra, I., Iglesias, R., Staels, B., Villarroya, F., & Giralt, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.092 · Cited by 120 · see citing works

Selective activation of PPARγ in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance

Amin, R., Mathews, S. T., Camp, H. S., Ding, L., & Leff, T. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2009 · Cited by 118 · see citing works

Skeletal muscle GLUT4 protein concentration and aging in humans

Houmard, J. A., Weidner, M. D., Dolan, P. L., Leggett-Frazier, N., Gavigan, K. E., Hickey, M. S., Tyndall, G. L., Zheng, D., Alshami, A., & Dohm, G. L. (1995) · Diabetes · doi:10.2337/diab.44.5.555 · Cited by 115 · see citing works

Skeletal muscle GLUT4 protein concentration and aging in humans

Houmard, J. A., Weidner, M. D., Dolan, P. L., Leggett-Frazier, N., Gavigan, K. E., Hickey, M. S., Tyndall, G. L., Zheng, D., Alshami, A., & Dohm, G. L. (1995) · Diabetes · doi:10.2337/diabetes.44.5.555 · Cited by 115 · see citing works

PPARα gene variation and physical performance in Russian athletes

Ahmetov, I. I., Mozhayskaya, I. A., Flavell, D. M., Astratenkova, I. V., Komkova, A. I., Lyubaeva, E. V., Tarakin, P. P., Shenkman, B. S., Vdovina, A. B., Netreba, A. I., et al. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0154-4 · Cited by 112 · see citing works

CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity

Jordan, S. D., Kriebs, A., Vaughan, M. E., Duglan, D., Fan, W., Henriksson, E., Huber, A., Papp, S. J., Nguyen, M., Afetian, M. E., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.002 · Cited by 112 · see citing works

Pharmacological activation of PPAR / stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice

Miura, P., Chakkalakal, J. V., Boudreault, L., Belanger, G., Hébert, R., Renaud, J.-M., & Jasmin, B. J. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp431 · Cited by 110 · see citing works

Balanced pan-PPAR activator bezafibrate in combination with statin: comprehensive lipids control and diabetes prevention?

Tenenbaum, A., & Fisman, E. Z. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-140 · Cited by 108 · see citing works

Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity

Johannsen, D. L., Conley, K. E., Bajpeyi, S., Punyanitya, M., Gallagher, D., Zhang, Z., Covington, J. D., Smith, S. R., & Ravussin, É. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1798 · Cited by 107 · see citing works

Adiponectin action in skeletal muscle

Liu, Y., & Sweeney, G. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.08.003 · Cited by 107 · see citing works

Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPARγ Agonists

Jiang, G., Dallas-Yang, Q., Li, Z., Szalkowski, D., Liu, F., Shen, X., Wu, M. S., Zhou, G., Doebber, T. W., Berger, J., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2412 · Cited by 106 · see citing works

Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus

Minnaard, R., Schrauwen, P., Schaart, G., Jörgensen, J. A., Lenaers, E., Mensink, M., & Hesselink, M. K. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0352 · Cited by 104 · see citing works

Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting

Spriet, L. L., Tunstall, R. J., Watt, M. J., Carey, K. A., Hargreaves, M., & Cameron‐Smith, D. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01318.2003 · Cited by 102 · see citing works

Role of PPAR in Hepatic Carbohydrate Metabolism

Peeters, A., & Baes, M. I. (2010) · PPAR Research · doi:10.1155/2010/572405 · Cited by 102 · see citing works

Hormones and the Aging Process

Morley, J. E. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1365-2389.2003.51344.x · Cited by 100 · see citing works

Human skeletal muscle fibre type variations correlate with PPARα, PPARδ and PGC‐1α mRNA

Kramer, D., Ahlsén, M., Norrbom, J., Jansson, E., Hjeltnes, N., Gustafsson, T. P., & Krook, A. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01620.x · Cited by 99 · see citing works

PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise

Koh, J., Hancock, C. R., Terada, S., Higashida, K., Holloszy, J. O., & Han, D.-H. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.029 · Cited by 95 · see citing works

Adiponectin Increases Skeletal Muscle Mitochondrial Biogenesis by Suppressing Mitogen-Activated Protein Kinase Phosphatase-1

Qiao, L., Kinney, B., Yoo, H. S., Lee, B., Schaack, J. B., & Shao, J. (2012) · Diabetes · doi:10.2337/db11-1475 · Cited by 94 · see citing works

Three Members of the Human Pyruvate Dehydrogenase Kinase Gene Family Are Direct Targets of the Peroxisome Proliferator-activated Receptor β/δ

Degenhardt, T., Saramäki, A., Malinen, M., Rieck, M., Vaïsänen, S., Huotari, A., Herzig, K., Müller, R., & Carlberg, C. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.06.091 · Cited by 92 · see citing works

The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation

Wadosky, K. M., & Willis, M. S. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00703.2011 · Cited by 90 · see citing works

Muscle Injuries in Athletes

Delos, D., Maak, T. G., & Rodeo, S. A. (2013) · Sports Health A Multidisciplinary Approach · doi:10.1177/1941738113480934 · Cited by 88 · see citing works

Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment

Liu, Y., Chewchuk, S., Lavigne, C., Brûlé, S., Pilon, G., Houde, V. P., Xu, A., Marette, A., & Sweeney, G. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00186.2009 · Cited by 86 · see citing works

Integrative and Systemic Approaches for Evaluating PPARβ/δ (PPARD) Function

Attianese, G. M. P. G., & Desvergne, B. (2015) · Nuclear Receptor Signaling · doi:10.1621/nrs.13001 · Cited by 84 · see citing works

Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance

Dubé, J. J., Coen, P. M., DiStefano, G., Chacon, A. C., Helbling, N. L., Desimone, M. E., Stafanovic-Racic, M., Hames, K. C., Despines, A. A., Toledo, F. G. S., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2014 · Cited by 83 · see citing works

Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training

Peters, S. J., Samjoo, I. A., Devries, M. C., Stevic, I., Robertshaw, H. A., & Tarnopolsky, M. A. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-059 · Cited by 81 · see citing works

Metabolomics of the interaction between PPAR‐α and age in the PPAR‐α‐null mouse

Atherton, H. J., Gulston, M. K., Bailey, N. J. C., Cheng, K., Zhang, W., Clarke, K., & Griffin, J. L. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.18 · Cited by 80 · see citing works

Muscle fiber type comparison of PDH kinase activity and isoform expression in fed and fasted rats

Peters, S. J., Harris, R. A., Heigenhauser, G. J. F., & Spriet, L. L. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.3.r661 · Cited by 78 · see citing works

Regulation of adipose tissue lipolysis revisited

Bézaire, V., & Langin, D. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990279 · Cited by 77 · see citing works

Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle

Holloway, G. P., Lally, J., Nickerson, J. G., Alkhateeb, H. H., Snook, L. A., Heigenhauser, G. J. F., Calles-Escandón, J., Glatz, J. F. C., Luiken, J. J. F. P., Spriet, L. L., et al. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135301 · Cited by 74 · see citing works

Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ

Tan, N. S., Vázquez‐Carrera, M., Montagner, A., Sng, M. K., Guillou, H., & Wahli, W. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.09.001 · Cited by 74 · see citing works

Pharmacological activation of PPARβ promotes rapid and calcineurin-dependent fiber remodeling and angiogenesis in mouse skeletal muscle

Gaudel, C., Schwartz, C., Giordano, C., Abumrad, N. A., & Grimaldi, P. A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00581.2007 · Cited by 73 · see citing works

Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome

Tan, C. K., Zhuang, Y., & Wahli, W. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1280467 · Cited by 70 · see citing works

Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific

Jocken, J. W. E., Smit, E., Goossens, G. H., Essers, Y. P. G., van Baak, M. A., Mensink, M., Saris, W. H. M., & Blaak, E. E. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0386-y · Cited by 68 · see citing works

Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21

Harris, L.-A. L. S., Skinner, J. R., Shew, T. M., Pietka, T., Abumrad, N. A., & Wolins, N. E. (2015) · Diabetes · doi:10.2337/db14-1035 · Cited by 68 · see citing works

Fenofibrate and the kidney: an overview

Kostapanos, M. S., Florentin, M., & Elisaf, M. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12068 · Cited by 66 · see citing works

Combined cDNA array/RT‐PCR analysis of gene expression profile in rat gastrocnemius muscle: relation to its adaptive function in energy metabolism during fasting

de Lange, P., Ragni, M., Silvestri, E., Moreno, M., Schiavo, L., Lombardi, A., Farina, P., Feola, A., Goglia, F., & Lanni, A. (2003) · The FASEB Journal · doi:10.1096/fj.03-0342fje · Cited by 66 · see citing works

Fatty acids regulate perilipin5 in muscle by activating PPARδ

Bindesb⊘ll, C., Berg, O., Arntsen, B. M., Nebb, H. I., & Dalen, K. T. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m038992 · Cited by 63 · see citing works

Intramyocellular lipid droplets and insulin sensitivity, the human perspective

Gemmink, A., Goodpaster, B. H., Schrauwen, P., & Hesselink, M. K. C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.07.010 · Cited by 62 · see citing works

PPARδ regulates satellite cell proliferation and skeletal muscle regeneration

Angione, A. R., Jiang, C., Pan, D., Wang, Y., & Kuang, S. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-33 · Cited by 62 · see citing works

Skeletal intramyocellular lipid metabolism and insulin resistance

Li, Y., Xu, S.-M., Zhang, X.-L., Yi, Z., & Cichello, S. (2015) · Biophysics Reports · doi:10.1007/s41048-015-0013-0 · Cited by 61 · see citing works

Regulation of skeletal muscle capillary growth in exercise and disease

Haas, T. L., & Nwadozi, E. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0336 · Cited by 61 · see citing works

Adipophilin distribution and colocalisation with lipid droplets in skeletal muscle

Shaw, C. S., Sherlock, M., Stewart, P. M., & Wagenmakers, A. J. M. (2009) · Histochemistry and Cell Biology · doi:10.1007/s00418-009-0558-4 · Cited by 59 · see citing works

The Functions of PPARs in Aging and Longevity

Erol, A. (2007) · PPAR Research · doi:10.1155/2007/39654 · Cited by 54 · see citing works

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

Meex, R. C. R., Hoy, A. J., Mason, R. R., Martin, S. D., McGee, S. L., Bruce, C. R., & Watt, M. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00598.2014 · Cited by 54 · see citing works

Skeletal muscle remodeling

Potthoff, M. J., Olson, E. N., & Bassel‐Duby, R. (2007) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3282efb761 · Cited by 53 · see citing works

Regulators of blood lipids and lipoproteins? PPARδ and AMPK, induced by exercise, are correlated with lipids and lipoproteins in overweight/obese men and women

Greene, N. P., Fluckey, J. D., Lambert, B. S., Greene, E. S., Riechman, S. E., & Crouse, S. F. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00309.2012 · Cited by 49 · see citing works

Effect of heterozygous PPARγ deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding

Miles, P. D. G., Barak, Y., Evans, R. M., & Olefsky, J. M. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00312.2002 · Cited by 49 · see citing works

Effects of Bezafibrate Treatment in a Patient and a Carrier With Mutations in the PNPLA2 Gene, Causing Neutral Lipid Storage Disease With Myopathy

van de Weijer, T., Havekes, B., Bilet, L., Joris Hoeks, J., Sparks, L. M., Bosma, M., Paglialunga, S., Jörgensen, J. A., Janssen, M. C. H., Schaart, G., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.300944 · Cited by 45 · see citing works

PPARa‐ATGL pathway improves muscle mitochondrial metabolism: implication in aging

Biswas, D., Ghosh, M., Kumar, S., & Chakrabarti, P. (2016) · The FASEB Journal · doi:10.1096/fj.201600571rr · Cited by 45 · see citing works

Sports genetics: the PPARA gene and athletes' high ability in endurance sports. A systematic review and meta-analysis.

López‐León, S., Tuvblad, C., & Forero, D. A. (2016) · Europe PMC (PubMed Central) · doi:10.5604/20831862.1180170 · Cited by 44 · see citing works

Peroxisome proliferator-activated receptor-δ activates endothelial progenitor cells to induce angio-myogenesis through matrix metallo-proteinase-9-mediated insulin-like growth factor-1 paracrine networks

Han, J., Kim, H., Jeon, K., Choi, Y.-E., Lee, H., Kwon, Y., Jang, J., Cho, H.-J., Kang, H., Oh, B., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr365 · Cited by 43 · see citing works

Contraction‐induced lipolysis is not impaired by inhibition of hormone‐sensitive lipase in skeletal muscle

Alsted, T. J., Ploug, T., Prats, C., Serup, A. K., Høeg, L. D., Schjerling, P., Holm, C., Zimmermann, R., Fledelius, C., Galbo, H., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.260794 · Cited by 43 · see citing works

Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-induced diabetic mice

Franko, A., Huypens, P., Neschen, S., Irmler, M., Rozman, J., Rathkolb, B., Neff, F., Prehn, C., Dubois, G., Baumann, M., et al. (2016) · Diabetes · doi:10.2337/db15-1670 · Cited by 42 · see citing works

PPARγ and stress: Implications for aging

Ulrich‐Lai, Y. M., & Ryan, K. K. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.08.011 · Cited by 41 · see citing works

Block of Nuclear Receptor Ubiquitination

Genini, D., & Catapano, C. V. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609149200 · Cited by 38 · see citing works

Inborn errors of cytoplasmic triglyceride metabolism

Wu, J. W., Yang, H., Wang, S. P., Soni, K. G., Brunel‐Guitton, C., & Mitchell, G. A. (2014) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-014-9767-7 · Cited by 37 · see citing works

From pre-diabetes to diabetes: diagnosis, treatments and translational research

Khan, R., Chua, Z., Tan, J., Yang, Y., Liao, Z., & Zhao, Y. (2019) · Medicina · doi:10.3390/medicina55090546 · Cited by 484 · see citing works

PPAR-α Modulators as Current and Potential Cancer Treatments

Chi, T., Wang, M., Wang, X., Ke, Y., Xie, F., Zehuan, L., & Wei, P. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.599995 · Cited by 244 · see citing works

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Jiménez-Gutiérrez, G. E., Martínez-Gómez, L. E., Martínez-Armenta, C., Pineda, C., Martínez‐Nava, G. A., & López-Reyes, A. G. (2022) · Cells · doi:10.3390/cells11152359 · Cited by 243 · see citing works

Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments

Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works

Diabetes and cancer: Epidemiological and biological links

Wang, M., Yang, Y., & Liao, Z. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i6.227 · Cited by 158 · see citing works

<p>Mechanism of Traditional Chinese Medicine in Treating Knee Osteoarthritis</p>

Wang, M., Liu, L., Zhang, C. S., Liao, Z., Jing, X., Fishers, M., Zhao, L., Xu, X., & Li, B. (2020) · Journal of Pain Research · doi:10.2147/jpr.s247827 · Cited by 104 · see citing works

PPARs and Microbiota in Skeletal Muscle Health and Wasting

Manickam, R., Duszka, K., & Wahli, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218056 · Cited by 98 · see citing works

Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles

Camps, J., Breuls, N., Sifrim, A., Giarratana, N., Corvelyn, M., Danti, L., Grosemans, H., Vanuytven, S., Thiry, I., Belicchi, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107597 · Cited by 87 · see citing works

Cellular Senescence: Mechanisms and Therapeutic Potential

Liao, Z., Yeo, H. L., Wong, S. W., & Zhao, Y. X. (2021) · Biomedicines · doi:10.3390/biomedicines9121769 · Cited by 86 · see citing works

Tissue-Engineered Skeletal Muscle Models to Study Muscle Function, Plasticity, and Disease

Khodabukus, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.619710 · Cited by 82 · see citing works

PPAR-γ Partial Agonists in Disease-Fate Decision with Special Reference to Cancer

Ballav, S., Biswas, B., Sahu, V. K., Ranjan, A., & Basu, S. (2022) · Cells · doi:10.3390/cells11203215 · Cited by 63 · see citing works

Concentrated ambient PM_2.5exposure affects mice sperm quality and testosterone biosynthesis

Yang, Y., Yang, T., Liu, S., Cao, Z., Zhao, Y., Su, X., Liao, Z., Teng, X., & Hua, J. (2019) · PeerJ · doi:10.7717/peerj.8109 · Cited by 58 · see citing works

Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function

Alatshan, A., & Benkő, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.630569 · Cited by 57 · see citing works

Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management

Chi, T., Lin, J., Wang, M., Zhao, Y., Liao, Z., & Wei, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.630032 · Cited by 57 · see citing works

The Impact of Vegan and Vegetarian Diets on Physical Performance and Molecular Signaling in Skeletal Muscle

Pohl, A., Schünemann, F., Bersiner, K., & Gehlert, S. (2021) · Nutrients · doi:10.3390/nu13113884 · Cited by 55 · see citing works

The role of peroxisome proliferator-activated receptors in the tumor microenvironment, tumor cell metabolism, and anticancer therapy

Sun, J., Yu, L., Qu, X., & Huang, T. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1184794 · Cited by 52 · see citing works

Increased Expression of Lipid Metabolism Genes in Early Stages of Wooden Breast Links Myopathy of Broilers to Metabolic Syndrome in Humans

Lake, J. A., Papah, M. B., & Abasht, B. (2019) · Genes · doi:10.3390/genes10100746 · Cited by 50 · see citing works

Disrupted expression of genes essential for skeletal muscle fibre integrity and energy metabolism in Vitamin D deficient rats

Gogulothu, R., Nagar, D. N., Gopalakrishnan, S., Garlapati, V. R., Kallamadi, P. R., & Ismail, A. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105525 · Cited by 47 · see citing works

Skeletal Muscle Metabolic Alternation Develops Sarcopenia

Yang, Q., & Chan, P. (2022) · Aging and Disease · doi:10.14336/ad.2021.1107 · Cited by 47 · see citing works

The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis

Crossland, H., Constantin‐Teodosiu, D., & Greenhaff, P. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189775 · Cited by 45 · see citing works

Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism

Tavasoli, M., Lahire, S., Sokolenko, S., Novorolsky, R. J., Reid, S. A., Lefsay, A., Otley, M. O. C., Uaesoontrachoon, K., Rowsell, J., Srinivassane, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29270-z · Cited by 31 · see citing works

Molecular Mechanisms and Current Treatment Options for Cancer Cachexia

Ahmad, S. S., Ahmad, K., Shaikh, S., You, H. J., Lee, E., Ali, S. M., Lee, E. J., & Choi, I. (2022) · Cancers · doi:10.3390/cancers14092107 · Cited by 31 · see citing works

γ‐Oryzanol Improves Exercise Endurance and Muscle Strength by Upregulating PPARδ and ERRγ Activity in Aged Mice

Ahn, J., Son, H. J., Seo, H., Ha, T. Y., Ahn, J., Lee, H., Shin, S. H., Jung, C. H., & Jang, Y. J. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000652 · Cited by 28 · see citing works

Multimodal high-resolution nano-DESI MSI and immunofluorescence imaging reveal molecular signatures of skeletal muscle fiber types

Unsihuay, D., Hu, H., Qiu, J., Latorre-Palomino, A., Yang, M., Yue, F., Yin, R., Kuang, S., & Laskin, J. (2023) · Chemical Science · doi:10.1039/d2sc06020e · Cited by 26 · see citing works

Targeting Peroxisome Proliferator-Activated Receptor Delta (PPARδ): A Medicinal Chemistry Perspective

Kadayat, T. M., Shrestha, A., Jeon, Y. H., An, H., Kim, J., Cho, S. J., & Chin, J. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01882 · Cited by 26 · see citing works

Oxidative Stress, Inflammation, and Activators of Mitochondrial Biogenesis: Tempol Targets in the Diaphragm Muscle of Exercise Trained-mdx Mice

da Silva, H. N. M., Covatti, C., da Rocha, G. L., Mizobuti, D. S., Mâncio, R. D., Hermes, T. D. A., Kido, L. A., Cagnon, V. H. A., Pereira, E. C. L., & Minatel, E. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.649793 · Cited by 24 · see citing works

Dietary glycemic index, glycemic load, insulin index, insulin load and risk of diabetes-related cancers: A systematic review of cohort studies

Marbini, M. H., Amiri, F., & Hezaveh, Z. S. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.02.008 · Cited by 22 · see citing works

Nutraceuticals and the Network of Obesity Modulators

Ammendola, S., & d’Abusco, A. S. (2022) · Nutrients · doi:10.3390/nu14235099 · Cited by 21 · see citing works

COVID-19 associated liver injury: An updated review on the mechanisms and management of risk groups

Shi, Y., Wang, M., Wu, L., Li, X., & Liao, Z. (2023) · Liver Research · doi:10.1016/j.livres.2023.07.001 · Cited by 20 · see citing works

Nutrigenomic effect of conjugated linoleic acid on growth and meat quality indices of growing rabbit

Abdelatty, A. M., Mohamed, S. A., Moustafa, M. M. A., Al‐Mokaddem, A. K., Baker, M. R., Elolimy, A. A., El-Medany, S. A., Hussein, S., Ahmed-Farid, O. A.-H., Sakr, O. G., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222404 · Cited by 18 · see citing works

Vachellia farnesiana Pods or a Polyphenolic Extract Derived from Them Exert Immunomodulatory, Metabolic, Renoprotective, and Prebiotic Effects in Mice Fed a High-Fat Diet

Delgadillo-Puga, C., Sánchez-Castillo, D. R., Cariño-Cervantes, Y. Y., Torre-Villalvazo, I., Tovar‐Palacio, C., Vásquez‐Reyes, S., Furuzawa‐Carballeda, J., Acevedo-Carabantes, J. A., Camacho‐Corona, M. D. R., Guzmán‐Mar, J. L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097984 · Cited by 15 · see citing works

Effects of copper hydroxychloride on growth performance and abundance of genes involved in lipid metabolism of growing pigs

Espinosa, C. D., Fry, R. S., Kocher, M. E., & Stein, H. H. (2020) · Journal of Animal Science · doi:10.1093/jas/skz369 · Cited by 15 · see citing works

PPARβ/δ Agonism Upregulates Forkhead Box A2 to Reduce Inflammation in C2C12 Myoblasts and in Skeletal Muscle

Phua, W. W. T., Tan, W., Yip, Y. S., Hew, I. D., Wee, J. W. K., Cheng, H. S., Leow, M. K., Wahli, W., & Tan, N. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051747 · Cited by 15 · see citing works

Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki)

Lai, N., Fealy, C. E., Kummitha, C., Cabras, S., Kirwan, J. P., & Hoppel, C. L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00677 · Cited by 15 · see citing works

The Molecular Mechanisms of Fuel Utilization during Exercise

Pi, A., Villivalam, S. D., & Kang, S. (2023) · Biology · doi:10.3390/biology12111450 · Cited by 14 · see citing works

Effect of Supplementation with Omega-3 Polyunsaturated Fatty Acids on Metabolic Modulators in Skeletal Muscle of Rats with an Obesogenic High-Fat Diet

Ortega, M. P. C., Almanza-Pérez, J. C., Sánchez‐Muñoz, F., Hong, E., Velázquez-Reyes, E., Romero‐Nava, R., Villafaña, S., Pérez-Ontiveros, A., Blancas‐Flores, G., & Huang, F. (2024) · Pharmaceuticals · doi:10.3390/ph17020222 · Cited by 10 · see citing works

MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice

Wang, T., Xiao, Y., Hu, Z., Gu, J., Hua, R., Hai, Z., Chen, X., Zhang, J. V., Yu, Z., Wu, T., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.862506 · Cited by 10 · see citing works

Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle

Valentine, W. J., Mostafa, S. F., Tokuoka, S. M., Hamano, F., Inagaki, N. F., Nordin, J. Z., Motohashi, N., Kita, Y., Aoki, Y., Shimizu, T., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.698166 · Cited by 9 · see citing works

Pterostilbene Inhibits Dyslipidemia-Induced Activation of Progenitor Adipose Gene Under High-Fat Diet and Radiation Stressor

Moustafa, E. M., Rashed, E. R., & Rashed, R. R. (2021) · Natural Product Communications · doi:10.1177/1934578x211001267 · Cited by 8 · see citing works

Effects of Long-Term Serum Starvation on Autophagy, Metabolism, and Differentiation of Porcine Skeletal Muscle Satellite Cells

Wang, Y., Gao, J., Fan, B., Hu, Y., Yang, Y., Wu, Y., Zhu, J., Li, J., Li, F., & Ju, H. (2024) · Veterinary Sciences · doi:10.3390/vetsci12010011 · Cited by 7 · see citing works

Skeletal Muscle Metabolomic Responses to Endurance and Resistance Training in Rats under Chronic Unpredictable Mild Stress

Liu, X., Xue, X., Tian, J., Qin, X., Zhou, S., Chen, A., & Han, Y. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041645 · Cited by 7 · see citing works

Cross-talk between TRPC-1, mTOR, PGC-1α and PPARδ in the dystrophic muscle cells treated with tempol

da Rocha, G. L., Rupcic, I. F., Mizobuti, D. S., Hermes, T. D. A., Covatti, C., da Silva, H. N. M., Araújo, H. N., de Lourenço, C. C., Silveira, L. R., Pereira, E. C. L., et al. (2022) · Free Radical Research · doi:10.1080/10715762.2022.2074842 · Cited by 7 · see citing works

Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens

Li, Z., Azad, M. A. K., Meng, C., Kong, X., Gui, J., Lin, W., Cui, Y., Lan, W., & He, Q. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01150-8 · Cited by 6 · see citing works

Identification and analysis of the molecular targets of statins in colorectal cancer

Firouzjaei, A. A., Mahmoudi, A. A., Almahmeed, W. A., Teng, Y., Kesharwani, P., & Sahebkar, A. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155258 · Cited by 5 · see citing works

Impact of the Gut Microbiota–Metabolite Axis on Intestinal Fatty Acid Absorption in Huainan Pigs

Wang, J., Zhu, L., Wang, Y., Ma, Q., Yan, X., Li, M., & Xing, B. (2025) · Microorganisms · doi:10.3390/microorganisms13071609 · Cited by 5 · see citing works

A systematic review and meta-analysis of the comparative curative effects of warm acupuncture and other traditional Chinese medicines in the treatment of knee osteoarthritis

Jin, S., & Guan, X. (2022) · Annals of Palliative Medicine · doi:10.21037/apm-21-3972 · Cited by 5 · see citing works

Integrated multi‐omics approach reveals the role of striated muscle preferentially expressed protein kinase in skeletal muscle including its relationship with myospryn complex

Li, Q., Lin, J., Luo, S., Schmitz‐Abe, K., Agrawal, R., Meng, M., Moghadaszadeh, B., Beggs, A. H., Liu, X., Perrella, M. A., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13470 · Cited by 4 · see citing works

Myogenic Classical Endocannabinoids, Their Targets and Activity

Balezina, O. P., Tarasova, E. O., & Bogacheva, P. O. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924100080 · Cited by 4 · see citing works

Identification of differentially expressed genes in early-postmortem Semimembranosus muscle of Italian Large White heavy pigs divergent for glycolytic potential

Davoli, R., Vegni, J., Cesarani, A., Dimauro, C., Zappaterra, M., & Zambonelli, P. (2022) · Meat Science · doi:10.1016/j.meatsci.2022.108754 · Cited by 4 · see citing works

Maternal Nutrient Excess Induces Stress Signaling and Decreases Mitochondrial Number in Term Fetal Baboon Skeletal Muscle

Yan, X., Tocantins, C., Zhu, M. J., Pereira, S. P., & Du, ‬. (2025) · Biology · doi:10.3390/biology14070868 · Cited by 3 · see citing works

Antidiabetic and Hypolipidemic Properties of Newly Isolated Wild Lacticaseibacillus paracasei Strains in Mature Adipocytes

Григорова, Н., Ivanova, Z., Vachkova, Е., Petrova, V., & Beev, G. (2023) · Applied Sciences · doi:10.3390/app13116489 · Cited by 3 · see citing works

Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle

Schneider‐Heieck, K., Pérez‐Schindler, J., Blatter, J., de Smalen, L. M., Duchemin, W., Steurer, S. A., Karrer‐Cardel, B., Ritz, D., & Handschin, C. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102154 · Cited by 3 · see citing works

Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A

Dioh, W., Narkar, V. A., Singh, A., Malik, F. I., Ferrucci, L., Tourette, C., Mariani, J., van Maanen, R., & Fielding, R. A. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad072 · Cited by 3 · see citing works

Tissue-Specific Variations in Transcription Factors Elucidate Complex Immune System Regulation

Lu, H., Tang, Y.-C., & Gottlieb, A. (2022) · Genes · doi:10.3390/genes13050929 · Cited by 2 · see citing works

Frontier advances on biomechanical therapies

Chakraborty, K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90597-8.00013-x · Cited by 2 · see citing works

Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway

Luo, P., Yang, J., Jian, L.-P., Dong, J., Yin, S., Luo, C., & Zhou, S. F. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5643 · Cited by 2 · see citing works

DeepGCGR: an interpretable two-layer deep learning model for the discovery of GCGR-activating compounds

Tang, X., Chen, H., Zhang, G., Li, H., Zhao, D., Bi, Z., Wang, P., Zhou, J., Chen, S., Cong, Z., et al. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(25)60969-1 · Cited by 1 · see citing works

Peroxisome proliferator-activated receptor γ coordinates the “growth-defense trade-off” in intensive aquaculture of grass carp (Ctenopharyngodon idella)

Huang, W., Zang, S., Liu, H., Ren, X., Zhang, R., Yang, Y., Wang, W., Tan, S., Li, T., Shi, K., et al. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.743853 · Cited by 1 · see citing works

Piceatannol Enhances Intracellular Energy Metabolism via SIRT1 in C2C12 Cells

Tsuda, H., Uchida, T., Okuno, S., Ulla, A., Kawakami, S., Mori, S., Maruki‐Uchida, H., & Nikawa, T. (2025) · Advances in Biological Chemistry · doi:10.4236/abc.2025.153005 · Cited by 1 · see citing works

Mechanistic Rationale of Seladelpar’s Clinical Efficacy through the Selective PPAR-δ Activation in Primary Biliary Cholangitis

Gerussi, A., & Fornai, M. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108144 · Cited by 1 · see citing works

Different weight loss strategies and their impact on fat and muscle tissue

Voznesenskaya, А. А., Rozhevskaya, E. E., & Shestakova, M. (2026) · Diabetes Mellitus · doi:10.14341/dm13372 · Cited by 1 · see citing works

Roles of PPARα and PPARγ As Regulator of Free Fatty Acids in Nonalcoholic SteatohepatitisPreprint

Vu, H. T., Nguyen, V. D., & Matsubara, T. (2023) · Preprints.org · doi:10.20944/preprints202304.0356.v1 · Cited by 1 · see citing works

Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?

El-Bassouny, D. R., Mansour, A. A., Ellakkany, A. S., Ayuob, N. N., & AbdElfattah, A. A. (2023) · Histochemistry and Cell Biology · doi:10.1007/s00418-023-02205-5

The role of forkhead box A2 in skeletal muscle

Phua, W. W. T. (2019) · doi:10.32657/10220/49672

Insulin receptor turnover in fasting is dependent on β-dystroglycan deglycosylationPreprint

Joseph, S., Zbidat, S., Volodin, A., Kasiviswanathan, D., Fried, A. I., Armani, A., Gilda, J. E., & Cohen, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.24.497215

Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis

Liao, Z. (2023) · doi:10.32657/10356/173585

Telmisartan modulates exercise responses in peripheral artery disease: Analyses of skeletal muscle from the TELEX Trial

Kosmac, K., Joshi, J. K., McDermott, M. M., Stewart, J. C., Zhang, D., Xu, S., Ho, K. J., Sufit, R. L., Ferrucci, L., Peterson, C. A., et al. (2025) · JVS Vascular Science · doi:10.1016/j.jvssci.2025.100294

Peroxisome proliferator-activated receptors as novel targets of small cell lung cancer circulating tumor cells

Hamilton, G., Eggerstorfer, M.-T., Weigl, L. G., Hochmair, M. J., & Stickler, S. (2025) · Neoplasma · doi:10.4149/neo_2025_250917n396

Efecto de los ácidos eicosapentaenoico y docosahexaenoico sobre los modulares metabólicos en el hígado, músculo y tejido adiposo de ratas con una dieta obesogénica

Ortega, M. P. C. (2025) · doi:10.24275/uami.r494vk95w

An Overview of Diabetes and Cancer Risks: Types and Mechanisms

Muruganantham, J. K., & Veerabathiran, R. (2026) · Springer eBooks · doi:10.1007/978-981-95-5651-9_1

Effet thérapeutique des MSC dans l'infarctus du myocarde : potentialisation par le pré-conditionnement par une voie de récepteur nucléaire

Sarre, C. (2020) · theses.fr (ABES) · doi:10.70675/72e3db20zb9a3z4395zad56z3dbf2bed0f53

Pioglitazone increases adiponectin and attenuates the appearance of diet-induced insulin resistance in high-fat-fed beagles

Kraft, G., Tovar, A. P., Yankey, K. C., Scott, M., Graves, J., Farmer, B., Peloquin, M., & Cherrington, A. D. (2026) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00515.2025

Peroxisome Proliferator–Activated Receptor Delta Regulates Myogenic Differentiation via Lipid Droplet–Associated Metabolic Remodeling and p38 MAPK Signaling

SP, M. T. M., Habib, M. R., Tokutake, Y., & Yonekura, S. (2026) · Animal Science Journal · doi:10.1111/asj.70221

BindingDB Entry 50010994: Targeting Peroxisome Proliferator-Activated Receptor Delta (PPARδ): A Medicinal Chemistry Perspective.

BindingDB (2021) · UC San Diego · doi:10.7270/q2hh6pnh

Roles of Peroxisome Proliferator-Activated Receptor β/δ in skeletal muscle physiology

Manickam, R., & Wahli, W. (2016) · Biochimie · doi:10.1016/j.biochi.2016.11.010 · Cited by 98 · see citing works

Peroxisome proliferator-activated receptor β/δ: a master regulator of metabolic pathways in skeletal muscle

Lahiri, S., & Wahli, W. (2017) · reroDoc Digital Library

The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis

Crossland, H., Constantin‐Teodosiu, D., & Greenhaff, P. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189775 · Cited by 45 · see citing works

Running head: Effects of PPAR on Skeletal Muscle Metabolism

Jucker, B. M., Yang, D., Olzinski, A. R., Williams, C., Lenhard, S. C., Legos, J. J., Hawk, C. T., Sarkar, S. K., & Stephen, J. (2016)

Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis

Lamichane, S., Lamichane, B. D., & Kwon, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040949 · Cited by 157 · see citing works