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Cited by 300

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Osteochondral tissue engineering: scaffolds, stem cells and applications

Open access
Nooeaid, Patcharakamon, Salih, Vehid, Beier, Justus P., Boccaccini, Aldo R.·2012·Journal of Cellular and Molecular Medicine

Abstract

Osteochondral tissue engineering has shown an increasing development to provide suitable strategies for the regeneration of damaged cartilage and underlying subchondral bone tissue. For reasons of the limitation in the capacity of articular cartilage to self‐repair, it is essential to develop approaches based on suitable scaffolds made of appropriate engineered biomaterials. The combination of biodegradable polymers and bioactive ceramics in a variety of composite structures is promising in this area, whereby the fabrication methods, associated cells and signalling factors determine the success of the strategies. The objective of this review is to present and discuss approaches being proposed in osteochondral tissue engineering, which are focused on the application of various materials forming bilayered composite scaffolds, including polymers and ceramics, discussing the variety of scaffold designs and fabrication methods being developed. Additionally, cell sources and biological protein incorporation methods are discussed, addressing their interaction with scaffolds and highlighting the potential for creating a new generation of bilayered composite scaffolds that can mimic the native interfacial tissue properties, and are able to adapt to the biological environment.

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Crossref · 10.1111/j.1582-4934.2012.01571.x

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Metadata

Authors
Nooeaid, P., Salih, V., Beier, J. P., & Boccaccini, A. R.
Venue
Journal of Cellular and Molecular Medicine
Publisher
Wiley
Published
2012-09-26
Volume
16
Issue
10
Pages
2247-2270
ISSN
  • 1582-1838 (ISSN-L)
  • 1582-4934
OpenAlex
W2042065329
Cited by
300
References
1
FWCI
12.38
Type
journal article
Language
en
Open access
gold

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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