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Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats
Abstract
Rats with different levels of blood glucose concentration were exposed to 10 min of complete brain ischemia achieved by compression of neck vessels by a pneumatic cuff. All normoglycemic rats survived the ischemic period and made the best clinical recovery. Hyperglycemic rats died within 12 h. Seizure activity was observed in all animals in this group. Three of eight hypoglycemic rats died between 3 and 16 days. The clinical recovery was less complete than in the control group. Thus, recovery from cerebral ischemia depends upon preischemic blood glucose concentration. Hyper- and hypoglycemia hamper the clinical recovery after transient cerebral ischemia.
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Cited by
Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681
The New Neurometabolic Cascade of Concussion
Giza, C. C., & Hovda, D. A. (2014) · Neurosurgery · doi:10.1227/neu.0000000000000505 · Cited by 1,353
Rodent models of cerebral ischemia.
Ginsberg, M. D., & Busto, R. (1989) · Stroke · doi:10.1161/01.str.20.12.1627 · Cited by 659
Animal models of focal and global cerebral ischemia
Traystman, R. J. (2003) · ILAR Journal · doi:10.1093/ilar.44.2.85 · Cited by 413
Regional cerebral blood flow decreases during chronic and acute hyperglycemia.
Duckrow, R. B., Beard, D. C., & Brennan, R. W. (1987) · Stroke · doi:10.1161/01.str.18.1.52 · Cited by 158
Metadata
- Authors
- Siemkowicz, E., & Hansen, A. J.
- Venue
- Acta Neurologica Scandinavica
- Publisher
- Hindawi Limited
- Published
- 2009-01-29
- Volume
- 58
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0001-6314 (ISSN-L)
- 1600-0404
- OpenAlex
- W2113478259
- Cited by
- 381
- References
- 0
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Siemkowicz, E., & Hansen, A. J. (2009). Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats. Acta Neurologica Scandinavica. https://doi.org/10.1111/j.1600-0404.1978.tb02855.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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