Animal models of focal and global cerebral ischemia

Traystman, R. J.

doi:10.1093/ilar.44.2.85

Cited by 413Acute Ischemic Stroke ManagementNeurological Disease Mechanisms and TreatmentsTraumatic Brain Injury and Neurovascular Disturbances

Animal models of focal and global cerebral ischemia

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Traystman, R. J.·2003·ILAR Journal

DOI 10.1093/ilar.44.2.85

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Abstract

The use of appropriate animal models is essential to predict the value and effect of therapeutic approaches in human subjects. Focal (stroke) and global (cardiac arrest) cerebral ischemia represents diseases that are common in the human population. Stroke and cardiac arrest, which are major causes of death and disability, affect millions of individuals around the world and are responsible for the leading health care costs of all diseases. Understanding the mechanisms of injury and neuroprotection in these diseases is critical if we are ever to learn new target sites to treat ischemia. There are many animal models available to investigate injury mechanisms and neuroprotective strategies. This review summarizes many (but not all) small and large animal models of focal and global cerebral ischemia and discusses their advantages and disadvantages.

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Most previous work in rodent global ischemia concerns the selective delayed death of hippocampal CA1 neurons triggered by ischemia in excess of 10 min.
“Most previous work in rodent global ischemia concerns the selective delayed death of hippocampal CA1 neurons triggered ischemia in excess of 10 min (Traystman, 2003;Yonekura et al., 2004).”
From Two-Photon Imaging of Stroke Onset<i>In Vivo</i>Reveals That NMDA-Receptor Independent Ischemic Depolarization Is the Major Cause of Rapid Reversible Damage to Dendrites and Spines (2008) · cites this paper as Traystman, 2003
The Global Cerebral Ischemia Models section identifies hippocampal CA1 neurons as vulnerable to injury in rodent global-ischemia models. It does not establish that most previous work focused on delayed CA1 death, and its reported durations do not support the claimed threshold: it describes CA1 injury after 5 minutes of ischemia in gerbils and hippocampal damage after 2 minutes in another model. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Guide for the Care and Use of Laboratory Animals: Eighth Edition
(2011) · doi:10.17226/12910 · Cited by 16,199 · see citing works
Reversible middle cerebral artery occlusion without craniectomy in rats.
Longa, E. Z., Weinstein, P. R., Carlson, S., & Cummins, R. (1989) · Stroke · doi:10.1161/01.str.20.1.84 · Cited by 7,463 · see citing works
Pathobiology of ischaemic stroke: an integrated view
Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943 · see citing works
Delayed neuronal death in the gerbil hippocampus following ischemia
Kirino, T. (1982) · Brain Research · doi:10.1016/0006-8993(82)90833-2 · Cited by 2,856 · see citing works
Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.
Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681 · see citing works
Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain
Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., & Schulz, D. W. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51740-3 · Cited by 2,222 · see citing works
A new model of bilateral hemispheric ischemia in the unanesthetized rat.
Pulsinelli, W. A., & Brierley, J. B. (1979) · Stroke · doi:10.1161/01.str.10.3.267 · Cited by 1,947 · see citing works
Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury
Busto, R., Dietrich, W. D., Globus, M. Y. ‐., Valdés, I., Scheinberg, P., & Ginsberg, M. D. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.127 · Cited by 1,786 · see citing works
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase
Huang, Z., Huang, P. L., Panahian, N., Dalkara, T., Fishman, M. C., & Moskowitz, M. A. (1994) · Science · doi:10.1126/science.7522345 · Cited by 1,562 · see citing works
Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion
Tamura, A., Graham, D., McCulloch, J., & Teasdale, G. M. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.6 · Cited by 1,432 · see citing works
Recommendations for standards regarding preclinical neuroprotective and restorative drug development.
Roundtable, S. T. A. I. (1999) · Stroke · doi:10.1161/01.str.30.12.2752 · Cited by 1,258 · see citing works
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A. A., Wang, Z., Dawson, T. M., Snyder, S. H., et al. (1997) · Nature Medicine · doi:10.1038/nm1097-1089 · Cited by 1,019 · see citing works
Self-citation
Experimental studies of ischemic brain edema
Koizumi, J.-I., Yoshida, Y., Nakazawa, T., & Ooneda, G. (1986) · Nosotchu · doi:10.3995/jstroke.8.1 · Cited by 996 · see citing works
The density and distribution of ischemic brain injury in the rat following 2?10 min of forebrain ischemia
Smith, M., Auer, R. N., & Siesj�, B. K. (1984) · Acta Neuropathologica · doi:10.1007/bf00690397 · Cited by 955 · see citing works
Middle Cerebral Artery Occlusion in the Rat by Intraluminal Suture
Belayev, L., Alonso, O. F., Busto, R., Zhao, W., & Ginsberg, M. D. (1996) · Stroke · doi:10.1161/01.str.27.9.1616 · Cited by 815 · see citing works
Experimental studies of ischemic brain edema : a new experimental study of ischemic brain edema : 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area
Koizumi, J. (1986) · Medical Entomology and Zoology · Cited by 762 · see citing works
Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model
Smith, M., Bendek, G., Dahlgren, N., et al. (1984) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1984.tb07822.x · Cited by 740 · see citing works
Rodent models of cerebral ischemia.
Ginsberg, M. D., & Busto, R. (1989) · Stroke · doi:10.1161/01.str.20.12.1627 · Cited by 665 · see citing works
OPTIMAL FREEZING CONDITIONS FOR CEREBRAL METABOLITES IN RATS
Pontén, U., Ratcheson, R. A., Salford, L. G., & Siesjö, B. K. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07567.x · Cited by 627 · see citing works
Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase
Endres, M., Wang, Z., Namura, S., Waeber, C., & Moskowitz, M. A. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199711000-00002 · Cited by 622 · see citing works
A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction.
Chen, S. T., Hsu, C. Y., HOGAN, E. L., Maricq, H. R., & Balentine, J. D. (1986) · Stroke · doi:10.1161/01.str.17.4.738 · Cited by 594 · see citing works
Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.
Yang, G., Chan, P. H., Chen, J., Carlson, E. J., Chen, S. F., Weinstein, P. R., Epstein, C. J., & Kamii, H. (1994) · Stroke · doi:10.1161/01.str.25.1.165 · Cited by 567 · see citing works
Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia
Pulsinelli, W. A., Levy, D. E., & Duffy, T. E. (1982) · Annals of Neurology · doi:10.1002/ana.410110510 · Cited by 536 · see citing works
Focal Brain Ischemia in the Rat: Methods for Reproducible Neocortical Infarction Using Tandem Occlusion of the Distal Middle Cerebral and Ipsilateral Common Carotid Arteries
Brint, S., Jacewicz, M., Kiessling, M., Tanabe, J., & Pulsinelli, W. A. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.88 · Cited by 489 · see citing works
Intraischemic but Not Postischemic Brain Hypothermia Protects Chronically following Global Forebrain Ischemia in Rats
Dietrich, W. D., Busto, R., Alonso, O. F., et al. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.71 · Cited by 478 · see citing works
Reversibility of Ischemic Brain Damage
Hossmann, K., & Kleihues, P. (1973) · Archives of Neurology · doi:10.1001/archneur.1973.00490300037004 · Cited by 465 · see citing works
Mechanisms by which epinephrine augments cerebral and myocardial perfusion during cardiopulmonary resuscitation in dogs.
Michael, J. R., Guerci, A. D., Koehler, R. C., Shi, A. Y., Tsitlik, J. E., CHANDRA, N. C., Niedermeyer, E., Rogers, M. C., Traystman, R. J., & Weisfeldt, M. L. (1984) · Circulation · doi:10.1161/01.cir.69.4.822 · Cited by 449 · see citing works
Self-citation
Nervous System Effects of Cardiac Arrest in Monkeys
Myers, R. E. (1977) · Archives of Neurology · doi:10.1001/archneur.1977.00500140019003 · Cited by 408 · see citing works
Reduced susceptibility to ischemic brain injury and N -methyl- d -aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice
Iadecola, C., Niwa, K., Nogawa, S., Zhao, X., Nagayama, M., Araki, E., Morham, S. G., & Ross, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1294 · Cited by 408 · see citing works
The Quantification of Cerebral Infarction following Focal Ischemia in the Rat: Influence of Strain, Arterial Pressure, Blood Glucose Concentration, and Age
Duverger, D., & MacKenzie, E. T. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.86 · Cited by 397 · see citing works
Cerebrovascular Disease: Pathophysiology, Diagnosis and Management
Ginsberg, M. D., & Bogousslavsky, J. (1998) · Medical Entomology and Zoology · Cited by 392 · see citing works
Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats
Siemkowicz, E., & Hansen, A. J. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1978.tb02855.x · Cited by 380 · see citing works
Cerebral Blood Flow
McHenry, L. C. (1966) · New England Journal of Medicine · doi:10.1056/nejm196601132740206 · Cited by 372 · see citing works
Effects of ischemia and other procedures on the brain and retina of the gerbil (Meriones unguiculatus)
Levine, S., & PAYAN, H. M. (1966) · Experimental Neurology · doi:10.1016/0014-4886(66)90062-8 · Cited by 314 · see citing works
Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat
Memezawa, H., Minamisawa, H., Smith, M., et al. (1992) · Experimental Brain Research · doi:10.1007/bf00229002 · Cited by 313 · see citing works
Regional Energy Balance in Rat Brain After Transient Forebrain Ischemia
Pulsinelli, W. A., & Duffy, T. E. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb13599.x · Cited by 312 · see citing works
Comparative Effect of Transient Global Ischemia on Extracellular Levels of Glutamate, Glycine, and γ‐Aminobutyric Acid in Vulnerable and Nonvulnerable Brain Regions in the Rat
Globus, M. Y. ‐., Busto, R., Martinez, E., Valdés, I., Dietrich, W. D., & Ginsberg, M. D. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb03775.x · Cited by 299 · see citing works
Focal Cerebral Ischaemia in the Rat: 2. Regional Cerebral Blood Flow Determined by [ 14 C]Iodoantipyrine Autoradiography following Middle Cerebral Artery Occlusion
Tamura, A., Graham, D., McCulloch, J., & Teasdale, G. M. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.7 · Cited by 298 · see citing works
Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area
Koizumi, J. (1986) · Medical Entomology and Zoology · Cited by 292 · see citing works
The natural course of experimental cerebral infarction in the gerbil
Kahn, K. A. (1972) · Neurology · doi:10.1212/wnl.22.5.510 · Cited by 282 · see citing works
The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation.
Pulsinelli, W. A., & Buchan, A. M. (1988) · Stroke · doi:10.1161/01.str.19.7.913 · Cited by 261 · see citing works
Effect of experimental cerebral infarction in rat brain on catecholamines and behaviour
Robinson, R. G., Shoemaker, W. J., Schlumpf, M., VALK, T., & Bloom, F. E. (1975) · Nature · doi:10.1038/255332a0 · Cited by 253 · see citing works
Amelioration of Brain Damage After 12 Minutes' Cardiac Arrest in Dogs
Safar, P., Stezoski., W. S., & Nemoto, E. M. (1976) · Archives of Neurology · doi:10.1001/archneur.1976.00500020019004 · Cited by 244 · see citing works
The Effect of Bilateral Carotid Artery Ligation upon the Blood Flow and the Energy State of the Rat Brain
Eklöf, B., & Siesjö, B. K. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05322.x · Cited by 229 · see citing works
The Distribution and Density of Reduced Cerebral Blood Flow Following Acute Middle Cerebral Artery Occlusion: An Experimental Study by the Technique of Hydrogen Clearance in Baboons
Symon, L., Pasztor, E., & Branston, N. M. (1974) · Stroke · doi:10.1161/01.str.5.3.355 · Cited by 224 · see citing works
Influence of transient ischemia on lipid-soluble antioxidants, free fatty acids and energy metabolites in rat brain
Yoshida, S., Abe, K., Busto, R., Watson, B. D., Kogure, K., & Ginsberg, M. D. (1982) · Brain Research · doi:10.1016/0006-8993(82)90813-7 · Cited by 224 · see citing works
Experimental ischemic stroke: a review.
García, J. H. (1984) · Stroke · doi:10.1161/01.str.15.1.5 · Cited by 215 · see citing works
Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment.
Clark, W. M., Madden, K. P., Rothlein, R., & Zivin, J. A. (1991) · Stroke · doi:10.1161/01.str.22.7.877 · Cited by 201 · see citing works
Cognitive Deficits After Focal Cerebral Ischemia in Mice
Hattori, K., Lee, H., Hurn, P. D., Crain, B. J., Traystman, R. J., & DeVries, A. C. (2000) · Stroke · doi:10.1161/01.str.31.8.1939 · Cited by 199 · see citing works
Self-citation
Double origin of the pericellular baskets of the pyramidal cells of the human motor cortex: A Golgi study
Marín‐Padilla, M. (1972) · Brain Research · doi:10.1016/0006-8993(72)90585-9 · Cited by 193 · see citing works
Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia
Globus, M. Y. ‐., Busto, R., Dietrich, W. D., Martinez, E., Valdés, I., & Ginsberg, M. D. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90245-5 · Cited by 188 · see citing works
The differential effect of right versus left hemispheric cerebral infarction on catecholamines and behavior in the rat
Robinson, R. G., & Coyle, J. T. (1980) · Brain Research · doi:10.1016/0006-8993(80)90557-0 · Cited by 181 · see citing works
Resuscitation of the monkey brain after 1 H complete ischemia. I. Physiological and morphological observations
Hossmann, K., & Zimmermann, V. (1974) · Brain Research · doi:10.1016/0006-8993(74)90478-8 · Cited by 179 · see citing works
Augmentation of cerebral perfusion by simultaneous chest compression and lung inflation with abdominal binding after cardiac arrest in dogs.
Koehler, R. C., CHANDRA, N. C., Guerci, A. D., et al. (1983) · Circulation · doi:10.1161/01.cir.67.2.266 · Cited by 177 · see citing works
Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion
Mohamed, A. A., Gotoh, O., Graham, D. I., et al. (1985) · Annals of Neurology · doi:10.1002/ana.410180613 · Cited by 174 · see citing works
An animal model of cerebral infarction. Homologous blood clot emboli in rats.
Kudo, M., Aoyama, A., Ichimori, S., et al. (1982) · Stroke · doi:10.1161/01.str.13.4.505 · Cited by 173 · see citing works
Emergency cardiopulmonary bypass for resuscitation from prolonged cardiac arrest
Safar, P., Abramson, N. S., Angelos, M. G., et al. (1990) · The American Journal of Emergency Medicine · doi:10.1016/0735-6757(90)90298-e · Cited by 173 · see citing works
Polyphosphoinositides as a Probable Source of Brain Free Fatty Acids Accumulated at the Onset of Ischemia
Ikeda, M., Yoshida, S., Busto, R., et al. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb02839.x · Cited by 173 · see citing works
Effects of phenobarbital in cerebral ischemia. Part II: restitution of cerebral energy state, as well as of glycolytic metabolites, citric acid cycle intermediates and associated amino acids after pronounced incomplete ischemia.
Nordström, C., Rehncrona, S., & Siesjö, B. K. (1978) · Stroke · doi:10.1161/01.str.9.4.335 · Cited by 163 · see citing works
Global brain ischemia: a reproducible monkey model.
Nemoto, E. M., Bleyaert, A. L., Stezoski, S. W., et al. (1977) · Stroke · doi:10.1161/01.str.8.5.558 · Cited by 161 · see citing works
Recirculation in the Rat Brain following Incomplete Ischemia
Kågström, E., Smith, M., & Siesjö, B. K. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.25 · Cited by 159 · see citing works
Cerebral blood flow and edema following carotid occlusion in the gerbil.
Crockard, A. H., Iannotti, F., Hunstock, A. T., et al. (1980) · Stroke · doi:10.1161/01.str.11.5.494 · Cited by 156 · see citing works
Comparative effect of graded doses of epinephrine on regional brain blood flow during CPR in a swine model
Brown, C. G., Werman, H. A., Davis, E. A., et al. (1986) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(86)80853-8 · Cited by 156 · see citing works
Focal cerebral ischemia in the rat: Topography of hemodynamic and histopathological changes
Tyson, G. W., Teasdale, G. M., Graham, D. I., et al. (1984) · Annals of Neurology · doi:10.1002/ana.410150608 · Cited by 155 · see citing works
Cerebral Phosphoinositide, Triacylglycerol, and Energy Metabolism in Reversible Ischemia: Origin and Fate of Free Fatty Acids
Yoshida, S., Ikeda, M., Busto, R., et al. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb00675.x · Cited by 154 · see citing works
Cognitive and behavioral assessment in experimental stroke research: will it prove useful?
DeVries, A. C., Nelson, R. J., Traystman, R. J., & Hurn, P. D. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00017-3 · Cited by 147 · see citing works
Self-citation
Effects of phenobarbital in cerebral ischemia. Part I: cerebral energy metabolism during pronounced incomplete ischemia.
Nordström, C., & Siesjö, B. K. (1978) · Stroke · doi:10.1161/01.str.9.4.327 · Cited by 145 · see citing works
Recirculation model following MCA occlusion in rats
Shigeno, T., Teasdale, G. M., McCulloch, J., et al. (1985) · Journal of neurosurgery · doi:10.3171/jns.1985.63.2.0272 · Cited by 141 · see citing works
Cerebral ischemia in infant and adult gerbils. Relation to incomplete circle of Willis.
Levine, S., & Sohn, D. (1969) · PubMed · Cited by 133 · see citing works
Postischemic Cerebral Lipid Peroxidation In Vitro: Modification by Dietary Vitamin E
Yoshida, S., Busto, R., Watson, B. D., Santiso, M., & Ginsberg, M. D. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb08800.x · Cited by 127 · see citing works
Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia
Chan, P. H., Kamii, H., Yang, G., Gafni, J., Epstein, C. J., Carlson, E. J., & Reola, L. (1993) · Neuroreport · doi:10.1097/00001756-199312000-00028 · Cited by 125 · see citing works
Neuropathology of systemic circulatory arrest in adult monkeys
Miller, J. R., & Myers, R. E. (1972) · Neurology · doi:10.1212/wnl.22.8.888 · Cited by 125 · see citing works
Cortical steady potential, impedance and excitability changes during and after total ischemia of cat brain
Hossmann, K. (1971) · Experimental Neurology · doi:10.1016/0014-4886(71)90060-4 · Cited by 120 · see citing works
Effect of epinephrine on cerebral and myocardial perfusion in an infant animal preparation of cardiopulmonary resuscitation.
Schleien, C. L., Dean, J. M., Koehler, R. C., et al. (1986) · Circulation · doi:10.1161/01.cir.73.4.809 · Cited by 116 · see citing works
Local Cerebral Blood Flow and Vascular Reactivity in a Chronic Stable Stroke in Baboons
SYMON, L., CROCKARD, H. A., C.DORSCH, N. W., BRANSTON, N. M., & JUHASZ, J. (1975) · Stroke · doi:10.1161/01.str.6.5.482 · Cited by 114 · see citing works
On the relationship of brain vasculature to production of neurological deficit and morphological changes following acute unilateral common carotid artery ligation in gerbils
Berry, K., Wı́sniewski, H. M., Svarzbein, L., & Baez, S. (1975) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(75)90188-4 · Cited by 113 · see citing works
The development of a new mouse model of global ischemia: focus on the relationships between ischemia duration, anesthesia, cerebral vasculature, and neuronal injury following global ischemia in mice
Murakami, K., Kondo, T., Kawase, M., et al. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01217-1 · Cited by 111 · see citing works
Regional Prevalence and Distribution of Ischemic Neurons in Dog Brains 96 Hours After Cardiac Arrest of 0 to 20 Minutes
Radovsky, A. E., Safar, P. J., Sterz, F. R., et al. (1995) · Stroke · doi:10.1161/01.str.26.11.2127 · Cited by 110 · see citing works
Epinephrine Dosage Effects on Cerebral and Myocardial Blood Flow in an Infant Swine Model of Cardiopulmonary Resuscitation
Berkowitz, I., Gervais, H. W., Schleien, C. L., et al. (1991) · Anesthesiology · doi:10.1097/00000542-199112000-00017 · Cited by 109 · see citing works
Comparative histopathologic consequences of photothrombotic occlusion of the distal middle cerebral artery in Sprague-Dawley and Wistar rats.
Markgraf, C. G., Kraydieh, S., Prado, R., et al. (1993) · Stroke · doi:10.1161/01.str.24.2.286 · Cited by 103 · see citing works
Neurological deficit and cerebral infarction after temporary middle cerebral artery occlusion in unanesthetized cats.
Weinstein, P. R., Anderson, G. G., & Telles, D. A. (1986) · Stroke · doi:10.1161/01.str.17.2.318 · Cited by 101 · see citing works
Recovery of Monkey Brain after Prolonged Ischemia. II. Protein Synthesis and Morphological Alterations
Bodsch, W., Barbier, A., Oehmichen, M., Ophoff, B. G., & Hossmann, K. (1986) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1986.4 · Cited by 99 · see citing works
Cerebrovascular Responses under Controlled and Monitored Physiological Conditions in the Anesthetized Mouse
Dalkara, T., Irikura, K., Huang, Z., Panahian, N., & Moskowitz, M. A. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.78 · Cited by 98 · see citing works
Cerebral Endothelial Microvilli: Formation Following Global Forebrain Ischemia
Dietrich, W. D., Busto, R., & Ginsberg, M. D. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198401000-00006 · Cited by 97 · see citing works
Isolated Angiitis/Angiopathy of the Central Nervous System
Hankey, G. J. (1990) · Cerebrovascular Diseases · doi:10.1159/000108809 · Cited by 97 · see citing works
Cerebral Edema Following Carotid Artery Ligation in the Gerbil
Harrison, M. J., Brownbill, D., Lewis, P. D., & Russell, R. W. R. (1973) · Archives of Neurology · doi:10.1001/archneur.1973.00490240049008 · Cited by 96 · see citing works
Regional cerebral blood flow and histopathologic changes after middle cerebral artery occlusion in rats.
Bolander, H. G., Persson, L., Hillered, L., et al. (1989) · Stroke · doi:10.1161/01.str.20.7.930 · Cited by 95 · see citing works
Effect of mild hyperthermia on recovery of metabolic function after global cerebral ischemia in cats.
Chopp, M., Welch, K. M. A., Tidwell, C. D., et al. (1988) · Stroke · doi:10.1161/01.str.19.12.1521 · Cited by 93 · see citing works
Post‐ischemic coma in rat: effect of different pre‐ischemic blood glucose levels on cerebral metabolic recovery after ischemia
Siemkowicz, E., & GJEDDE, A. H. (1980) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1980.tb06658.x · Cited by 89 · see citing works
Conjugated superoxide dismutase reduces extent of caudate injury after transient focal ischemia in cats.
Matsumiya, N., Koehler, R. C., Kirsch, J. R., et al. (1991) · Stroke · doi:10.1161/01.str.22.9.1193 · Cited by 87 · see citing works
Cerebral infarction in rats using homologous blood emboli: development of a new experimental model.
Kaneko, D., Nakamura, N., & Ogawa, T. (1985) · Stroke · doi:10.1161/01.str.16.1.76 · Cited by 86 · see citing works
RECOVERY OF FUNCTION FOLLOWING ARREST OF THE BRAIN CIRCULATION
Kabat, H., Dennis, C., & Baker, A. B. (1941) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1941.132.3.737 · Cited by 86 · see citing works
Cerebral ischemia in the gerbil: Transmission electron microscopic and immunoelectron microscopic investigation
Yamamoto, K., Morimoto, K., & Yanagihara, T. (1986) · Brain Research · doi:10.1016/0006-8993(86)91212-6 · Cited by 85 · see citing works
CENTRAL NERVOUS SYSTEM RESISTANCE
Grenell, R. G. (1946) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-194604000-00004 · Cited by 82 · see citing works
Increased Susceptibility to Ischemic Brain Injury in Cyclooxygenase-1–Deficient Mice
Iadecola, C., Sugimoto, K., Niwa, K., Kazama, K., & Ross, M. E. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200112000-00008 · Cited by 81 · see citing works
Sodium, ATP, and intracellular pH transients during reversible complete ischemia of dog cerebrum.
Eleff, S. M., Maruki, Y., Monsein, L. H., et al. (1991) · Stroke · doi:10.1161/01.str.22.2.233 · Cited by 76 · see citing works
The effect of ischemia on sensorimotor cortex of cat
Hossmann, K., & Sato, K. (1970) · Journal of Neurology · doi:10.1007/bf00316134 · Cited by 76 · see citing works
Differing Neurochemical and Morphological Sequelae of Global Ischemia: Comparison of Single‐ and Multiple‐Insult Paradigms
Lin, B., Globus, M. Y. ‐., Dietrich, W. D., et al. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10113.x · Cited by 70 · see citing works
Resuscitation of the monkey brain after one hour's complete ischemia. II. Brain water and electrolytes
Zimmermann, V., & Hossmann, K. (1975) · Brain Research · doi:10.1016/0006-8993(75)90997-x · Cited by 69 · see citing works
Monoclonal leukocyte antibody does not decrease the injury of transient focal cerebral ischemia in cats.
Takeshima, R., Kirsch, J. R., Koehler, R. C., et al. (1992) · Stroke · doi:10.1161/01.str.23.2.247 · Cited by 69 · see citing works
A reproducible experimental model of focal cerebral ischemia in the cat
Bose, B., Osterholm, J. L., & Berry, R. G. (1984) · Brain Research · doi:10.1016/0006-8993(84)90106-9 · Cited by 67 · see citing works
Cerebral Blood Flow
Osburne, R. C. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490490061005 · Cited by 67 · see citing works
CIRCULATION AND METABOLISM FOLLOWING EXPERIMENTAL CEREBRAL EMBOLISM
Meyer, J. S., Gotoh, F., & Tazaki, Y. (1962) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196201000-00002 · Cited by 66 · see citing works
Intracellular acidosis during and after cerebral ischemia: in vivo nuclear magnetic resonance study of hyperglycemia in cats.
Chopp, M., Frinak, S., Walton, D., et al. (1987) · Stroke · doi:10.1161/01.str.18.5.919 · Cited by 64 · see citing works
Morphological comparisons between outer and inner ramifying alpha cells of the albino rat retina
Tauchi, M., Morigiwa, K., & Fukuda, Y. (1992) · Experimental Brain Research · doi:10.1007/bf02259129 · Cited by 62 · see citing works
Postocclusive cerebral hyperemia is markedly attenuated by chronic trigeminal ganglionectomy
Moskowitz, M. A., Sakas, D. E., Wei, E. P., et al. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.257.5.h1736 · Cited by 57 · see citing works
The Effect of Bilateral Carotid Artery Ligation upon Acid‐Base Parameters and Substrate Levels in the Rat Brain
Eklöf, B., & Siesjö, B. K. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05354.x · Cited by 57 · see citing works
Methoxamine versus epinephrine on regional cerebral blood flow during cardiopulmonary resuscitation
Brown, C. G., Davis, E. A., Werman, H. A., et al. (1987) · Critical Care Medicine · doi:10.1097/00003246-198707000-00011 · Cited by 56 · see citing works
Effect of mild hyperthermia on recovery of metabolic function after global cerebral ischemia in cats.
MChopp, MWelch, K., DTidwell, C., et al. (1988) · Stroke · Cited by 52 · see citing works
PPBP [4-Phenyl-1-(4-phenylbutyl) Piperidine], a Potent ς-Receptor Ligand, Decreases Brain Injury After Transient Focal Ischemia in Cats
Takahashi, H., Kirsch, J. R., Hashimoto, K., et al. (1995) · Stroke · doi:10.1161/01.str.26.9.1676 · Cited by 51 · see citing works
Local hemodynamic changes during transient middle cerebral artery occlusion and recirculation in the rat: a [14C]iodoantipyrine autoradiographic study
Takagi, K., Zhao, W., Busto, R., et al. (1995) · Brain Research · doi:10.1016/0006-8993(95)00657-c · Cited by 48 · see citing works
Animal Models of Cerebral Ischemia. 1. Review of Literature
Hossmann, K.-A. (1991) · Cerebrovascular Diseases · doi:10.1159/000108875 · Cited by 48 · see citing works
Age-related changes in chest geometry during cardiopulmonary resuscitation
Dean, J. M., Koehler, R. C., Schleien, C. L., et al. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.62.6.2212 · Cited by 47 · see citing works
Recovery of Monkey Brain after Prolonged Ischemia. I. Electrophysiology and Brain Electrolytes
Hossmann, K. A., & Ophoff, B. G. (1986) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1986.3 · Cited by 46 · see citing works
Experimental model of stroke in the baboon.
Symon, L. (1975) · PubMed · Cited by 45 · see citing works
α-Tocopherol and ubiquinones in rat brain subjected to decapitation ischemia
Abe, K., Yoshida, S., Watson, B. D., et al. (1983) · Brain Research · doi:10.1016/0006-8993(83)91107-1 · Cited by 44 · see citing works
Effect of postischemic hypoperfusion on vasodilatory mechanisms in cats
Clavier, N., Kirsch, J. R., Hurn, P. D., et al. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.5.h2012 · Cited by 39 · see citing works
Consistency of cerebral blood flow and evoked potential alterations with reversible focal ischemia in cats.
Matsumiya, N., Koehler, R. C., & Traystman, R. J. (1990) · Stroke · doi:10.1161/01.str.21.6.908 · Cited by 37 · see citing works
Self-citation
The Production and Clinical Features of a Chronic Stroke Model in Experimental Primates
Symon, L., Dorsch, N. W. C., & Crockard, H. A. (1975) · Stroke · doi:10.1161/01.str.6.5.476 · Cited by 36 · see citing works
Quantitative analysis of acoustic emission signals
Yu, Z., & Clapp, P. C. (1987) · Journal of Applied Physics · doi:10.1063/1.339525 · Cited by 36 · see citing works
A brief episode of severe arterial hypertension induces delayed deterioration of brain function and worsens blood flow after transient multifocal cerebral ischemia.
Dutka, A. J., Hallenbeck, J. M., & Kochanek, P. M. (1987) · Stroke · doi:10.1161/01.str.18.2.386 · Cited by 33 · see citing works
Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient focal ischemia in cats.
Nishikawa, T., Kirsch, J. R., Koehler, R. C., et al. (1994) · Stroke · doi:10.1161/01.str.25.11.2258 · Cited by 33 · see citing works
Tirilazad treatment does not decrease early brain injury after transient focal ischemia in cats.
Takeshima, R., Kirsch, J. R., Koehler, R. C., et al. (1994) · Stroke · doi:10.1161/01.str.25.3.670 · Cited by 28 · see citing works
Streptokinase treatment versus calcium overload blockade in experimental thromboembolic stroke.
Ley, G. D., Weyne, J., Demeester, G., et al. (1989) · Stroke · doi:10.1161/01.str.20.3.357 · Cited by 20 · see citing works
Effects of ischemia duration on neurological outcome, CA1 histopathology, and nonmatching to sample learning in monkeys.
Scheller, M. S., Grafe, M. R., Zornow, M. H., et al. (1992) · Stroke · doi:10.1161/01.str.23.10.1471 · Cited by 17 · see citing works
Animal Models of Cerebral Ischemia. 2. Rat Models
Takizawa, S., & Hakim, A. M. (1991) · Cerebrovascular Diseases · doi:10.1159/000108876 · Cited by 14 · see citing works
What animal models have taught us about the treatment of acute stroke and brain protection
Ahmed, S.-H., Shaikh, A. Y., Shaikh, Z. Y., & Hsu, C. Y. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0112-2 · Cited by 14 · see citing works
THE EFFECTS OF VOLATILE GENERAL ANESTHETICS AND ALCOHOLS ON SPINAL CORD PROTEIN KINASE-C
Austin, J. A., & Firestone, L. L. (1991) · Anesthesiology · doi:10.1097/00000542-199109001-01040 · Cited by 7 · see citing works
Introduction
Klein, H. J., & Nelson, R. J. (2002) · ILAR Journal · doi:10.1093/ilar.43.3.121 · Cited by 3 · see citing works
Introduction
Landi, M. S. (2001) · ILAR Journal · doi:10.1093/ilar.42.3.187 · Cited by 3 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

[39]39. Ginsberg MD, Busto R, Martinez E. 1992. The effects of cerebral ischemia on energy metabolism. In: Schousboe A, Diemer NH, Kofod H, eds. Drug Research Related to Neuroactive Amino Acids. Alfred Benson Symposium 32. Copenhagen: Munksgaard. p 207-224.
[62]62. Koehler RC. 1997. Large animal models of focal and global cerebral is- chemia. In: Ginsberg MD, Bogousslavsky J, eds. Cerebrovascular Dis- ease: Pathophysiology, Diagnosis and Management. Oxford: Blackwell Science. p 36-51.
[64]64. Kofler J, Sawada M, Hattori K, Dawson VL, Hurn PD. 2002. Brain injury after cardiac arrest and cardiopulmonary resuscitation (CPR). In: Krieglstein J, ed. Pharmacology of Cerebral Ischemia. Stuttgart: Med- pharm Scientific Publishers (In Press).

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Murphy, T. H., Li, P., Betts, K., & Liu, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5128-07.2008 · Cited by 261 · see citing works
“Relationship to selective neuronal loss in global ischemia models Most previous work in rodent global ischemia concerns the selective delayed death of hippocampal CA1 neurons triggered ischemia in excess of 10 min (Traystman, 2003; Yonekura et al., 2004).”
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Déziel, R. A., Ryan, C. L., & Tasker, R. A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.003 · Cited by 30 · see citing works

Microglia and neuroprotection: implications for Alzheimer's disease
Streit, W. J. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.013 · Cited by 256 · see citing works
Neuroprotective Effect of Neuroglobin in Simultaneous Incomplete Ischemia
Bon, E. I. (2023) · Psychiatry and Psychological Disorders · doi:10.58489/2836-3558/002
Resveratrol neuroprotection in cerebral ischemia
Wang, Y., & Gong, Z.-Q. (2012) · Int J Cerebrovasc Dis · doi:10.3760/cma.j.issn.1673-4165.2012.07.012
The decrease of tissue oxygen correlates with the level ofapoptosis in a focal ischemia in rat - the neuroprotective roleof systemic hypertension
Otevřel, F., Kuchtíčková, Š., & Smrčka, M. (2006)
17β-Estradiol and Inflammation: Implications for Ischemic Stroke
Petrone, A. B. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500340 · Cited by 60 · see citing works

Authors: Traystman, R. J.
Affiliations: Johns Hopkins University (US)
Corresponding author: Traystman, R. J.
Venue: ILAR Journal
Publisher: Oxford University Press (OUP)
Published: 2003-01-01
Volume: 44
Issue: 2
Pages: 85-95
ISSN: 1084-2020 (ISSN-L)
DOI: 10.1093/ilar.44.2.85
OpenAlex: W2141210606
Cited by: 413
References: 130
Citations by year: 2026: 7 · 2025: 12 · 2024: 17 · 2023: 11 · 2022: 19 · 2021: 19 · 2020: 26 · 2019: 20 · 2018: 19 · 2017: 28 · 2016: 21 · 2015: 18 · 2014: 25 · 2013: 23 · 2012: 18
FWCI: 1.70
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: ILAR Journal (publishedVersion)
PubMed (publishedVersion)
Funders: Johns Hopkins University
National Institutes of Health (NS20020)
National Institute of Neurological Disorders and Stroke (P01NS020020, P01 NS-20020)
Topics: Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: animal models, cerebral ischemia, focal cerebral ischemia, global cerebral ischemia, stroke, cardiac arrest, neuroprotection, translational research
MeSH terms: Animals, Haplorhini, Cats, Brain Ischemia, Disease Models, Animal, Dogs, Gerbillinae, Humans, Rabbits, Sheep, Swine, Neuroprotective Agents, Stroke, Mice, Rats

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Animal models of focal and global cerebral ischemia

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