The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Is late‐onset schizophrenia a subtype of schizophrenia?
Open accessAbstract
Vahia IV, Palmer BW, Depp C, Fellows I, Golshan S, Kraemer HC, Jeste DV. Is late‐onset schizophrenia a subtype of schizophrenia? Objective: To determine whether late‐onset schizophrenia (LOS, onset after age 40) should be considered a distinct subtype of schizophrenia. Method: Participants included 359 normal comparison subjects (NCs) and 854 schizophrenia out‐patients age >40 (110 LOS, 744 early‐onset schizophrenia or EOS). Assessments included standardized measures of psychopathology, neurocognition, and functioning. Results: Early‐onset schizophrenia and LOS groups differed from NCs on all measures of psychopathology and functioning, and most cognitive tests. Early‐onset schizophrenia and LOS groups had similar education, severity of depressive, negative, and deficit symptoms, crystallized knowledge, and auditory working memory, but LOS patients included more women and married individuals, had less severe positive symptoms and general psychopathology, and better processing speed, abstraction, verbal memory, and everyday functioning, and were on lower antipsychotic doses. Most EOS–LOS differences remained significant after adjusting for age, gender, severity of negative or deficit symptoms, and duration of illness. Conclusion: Late‐onset schizophrenia should be considered a subtype of schizophrenia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Late‐onset schizophrenia appeared to be as stable a diagnosis as early‐onset schizophrenia; both diagnoses remained unchanged in up to 93% of cases in a follow‐up, and only rarely were they reclassified as mood disorders263, 264.”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [264]
In the citing paper
“Sensory deficits, especially long‐standing conductive deafness, are common in the late‐onset form 264 , but may primarily reflect the patients' reluctance to seek corrective measures or their inability to get correction of these deficits because of poor access to quality health care.”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [264]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410
The processing-speed theory of adult age differences in cognition
Salthouse, T. A. (1996) · Psychological Review · doi:10.1037/0033-295x.103.3.403 · Cited by 5,902 · cited 1×
“The difference in processing speed was particularly surprising as the LOS group was, on average, 6 years older than the EOS group, and processing speed tends to decline steadily with normal aging (86).”
BackgroundDiagnostic criteria for use in psychiatric research.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G., & Munoz, R. A. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750190059011 · Cited by 5,491
Dementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407
What are the functional consequences of neurocognitive deficits in schizophrenia?
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.321 · Cited by 3,516
Wisconsin Card Sorting Test Manual – Revised and Expanded
Heaton, R. K., Chelune, C., Talley, J., Kay, G., & Curtiss, G. (1981) · Medical Entomology and Zoology · Cited by 2,975
Dementia Praecox and Paraphrenia.
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-6-1058_8 · Cited by 2,907
Psychiatric disorders in America: the epidemiologic catchment area study
(1991) · Choice Reviews Online · doi:10.5860/choice.28-5931 · Cited by 2,561
Research works printed but not linked: 15
- Oxford University Press.Oxford English Dictionary Online.2008. Available at:http://www.oed.com(accessed 18 February 2009).
- Bleuler M, 1943, Die spatschizophrenen krankheitsbilder, Fortschritte der Neurologie Psychiatrie, 15, 259
- Takei N, 1999, Late‐onset schizophrenia, 93
- Ableskov K, 1999, Late‐onset schizophrenia, 89
- Riecher‐Rössler A, 1999, Late‐onset schizophrenia, 55
- Howard R, 2009, Schizophrenia
- Rabins PV, 1999, Late onset schizophrenia, 47
- 10.1097/00019442-200512000-00009 · DOI
- Guy W, 1976, ECDEU Assessment Manual for Psychopharmacology: U.S. Department of Health, Education, and Welfare (ADM) 76‐338
- Wechsler D, 1981, Wechsler adult intelligence scale – revised
- Wechsler D, 1997, Wechsler adult intelligence scale ‐ third edition (WAIS‐III). Administration and scoring manual
- Kongs SK, 2000, Wisconsin card sorting test – 64 card version. Professional manual
- Delis DC, 1987, California verbal learning test (CVLT)
- Spitzer RL, 1990, Structured clinical interview for the DSM‐III‐R, patient edition/non‐patient edition. (SCID‐P/SCID‐NP)
- First MB, 2002, Structured clinical interview for DSM‐IV‐TR axis I disorders, research version, patient edition with psychotic screen (SCID‐I/P W/ PSY SCREEN)
Cited by
Sorted by citations
Galletly, C., Castle, D., Dark, F., Humberstone, V., Jablensky, A., Killackey, E., Kulkarni, J., McGorry, P., Nielssen, O., & Tran, N. (2016) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416641195 · Cited by 877
“Compared with earlier onset, late-onset schizophrenia is associated with less severe positive symptoms and response to lower doses of antipsychotic medications (Maglione et al., 2014; Vahia et al., 2010).”
BackgroundReynolds, C. F., Jeste, D. V., Sachdev, P. S., & Blazer, D. G. (2022) · World Psychiatry · doi:10.1002/wps.20996 · Cited by 465
Self-citationSystematic review and collaborative recalculation of 133 693 incident cases of schizophrenia
van der Werf, M., Hanssen, M., Köhler, S., Verkaaik, M., Verhey, F. R., RISE Investigators, van Winkel, R., van Os, J., & Allardyce, J. (2014) · Psychological Medicine · doi:10.1017/s0033291712002796 · Cited by 148
“…causal pathways involving additive and interactive psychosocial, neural or hormonal protective factors (or lack of risk factors) in the context of pathoplastic normal or pathological age-related processes that impact on a milder or absent neurodevelopmental vulnerability (Vahia et al. 2010).”
BackgroundNew perspectives on schizophrenia in later life: implications for treatment, policy, and research
Cohen, C. I., Meesters, P. D., & Zhao, J. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00003-6 · Cited by 148
Meesters, P. D., de Haan, L., Comijs, H. C., Stek, M. L., Smeets-Janssen, M. M. J., Weeda, M. R., Eikelenboom, P., Smit, J. H., & Beekman, A. T. F. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3182011b7f · Cited by 106
Cannabis use, gender and age of onset of schizophrenia: Data from the ÆSOP study
Donoghue, K., Doody, G. A., Murray, R. M., Jones, P. B., Morgan, C., Dazzan, P., Hart, J., Mazzoncini, R., & MacCabe, J. H. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2013.12.038 · Cited by 101
“This is because late onset of schizophrenia may represent a distinct sub-sample of the disorder characterised by less severe positive symptoms, better cognitive function, lower dose antipsychotics, better every day functioning and increased prevalence in women (Vahia et al., 2010).”
Menstrual exacerbation of schizophrenia symptoms
Seeman, M. V. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01822.x · Cited by 68
“2 on lifetime distribution of estrogen and testosterone), is an illness mainly of women (49).”
BackgroundMaglione, J. E., Thomas, S. E., & Jeste, D. V. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000049 · Cited by 66
“A greater proportion of LOS patients have successful occupational and marital histories compared with EOS patients [10].”
BackgroundResultInfluentialSelf-citationNo sex differences in neuropsychological performance in first episode psychosis patients
Ayesa‐Arriola, R., Rodríguez-Sánchez, J. M., Gómez-Ruíz, E., Roiz‐Santiáñez, R., Reeves, L. E., & Crespo‐Facorro, B. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.009 · Cited by 58
“Criterion based on convention considers late onset when prodromal symptoms begin after age 40 (Vahia et al., 2010).”
New Wine in Old Bottle: Late-Life Psychosis
Iglewicz, A., Meeks, T. W., & Jeste, D. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.02.008 · Cited by 38
“However, the most current findings from the research group at the University of California, San Diego (UCSD) synthesizing the data on middle-age and older adults with schizophrenia collected over the past 20 years challenge some of the accepted similarities and distinctions between individuals with EOS and LOS [57].”
BackgroundInfluentialSelf-citationAssche, L. V., Morrens, M., Luyten, P., de Ven, L. V., & Vandenbulcke, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.024 · Cited by 60
“Interestingly, studies have quite consistently described a reduced intellectual capacity in LOS or VLOSLP compared with normal controls (Almeida et al., 1995a; Heaton et al., 1994; Jeste et al., 1995; Moore et al., 2006; Östling et al., 2004; Sachdev et al., 1999a; Vahia et al., 2010).”
InfluentialStafford, J., Dykxhoorn, J. L., Sommerlad, A., Dalman, C., Kirkbride, J. B., & Howard, R. J. (2021) · Psychological Medicine · doi:10.1017/s0033291721002099 · Cited by 57
“There is ongoing debate about the aetiology of VLOSLP and its relationship with neurodegeneration and dementia (Brodaty, Sachdev, Koschera, Monk, & Cullen, 2003; Vahia et al., 2010; Van Assche, Morrens, Luyten, Van de Ven, & Vandenbulcke, 2017).”
BackgroundThompson, W. K., Savla, G. N., Vahia, I. V., Depp, C. A., O'Hara, R. M., Jeste, D. V., & Palmer, B. W. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.10.033 · Cited by 51
“Antipsychotic medication use Antipsychotic medication use was determined by calculating the Chlorpromazine Equivalent dosage (CPZE) for all antipsychotic medications, based on standardized formulas (Jeste and Wyatt, 1982; Vahia et al., 2010).”
MethodSelf-citationLate-onset psychosis and very-late-onset-schizophrenia-like-psychosis: an updated systematic review
Suen, Y. N., Wong, S. M. Y., Hui, C. L. M., Chan, S. K. W., Lee, E. H. M., Chang, W. C., & Chen, E. Y. H. (2019) · International Review of Psychiatry · doi:10.1080/09540261.2019.1670624 · Cited by 45
“Psychopathological Psychopathological symptoms of patients with LOP or VLOSLP were studied in ten included studies (Brichant-Petitjean et al., 2013; Brodaty et al., 2003; Hanssen et al., 2015; Huang & Zhang, 2009; Hussein et al., 2012; Mason et al., 2013; Reeves et al., 2002; Sato et al., 2004; Vahia et al., 2010; Wak…”
BackgroundResultInfluentialLin, C., Lane, H., Chen, T., Wu, Y., Wu, C., & Wu, V. Y. (2013) · Cancer Science · doi:10.1111/cas.12094 · Cited by 40
Cognitive impairment in late life schizophrenia and bipolar I disorder
Meesters, P. D., Schouws, S. N. T. M., Stek, M. L., de Haan, L., Smit, J. H., Eikelenboom, P., Beekman, A. T. F., & Comijs, H. C. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3793 · Cited by 44
“cognitive deficits (Vahia et al., 2010), the reverse may apply to bipolar patients (Schouws et al.”
BackgroundCognitive deficit in patients with paranoid schizophrenia: Its clinical and laboratory correlates
Dorofeikova, M., Незнанов, Н. Г., & Петрова, Н. Н. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.09.041 · Cited by 37
Block, N., Sha, S. J., Karydas, A. M., Fong, J. C., May, M. G. D., Miller, B. L., & Rosen, H. J. (2015) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2015.04.007 · Cited by 35
“Studies attempting to identify other features that differentiate late- versus early-onset bipolar disorder and schizophrenia have only found relatively subtle differences, including less severe psychopathology in late-onset disorders.(17) Findings on cognitive assessment have been variable, with some”
ResultOverview of late-onset psychoses
Devanand, D. P., Jeste, D. V., Stroup, T. S., & Goldberg, T. E. (2023) · International Psychogeriatrics · doi:10.1017/s1041610223000157 · Cited by 43
“Compared to EOS, LOS has been associated with lateral ventricular enlargement, larger thalamic volumes, decreased white matter integrity, and reduced cerebral blood fl ow in both postcentral gyri compared to EOS (Chen et al ., 2013; Tonkonogy and Geller, 1999; Wake et al ., 2016).”
BackgroundInfluentialSelf-citationSeeman, M. V. (2012) · Women s Health · doi:10.2217/whe.11.97 · Cited by 34
“Aging & mortality in schizophrenia Among older schizophrenia patients, there is a preponderance of women [38].”
Non-affective psychotic disorders and risk of dementia: a systematic review and meta-analysis
Miniawi, S. E., Orgeta, V., & Stafford, J. (2022) · Psychological Medicine · doi:10.1017/s0033291722002781 · Cited by 32
“Differences in epidemiology and presentation have been found in those with LOS and VLOSLP, including a higher prevalence among women and fewer negative symptoms (Howard et al., 2000; Stafford, Howard, & Kirkbride, 2018; Stafford, Howard, Dalman, & Kirkbride, 2019; Vahia et al., 2010).”
Lasalvia, A., Bonetto, C., Lenzi, J., Rucci, P., Iozzino, L., Cellini, M., Comacchio, C., Cristofalo, D., D’Agostino, A., de Girolamo, G., et al. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.116.190058 · Cited by 31
Cognitive Functioning in Older Adults With Schizophrenia
Murante, T., & Cohen, C. I. (2017) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20160032 · Cited by 28
Hanssen, M., van der Werf, M., Verkaaik, M., Arts, B. M. G., Myin‐Germeys, I., van Os, J., Verhey, F. R. J., & Köhler, S. (2014) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2014.10.007 · Cited by 29
Dimensions of positive symptoms in late versus early onset psychosis
Mason, O. J., Stott, J. C. H., & Sweeting, R. (2012) · International Psychogeriatrics · doi:10.1017/s1041610212001731 · Cited by 28
“Schneiderian first-rank symptoms are common regardless of age of onset (Pearlson et al., 1989; Cohen et al., 2008; Vahia et al., 2010), and similar levels of delusional perception, bizarre delusions, and delusions of reference have been found (Howard et al., 1993a; 1993b; Castle et al., 1997).”
BackgroundResultInfluentialInteraction of emotion and cognitive control along the psychosis continuum: A critical review
Duggirala, S. X., Schwartze, M., Pinheiro, A. P., & Kotz, S. A. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.11.004 · Cited by 28
Cognitive functioning and age at onset in non‐affective psychotic disorder
van der Werf, M., Köhler, S., Verkaaik, M., Verhey, F. R. J., van Os, J., & GROUP Investigators (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2012.01873.x · Cited by 27
“The current findings add to previous reports of more compromised verbal learning and memory (13, 14, 38) and sustained attention (39) in schizophrenia with earlier onset, but contradict others Table 3.”
ResultAdvances in the Conceptualization and Study of Schizophrenia in Later Life: 2020 Update
Cohen, C. I., Freeman, K., Ghoneim, D., Vengassery, A., Ghezelaiagh, B., & Reinhardt, M. M. (2019) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.11.004 · Cited by 24
Fagerlund, B., Pantelis, C., Jepsen, J. R. M., Raghava, J. M., Rostrup, E., Thomas, M. B., Nielsen, M. Ø., Bojesen, K. B., Jensen, K. G., Decara, M. S., et al. (2020) · Psychological Medicine · doi:10.1017/s0033291720000409 · Cited by 23
“Nevertheless, most studies support late onset as a subtype of schizophrenia (Vahia et al., 2010), with a similar symptom profile, although some suggest fewer negative symptoms in the late-onset group (Howard, Rabins, Seeman, & Jeste, 2000).”
ResultChapter 6. Schizophrenia and Paranoid Disorders
Vahia, I. V., Lanouette, N. M., & Jeste, D. V. (2013) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615370016.mt06 · Cited by 22
Self-citationAdvances in the Conceptualization and Study of Schizophrenia in Later Life
Cohen, C. I., Freeman, K., Ghoneim, D., Vengassery, A., Ghezelaiagh, B., & Reinhardt, M. M. (2017) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2017.10.004 · Cited by 22
Kiviniemi, M. (2014) · Cited by 20
Psychosis-related matricide associated with a lesion of the ventromedial prefrontal cortex.
Orellana, G., Alvarado, L., Muñoz‐Neira, C., Ávila, R., Méndez, M. F., & Slachevsky, A. (2013) · PubMed · Cited by 20
Clinical Approaches to Late-Onset Psychosis
Kim, K., Jeon, H. J., Myung, W., Suh, S. W., Seong, S. J., Hwang, J. Y., Ryu, J. I., & Park, S. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12030381 · Cited by 23
“They proposed the terms with ‘Late-Onset Schizophrenia’ and ‘Very Late-Onset Schizophrenia-Like Psychosis’ for disorders with onset between 40 to 60 years and after the age of 60, respectively [8,9].”
BackgroundMemory deficits in late-onset schizophrenia
Brichant‐Petitjean, C., Legauffre, C., Ramoz, N., Adès, J., Gorwood, P. A. P. M., & Dubertret, C. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.08.021 · Cited by 17
Exosome and exosomal contents in schizophrenia
Zhang, T., Fang, Y., Wang, L., Gu, L., & Tang, J. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.05.072 · Cited by 18
The Age of Onset of Schizophrenia Spectrum Disorders
Miettunen, J., Immonen, J., McGrath, J. J., Isohanni, M. K., & Jääskeläinen, E. (2018) · Springer eBooks · doi:10.1007/978-3-319-72619-9_4 · Cited by 16
Verhoeven, E. W. M., Smeekens, I., & Didden, R. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1843-6 · Cited by 16
“The SSPA has frequently been used in individuals with schizophrenia (e.g. Adelsky et al. 2011; Leifker et al. 2009; Vahia et al. 2010) and has good reliability and validity in this population.”
Quee, P. J., Alizadeh, B. Z., Aleman, A., van den Heuvel, E. R., & GROUP Investigators (2013) · Psychological Medicine · doi:10.1017/s0033291713000809 · Cited by 16
Older Patients With Schizophrenia: Does Military Veteran Status Matter?
Thorp, S. R., Sones, H. M., Glorioso, D., Thompson, W., Light, G. A., Golshan, S., & Jeste, D. V. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3182096ae5 · Cited by 14
Self-citationLate-Onset Psychosis; Is It Real?
Kwak, Y. T., Yang, Y., & Koo, M. (2015) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2015.14.1.1 · Cited by 13
Clinical practice guideline for management of psychoses in elderly
Gautam, S., Jain, A., Gautam, M., & Gautam, A. (2018) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.224475 · Cited by 13
Late-Onset Schizophrenia: A Review for Clinicians
Pearman, A. M., & Batra, A. (2012) · Clinical Gerontologist · doi:10.1080/07317115.2011.642943 · Cited by 13
“While many clinicians may categorize LOS and VLOSP together, the current consensus is that they are separate entities and should be treated as such ( Howard et al, 2000 ; Vahia et al, 2010 ).”
BackgroundNew horizons in schizophrenia in older people
Meesters, P. D. (2023) · Age and Ageing · doi:10.1093/ageing/afad161 · Cited by 12
Ohi, K., Fujikane, D., & Shioiri, T. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105900 · Cited by 13
Effect of age onset on schizophrenia-like phenotypes and underlying mechanisms in model mice
Ju, J., Liu, L., Zhang, Y., & Zhou, Q. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.07.015 · Cited by 12
“In addition, compared to EOS, LOS require lower daily antipsychotic dose (Vahia et al., 2010).”
Li, H., Tang, J., Chen, L., Liao, Y., Zhou, B. R., He, Y. Z., Li, Z., Lv, L., Zeng, Y., & Chen, X. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-015-1525-1 · Cited by 12
“Neurosci Bull October 1, 2015, 31(5): 626–627. http://www.neurosci.cn DOI: 10.1007/s12264-015-1525-1626 Reduced middle cingulate gyrus volume in late-onset schizophrenia in a Chinese Han population: a voxel-based structural MRI study ·Letter to the Editor·”
InfluentialCan the neurodevelopmental theory account for sex differences in schizophrenia across the life span?
Baldwin, C. H., & Srivastava, L. K. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150014 · Cited by 12
Clinical features of late‐onset schizophrenia in J apan: comparison with early‐onset cases
Yasuda, M., Kobayashi, T., Kato, S., & Kishi, K. (2013) · Psychogeriatrics · doi:10.1111/psyg.12032 · Cited by 10
Chai, Y., Tang, J. Y. ‐., Ma, D. C. F., Luo, H., & Chan, S. K. W. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.26795 · Cited by 13
Shao, Y., Xu, H., Wang, J., Dai, X., Liang, W., Ren, L., & Wang, Y. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03210-5 · Cited by 9
Kiviniemi, M., Suvisaari, J., Isohanni, M. K., Saarento, O., Häkkinen, U., Pirkola, S. P., & Hakko, H. H. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12226 · Cited by 9
Szabo, S. M., Merikle, E. P., Lozano‐Ortega, G., Powell, L., Macek, T. A., & Cline, S. K. (2018) · Schizophrenia Research and Treatment · doi:10.1155/2018/9075174 · Cited by 8
“The full UPSA and the Quality of Well-being Scale (QWB) were jointly evaluated in two studies [10, 74].”
MethodErkrankungen des schizophrenen Formenkreises im Alter
Jagsch, C., & Hofer, A. (2018) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-018-1436-2 · Cited by 8
Ramin, T., Peter, J., Schneider, M., Heinze, M., Riedel, O., Langbein, S., Haug, U., & Zolk, O. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01867-z · Cited by 7
“Vahia et al. found that positive symptoms and general psychopathology were less severe in late-onset schizophrenia (LOS) patients than in early-onset (EOS) patients, but the groups did not differ in the severity of negative symptoms [6].”
Feller, C. M., Ilen, L., Eliez, S., & Schneider, M. (2024) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-024-09527-y · Cited by 10
“For instance, the Social Skills Performance Assessment (SSPA; [51]) was initially developed to assess individuals with schizophrenia through role-plays (e.g., [52–54]) but was also used in other conditions (e.g., [55]), including ASD.”
MethodZhang, M., Yang, F., Fan, H., Fan, F., Wang, Z., Xiang, H., Huang, W., Tan, Y., Tan, S., & Hong, L. E. (2022) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2022.111535 · Cited by 6
Yin, Y., Li, S., Tong, J., Huang, J., Tian, B., Chen, S., Cui, Y., Tan, S., Wang, Z., Yang, F., et al. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.05.015 · Cited by 6
Edad de inicio de los síntomas y sexo en pacientes con trastorno del espectro esquizofrénico
Sánchez, R., Téllez, G., & Jaramillo, L. E. (2012) · Biomédica · doi:10.7705/biomedica.v32i2.423 · Cited by 5
Assche, L. V., Takamiya, A., den Stock, J. V., de Ven, L. V., Luyten, P., Emsell, L., & Vandenbulcke, M. (2023) · Psychological Medicine · doi:10.1017/s0033291723002258 · Cited by 6
“Several aspects of processing speed are affected, such as cognitive speed, psychomotor and complex visuo-perceptual speed (Henderson et al., 1998; Jeste et al., 1995; Naguib & Levy, 1987; Vahia et al., 2010).”
BackgroundKassm, S. A., Limosin, F., Naja, W., Vandel, P., Rico, M. S., Alvarado, J. M., von Gunten, A., Hoertel, N., & CSA Study group (2021) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5512 · Cited by 5
“The VLOSLP type raises more controversy as reflected by its name.(6,11,12) It may be distinguished by its much greater preponderance in women, greater exposure to a range of social disadvantages and social isolation,(6) higher rates of sensory impairment,(6) lower rate of family history of schizophrenia,(6) and a poss…”
BackgroundMethodAgeing with psychosis – Fifty and beyond
Galletly, C. A., Suetani, S., Hahn, L. A., McKellar, D., & Castle, D. J. (2021) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674211009619 · Cited by 5
“Most research relating to older patients with psychosis has focused on people with late-onset disorders (Castle and Murray, 1993; Cohen et al., 2020; Vahia et al., 2010).”
BackgroundCognitive functions in late-onset psychosis
Гаяровна, А. Е., Ma, S., Rupchev, G., Sheshenin, V., & Витальевна, П. В. (2022) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202212206163 · Cited by 5
Processing Speed Impairment in Schizophrenia
Pratt, D. N., Linares, N. N., Spencer, C., Olson, G. M., Maeve, H., Parmacek, S. N., Lee, L. E., Alliende, L. M., Zarubin, V. C., Dickinson, D., et al. (2025) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2025.3893 · Cited by 5
Risk Factors for Late-Onset Psychosis: A Case-Control Study
Skinner, J. P., Shinn, A. K., & Moran, L. V. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae164 · Cited by 4
Gilabert‐Juan, J., Ivorra, J. L., Tolosa, A., Gratacòs, M., Costas, J., Sanjuán, J., & Moltó, M. D. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.07.005 · Cited by 4
Tanra, A. J., Sabaruddin, H., Liaury, K., & Zainuddin, A. A. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.7086 · Cited by 3
“This resultantly inhibits nerve damage in the brain and symptoms of developmental disability [15].”
BackgroundPotential Explanatory Models of the Female Preponderance in Very Late Onset Schizophrenia
Johnstone, S., Cruz, G. A. D., Girard, T. A., Rajji, T. K., & Castle, D. J. (2022) · Women · doi:10.3390/women2040033 · Cited by 3
Vannorsdall, T. D., & Schretlen, D. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3106-0_30 · Cited by 3
Girard, C., & Simard, M. (2012) · Open Journal of Psychiatry · doi:10.4236/ojpsych.2012.24043 · Cited by 3
Sheshenin, V., & Витальевна, П. В. (2019) · Psikhiatriya · doi:10.30629/2618-6667-2019-81-101-110 · Cited by 3
Pashkovskiy, V. E. (2020) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2020-4-3-11 · Cited by 3
The age of onset and cognitive impairment at the early stage of schizophrenia
Yin, Y., Li, S., Tong, J., Huang, J., Tian, B., Chen, S., Cui, Y., Tan, S., Wang, Z., Yang, F., et al. (2022) · Cognitive Neurodynamics · doi:10.1007/s11571-022-09814-1 · Cited by 3
“…was consistent with a study that detected the individuals with LOS were less impaired in verbal learning, assessed using the corrected long-delay free recall score of the California Verbal Learning Test, than those whose age of onset schizophrenia was before 40 years old (Vahia et al. 2010).”
BackgroundResultInfluentialMental Health and Treatment Considerations for Older Adults
Edelstein, B. A., Spalding, R., & Katz, E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818697-8.00137-0 · Cited by 3
Diagnostik und medikamentöse Therapie bei schizophrenen Patienten im Alter
Jagsch, C., Dietmaier, G., Jagsch, M., & Kurz, M. (2016) · Neuropsychiatrie · doi:10.1007/s40211-016-0183-0 · Cited by 2
A Case of Very-late-onset Schizophrenia-like Psychosis
Son, J. H., & Kee, B. S. (2011) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2011.9.2.91 · Cited by 2
Psychoseerkrankungen im höheren Lebensalter
Supprian, T. (2020) · Elsevier eBooks · doi:10.1016/b978-3-437-24436-0.00018-9 · Cited by 2
Cauliflower ear in late onset psychosis
Singh, L. K., Spoorthy, M. S., Das, S., Tikka, S. K., & Arora, R. D. (2018) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2018.10.025 · Cited by 2
Гаяровна, А. Е., Александровна, С. М., Rupchev, G., Ma, M., Витальевна, П. В., & Sheshenin, V. (2020) · Neurology Bulletin · doi:10.17816/nb16461 · Cited by 2
Comparative Study of Clinical Features between Early- and Late-Onset Schizophrenia in South Korea
Ko, M.-A., Lee, S.-K., & Lee, J. S. (2019) · Korean Journal of Schizophrenia Research · doi:10.16946/kjsr.2019.22.2.51 · Cited by 1
Jagsch, C., & Hofer, A. (2018) · Zeitschrift für Gerontologie und Geriatrie · Cited by 1
Nagaratnam, N., Nagaratnam, K., & Cheuk, G. (2018) · Springer eBooks · doi:10.1007/978-3-319-33434-9_76 · Cited by 1
Chapter 11. Schizophrenia Spectrum and Other Psychotic Disorders
Graham, S. A., Adamowicz, D. H., Jeste, D. V., & Lee, E. (2022) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375196.ds11 · Cited by 1
Self-citationLate-Onset Schizophrenia: Epidemiology, Clinical Profile, Prognosis, and Treatment Considerations
Sacchetti, E., Turrina, C., Peri, L. M. D., & Vita, A. (2011) · Springer eBooks · doi:10.1007/978-94-007-0831-0_12 · Cited by 1
“et al. [ 42 ] Symptom profile, functioning and neuropsychology Higher rate in LO Less positive symptoms LO=EO CVLT, WCST, Digit symbol, and block design: LO > EO”
BackgroundResultInfluentialVascular psychosis in the elderly: response to clozapine.
Soriano-Barceló, J., Mota-Rodríguez, M. J., & Arauxo, A. (2012) · PubMed · Cited by 1
La psychose à la frontière de la psychiatrie
Azuar, C., & Samama, D. (2016) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/j.amp.2015.12.020 · Cited by 1
Schizophrenia Spectrum and Other Psychotic Disorders
Reinhardt, M. M., Ghoneim, D., Huggins, B., Mani, A., Murante, T., & Cohen, C. I. (2018) · Springer eBooks · doi:10.1007/978-3-319-73078-3_19 · Cited by 1
Schizophrénies et troubles délirants tardifs à l'âge avancé
Mendez, M., von Gunten, A., & Antunes, M. (2015) · Schweizer Archiv für Neurologie und Psychiatrie · doi:10.4414/sanp.2015.00334 · Cited by 1
Social Functioning among Older Community-Dwelling Persons with Schizophrenia
Meesters, P. D. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108539593.011 · Cited by 1
Admixture analysis of age at onset in older patients with schizophrenia spectrum disorders
Smeets-Janssen, M. M. J., Aderka, I. M., Meesters, P. D., Lange, S. M. M., Schouws, S. N. T. M., & Rhebergen, D. (2020) · International Psychogeriatrics · doi:10.1017/s104161022000085x · Cited by 1
“Interpretation of results is complicated by the fact that age cut-off points for LOS vary between these studies (Hafner et al., 1998; Hanssen et al., 2015; Vahia et al., 2010).”
BackgroundMethodResultInfluentialVannorsdall, T. D., & Schretlen, D. J. (2019) · Clinical handbooks in neuropsychology · doi:10.1007/978-3-319-93497-6_42 · Cited by 1
Ryssia Wolfsohn's 1907 dissertation on “the heredity of dementia praecox”
Kendler, K. S., & Klee, A. (2023) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32953 · Cited by 1
“…on Wolfsohn's the age-of-onset data of male and female patients, in which it is female patients display a slight increase in the ages of 40 – 45 years, Bleuler suggests that this could be due to menopause (pp. 278 – 279) (Bleuler, 1911), anticipating more recent ideas (Vahia et al., 2010).”
BackgroundMuralidharan, A., & Harvey, P. D. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_964 · Cited by 1
Psychiatric symptoms and disorders in old age: prevalence, course and diagnostic thresholds
Sigström, R. (2015) · Gothenburg University Publications Electronic Archive (Gothenburg University)
New Perspectives on Late-Life Psychosis
Köhler, S., & Palmer, B. W. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.11.003
Self-citationNagaratnam, N., Nagaratnam, K., & Cheuk, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-32700-6_76-1
Psychoseerkrankungen im höheren Lebensalter
Supprian, T. (2017) · Elsevier eBooks · doi:10.1016/b978-3-437-21155-3.00020-4
Shizofrenija z začetkom v poznem življenjskem obdobju
Veranič, L. Ž., Grilj, V., & Bergant, G. (2018) · Slovenian Medical Journal · doi:10.6016/zdravvestn.1952
Schizophrenie bei Kindern, Jugendlichen und alten Menschen
SCHIMMELMANN, B. G., Falkai, P., & Förstl, H. (2016) · Elsevier eBooks · doi:10.1016/b978-3-437-22305-1.00005-3
Metadata
- Authors
- Vahia, I. V., Palmer, B. W., Depp, C., Fellows, I., Golshan, S., Kraemer, H. C., & Jeste, D. V.
- Affiliations
- University of California San Diego (US)
- Stanford Medicine (US)
- Corresponding author
- Jeste, D. V.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2010-02-25
- Volume
- 122
- Issue
- 5
- Pages
- 414-426
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- PMC
- PMC3939834
- OpenAlex
- W1752961086
- Cited by
- 119
- References
- 95
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 10 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 12 · 2017: 8 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 10 · 2012: 13
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of California, San Diego
- National Institute of Mental Health (P30MH080002, MH-43693, MH080002, MH019934, R01MH064722, MH 064722, T32MH019934)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- late-onset schizophrenia, early-onset schizophrenia, schizophrenia subtypes, schizophrenia diagnosis, neurocognitive function, functioning, psychopathology, negative symptoms, processing speed, auditory working memory, antipsychotic dosing, age of onset
- MeSH terms
- Activities of Daily Living, Adult, Age Factors, Aged, Analysis of Variance, Cognition, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Sex Factors, Chi-Square Distribution, Linear Models, Age of Onset
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
