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Cited by 119Schizophrenia research and treatmentMental Health and PsychiatryDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.

Is late‐onset schizophrenia a subtype of schizophrenia?

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Vahia, I. V., Palmer, B. W., Depp, C., Fellows, I., Golshan, S., Kraemer, H. C., Jeste, D. V.·2010·Acta Psychiatrica Scandinavica
DOI 10.1111/j.1600-0447.2010.01552.xPMC PMC3939834
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Abstract

Vahia IV, Palmer BW, Depp C, Fellows I, Golshan S, Kraemer HC, Jeste DV. Is late‐onset schizophrenia a subtype of schizophrenia? Objective: To determine whether late‐onset schizophrenia (LOS, onset after age 40) should be considered a distinct subtype of schizophrenia. Method: Participants included 359 normal comparison subjects (NCs) and 854 schizophrenia out‐patients age >40 (110 LOS, 744 early‐onset schizophrenia or EOS). Assessments included standardized measures of psychopathology, neurocognition, and functioning. Results: Early‐onset schizophrenia and LOS groups differed from NCs on all measures of psychopathology and functioning, and most cognitive tests. Early‐onset schizophrenia and LOS groups had similar education, severity of depressive, negative, and deficit symptoms, crystallized knowledge, and auditory working memory, but LOS patients included more women and married individuals, had less severe positive symptoms and general psychopathology, and better processing speed, abstraction, verbal memory, and everyday functioning, and were on lower antipsychotic doses. Most EOS–LOS differences remained significant after adjusting for age, gender, severity of negative or deficit symptoms, and duration of illness. Conclusion: Late‐onset schizophrenia should be considered a subtype of schizophrenia.

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Research works printed but not linked: 15

  1. Oxford University Press.Oxford English Dictionary Online.2008. Available at:http://www.oed.com(accessed 18 February 2009).
  2. Bleuler M, 1943, Die spatschizophrenen krankheitsbilder, Fortschritte der Neurologie Psychiatrie, 15, 259
  3. Takei N, 1999, Late‐onset schizophrenia, 93
  4. Ableskov K, 1999, Late‐onset schizophrenia, 89
  5. Riecher‐Rössler A, 1999, Late‐onset schizophrenia, 55
  6. Howard R, 2009, Schizophrenia
  7. Rabins PV, 1999, Late onset schizophrenia, 47
  8. 10.1097/00019442-200512000-00009 · DOI
  9. Guy W, 1976, ECDEU Assessment Manual for Psychopharmacology: U.S. Department of Health, Education, and Welfare (ADM) 76‐338
  10. Wechsler D, 1981, Wechsler adult intelligence scale – revised
  11. Wechsler D, 1997, Wechsler adult intelligence scale ‐ third edition (WAIS‐III). Administration and scoring manual
  12. Kongs SK, 2000, Wisconsin card sorting test – 64 card version. Professional manual
  13. Delis DC, 1987, California verbal learning test (CVLT)
  14. Spitzer RL, 1990, Structured clinical interview for the DSM‐III‐R, patient edition/non‐patient edition. (SCID‐P/SCID‐NP)
  15. First MB, 2002, Structured clinical interview for DSM‐IV‐TR axis I disorders, research version, patient edition with psychotic screen (SCID‐I/P W/ PSY SCREEN)

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Metadata

Authors
Vahia, I. V., Palmer, B. W., Depp, C., Fellows, I., Golshan, S., Kraemer, H. C., & Jeste, D. V.
Affiliations
  • University of California San Diego (US)
  • Stanford Medicine (US)
Corresponding author
Jeste, D. V.
ORCID
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2010-02-25
Volume
122
Issue
5
Pages
414-426
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/j.1600-0447.2010.01552.x
PMC
PMC3939834
OpenAlex
W1752961086
Cited by
119
References
95
Citations by year
2026: 2 · 2025: 2 · 2024: 10 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 12 · 2017: 8 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 10 · 2012: 13
FWCI
6.34
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • University of California, San Diego
  • National Institute of Mental Health (P30MH080002, MH-43693, MH080002, MH019934, R01MH064722, MH 064722, T32MH019934)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
late-onset schizophrenia, early-onset schizophrenia, schizophrenia subtypes, schizophrenia diagnosis, neurocognitive function, functioning, psychopathology, negative symptoms, processing speed, auditory working memory, antipsychotic dosing, age of onset
MeSH terms
Activities of Daily Living, Adult, Age Factors, Aged, Analysis of Variance, Cognition, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Sex Factors, Chi-Square Distribution, Linear Models, Age of Onset

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