The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
The chemokine system – a major regulator of angiogenesis in health and disease
Abstract
The chemokine system controls leukocyte trafficking during homeostasis as well as during inflammation and is necessary for the linkage between innate and adaptive immunity. Tissue regulation outside the hematopoietic compartment, for instance, angiogenesis, organogenesis and tumor development, growth and metastasis, is another important function of the chemokine system. The chemokine‐mediated regulation of angiogenesis is highly sophisticated and fine tuned, and involves pro‐angiogenic chemokines, for instance, CXCL8/IL8 interacting with the CXCR2 receptor, and anti‐angiogenic (i.e. angiostatic) chemokines, for instance, CXCL10/IP10 interacting with the CXCR3 receptor. Chemokines also regulate angiogenesis in a receptor‐independent manner by means of a perturbation of bFGF and VEGF function. The current review focuses on the influence of the chemokine system in angiogenesis. Examples of the delicate angiogenesis regulation by the chemokine system in, for instance, wound healing and of the dysregulation in, for instance, tumor development are provided along with the interesting phenomenon of molecular piracy of host‐encoded genes within the chemokine system. This phenomenon is a general strategy to circumvent and exploit the immune system – and thereby improve survival – for many viruses. Yet, a certain group of herpesviruses – the γ2‐herpesviruses – encode a functional CXCR2 receptor homolog that is activated by angiogenic chemokines and antagonized by angiostatic chemokines, and this particular gene seems to cause the development of a vascular tumor – Kaposi's sarcoma – in the host.
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Cites
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Cited by
Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160
Bachelerie, F., Ben-Baruch, A., Burkhardt, A. M., Combadiere, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre-Ulrich, A. H., Locati, M., Luster, A. D., et al. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 850
Self-citationRole of chemokines in tumor growth
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CXCR3 ligands in disease and therapy
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Metadata
- Authors
- ROSENKILDE, M. M., & SCHWARTZ, T. W.
- Venue
- APMIS
- Publisher
- Wiley
- Published
- 2004-07
- Volume
- 112
- Issue
- 7-8
- Pages
- 481-495
- ISSN
- 0903-4641 (ISSN-L)
- 1600-0463
- OpenAlex
- W2057022448
- Cited by
- 255
- References
- 101
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- ROSENKILDE, M. M., & SCHWARTZ, T. W. (2004). The chemokine system – a major regulator of angiogenesis in health and disease. APMIS. https://doi.org/10.1111/j.1600-0463.2004.apm11207-0808.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
