The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
The pathogenesis of drug‐induced gingival overgrowth
Abstract
Abstract Gingival overgrowth is a well‐documented unwanted effect, associated with phenytoin, cyclosporin. and the calcium channel blockers. The pathogenesis of drug‐induced gingival overgrowth is uncertain, and there appears to be no unifying hypothesis that links together the 3 commonly implicated drugs. In this review, we consider a multifactorial model which expands on the interaction between drug and/or metabolite, with the gingival fibroblasts. Factors which impact upon this model include age. genetic predisposition, pharmacokinetic variables, plaque‐induced inflammatory and immunological changes and activation of growth factors. Of these, genetic factors which give rise to fibroblast heterogeneity, gingival inflammation, and pharmacokinetic variables appear to be significant in the expression of gingival overgrowth, A more thorough understanding of the pathogenesis of this unwanted effect will hopefully elucidate appropriate mechanisms for its control.
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Cites
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Kronbach, T., Fischer, V., & Meyer, U. A. (1988) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1988.87 · Cited by 533
Interleukin 1 stimulation of collagenase production by cultured fibroblasts.
Postlethwaite, A. E., Lachman, L. B., Mainardi, C. L., & Kang, A. H. (1983) · The Journal of experimental medicine · doi:10.1084/jem.157.2.801 · Cited by 368
Human cytochromes P450: problems and prospects
Gonzalez, F. J. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90107-h · Cited by 363
Isolation and amino acid sequence of cyclophilin.
Harding, M. W., Handschumacher, R. E., & Speicher, D. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83945-5 · Cited by 293
THE TREATMENT OF EPILEPSY WITH SODIUM DIPHENYL HYDANTOINATE
KIMBALL, O. P. (1939) · Journal of the American Medical Association · doi:10.1001/jama.1939.02800130028009 · Cited by 267
Initial observation that cyclosporin‐A induces gingival enlargement in man
Rateitschak‐Plüss, E. M., Hefti, A., Lörtscher, R., & Thiel, G. (1983) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1983.tb01272.x · Cited by 266
Incidence of diphenylhydantoin gingival hyperplasia
Angelopoulos, A. P., & Goaz, P. W. (1972) · Oral Surgery, Oral Medicine, Oral Pathology · doi:10.1016/0030-4220(72)90228-9 · Cited by 233
Fibrous hyperplasia of the gingiva: A side effect of cyclosporin A therapy
Wysocki, G. P., Gretzinger, H. A., Laupacis, A., Ulan, R. A., & Stiller, C. R. (1983) · Oral Surgery, Oral Medicine, Oral Pathology · doi:10.1016/0030-4220(83)90327-4 · Cited by 220
Diphenylhydantoin (dilantin) gingival hyperplasia: drug-induced abnormality of connective tissue.
Hassell, T. M., Page, R. C., Narayanan, A. S., & Cooper, C. G. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.8.2909 · Cited by 215
Cited by
Dental plaque-induced gingival conditions
Murakami, S., Mealey, B. L., Mariotti, A., & Chapple, I. L. C. (2018) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12937 · Cited by 358
Dental Plaque‐Induced Gingival Diseases
Mariotti, A. (1999) · Annals of Periodontology · doi:10.1902/annals.1999.4.1.7 · Cited by 332
Prevalence of Gingival Overgrowth Induced by Calcium Channel Blockers: A Community‐Based Study
Ellis, J. S., Seymour, R. A., Steele, J. G., Robertson, P., Butler, T. J., & Thomason, J. M. (1999) · Journal of Periodontology · doi:10.1902/jop.1999.70.1.63 · Cited by 273
Self-citationHallmon, W. W., & Rossmann, J. A. (1999) · Periodontology 2000 · doi:10.1111/j.1600-0757.1999.tb00175.x · Cited by 148
Gingival Overgrowth in Children: Epidemiology, Pathogenesis, and Complications. A Literature Review
Doufexi, A., Mina, M., & Ioannidou, E. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.1.3 · Cited by 146
Metadata
- Authors
- Seymour, R. A., Thomason, J. M., & Ellis, J. S.
- Venue
- Journal of Clinical Periodontology
- Publisher
- Wiley
- Published
- 1996-03
- Volume
- 23
- Issue
- 3
- Pages
- 165-175
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W2166027006
- Cited by
- 403
- References
- 78
- FWCI
- 44.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Seymour, R. A., Thomason, J. M., & Ellis, J. S. (1996). The pathogenesis of drug‐induced gingival overgrowth. Journal of Clinical Periodontology. https://doi.org/10.1111/j.1600-051x.1996.tb02072.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
