The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Host response modulation in the management of periodontal diseases
Abstract
Objective: To review the biological mechanisms and clinical utility of therapeutic modulation of the host response in the management of periodontal diseases. Material and methods: A search of MEDLINE–PubMed was performed up to and including December 2004. The search was limited to in vitro, experimental animal and clinical studies published in English. The selection criteria included all levels of available evidence: systematic reviews, randomised‐controlled clinical trials, controlled clinical trials, prospective and retrospective cohort studies and case reports of human and experimental animal studies. Results: Six targets for non‐microbial chemotherapeutic intervention were identified. Clinical trials have demonstrated the ability of non‐steroidal anti‐inflammatory drugs to slow periodontal disease progression. However, recently reported serious adverse effects preclude the use of cyclooxygenase‐2 inhibitors as an adjunct to periodontal therapy. Adjunctive use of subantimicrobial dose doxycycline to non‐surgical periodontal therapy is beneficial in the management of chronic periodontitis over 12 months. Controversial data exist on the effects of bisphosphonate administration as an adjunct to periodontal therapy. Evidence on modulation of other host mediators including lipoxins, cytokines and nitric oxide synthase is limited to animal research. Conclusion: After validation in long‐term clinical trials, adjunctive host modulation therapy may prove advantageous in the management of periodontal diseases.
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Cited by
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Evolutionary divergence and functions of the human interleukin (IL) gene family
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Mangiferin: A possible strategy for periodontal disease to therapy
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Metadata
- Authors
- Salvi, G. E., & Lang, N. P.
- Venue
- Journal of Clinical Periodontology
- Publisher
- Wiley
- Published
- 2005-08-26
- Volume
- 32
- Issue
- s6
- Pages
- 108-129
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W1980620743
- Cited by
- 276
- References
- 166
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
