A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17
Open accessAbstract
For almost two decades, the Th1/Th2 paradigm has offered a productive conceptual framework for investigating the pathogenesis of periodontitis. However, as with many other inflammatory diseases, the observed role of T-cell-mediated immunity in periodontitis did not readily fit this model. A new subset of CD4+ T-cells was recently discovered that explains many of the discrepancies in the classic Th1/Th2 model, and has been termed “Th17” based on its secretion of the novel pro-inflammatory cytokine IL-17. The identification of Th17 cells as a novel effector T-cell population compels re-examination of periodontitis in the context of the new subset and its signature cytokines. This review aims to offer a clarifying insight into periodontal pathogenesis under the extended Th1/Th2/Th17 paradigm, and is predicated on the principle that periodontal disease activity is determined by a complex interplay between the immune system and periodontal pathogens. The re-examination of existing periodontal literature and further studies in the light of these new discoveries may help explain how the inflammatory response results in damage to the periodontium while generally failing to control the pathogens. This knowledge is essential for the development of immunomodulatory intervention strategies for fine-tuning the host response to maximize the protective and minimize the destructive aspects of the periodontal host response. Moreover, with the advent of anti-cytokine biologic drugs that target the Th1 and Th17 pathways in autoimmunity, the potential consequences to periodontal disease susceptibility in humans need to be understood.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-17, produced primarily by CD4+ Th17 cells, acts to enhance chemokine production by target cells in various tissues to promote/attract monocytes and neutrophils to those tissue (especially mucosal) sites, and in combination with sICAM suggests the predominance of a Th1 phenotypic response (acute pro-inflammatory state).
“IL-17, produced primarily by CD4+ Th17 cells, acts to enhance chemokine production by target cells in various tissues to promote/attract monocytes and neutrophils to those tissue (especially mucosal) sites, and in combination with sICAM suggests the predominance of a Th1 phenotypic response (acute pro-inflammatory state) [25-30].”
From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [25]
Split into 2 atoms — 0 confirmed, 1 partially supported, 1 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThis increased expression of adhesion molecules stimulates the trans-endothelial migration of neutrophils.
“This increased expression of adhesion molecules stimulates the trans-endothelial migration of neutrophils) [25-29].”
From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [25]
The section “Th17 Cells in Experimental Animal Disease and in Humans” (page unavailable) says that ICAM-1 is a target of IL-17 signaling and links that signaling to neutrophil migration and recruitment. It does not specifically say that increased adhesion-molecule expression stimulates neutrophils’ trans-endothelial migration. (LLM, conf=0.80)
Experimental — accuracy not yet measuredIL-17 promotes endothelial activation by inducing the expression of endothelial adhesion markers (E-selectin, VCAM-1, and ICAM-1) in a p38 MAPK-dependent manner.
“IL-17 promotes endothelial activation by inducing the expression of endothelial adhesion markers (E-selectin, VCAM-1, and ICAM-1) in a p38 MAPK-dependent manner.”
From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [25]
The passages from “Revising the Th1/Th2 Paradigm” discuss IL-17’s inflammatory signaling and synergy with TNFα, but do not address endothelial activation. Searches of our copy for endothelial cells, adhesion molecules, ICAM-1, and p38 MAPK found no passage connecting IL-17 to the three named markers through that pathway; page numbers were not provided. (LLM, conf=0.73)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,438 · see citing works
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742 · see citing works
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713 · see citing works
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265 · see citing works
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166 · see citing works
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works
Pihlstrom, B. L., Michalowicz, B. S., & Johnson, N. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67728-8 · Cited by 3,718 · see citing works
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087 · see citing works
A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works
Cytokines in the pathogenesis of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,523 · see citing works
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371 · see citing works
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330 · see citing works
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Collison, L., Workman, C., Kuo, T. T., Boyd, K., Wang, Y., Vignali, K. M., Cross, R., Sehy, D., Blumberg, R., & Vignali, D. (2007) · Nature · doi:10.1038/nature06306 · Cited by 2,152 · see citing works
Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,134 · see citing works
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861 · see citing works
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848 · see citing works
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842 · see citing works
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,841 · see citing works
Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S., Inoue, K., Kamatani, N., Gillespie, M. T., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5703 · Cited by 1,696 · see citing works
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669 · see citing works
T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605 · see citing works
Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
Girardin, S. E., Boneca, I. G., Carneiro, L. A. M., Antignac, A., Jéhanno, M., Viala, J., Tedin, K., Taha, M., Labigne-Roussel, A., Zäthringer, U., et al. (2003) · Science · doi:10.1126/science.1084677 · Cited by 1,574 · see citing works
Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061775 · Cited by 1,554 · see citing works
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 1× · see citing works
“These findings were consistent with reports that IL-17 is not made by Th2 or Th1 cells, despite being CD4+ cell-derived (Fossiez et al., 1996; Aarvak et al., 1999).”
Ye, P., Rodriguez, F. H., Kanaly, S. T., Stocking, K. L., Schurr, J. R., Schwarzenberger, P. O., Oliver, P., Huang, W., Zhang, P., Zhang, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.519 · Cited by 1,522 · see citing works
McGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T., & Cua, D. J. (2007) · Nature Immunology · doi:10.1038/ni1539 · Cited by 1,520 · see citing works
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507 · see citing works
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466 · see citing works
Pflanz, S., Timans, J. C., Cheung, J., Rosales, R., Kanzler, H., Gilbert, J., Hibbert, L., Churakova, T., Travis, M. A., Vaisberg, E., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00324-2 · Cited by 1,462 · see citing works
Steinman, L. (2007) · Nature Medicine · doi:10.1038/nm1551 · Cited by 1,367 · see citing works
Prostaglandins as modulators of immunity
Harris, S. G., Padilla, J., Koumas, L., Ray, D. M., & Phipps, R. P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02154-8 · Cited by 1,168 · see citing works
Dectin-1 is required for β-glucan recognition and control of fungal infection
Taylor, P. R., Tsoni, S. V., Willment, J. A., Dennehy, K. M., Rosas, M., Findon, H., Haynes, K., Steele, C. H., Botto, M., Gordon, S., et al. (2006) · Nature Immunology · doi:10.1038/ni1408 · Cited by 1,155 · see citing works
Pathogenesis of inflammatory periodontal disease. A summary of current work.
Rc, P., & Schroeder, H. E. (1976) · PubMed · Cited by 1,102 · see citing works
Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,053 · see citing works
Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,009 · see citing works
The Contribution of Interleukin‐1 and Tumor Necrosis Factor to Periodontal Tissue Destruction
Graves, D. T., & Cochran, D. L. (2003) · Journal of Periodontology · doi:10.1902/jop.2003.74.3.391 · Cited by 1,006 · see citing works
Stumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A., Sehy, D., et al. (2006) · Nature Immunology · doi:10.1038/ni1376 · Cited by 955 · see citing works
Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17
Stark, M. A., Huo, Y., Burcin, T. L., MORRIS, M. A., Olson, T. S., & Ley, K. F. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.011 · Cited by 945 · see citing works
Hirota, K., Yoshitomi, H., Hashimoto, M., Maeda, S., Teradaira, S., Sugimoto, N., Yamaguchi, T., Nomura, T., Ito, H., Nakamura, T., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071397 · Cited by 937 · see citing works
The IL-12 Family of Heterodimeric Cytokines
Trinchieri, G., Pflanz, S., & Kastelein, R. A. (2003) · Immunity · doi:10.1016/s1074-7613(03)00296-6 · Cited by 920 · see citing works
Agrawal, S., Agrawal, A., Doughty, B. L., Gerwitz, A., Blenis, J., Dyke, T. E. V., & Pulendran, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.4984 · Cited by 726 · see citing works
Differentiation and function of Th17 T cells
Stockinger, B., & Veldhoen, M. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.04.005 · Cited by 716 · see citing works
Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells
Re, F., & Strominger, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105927200 · Cited by 691 · see citing works
O’Shea, J. J., Ma, A. I., & Lipsky, P. E. (2002) · Nature reviews. Immunology · doi:10.1038/nri702 · Cited by 677 · see citing works
Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases
Lucey, D. R., Clerici, M., & Shearer, G. M. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.4.532 · Cited by 664 · see citing works
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 648 · see citing works
TH1 cells control themselves by producing interleukin-10
O’Garra, A., & Vieira, P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2097 · Cited by 614 · see citing works
Assuma, R., Oates, T. W., Cochran, D. L., Amar, S., & Graves, D. T. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.403 · Cited by 598 · see citing works
Microbial lipopeptides induce the production of IL-17 in Th cells
Infante-Duarte, C., Horton, H. F., Byrne, M. C., & Kamradt, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6107 · Cited by 586 · see citing works
Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus
Karp, C. L., Wysocka, M., Wahl, L. M., Ahearn, J. M., Cuomo, P. J., Sherry, B. A., Trinchieri, G., & Griffin, D. E. (1996) · Science · doi:10.1126/science.273.5272.228 · Cited by 548 · see citing works
Hymowitz, S. G., Filvaroff, E. H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R. F., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5332 · Cited by 548 · see citing works
Abdollahi-Roodsaz, S., Joosten, L. A. B., Koenders, M. I., Devesa, I., Roelofs, M. F., Radstake, T. R. D. J., Heuvelmans-Jacobs, M., Akira, S., Nicklin, M. J. H., Ribeiro-Dias, F., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32639 · Cited by 527 · see citing works
van Beelen, A. J., Zelinková, Z., Taanman-Kueter, E. W., Muller, F. J. M., Hommes, D. W., Zaat, S. A. J., Kapsenberg, M. L., & de Jong, E. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.013 · Cited by 516 · see citing works
Resolution of Inflammation: A New Paradigm for the Pathogenesis of Periodontal Diseases
Dyke, T. E. V., & Serhan, C. N. (2003) · Journal of Dental Research · doi:10.1177/154405910308200202 · Cited by 513 · see citing works
Lipopolysaccharides from Distinct Pathogens Induce Different Classes of Immune Responses In Vivo
Pulendran, B., Kumar, P., Cutler, C. W., Mohamadzadeh, M., Dyke, T. E. V., & Banchereau, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5067 · Cited by 483 · see citing works
Gowen, M., & Mundy, G. R. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2478 · Cited by 479 · see citing works
Wong, C. K., Ho, C. Y., Li, E. K., & Lam, C. (2000) · Lupus · doi:10.1191/096120300678828703 · Cited by 471 · see citing works
Immune Response: The Key to Bone Resorption in Periodontal Disease
Taubman, M. A., Valverde, P., Han, X., & Kawai, T. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.11-s.2033 · Cited by 460 · see citing works
Happel, K. I., Zheng, M., Young, E. A., Quinton, L. J., Lockhart, E., Ramsay, A. J., Shellito, J. E., Schurr, J. R., Bagby, G. J., Nelson, S., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4432 · Cited by 448 · see citing works
IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells
Aarvak, T., Chabaud, M., Miossec, P., & Natvig, J. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1246 · Cited by 410 · see citing works
The use of rodent models to investigate host–bacteria interactions related to periodontal diseases
Graves, D. T., Fine, D. H., Teng, Y. A., Dyke, T. E. V., & Hajishengallis, G. (2008) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01172.x · Cited by 406 · see citing works
Self-citationRegulation of the T cell response
Romagnani, S. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02606.x · Cited by 402 · see citing works
Yu, J. J., Ruddy, M. J., Wong, G. C., Sfintescu, C., Baker, P. J., Smith, J. B., Evans, R. T., & Gaffen, S. L. (2007) · Blood · doi:10.1182/blood-2005-09-010116 · Cited by 372 · see citing works
Self-citationLiang, S. C., Long, A. J., Bennett, F., Whitters, M. J., Karim, R., Collins, M. A., Goldman, S. J., Dunussi‐Joannopoulos, K., Williams, C. M. M., Wright, J. F., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7791 · Cited by 368 · see citing works
Ruddy, M. J., Wong, G. C., Liu, X. K., Yamamoto, H., Kasayama, S., Kirkwood, K. L., & Gaffen, S. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308809200 · Cited by 364 · see citing works
Self-citationKelly, M. N., Kolls, J. K., Happel, K., Schwartzman, J. D., Schwarzenberger, P. O., Combe, C. L., Moretto, M. M., & Khan, I. A. (2004) · Infection and Immunity · doi:10.1128/iai.73.1.617-621.2005 · Cited by 351 · see citing works
Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F
Kuestner, R. E., Taft, D. W., Haran, A. C., Brandt, C. S., Brender, T., Lum, K. D., Harder, B., Okada, S. L., Ostrander, C. D., Kreindler, J. L., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5462 · Cited by 349 · see citing works
Baker, P. J., Dixon, M., Evans, R. T., Dufour, L., Johnson, E. A., & Roopenian, D. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.2804-2809.1999 · Cited by 337 · see citing works
Schwarzenberger, P. O., Russa, V. L., Miller, A., Ye, P., Huang, W., Zieske, A. W., Nelson, S., Bagby, G. J., Stoltz, D. A., Mynatt, R. L., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6383 · Cited by 325 · see citing works
Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
Wright, J. F., Guo, Y., Quazi, A., Luxenberg, D. P., Bennett, F., Ross, J. F., Qiu, Y., Whitters, M. J., Tomkinson, K. N., Dunussi-Joannopoulos, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700499200 · Cited by 319 · cited 3× · see citing works
“Not surprisingly, the IL-17A/F heterodimer signals with intermediate potency (Chang and Dong, 2007; Wright et al., 2007).”
The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation
Kikly, K. K., Liu, L., Na, S., & Sedgwick, J. D. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.09.008 · Cited by 302 · see citing works
Akimzhanov, A. M., Yang, X. O., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600322200 · Cited by 302 · see citing works
Identification of Common Transcriptional Regulatory Elements in Interleukin-17 Target Genes
Shen, F., Hu, Z., Goswami, J., & Gaffen, S. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604597200 · Cited by 294 · see citing works
Self-citationBaker, P. J., Evans, R. T., & Roopenian, D. C. (1994) · Archives of Oral Biology · doi:10.1016/0003-9969(94)90055-8 · Cited by 290 · see citing works
Sheibanie, A. F., Yen, J.-H. J., Khayrullina, T., Emig, F. A., Zhang, M., Tuma, R. F., & Ganea, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.8138 · Cited by 283 · see citing works
Regulation of Interleukin-12 by Complement Receptor 3 Signaling
Marth, T., & Kelsall, B. L. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.11.1987 · Cited by 281 · see citing works
A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
Chang, S. H., & Dong, C. (2007) · Cell Research · doi:10.1038/cr.2007.35 · Cited by 280 · see citing works
Design of effective immunotherapy for human autoimmunity
Feldmann, M., & Steinman, L. (2005) · Nature · doi:10.1038/nature03727 · Cited by 277 · see citing works
Host response modulation in the management of periodontal diseases
Salvi, G. E., & Lang, N. P. (2005) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00785.x · Cited by 275 · see citing works
Burns, E., Bachrach, G., Shapira, L., & Nussbaum, G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8296 · Cited by 275 · see citing works
Stimulation of lymphocyte transformation by bacterial antigens in patients with periodontal disease
Ivanyi, L., & Lehner, T. (1970) · Archives of Oral Biology · doi:10.1016/0003-9969(70)90121-4 · Cited by 274 · see citing works
C-type lectin receptors in antifungal immunity
Willment, J. A., & Brown, G. D. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2007.10.012 · Cited by 268 · see citing works
Shen, F., Ruddy, M. J., Plamondon, P., & Gaffen, S. L. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0904490 · Cited by 268 · see citing works
Self-citationMMPs, IL-1, and TNF are Regulated by IL-17 in Periodontitis
Beklen, A., Ainola, M., Hukkanen, M., Gürgan, C. A., Sorsa, T. A., & Konttinen, Y. T. (2007) · Journal of Dental Research · doi:10.1177/154405910708600409 · Cited by 259 · see citing works
Shen, F., & Gaffen, S. L. (2008) · Cytokine · doi:10.1016/j.cyto.2007.11.013 · Cited by 255 · see citing works
Self-citationVernal, R., Dutzan, N., Chaparro, A. P., Puente, J., Valenzuela, M. A., & Gamonal, J. A. (2005) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00684.x · Cited by 253 · see citing works
IL-12 Alone and in Synergy with IL-18 Inhibits Osteoclast Formation In Vitro
Horwood, N. J., Elliott, J., Martin, T. J., & Gillespie, M. T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.4915 · Cited by 248 · see citing works
TH1-TH2: a Procrustean paradigm
Gor, D. O., Rose, N. R., & Greenspan, N. S. (2003) · Nature Immunology · doi:10.1038/ni0603-503 · Cited by 240 · see citing works
Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes
Chung, Y., Yang, X. O., Chang, S. H., Ma, L., Tian, Q., & Dong, C. (2006) · Cell Research · doi:10.1038/sj.cr.7310106 · Cited by 232 · see citing works
Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation
Kawashima, N., & Stashenko, P. (1999) · Archives of Oral Biology · doi:10.1016/s0003-9969(98)00094-6 · Cited by 223 · see citing works
The potential role of interleukin‐17 in the immunopathology of periodontal disease
Takahashi, K., Azuma, T., Motohira, H., Kinane, D. F., & Shin, K. (2005) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00676.x · Cited by 208 · see citing works
Ruddy, M. J., Shen, F., Smith, J. B., Sharma, A., & Gaffen, S. L. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0204065 · Cited by 208 · see citing works
Self-citationCompromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice
Ghilardi, N., Kljavin, N. M., Chen, Q., Lucas, S., Gurney, A. L., & de Sauvage, F. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2827 · Cited by 206 · see citing works
Garlet, G. P., Cardoso, C. R. D. B., Silva, T. A., Ferreira, B. R., Ávila‐Campos, M. J., Cunha, F. Q., & Silva, J. S. (2006) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2005.00245.x · Cited by 201 · see citing works
D estructive P eriodontitis L esions are D etermined by the N ature of the L ymphocytic R esponse
Gemmell, E., Yamazaki, K., & Seymour, G. J. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300104 · Cited by 199 · see citing works
Wang, M., Shakhatreh, M.-A. K., James, D., Liang, S., Nishiyama, S.-I., Yoshimura, F., Demuth, D. R., & Hajishengallis, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2349 · Cited by 191 · see citing works
Self-citationThe role of T cells in periodontal disease: homeostasis and autoimmunity
Gemmell, E., Yamazaki, K., & Seymour, G. J. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00173.x · Cited by 189 · see citing works
Interleukin‐11 and IL‐17 and the Pathogenesis of Periodontal Disease
Johnson, R. B., Wood, N., & Serio, F. G. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.1.37 · Cited by 185 · see citing works
IL-10, But Not IL-4, Suppresses Infection-Stimulated Bone Resorption In Vivo
Sasaki, H., Hou, L. A., Belani, A., Wang, C., Uchiyama, T., Müller, R., & Stashenko, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3626 · Cited by 180 · see citing works
Interleukin-17: A novel inflammatory cytokine that bridges innate and adaptive immunity
Jeffrey, J. Y. (2007) · Frontiers in bioscience · doi:10.2741/2667 · Cited by 177 · see citing works
Orozco, A., Gemmell, E., Bickel, M., & Seymour, G. J. (2006) · PubMed · doi:10.1111/j.1399-302x.2006.00292.x · Cited by 177 · see citing works
Hajishengallis, G., Tapping, R. I., Harokopakis, E., Nishiyama, S.-I., Ratti, P., Schifferle, R. E., Lyle, E. A., Triantafilou, M., Triantafilou, K., & Yoshimura, F. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00730.x · Cited by 176 · see citing works
Self-citationHow microorganisms tip the balance between interleukin-12 family members
Goriely, S., Neurath, M. F., & Goldman, M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2225 · Cited by 175 · see citing works
Prostaglandin E2 induces IL‐23 production in bone marrow‐derived dendritic cells
Sheibanie, A. F., Tadmori, I., Jing, H., Vassiliou, E. K., & Ganea, D. (2004) · The FASEB Journal · doi:10.1096/fj.03-1367fje · Cited by 168 · see citing works
TH-17 differentiation: of mice and men
Laurence, A. D. J., & O’Shea, J. J. (2007) · Nature Immunology · doi:10.1038/ni0907-903 · Cited by 166 · see citing works
Maitra, A., Shen, F., Hanel, W., Mossman, K., Tocker, J., Swart, D., & Gaffen, S. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611589104 · Cited by 165 · see citing works
Self-citationMannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
Ip, W., Takahashi, K., Moore, K. J., Stuart, L. M., & Ezekowitz, R. A. B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071164 · Cited by 163 · see citing works
Cytokine Profiles of T-lymphocytes from Gingival Tissues with Pathological Pocketing
Takeichi, O., Haber, J. E., Kawai, T., Smith, D. J., Moro, I., & Taubman, M. A. (2000) · Journal of Dental Research · doi:10.1177/00220345000790080401 · Cited by 159 · see citing works
Kawai, T., Eisen-Lev, R., Seki, M., Eastcott, J. W., Wilson, M. E., & Taubman, M. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.2102 · Cited by 156 · see citing works
Yoshimura, A., Kaneko, T., Kato, Y., Golenbock, D. T., & Hara, Y. (2002) · Infection and Immunity · doi:10.1128/iai.70.1.218-225.2002 · Cited by 156 · see citing works
The role of immune responses in bone loss during periodontal disease
Baker, P. J. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)01272-7 · Cited by 152 · see citing works
Preferential inhibition of cytokine-stimulated bone resorption by recombinant interferon gamma
Gowen, M., Nedwin, G. E., & Mundy, G. R. (1986) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650010511 · Cited by 151 · see citing works
Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue
Lappin, D. F., MacLeod, C., Kerr, A. R., Mitchell, T., & Kinane, D. F. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01448.x · Cited by 150 · see citing works
Interleukin‐17: A New Paradigm in Inflammation, Autoimmunity, and Therapy
Kramer, J. M., & Gaffen, S. L. (2007) · Journal of Periodontology · doi:10.1902/jop.2007.060392 · Cited by 147 · see citing works
Self-citationIL-6 Secretion by Human Pancreatic Periacinar Myofibroblasts in Response to Inflammatory Mediators
Shimada, M., Andoh, A., Hata, K., Tasaki, K., Araki, Y., Fujiyama, Y., & Bamba, T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.861 · Cited by 142 · see citing works
Gaffen, S. L., Kramer, J. M., Yu, J. J., & Shen, F. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74010-9 · Cited by 135 · see citing works
Self-citationEssential Roles of c-Rel in TLR-Induced IL-23 p19 Gene Expression in Dendritic Cells
Carmody, R. J., Ruan, Q., Liou, H., & Chen, Y. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.186 · Cited by 131 · see citing works
Detection of Local and Systemic Cytokines in Adult Periodontitis
Prabhu, A., Michalowicz, B. S., & Mathur, A. (1996) · Journal of Periodontology · doi:10.1902/jop.1996.67.5.515 · Cited by 131 · see citing works
Sasaki, H., Okamatsu, Y., Kawai, T., Kent, R., Taubman, M. A., & Stashenko, P. (2004) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2004.00760.x · Cited by 131 · see citing works
Hajishengallis, G., Shakhatreh, M.-A. K., Wang, M., & Liang, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2359 · Cited by 119 · see citing works
Self-citationFujihashi, K., Yamamoto, M., Hiroi, T., Bamberg, T. V., McGhee, J. R., & Kiyono, H. (1996) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1996.tb08297.x · Cited by 113 · see citing works
Lester, S. R., Bain, J. L., Johnson, R. B., & Serio, F. G. (2007) · Journal of Periodontology · doi:10.1902/jop.2007.060458 · Cited by 113 · see citing works
Yang, C., Song, C., Lee, J., Jung, S.-B., Oh, J.-H., Park, J., Kim, H., Park, J., Paik, T.-H., & Jo, E. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00699.x · Cited by 108 · see citing works
Human variability in innate immunity
Kinane, D. F., Demuth, D. R., Gorr, S., Hajishengallis, G., & Martin, M. H. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2007.00220.x · Cited by 107 · see citing works
Self-citationDarveau, R. P., Arbabi, S., Garcia, I. A., Bainbridge, B., & Maier, R. V. (2002) · Infection and Immunity · doi:10.1128/iai.70.4.1867-1873.2002 · Cited by 107 · see citing works
Regulation of IL-17 production in human lymphocytes
Chen, Z., & O’Shea, J. J. (2007) · Cytokine · doi:10.1016/j.cyto.2007.09.009 · Cited by 106 · see citing works
Tokoro, Y., Matsuki, Y., Yamamoto, T., Suzuki, T., & Hara, K. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.d01-880.x · Cited by 104 · see citing works
Oda, T., Yoshie, H., & Yamazaki, K. (2003) · Oral Microbiology and Immunology · doi:10.1034/j.1399-302x.2003.180105.x · Cited by 96 · see citing works
Th1 Immune Response Promotes Severe Bone Resorption Caused by Porphyromonas gingivalis
Stashenko, P., Gonçalves, R. B., Lipkin, B., Ficarelli, A., Sasaki, H., & Campos‐Neto, A. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060597 · Cited by 95 · see citing works
Targeting the development and effector functions of TH17 cells
Ghilardi, N., & Ouyang, W. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.016 · Cited by 91 · see citing works
Gingival Cell IL‐2 and IL‐4 in Early‐Onset Periodontitis
Manhart, S. S., Reinhardt, R. A., Payne, J. B., Seymour, G. J., Gemmell, E., Dyer, J. K., & Petro, T. M. (1994) · Journal of Periodontology · doi:10.1902/jop.1994.65.9.807 · Cited by 88 · see citing works
Sigusch, B. W., Klinger, G., Glockmann, E., & Simon, H. (1998) · Journal of Periodontology · doi:10.1902/jop.1998.69.10.1098 · Cited by 85 · see citing works
Farah, C., Hu, Y., Riminton, S., & Ashman, R. (2006) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2006.00288.x · Cited by 82 · see citing works
Factors for progression of periodontal diseases
Ellis, S. D., Tucci, M. A., Serio, F. G., & Johnson, R. B. (1998) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.1998.tb01923.x · Cited by 82 · see citing works
Hajishengallis, G., Martin, M., Schifferle, R. E., & Genco, R. J. (2002) · Infection and Immunity · doi:10.1128/iai.70.12.6658-6664.2002 · Cited by 82 · see citing works
Self-citationInterleukin‐18 Concentrations and the Pathogenesis of Periodontal Disease
Johnson, R. B., & Serio, F. G. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.5.785 · Cited by 81 · see citing works
Beertsen, W., Willenborg, M., Everts, V. E., Zirogianni, A., Podschun, R., Schröder, B., Eskelinen, E., & Säftig, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.475 · Cited by 80 · see citing works
IL-10 or not IL-10: that is the question
Jankovic, D. L., & Trinchieri, G. (2007) · Nature Immunology · doi:10.1038/ni1207-1281 · Cited by 78 · see citing works
Some cytokine profiles of T‐helper cells in lesions of advanced periodontitis
Berglundh, T., Liljenberg, B., & Lindhe, J. (2002) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2002.290807.x · Cited by 76 · see citing works
Kikuchi, T., Hahn, C., Tanaka, S., Barbour, S. E., Schenkein, H. A., & Tew, J. G. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5089-5096.2004 · Cited by 75 · see citing works
Aoyagi, T., Sugawara‐Aoyagi, M., Yamazaki, K., & Hara, K. (1995) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.1995.tb00159.x · Cited by 70 · see citing works
Interleukin‐17 plays a role in exacerbation of inflammation within chronic periapical lesions
Čolić, M. J., Vasilijić, S., Gazivoda, D., Vučević, D., Marjanović, M., & Lukić, A. (2007) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2007.00460.x · Cited by 70 · see citing works
Th1 and Th2 cytokine profile in patients with early onset periodontitis and their healthy siblings
Bártová, J., Opatrna, Z., Procházková, J., Krejsa, O., Dušková, J., Mrklas, L., Tlaskalová, H., & Cukrowská, B. (2000) · Mediators of Inflammation · doi:10.1080/096293500411587 · Cited by 68 · see citing works
Noguchi, K., Shitashige, M., Yanai, M., Morita, I., Nishihara, T., Murota, S., & Ishikawa, I. (1996) · Inflammation · doi:10.1007/bf01487046 · Cited by 66 · see citing works
Zhang, Z., Hinrichs, D. J., Lu, H., Chen, H., Zhong, W., & Kolls, J. K. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.09.024 · Cited by 66 · see citing works
Yun, P. L. W., DeCarlo, A. A., Collyer, C. A., & Hunter, N. (2001) · Infection and Immunity · doi:10.1128/iai.69.9.5650-5660.2001 · Cited by 65 · see citing works
Trawling for treasure: tales of T-bet
Glimcher, L. H. (2007) · Nature Immunology · doi:10.1038/ni0507-448 · Cited by 62 · see citing works
Sasaki, H., Suzuki, N., Kent, R., Kawashima, N., Takeda, J., & Stashenko, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6193 · Cited by 61 · see citing works
Ukai, T., Mori, Y., 小野山, 美., & Hara, Y. (2001) · Archives of Oral Biology · doi:10.1016/s0003-9969(01)00057-7 · Cited by 61 · see citing works
Sasaki, H., Balto, K., Kawashima, N., Eastcott, J. W., Hoshino, K., Akira, S., & Stashenko, P. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.1.106-110.2004 · Cited by 55 · see citing works
The use of topical flurbiprofen as an adjunct to non‐surgical management of periodontal disease
Heasman, P. A., Benn, D. K., Kelly, P. J., Seymour, R. A., & Aitken, D. (1993) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1993.tb00389.x · Cited by 51 · see citing works
Jovanović, D., Battista, J. A. D., Martel‐Pelletier, J., Reboul, P., He, Y., Jolicoeur, F. C., & Pelletier, J. (2001) · PubMed · Cited by 47 · see citing works
Alveolar bone loss in T helper 1/T helper 2 cytokine‐deficient mice
Alayan, J., Ivanovski, S., & Farah, C. S. (2006) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00920.x · Cited by 45 · see citing works
Teng, Y.-T. A. (2002) · Infection and Immunity · doi:10.1128/iai.70.9.5269-5273.2002 · Cited by 40 · see citing works
Periodontitis Vaccine Decreases Local Prostaglandin E 2 Levels in a Primate Model
Roberts, F. A., Houston, L. S., Lukehart, S. A., Mancl, L., Persson, G. R., & Page, R. C. (2004) · Infection and Immunity · doi:10.1128/iai.72.2.1166-1168.2004 · Cited by 36 · see citing works
T-Cell Subsets: The More the Merrier
Weaver, C. T., & Murphy, K. M. (2007) · Current Biology · doi:10.1016/j.cub.2006.12.015 · Cited by 34 · see citing works
Effect of adoptive transfer of antigen‐specific B cells on periodontal bone resorption
Harada, Y., Han, X., Yamashita, K., Kawai, T., Eastcott, J. W., Smith, D. J., & Taubman, M. A. (2006) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2005.00839.x · Cited by 32 · see citing works
Increased release of IL‐12p70 by monocytes after periodontal therapy
Fokkema, S. J., Loos, B. G., slegte, C. D., Burger, W., Piscaer, M., IJzerman, Y., & van der Velden, U. (2003) · Journal Of Clinical Periodontology · doi:10.1046/j.0303-6979.2003.00435.x · Cited by 32 · see citing works
Evans, R. I., Mikulecky, M., & Seymour, G. J. (1989) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1989.tb01654.x · Cited by 22 · see citing works
Gemmell, E., Drysdale, K. E., & Seymour, G. J. (2006) · Journal of Periodontology · doi:10.1902/jop.2006.050211 · Cited by 19 · see citing works
Immune Mechanisms of Allergic Airway Disease: Regulation by Transcription Factors
Yamashita, M., Onodera, A., & Nakayama, T. (2007) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v27.i6.40 · Cited by 17 · see citing works
Anti–Interleukin-12 Antibody for Active Crohn's Disease
Jk, K., & Zhang, Z. (2005) · New England Journal of Medicine · doi:10.1056/nejm200502103520619 · Cited by 15 · see citing works
Matsunaga, K., Yamaguchi, H., Klein, T., Friedman, H. P., & Yamamoto, Y. (2003) · Infection and Immunity · doi:10.1128/iai.71.11.6672-6675.2003 · Cited by 14 · see citing works
The role of cytokines in a Porphyromonas gingivalis‐induced murine abscess model
Alayan, J., Gemmell, E., Ford, P. J., Hamlet, S. M., Bird, P. S., Ivanovski, S., & Farah, C. S. (2007) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2007.00360.x · Cited by 12 · see citing works
Rheumatology and the health of the workforce
Hadler, N. M. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200109)44:9 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046 · see citing works
Self-citationThe keystone-pathogen hypothesis
Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790 · see citing works
Self-citationHajishengallis, G., & Lamont, R. J. (2012) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2012.00663.x · Cited by 1,267 · see citing works
Self-citationImmunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
Hajishengallis, G. (2014) · Trends in Immunology · doi:10.1016/j.it.2013.09.001 · Cited by 1,150 · see citing works
Self-citationIL-17 Signaling: The Yin and the Yang
Amatya, N., Garg, A. V., & Gaffen, S. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.01.006 · Cited by 785 · see citing works
Self-citationMechanisms of Bone Resorption in Periodontitis
Hienz, S. A., Paliwal, S., & Ivanovski, S. (2015) · Journal of Immunology Research · doi:10.1155/2015/615486 · Cited by 762 · see citing works
Garlet, G. P. (2010) · Journal of Dental Research · doi:10.1177/0022034510376402 · Cited by 724 · see citing works
The cytokine network involved in the host immune response to periodontitis
Pan, W., Wang, Q., & Chen, Q. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0064-z · Cited by 709 · see citing works
Kaymaz, K., & Beikler, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143394 · Cited by 543 · see citing works
Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy
Hajishengallis, G., Chavakis, T., & Lambris, J. D. (2020) · Periodontology 2000 · doi:10.1111/prd.12331 · Cited by 533 · see citing works
Self-citationKhader, S. A., Gaffen, S. L., & Kolls, J. K. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.100 · Cited by 478 · see citing works
Self-citationHost response mechanisms in periodontal diseases
Silva, N., Abusleme, L., Bravo, D., Dutzan, N., García-Sesnich, J., Vernal, R., Hernández, M., & Gamonal, J. A. (2015) · Journal of Applied Oral Science · doi:10.1590/1678-775720140259 · Cited by 482 · see citing works
Basic biology and role of interleukin‐17 in immunity and inflammation
Zenobia, C., & Hajishengallis, G. (2015) · Periodontology 2000 · doi:10.1111/prd.12083 · Cited by 477 · see citing works
Self-citationThe case for periodontitis in the pathogenesis of rheumatoid arthritis
Potempa, J., Mydel, P. M., & Kozieł, J. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.132 · Cited by 440 · see citing works
The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss
Eskan, M. A., Jotwani, R., Abe, T., Chmelar, J., Lim, J.-H., Liang, S., Ciero, P. A., Krauss, J. L., Li, F., Rauner, M., et al. (2012) · Nature Immunology · doi:10.1038/ni.2260 · Cited by 429 · see citing works
Self-citationPreshaw, P. M., & Taylor, J. J. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01671.x · Cited by 425 · see citing works
Allogeneic Periodontal Ligament Stem Cell Therapy for Periodontitis in Swine
Ding, G., Liu, Y. F., Wang, W., Wei, F., Liu, D., Fan, Z., An, Y., Zhang, C., & Wang, S. (2010) · Stem Cells · doi:10.1002/stem.512 · Cited by 394 · see citing works
Breaking bad: Manipulation of the host response by Porphyromonas gingivalis
Hajishengallis, G., & Lamont, R. J. (2014) · European Journal of Immunology · doi:10.1002/eji.201344202 · Cited by 362 · see citing works
Self-citationInfection, Inflammation, and Bone Regeneration: a Paradoxical Relationship
Thomas, M. V., & Puleo, D. A. (2011) · Journal of Dental Research · doi:10.1177/0022034510393967 · Cited by 327 · see citing works
Cytokine responses against periodontal infection: protective and destructive roles
Liu, Y.-C. G., Lerner, U. H., & Teng, Y.-T. A. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00321.x · Cited by 304 · see citing works
Aging, inflammation, immunity and periodontal disease
Ebersole, J. L., Graves, C. L., González, O. A., Dawson, D. R., Morford, L. A., Emecen‐Huja, P., Hartsfield, J. K., Huja, S. S., Pandruvada, S. N. M., & Wallet, S. M. (2016) · Periodontology 2000 · doi:10.1111/prd.12135 · Cited by 308 · see citing works
Crosstalk pathways between Toll-like receptors and the complement system
Hajishengallis, G., & Lambris, J. D. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.002 · Cited by 277 · see citing works
Self-citationInterleukin-17 in chronic inflammatory neurological diseases
Milovanovic, J., Arsenijevic, A., Stojanovic, B., Kanjevac, T., Arsenijevic, D., Radosavljevic, G., Milovanovic, M., & Arsenijevic, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00947 · Cited by 250 · see citing works
Hajishengallis, G., & Korostoff, J. M. (2017) · Periodontology 2000 · doi:10.1111/prd.12181 · Cited by 245 · see citing works
Self-citationThe role of interleukin-17 in the pathogenesis of rheumatoid arthritis
Gaffen, S. L. (2009) · Current Rheumatology Reports · doi:10.1007/s11926-009-0052-y · Cited by 238 · see citing works
Self-citationThe periodontal war: microbes and immunity
Ebersole, J. L., Dawson, D. R., Emecen‐Huja, P., Nagarajan, R., Howard, K., Grady, M. E., Thompson, K. L., Peyyala, R., Al‐Attar, A., Lethbridge, K., et al. (2017) · Periodontology 2000 · doi:10.1111/prd.12222 · Cited by 212 · see citing works
Host modulation therapy with anti‐inflammatory agents
Preshaw, P. M. (2017) · Periodontology 2000 · doi:10.1111/prd.12148 · Cited by 188 · see citing works
Immunomodulatory drugs: Oral and systemic adverse effects
Martínez, A. B., Mattila, R., Font, R. G., & Meurman, J. H. (2013) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.19087 · Cited by 182 · see citing works
Kinane, D. F., Preshaw, P. M., Loos, B. G., & on Behalf of Working Group 2 of the Seventh European Workshop on Periodontology (in alphabetical order) (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01682.x · Cited by 177 · see citing works
Salivary cytokines as biomarkers of periodontal diseases
Jaedicke, K. M., Preshaw, P. M., & Taylor, J. J. (2015) · Periodontology 2000 · doi:10.1111/prd.12117 · Cited by 172 · see citing works
Maintaining homeostatic control of periodontal bone tissue
Hathaway‐Schrader, J. D., & Novince, C. M. (2021) · Periodontology 2000 · doi:10.1111/prd.12368 · Cited by 171 · see citing works
The presence, function and regulation of IL ‐17 and Th17 cells in periodontitis
Cheng, W., Hughes, F. J., & Taams, L. S. (2014) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12238 · Cited by 159 · see citing works
Frailty, aging, and periodontal disease: Basic biologic considerations
Clark, D. L., Kotronia, E., & Ramsay, S. E. (2021) · Periodontology 2000 · doi:10.1111/prd.12380 · Cited by 159 · see citing works
Olsen, I., Taubman, M. A., & Singhrao, S. K. (2016) · Journal of Oral Microbiology · doi:10.3402/jom.v8.33029 · Cited by 149 · see citing works
Cytokine gene expression profiles during initiation, progression and resolution of periodontitis
Ebersole, J. L., Kirakodu, S. S., Novak, M. J., Stromberg, A. J., Shen, S., Orraca, L., González‐Martínez, J., Burgos, A. G., & González, O. A. (2014) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12286 · Cited by 144 · see citing works
Immune Evasion Strategies of Porphyromonas gingivalis
Hajishengallis, G. (2011) · Journal of Oral Biosciences · doi:10.1016/s1349-0079(11)80006-x · Cited by 143 · see citing works
Self-citationAllogeneic Bone Marrow Mesenchymal Stem Cell Transplantation for Periodontal Regeneration
Du, J., Shan, Z., Ma, P., Wang, S., & Fan, Z. (2013) · Journal of Dental Research · doi:10.1177/0022034513513026 · Cited by 139 · see citing works
Too old to fight? Aging and its toll on innate immunity
Hajishengallis, G. (2010) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2009.00562.x · Cited by 138 · see citing works
Self-citationPeriodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia
Pussinen, P. J., Kopra, E., Pietiäinen, M., Lehto, M. J., Zarić, S., Paju, S., & Salminen, A. (2022) · Periodontology 2000 · doi:10.1111/prd.12433 · Cited by 138 · see citing works
A Physiological Function of Inflammation-Associated SerpinB2 Is Regulation of Adaptive Immunity
Schroder, W. A., Le, T. T., Major, L. D., Street, S. E. A., Gardner, J., Lambley, E., Markey, K. A., MacDonald, K. P. A., Fish, R. J., Thomas, R., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902187 · Cited by 137 · see citing works
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease
Basson, A. R., Trotter, A., Rodriguez‐Palacios, A., & Cominelli, F. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00290 · Cited by 136 · see citing works
Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis
Hajishengallis, G., Chavakis, T., Hajishengallis, E., & Lambris, J. D. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3vmr1014-468r · Cited by 134 · see citing works
Self-citationZenobia, C., & Hajishengallis, G. (2015) · Virulence · doi:10.1080/21505594.2014.999567 · Cited by 134 · see citing works
Self-citationHerpesviral–bacterial interactions in periodontal diseases
Slots, J. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00308.x · Cited by 132 · see citing works
Maekawa, T., & Hajishengallis, G. (2014) · Journal of Periodontal Research · doi:10.1111/jre.12164 · Cited by 127 · see citing works
Self-citationHerbert, B. A., Novince, C. M., & Kirkwood, K. L. (2015) · Molecular Oral Microbiology · doi:10.1111/omi.12119 · Cited by 127 · see citing works
Th17 Cells in Immunopathogenesis and treatment of rheumatoid arthritis
Azizi, G., Jadidi‐Niaragh, F., & Mirshafiey, A. (2013) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12132 · Cited by 124 · see citing works
Zhao, L., Zhou, Y., Xu, Y., Sun, Y., Li, L., & Wu, C. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01712.x · Cited by 122 · see citing works
Abe, T., Hosur, K. B., Hajishengallis, E., Reis, E. S., Ricklin, D., Lambris, J. D., & Hajishengallis, G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202339 · Cited by 119 · see citing works
Self-citationHajishengallis, G. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.017 · Cited by 116 · see citing works
Self-citationMicroRNAs and immunity in periodontal health and disease
Luan, X., Zhou, X. C., Naqvi, A. R., Francis, M., Foyle, D., Nares, S., & Diekwisch, T. G. H. (2018) · International Journal of Oral Science · doi:10.1038/s41368-018-0025-y · Cited by 115 · see citing works
Periodontal and inflammatory bowel diseases: Is there evidence of complex pathogenic interactions?
Lira‐Junior, R., & Figueredo, C. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i35.7963 · Cited by 111 · see citing works
The innate host response in caries and periodontitis
Meyle, J., Dommisch, H., Groeger, S. E., Giacaman, R. A., Costalonga, M., & Herzberg, M. C. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12781 · Cited by 104 · see citing works
Oxidative Stress in the Local and Systemic Events of Apical Periodontitis
Hernández‐Ríos, P., Pussinen, P. J., Vernal, R., & Hernández, M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00869 · Cited by 104 · see citing works
RANKL Expression in Periodontal Disease: Where Does RANKL Come from?
Chen, B., Wu, W., Sun, W., Zhang, Q., Yan, F., & Xiao, Y. (2014) · BioMed Research International · doi:10.1155/2014/731039 · Cited by 103 · see citing works
The Presence of IL-17 + /FOXP3 + Double-positive Cells in Periodontitis
Okui, T., Yudai, A. O. K. I., Ito, H., Honda, T., & Yamazaki, K. (2012) · Journal of Dental Research · doi:10.1177/0022034512446341 · Cited by 103 · see citing works
Periodontal inflammation and bone loss in aged mice
Liang, S., Hosur, K. B., Domon, H., & Hajishengallis, G. (2010) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2009.01245.x · Cited by 101 · see citing works
Self-citationIsola, G., Giudice, A. L., Polizzi, A., Alibrandi, A., Murabito, P., & Indelicato, F. (2020) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2020.104997 · Cited by 99 · see citing works
Liu, D., Wang, Y., Jia, Z., Wang, L., Wang, J., Yang, D., Song, J.-Q., Wang, S., & Fan, Z. (2015) · Stem Cells · doi:10.1002/stem.2018 · Cited by 98 · see citing works
Serum levels of interleukin‐10 and tumour necrosis factor‐α in chronic periodontitis
Passoja, A., Puijola, I., Knuuttila, M. L. E., Niemelä, O. J., Karttunen, R. A., Raunio, T., & Tervonen, T. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01602.x · Cited by 98 · see citing works
Han, N., Zhang, F., Li, G., Zhang, X., Lin, X., Yang, H., Wang, L., Cao, Y., Du, J., & Fan, Z. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0663-6 · Cited by 96 · see citing works
Central Regulatory Role of Cytokines in Periodontitis and Targeting Options
Plemmenos, G., Evangeliou, E., Polizogopoulos, N., Chalazias, A., Deligianni, M. L., & Piperi, C. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200824112732 · Cited by 96 · see citing works
Interleukin-17 and interleukin-18 levels in saliva and plasma of patients with chronic periodontitis
Özçaka, Ö., Nalbantsoy, A., & Buduneli, N. (2011) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2011.01377.x · Cited by 95 · see citing works
Mahlangu, T. J., Dludla, P. V., Nyambuya, T. M., Mxinwa, V., Mazibuko-Mbeje, S. E., Cirilli, I., Marcheggiani, F., Tiano, L., Louw, J., & Nkambule, B. B. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154892 · Cited by 94 · see citing works
Ford, P. J., Gamonal, J. A., & Seymour, G. J. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00349.x · Cited by 92 · see citing works
IL-17 in Sera from Patients with Aggressive Periodontitis
Schenkein, H. A., Koertge, T. E., Brooks, C. N., Sabatini, R., Purkall, D. E., & Tew, J. G. (2010) · Journal of Dental Research · doi:10.1177/0022034510369297 · Cited by 90 · see citing works
Signs of the presence of Th17 cells in chronic periodontal disease
Adibrad, M., Deyhimi, P., Ganjalıkhani-Hakemi, M., Behfarnia, P., Shahabuei, M., & Rafiee, L. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2011.01464.x · Cited by 87 · see citing works
A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss
Goswami, J., Hernández‐Santos, N., Zuniga, L. A., & Gaffen, S. L. (2009) · European Journal of Immunology · doi:10.1002/eji.200939670 · Cited by 87 · see citing works
Self-citationHascoët, E., Blanchard, F., Blin‐Wakkach, C., Guicheux, J., Lesclous, P., & Cloître, A. (2023) · Bone Research · doi:10.1038/s41413-023-00257-w · Cited by 88 · see citing works
Settem, R. P., Honma, K., Nakajima, T., Phansopa, C., Roy, S., Stafford, G. P., & Sharma, A. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.85 · Cited by 86 · see citing works
Feller, L., Altini, M., Khammissa, R. A. G., Chandran, R., Bouckaert, M., & Lemmer, J. (2013) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2013.07.013 · Cited by 85 · see citing works
Yu, J. J., Ruddy, M. J., Conti, H. R., Boonanantanasarn, K., & Gaffen, S. L. (2008) · Infection and Immunity · doi:10.1128/iai.01209-07 · Cited by 86 · see citing works
Self-citationGAS6 is a key homeostatic immunological regulator of host–commensal interactions in the oral mucosa
Nassar, M., Tabib, Y., Capucha, T., Mizraji, G., Nir, T., Pevsner‐Fischer, M., Zilberman-Schapira, G., Heyman, O., Nussbaum, G., Bercovier, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614926114 · Cited by 85 · see citing works
Liang, S., Domon, H., Hosur, K. B., Wang, M., & Hajishengallis, G. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.006 · Cited by 81 · see citing works
Self-citationDendritic cells and their role in periodontal disease
Wilensky, A., Segev, H., Mizraji, G., Shaul, Y., Capucha, T., Shacham, M., & Hovav, A.-H. (2013) · Oral Diseases · doi:10.1111/odi.12122 · Cited by 82 · see citing works
Novel Inflammatory Pathways in Periodontitis
Hajishengallis, G., & Sahingur, S. E. (2014) · Advances in Dental Research · doi:10.1177/0022034514526240 · Cited by 81 · see citing works
Self-citationChopra, A., Bhat, G. S., & Sivaraman, K. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2020.1801090 · Cited by 80 · see citing works
Mitani, A., Niedbała, W., Fujimura, T., Mogi, M., Miyamae, S., Higuchi, N., Abe, A., Hishikawa, T., Mizutani, M., Ishihara, Y., et al. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.140293 · Cited by 79 · see citing works
Quercetin Inhibits Inflammatory Bone Resorption in a Mouse Periodontitis Model
Napimoga, M. H., Clemente‐Napimoga, J. T., de Macedo, C. G., Freitas, F. F., Stipp, R. N., Pinho-Ribeiro, F. A., Casagrande, R., & Verri, W. A., Jr. (2013) · Journal of Natural Products · doi:10.1021/np400691n · Cited by 77 · see citing works
Crevicular fluid glutathione levels in periodontitis and the effect of non‐surgical therapy
Grant, M. M., Brock, G. R., Matthews, J. B., & Chapple, I. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01504.x · Cited by 77 · see citing works
Zeituni, A. E., Jotwani, R., Carrion, J. A., & Cutler, C. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901030 · Cited by 77 · see citing works
Krauss, J. L., Potempa, J., Lambris, J. D., & Hajishengallis, G. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00324.x · Cited by 76 · see citing works
Self-citationThe role of vitamin D in periodontal health and disease
Lu, E. M. (2022) · Journal of Periodontal Research · doi:10.1111/jre.13083 · Cited by 75 · see citing works
Natural and induced immune responses in oral cavity and saliva
Matsuoka, M., Soria, S. A., Pires, J. R., Sant’Ana, A. C. P., & Freire, M. (2025) · BMC Immunology · doi:10.1186/s12865-025-00713-8 · Cited by 86 · see citing works
Dutzan, N., Vernal, R., Vaque, J. P., García-Sesnich, J., Hernández, M., Abusleme, L., Dezerega, A., Gutkind, J. S., & Gamonal, J. A. (2011) · Journal of Periodontology · doi:10.1902/jop.2011.110482 · Cited by 75 · see citing works
T cells, teeth and tissue destruction – what do T cells do in periodontal disease?
Campbell, L., Millhouse, E., Malcolm, J., & Culshaw, S. (2015) · Molecular Oral Microbiology · doi:10.1111/omi.12144 · Cited by 74 · see citing works
Periodontal diagnosis and treatment – where does the future lie?
Chapple, I. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00319.x · Cited by 73 · see citing works
Cytokine regulation of immune responses to Porphyromonas gingivalis
Taylor, J. J. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00344.x · Cited by 72 · see citing works
Suppression of T-Cell Chemokines by Porphyromonas gingivalis
Jauregui, C. E., Wang, Q., Wright, C. J., Takeuchi, H., Uriarte, S. M., & Lamont, R. J. (2013) · Infection and Immunity · doi:10.1128/iai.00264-13 · Cited by 72 · see citing works
Shaker, O. G., & Ghallab, N. A. (2012) · Mediators of Inflammation · doi:10.1155/2012/174764 · Cited by 71 · see citing works
Negrini, T. D. C., Carlos, I. Z., Duque, C., Caiaffa, K. S., & Arthur, R. A. (2021) · Frontiers in Oral Health · doi:10.3389/froh.2021.697428 · Cited by 76 · see citing works
de Molon, R. S., Vernal, R., Oliveira, G. E., Steffens, J. P., Ervolino, E., Theodoro, L. H., van den Beucken, J. J. J. P., & Tetradis, S. (2026) · Bone Research · doi:10.1038/s41413-025-00478-1 · Cited by 83 · see citing works
Wallet, S. M., Puri, V., & Gibson, F. C. (2018) · Vaccines · doi:10.3390/vaccines6020021 · Cited by 69 · see citing works
Wang, C., Hao, Y., Gianfilippo, R. D., Sugai, J. V., Li, J., Gong, W., Kornman, K. S., Wang, H., Kamada, N., Xie, Y., et al. (2021) · Theranostics · doi:10.7150/thno.57775 · Cited by 67 · see citing works
Gaddis, D. E., Maynard, C. L., Weaver, C. T., Michalek, S. M., & Katz, J. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0512220 · Cited by 66 · see citing works
Th17 and Th1 Lymphocytes Are Correlated with Chronic Periodontitis
Chen, X.-T., Chen, L., Tan, J., Shi, D.-H., Ke, T., & Lei, L. (2016) · Immunological Investigations · doi:10.3109/08820139.2016.1138967 · Cited by 65 · see citing works
Re‐evaluating the role of vitamin D in the periodontium
Stein, S. H., Livada, R., & Tipton, D. A. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12149 · Cited by 64 · see citing works
Sulijaya, B., Takahashi, N., & Yamazaki, K. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.07.002 · Cited by 65 · see citing works
Wang, Z., Li, S., Tan, D., Abudourexiti, W., Yu, Z., Zhang, T., Ding, C., & Gong, J. (2023) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13782 · Cited by 62 · see citing works
Papathanasiou, E., Teles, F., Griffin, T. J., Arguello, E., Finkelman, M., Hanley, J. B., & Theoharides, T. C. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12078 · Cited by 63 · see citing works
- Authors
- Gaffen, S. L., & Hajishengallis, G.
- Affiliations
- University of Louisville (US)
- Corresponding author
- Gaffen, S.L.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2008-09
- Volume
- 87
- Issue
- 9
- Pages
- 817-828
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC2692983
- OpenAlex
- W2036608242
- Cited by
- 334
- References
- 171
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 14 · 2023: 11 · 2022: 8 · 2021: 17 · 2020: 18 · 2019: 22 · 2018: 14 · 2017: 24 · 2016: 19 · 2015: 20 · 2014: 27 · 2013: 29 · 2012: 25
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R21AI049329, AI49329, R01AI049329)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR054389, R01AR054389)
- National Institute of Dental and Craniofacial Research (R01DE018292, DE-015254, DE017138, R01DE015254, DE018292, R01DE017138)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- periodontitis, Th1/Th2 paradigm, Th17 cells, IL-17, CD4+ T cells, periodontal disease pathogenesis, T cell immunity, host-pathogen interaction, periodontal pathogens, immunomodulatory therapy, periodontal disease susceptibility
- MeSH terms
- Animals, Humans, Immunity, Cellular, Interleukins, Periodontitis, T-Lymphocyte Subsets, Th1 Cells, Th2 Cells, Models, Immunological, Interleukin-17
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
