Mangiferin: A possible strategy for periodontal disease to therapy
Abstract
Periodontitis is one of the most widespread infectious inflammatory diseases, characterized by chronic bacterial infection of the supporting structures of the teeth, leading to tooth loss in adults. Mangiferin, a naturally occurring glucosylxanthone, has recently gained great attention, owing to potent antioxidant, anti-inflammatory, antidiabetic, immunomodulatory, and antitumor properties. These studies confirm that mangiferin, exert excellent antioxidant effect and act rapidly in the face of oxidative stress. Meanwhile, mangiferin could significantly inhibit the expression of pro-inflammatory cytokines. Especially, treated with mangiferin, the alveolar bone loss of rats with experimental periodontitis has been remarkably reduced. Given these bioactivity exhibited for mangiferin, we hypothesized that mangiferin may play an efficient role in therapy of periodontitis, which may offer new therapeutic options for the management of patients with periodontitis.
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Mangiferin has been demonstrated to possess numerous pharmacological activities, including antioxidative, antiaging, antitumor, antibacterial, antiviral, immunomodulatory, antidiabetic, hepatoprotective and analgesic effects.
“It has been demonstrated to possess numerous pharmacological activities, including antioxidative, antiaging, antitumor, antibacterial, antiviral, immunomodulatory, antidiabetic, hepatoprotective and analgesic effects (1)(2)(3).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [2]
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- Authors
- Duang, X.-Y., Wang, Q., Zhou, X.-D., & Huang, D.-M.
- Affiliations
- Sichuan University (CN)
- ORCID
- Wang, Qian
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 76
- Issue
- 4
- Pages
- 486-488
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2143313663
- Cited by
- 45
- References
- 29
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- mangiferin, periodontitis, antioxidant activity, oxidative stress, anti-inflammatory activity, inflammatory cytokines, alveolar bone loss, periodontal treatment, tooth loss
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Anti-Bacterial Agents, Antioxidants, Humans, Periodontitis, Xanthones, Rats
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