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Cited by 360Oral microbiology and periodontitis researchDental Health and Care UtilizationDental materials and restorations

The complex oral microflora of high‐risk individuals and groups and its role in the caries process

Beighton, David·2005·Community Dentistry and Oral Epidemiology
DOI 10.1111/j.1600-0528.2005.00232.x
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Abstract

Abstract – The involvement of the oral biofilm in the caries process requires re‐evaluation. The essential role of mutans streptococci (Streptococcus mutans and Streptococcus sobrinus) in the caries process is not proven. Acid production by dental plaque is not dependent upon the presence of mutans streptococci; caries occurs in the absence of these species and their presence does not necessarily indicate caries activity. Other oral bacteria, non‐mutans streptococci, Actinomyces spp. and Bifidobacterium spp., are acidogenic and aciduric. They outnumber mutans streptococci in dental plaque, and there are data which support a role for these bacteria in the initiation and progression of caries. Molecular studies demonstrate the great diversity and complexity of the flora associated with caries. Many taxa identified have not been cultured and the role of these taxa is not known. We have, in mutans streptococci, good markers of disease but not necessarily the aetiological agents of the disease. Considerably more research is required to investigate the transition of tooth surfaces from being intact and sound to the white spot lesion stage. A combination of conventional and molecular approaches are required to elucidate the involvement of an individual taxon and of microbial populations with particular traits in the caries process.

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  • Streptococcus mutans is a key contributor to dental biofilms associated with formation of dental caries and plays a major role in development and establishment of extracellular polysaccharide matrices, which increase virulence of the biofilm and facilitate persistence of an acidic environment in the mouth.

    “Streptococcus mutans is a key contributor to dental biofilms associated with the formation of dental caries,44 and plays a major role in the development and establishment of extracellular polysaccharide matrices, which increase the virulence of the biofilm and facilitate persistence of an acidic environment in the mouth.”

    From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [44]

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Authors
Beighton, D.
Affiliations
King's College London (GB)
Corresponding author
Beighton, David
Venue
Community Dentistry and Oral Epidemiology
Publisher
Wiley
Published
2005-07-06
Volume
33
Issue
4
Pages
248-255
ISSN
  • 0301-5661 (ISSN-L)
  • 1600-0528
DOI
10.1111/j.1600-0528.2005.00232.x
OpenAlex
W1971627353
Cited by
360
References
35
Citations by year
2025: 12 · 2024: 18 · 2023: 10 · 2022: 15 · 2021: 16 · 2020: 11 · 2019: 17 · 2018: 13 · 2017: 19 · 2016: 12 · 2015: 24 · 2014: 20 · 2013: 20 · 2012: 40
FWCI
2.42
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Community Dentistry And Oral Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
  • Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
Keywords
oral microbiota, dental caries, mutans streptococci, Streptococcus mutans, Streptococcus sobrinus, Actinomyces, Bifidobacterium, dental plaque, acid production, caries etiology, white spot lesions, high-risk individuals, oral bacterial diversity
MeSH terms
Acids, Actinomyces, Animals, Bifidobacterium, Dental Caries, Dental Plaque, DNA, Bacterial, Humans, Hydrogen-Ion Concentration, Streptococcus mutans, Colony Count, Microbial, Streptococcus oralis

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