Metabolic Interactions between Bacteria and Fungi in Commensal Oral Biofilms
Open accessAbstract
Oral health is more than just the absence of disease. The key to oral health is a diverse microbiome in an ecological balance. The oral microbiota is one of the most complex and diverse microbial communities in the human body. To maintain oral health, balance between the human host and the intrinsic microorganisms is essential. The healthy oral cavity is represented by a great microbial diversity, including both bacteria and fungi. The bacterial microbiome is very well studied. In contrast, fungi inhabiting the oral cavity are often overlooked. All microbial species in the oral cavity form communities which establish a variety of micro-niches and inter- and intra-species interactions. These interactions can be classified into three main groups: physical, chemical and metabolic interactions. Different metabolic interactions are reviewed in this report, among which are the metabolism of sugars, carbon, lactate and oxygen. This review set out with the aim of assessing the importance of metabolic interactions between fungi and bacteria in the healthy oral cavity.
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Colonization by Corynebacterium provides long filaments on which distinct microenvironments are created, and streptococci at the periphery of oral biofilms produce lactate, which serves as a preferred substrate for catabolism by Veillonella, Corynebacterium, and Eubacterium species.
“For example, colonization by Corynebacterium provides long filaments on which distinct microenvironments are created, and streptococci at the periphery of oral biofilms produce lactate, which serves as a preferred substrate for catabolism by Veillonella, Corynebacterium, and Eubacterium species.61, 233”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [233]
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The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works
- Authors
- Lof, M., Janus, M., & Krom, B.
- Affiliations
- Academic Center for Dentistry Amsterdam (NL)
- Corresponding author
- Krom, Bastiaan
- ORCID
- Krom, Bastiaan
- Venue
- Journal of Fungi
- Publisher
- MDPI AG
- Published
- 2017-07-14
- Volume
- 3
- Issue
- 3
- Pages
- 40
- ISSN
- 2309-608X (ISSN-L)
- PMC
- PMC5715944
- OpenAlex
- W2735094314
- Cited by
- 51
- References
- 66
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 4
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Fungi (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- VU Research Portal (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Funders
- Universiteit van Amsterdam
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- dental plaque, commensalism, fungal-bacterial interactions, oral microbiota, fungal metabolism, sugar metabolism, carbon metabolism, lactate metabolism, oxygen metabolism, microbial interactions, oral health
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