Bacteria of Dental Caries in Primary and Permanent Teeth in Children and Young Adults
Open accessAbstract
Although Streptococcus mutans has been implicated as a major etiological agent of dental caries, our cross-sectional preliminary study indicated that 10% of subjects with rampant caries in permanent teeth do not have detectable levels of S. mutans . Our aims were to use molecular methods to detect all bacterial species associated with caries in primary and permanent teeth and to determine the bacterial profiles associated with different disease states. Plaque was collected from 39 healthy controls and from intact enamel and white-spot lesions, dentin lesions, and deep-dentin lesions in each of 51 subjects with severe caries. 16S rRNA genes were PCR amplified, cloned, and sequenced to determine species identities. In a reverse-capture checkerboard assay, 243 samples were analyzed for 110 prevalent bacterial species. A sequencing analysis of 1,285 16S rRNA clones detected 197 bacterial species/phylotypes, of which 50% were not cultivable. Twenty-two new phylotypes were identified. PROC MIXED tests revealed health- and disease-associated species. In subjects with S. mutans , additional species, e.g., species of the genera Atopobium , Propionibacterium , and Lactobacillus , were present at significantly higher levels than those of S. mutans . Lactobacillus spp., Bifidobacterium dentium , and low-pH non- S. mutans streptococci were predominant in subjects with no detectable S. mutans . Actinomyces spp. and non- S. mutans streptococci were predominant in white-spot lesions, while known acid producers were found at their highest levels later in disease. Bacterial profiles change with disease states and differ between primary and secondary dentitions. Bacterial species other than S. mutans , e.g., species of the genera Veillonella , Lactobacillus , Bifidobacterium , and Propionibacterium , low-pH non- S. mutans streptococci, Actinomyces spp., and Atopobium spp., likely play important roles in caries progression.
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Commensal microbiota comprise the majority of cells in the body and play a key role in human health.
“Commensal microbiota comprise the majority of cells in the body and play a key role in human health1-5,10.”
From Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions (2013) · cites this paper as [1]
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“These were not, however, the only species detected, as almost 200 distinct species/taxa were revealed in the samples, reflecting the complex microbiota in oral biofilms [124].”
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Simón‐Soro, Á., Tomás, I., Cabrera‐Rubio, R., Catalan, M. D., Nyvad, B., & Mira, Á. (2013) · Journal of Dental Research · doi:10.1177/0022034513488119 · Cited by 278 · see citing works
“Carious cavities, for instance, have been found to harbor a different set of bacterial species than dental plaque at sound surfaces, and the bacterial composition varies among enamel, dentin, and deep dentin samples (Aas et al., 2008; Belda-Ferre et al., 2012).”
BackgroundInfluentialRole of microbial communities in the pathogenesis of periodontal diseases and caries
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“…of DNA from © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd carious lesions confirmed the presence of many other bacterial species, like Atopobium, Prevotella or Corynebacterium, among others (Aas et al. 2008, Gross et al. 2012, Torlakovic et al. 2012, Sim on-Soro et al. 2013).”
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“One theory, the specific plaque hypothesis, has proposed that only a few specific species, such as Streptococcus mutans and Streptococcus sobrinus, are actively involved in the disease (185).”
BackgroundAnalysis of Oral Microbiota in Children with Dental Caries by PCR-DGGE and Barcoded Pyrosequencing
Ling, Z., Kong, J., Jia, P., Wei, C., Wang, Y., Pan, Z., Huang, W., Li, L., Chen, H., & Xiang, C. (2010) · Microbial Ecology · doi:10.1007/s00248-010-9712-8 · Cited by 268 · see citing works
“Previous studies have shown that Propionigenium, a putative etiological agent of root caries in elderly patients [68], was not significantly associated with dental caries in primary teeth of children [46].”
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Nyvad, B., Crielaard, W., Mira, Á., Takahashi, N., & Beighton, D. (2012) · Caries Research · doi:10.1159/000345367 · Cited by 262 · see citing works
“[2002], Aas et al. [2008], Takahashi et al.”
BackgroundHaukioja, A. (2010) · European Journal of Dentistry · doi:10.1055/s-0039-1697851 · Cited by 239 · see citing works
“19,20 In addition, caries-associat-ed lactobacilli and bifidobacteria have been characterized as exogenous and opportunistic colonizers possibly acquired from food.”
Clonal Analysis of the Microbiota of Severe Early Childhood Caries
Kanasi, E., Dewhirst, F. E., Chalmers, N. I., Kent, R., Moore, A., Hughes, C. V., Pradhan, N., Loo, C., & Tanner, A. C. R. (2010) · Caries Research · doi:10.1159/000320158 · Cited by 236 · see citing works
“This species, previously recognized as a nutritionally variant Streptococcus , has been detected in children with caries [Aas et al., 2008], but clinical significance of this species has not been reported.”
BackgroundMethodResultInfluentialSelf-citationStreptococcus Sanguinis Biofilm Formation & Interaction with Oral Pathogens
Zhu, B., Macleod, L. C., Kitten, T. O., & Xu, P. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0043 · Cited by 228 · see citing works
“Although not present in every case [89,90], S.”
BackgroundThe Dental Plaque Microbiome in Health and Disease
Peterson, S. N., Snesrud, E. C., Liu, J., Ong, A., Kilian, M., Schork, N. J., & Bretz, W. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058487 · Cited by 223 · see citing works
“, [17] used 16S rDNA analysis of caries-free and caries-active children and adults to reveal species associated with dental health such as Streptococcus sanguinis and genera associated with dental caries in both primary and permanent dentitions such as Streptococcus mutans and low-pH, non-mutans streptococci, Veillone…”
MethodSalivary biomarkers for dental caries
Gao, X., Jiang, S., Koh, D. S. Q., & Hsu, C. S. (2015) · Periodontology 2000 · doi:10.1111/prd.12100 · Cited by 225 · see citing works
Ultra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome
Graßl, N., Kulak, N. A., Pichler, G., Geyer, P. E., Jung, J., Schubert, S., Sinitcyn, P. G., Cox, J., & Mann, M. (2016) · Genome Medicine · doi:10.1186/s13073-016-0293-0 · Cited by 222 · see citing works
“In addition, tooth decay and other diseases of the oral cavity are known to be caused by bacteria but turn out to be insufficiently explained by one species alone [9, 10].”
BackgroundThe Caries Microbiome: Implications for Reversing Dysbiosis
Tanner, A. C. R., Kressirer, C. A., Rothmiller, S., Johansson, I., & Chalmers, N. I. (2018) · Advances in Dental Research · doi:10.1177/0022034517736496 · Cited by 225 · see citing works
“These included Atopobium, Propionibacterium, and Bifidobacterium in addition to Actinomyces and Lactobacillus (Aas et al. 2008).”
BackgroundComposition and development of oral bacterial communities
Palmer, R. J., Jr. (2013) · Periodontology 2000 · doi:10.1111/j.1600-0757.2012.00453.x · Cited by 222 · see citing works
“In a series of studies on childhood caries (1, 4), a reverse-capture assay of PCR products (56) for detection of 110 species was used to assess the prevalence of particular bacterial species.”
MethodMicrobiomes of Site-Specific Dental Plaques from Children with Different Caries Status
Richards, V. P., Alvarez, A. J., Luce, A. R., Bedenbaugh, M., Mitchell, M. L., Burne, R. A., & Nascimento, M. M. (2017) · Infection and Immunity · doi:10.1128/iai.00106-17 · Cited by 201 · see citing works
“Despite growing efforts to define the composition and activities of the oral microbiome in health and disease (7, 10, 21), the current understanding of the basis for the intraindividual and interindividual differences in microbial profiles is limited.”
BackgroundStahringer, S. S., Clemente, J. C., Corley, R. P., Hewitt, J. K., Knights, D., Walters, W. A., Knight, R. D., & Krauter, K. S. (2012) · Genome Research · doi:10.1101/gr.140608.112 · Cited by 199 · see citing works
Diet and Caries-associated Bacteria in Severe Early Childhood Caries
Palmer, C. A., Kent, R., Loo, C. Y., Hughes, C. V., Stutius, E., Pradhan, N., Dahlan, M., Kanasi, E., Vasquez, S. S. A., & Tanner, A. C. R. (2010) · Journal of Dental Research · doi:10.1177/0022034510376543 · Cited by 199 · see citing works
“Bifidobacteria were also strongly associated with S-ECC, as previously reported by DNA probes (Aas et al., 2008) and by selective culture (Mantzourani et al.”
BackgroundResultThe road to ruin: the formation of disease‐associated oral biofilms
Jakubovics, N., & Kolenbrander, P. (2010) · Oral Diseases · doi:10.1111/j.1601-0825.2010.01701.x · Cited by 198 · see citing works
“In the case of dental caries, the shift in population involves a reduction in the diversity of micro-organisms at active caries sites (Aas et al, 2008), because of the production of hydrogen ions by acidogenic bacteria.”
BackgroundCorrelations of oral bacterial arginine and urea catabolism with caries experience
Nascimento, M. M., Gordan, V. V., Garvan, C. W., Browngardt, C. M., & Burne, R. A. (2009) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2008.00477.x · Cited by 196 · see citing works
“dental health (1, 10, 12, 13, 24); including Streptococcus sanguinis and Streptococcus gordonii.”
BackgroundNitrate as a potential prebiotic for the oral microbiome
Rosier, B. T., Buetas, E., Moya-Gonzalvez, E. M., Artacho, A., & Mira, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-69931-x · Cited by 194 · see citing works
Bioactive glass fillers reduce bacterial penetration into marginal gaps for composite restorations
Khvostenko, D., Hilton, T., Ferracane, J. L., Mitchell, J. C., & Kruzic, J. J. (2015) · Dental Materials · doi:10.1016/j.dental.2015.10.007 · Cited by 192 · see citing works
Microbiota’s role in health and diseases
El-Sayed, A., Aleya, L., & Kamel, M. S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-14593-z · Cited by 192 · see citing works
“…(by Streptococcus mutans, Veil lonel la , Lactobacil lus , Bif idobacterium , and Propionibacterium) and periodontitis (by Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans , Treponema denticola, and Tannerella forsythia) (Bik et al. 2010; Aas et al. 2008; Belda-Ferre et al. 2011).”
BackgroundInfluentialLiu, Y., Nascimento, M. M., & Burne, R. A. (2012) · International Journal of Oral Science · doi:10.1038/ijos.2012.54 · Cited by 190 · see citing works
A comprehensive review of the application of probiotics and postbiotics in oral health
Rad, A. H., Pourjafar, H., & Mirzakhani, E. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1120995 · Cited by 200 · see citing works
“A study of 39 healthy and 51 caries people showed that the bacterial profiles of intact enamel in healthy people were significantly different from the bacterial profiles of intact enamel in sick people (Aas et al., 2008).”
BackgroundInfluentialCORE: A Phylogenetically-Curated 16S rDNA Database of the Core Oral Microbiome
Griffen, A. L., Beall, C. J., Firestone, N. D., Gross, E. L., DiFranco, J. M., Hardman, J., Vriesendorp, B., Faust, R. A., Janies, D. A., & Leys, E. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019051 · Cited by 182 · see citing works
“An initial list was generated by extracting the names of taxa (species and phylotypes) from published surveys of oral bacterial communities conducted using 16S rDNA sequencing [13,14,15,16,17,18,19,20,21].”
MethodSelf-citationVentura, M., Turroni, F., Zomer, A., Foroni, E., Giubellini, V., Bottacini, F., Canchaya, C. A., Claesson, M. J., He, F., Mantzourani, M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000785 · Cited by 176 · see citing works
“However, bifidobacteria have also been isolated from the human oral cavity, where their presence is linked to the progression of tooth decay: bifidobacteria have been detected in high numbers in infected dentine from carious lesions in children [9] and have been associated with childhood dental caries [10].”
BackgroundSiqueira, J. F., Jr., & Rôças, I. N. (2009) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2009.01.044 · Cited by 176 · see citing works
The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health
Gomez, A., & Nelson, K. E. (2017) · Microbial Ecology · doi:10.1007/s00248-016-0854-1 · Cited by 175 · see citing works
“Additional inconsistent results suggest windows of infectivity, strong interpersonal differences, and many different bacteria as being responsible for disease onset [82].”
Metatranscriptomics reveals overall active bacterial composition in caries lesions
Simón‐Soro, Á., Navarro, M. G., & Mira, Á. (2014) · Journal of Oral Microbiology · doi:10.3402/jom.v6.25443 · Cited by 170 · see citing works
“Furthermore, the application of molecular cloning and Sanger sequencing to study carious lesions at different stages of the disease revealed that although Streptococcus mutans levels correlated with disease severity, it could not be always amplified by polymerase chain reaction (PCR) whereas other bacteria were presen…”
BackgroundWarinner, C., Speller, C., Collins, M. J., & Lewis, C. M. (2015) · Journal of Human Evolution · doi:10.1016/j.jhevol.2014.10.016 · Cited by 171 · see citing works
“, 2013), periodontal disease and dental decay (Marsh, 2003; Pihlstrom et al., 2005; Kumar et al., 2006; Aas et al., 2008), atherosclerosis and endocarditis (Scannapieco et al.”
Bacterial Profile of Dentine Caries and the Impact of pH on Bacterial Population Diversity
Kianoush, N., Adler, C. J., Nguyen, K.-A. T., Browne, G. V., Simonian, M. R., & Hunter, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092940 · Cited by 169 · see citing works
“mutans, non-mutans streptococci and members of the genera Actinomyces, Bifidobacterium, Lactobacillus, Propionibacterium, Veillonella, Selenomonas and Atopobium are associated with different stages of carious lesions [20,22,25].”
BackgroundHurley, E., Barrett, M., Kinirons, M. J., Whelton, H. P., Ryan, C. A., Stanton, C., Harris, H. M. B., & O’Toole, P. W. (2019) · BMC Oral Health · doi:10.1186/s12903-018-0693-1 · Cited by 172 · see citing works
Pyrosequencing as a tool for better understanding of human microbiomes
Siqueira, J. F., Jr., FOUAD, A. F., & Rôças, I. N. (2012) · Journal of Oral Microbiology · doi:10.3402/jom.v4i0.10743 · Cited by 165 · see citing works
Veillonellae: Beyond Bridging Species in Oral Biofilm Ecology
Zhou, P., Manoil, D., Belibasakis, G. N., & Kotsakis, G. A. (2021) · Frontiers in Oral Health · doi:10.3389/froh.2021.774115 · Cited by 159 · see citing works
“[86] also demonstrated the association of genera Veillonella with caries progression.”
ResultCephas, K., Kim, J., Mathai, R. A., Barry, K. A., Dowd, S. E., Meline, B. S., & Swanson, K. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023503 · Cited by 156 · see citing works
“[11] not only demonstrated that 10% of children and young adults (2 to 21 yr old) with dental caries had no detectable levels of S.”
BackgroundMethodResultInfluentialA Tissue-Dependent Hypothesis of Dental Caries
Simón‐Soro, Á., Belda‐Ferre, P., Cabrera‐Rubio, R., Alcaraz, L. D., & Mira, Á. (2013) · Caries Research · doi:10.1159/000351663 · Cited by 156 · see citing works
“Caries samples were classified as enamel caries (including white-spot lesions), dentin caries and deep dentin caries [Aas et al., 2008].”
BackgroundMicrobial transformation from normal oral microbiota to acute endodontic infections
Hsiao, W., Li, K. L., Liu, Z., Jones, C., Fraser, C. M., & FOUAD, A. F. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-345 · Cited by 155 · see citing works
“Opportunistic pathogenic genera such as Fusobacterium, Treponema, Tannerella, Porphyromonas and Prevotella are more prevalent in diseased samples [17-19].”
BackgroundXiao, C., Ran, S., Huang, Z., & Liang, J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01145 · Cited by 149 · see citing works
“In Aas’s study, S. mutans was not detected in 10% of dental caries using checkerboard hybridization (Aas et al., 2008).”
MethodA review of the phytochemistry and pharmacological activities of Magnoliae officinalis cortex
Luo, H.-Y., Wu, H., Yu, X., Zhang, X. L., Lu, Y., Fan, J., Tang, L., & Wang, Z. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.02.041 · Cited by 152 · see citing works
Pyrosequencing Analysis of Oral Microbiota Shifting in Various Caries States in Childhood
Jiang, W. H., Ling, Z., Lin, X., Chen, Y., Zhang, J., Yu, J., Xiang, C., & Chen, H. (2014) · Microbial Ecology · doi:10.1007/s00248-014-0372-y · Cited by 151 · see citing works
“Atopobium has been suggested as putative etiological agents of root caries and dentinal caries [51, 52].”
BackgroundAssociations between dental caries and systemic diseases: a scoping review
Sabharwal, A., Stellrecht, E. M., & Scannapieco, F. A. (2021) · BMC Oral Health · doi:10.1186/s12903-021-01803-w · Cited by 149 · see citing works
Xylitol, Mutans Streptococci, and Dental Plaque
Söderling, E. (2009) · Advances in Dental Research · doi:10.1177/0895937409335642 · Cited by 149 · see citing works
“mutans has been implicated as a major etiological agent of dental caries, even though other bacterial species may also play important roles in caries progression (Aas et al., 2008).”
Salivary Biomarkers for Caries Risk Assessment
Guo, L., & Wenyuan, S. (2013) · Journal of the California Dental Association · doi:10.1080/19424396.2013.12222284 · Cited by 149 · see citing works
Edlund, A., Yang, Y., Hall, A. P., Guo, L., Lux, R., He, X., Nelson, K. E., Nealson, K. H., Yooseph, S., Shi, W., et al. (2013) · Microbiome · doi:10.1186/2049-2618-1-25 · Cited by 147 · see citing works
“This model can be used to gain a deeper understanding of molecular mechanisms that underlie the evolution of healthy oral microbiomes into disease-associated microbiomes where cariogenic groups such as mutans streptococci and Lactobaccilli become more abundant [7,19,33,34].”
ResultThe Biology, Prevention, Diagnosis and Treatment of Dental Caries
Zero, D. T., Fontana, M., Martinez-Mier, E. A., Zandoná, A. F., Ando, M., González‐Cabezas, C., & Bayne, S. C. (2009) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2009.0355 · Cited by 146 · see citing works
Xu, H., Hao, W., Zhou, Q., Wang, W., Xia, Z., Liu, C., Chen, X., Qin, M., & Chen, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089269 · Cited by 143 · see citing works
Correction: Exploring Microbial Diversity and Taxonomy Using SSU rRNA Hypervariable Tag Sequencing
Huse, S. M., Dethlefsen, L., Huber, J. A., Welch, D. B. M., Relman, D. A., & Sogin, M. L. (2008) · PLoS Genetics · doi:10.1371/annotation/3d8a6578-ce56-45aa-bc71-05078355b851 · Cited by 143 · see citing works
Temporal development of the oral microbiome and prediction of early childhood caries
Dashper, S. G., Mitchell, H. L., Cao, K. L., Carpenter, L. M., Gussy, M. G., Calache, H., Gladman, S. L., Bulach, D., Hoffmann, B., Catmull, D. V., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56233-0 · Cited by 140 · see citing works
Immune Cells and Molecular Networks in Experimentally Induced Pulpitis
Renard, E., Gaudin, A., Bienvenu, G., Amiaud, J., Farges, J., Cuturi, M. C., Moreau, A., & Alliot‐Licht, B. (2015) · Journal of Dental Research · doi:10.1177/0022034515612086 · Cited by 137 · see citing works
“Grampositive bacteria greatly dominate the microflora in initial and moderate dentin caries lesions, with the proportion of gramnegative bacteria growing with the progression of tooth decay (Hahn et al. 1989; Love and Jenkinson, 2002; Martin et al. 2002; Chhour et al. 2005; Aas et al. 2008).”
BackgroundMicrobiome Associated with Severe Caries in Canadian First Nations Children
Agnello, M., Marques, J., Cen, L., Mittermuller, B.-A., Huang, A., Tran, N. C., Shi, W., He, X., & Schroth, R. J. (2017) · Journal of Dental Research · doi:10.1177/0022034517718819 · Cited by 137 · see citing works
“Rothia spp. are commonly detected in plaque (Aas et al. 2008; Bik et al. 2010; Kanasi et al. 2010; Ling et al. 2010), but R. aeria has not been previously well associated with health.”
BackgroundA reproducible oral microcosm biofilm model for testing dental materials
Rudney, J. D., Chen, R., Lenton, P., Li, J., Li, Y., Jones, R. S., Reilly, C., Fok, A. S. L., & Aparicio, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05439.x · Cited by 136 · see citing works
“mutans can be a minority species even in persons with active caries (Aas et al. 2008).”
BackgroundNewby, E. E., Martinez-Mier, E. A., Zero, D. T., Kelly, S., Fleming, N., North, M., & Bosma, M. L. (2013) · International Dental Journal · doi:10.1111/idj.12082 · Cited by 136 · see citing works
Understanding dental caries as a non-communicable and behavioral disease: Management implications
Giacaman, R., Fernández, C. E., Muñoz-Sandoval, C., León, S., García-Manríquez, N., Echeverría, C., Valdés, S., Castro, R. J., & Gambetta-Tessini, K. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2022.764479 · Cited by 141 · see citing works
Prospects for the development of probiotics and prebiotics for oral applications
DeVine, D., & Marsh, P. D. (2009) · Journal of Oral Microbiology · doi:10.3402/jom.v1i0.1949 · Cited by 133 · see citing works
Exploring the oral bacterial flora: current status and future directions
Parahitiyawa, N., Scully, C. M., Leung, W. K., Yam, W., Jin, L., & Samaranayake, L. P. (2009) · Oral Diseases · doi:10.1111/j.1601-0825.2009.01607.x · Cited by 131 · see citing works
Clavel, T., Lepage, P., & Charrier, C. (2014) · Springer eBooks · doi:10.1007/978-3-642-30138-4_343 · Cited by 126 · see citing works
Paster, B. J., & Dewhirst, F. E. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00316.x · Cited by 127 · see citing works
“The reverse-capture checkerboard hybridization method has also been used to determine the role of bacteria in oral health and disease, including caries of the primary dentition (6, 11), caries of the secondary dentition (3), necrotizing ulcerative periodontitis (39) and periodontal diseases associated with human immun…”
Self-citationPhilip, N. I., Suneja, B., & Walsh, L. J. (2018) · BDJ · doi:10.1038/sj.bdj.2018.81 · Cited by 125 · see citing works
Oral Microbiome and Dental Caries Development
Zhang, J. S., Chu, C.-H., & Yu, O. Y. (2022) · Dentistry Journal · doi:10.3390/dj10100184 · Cited by 135 · see citing works
Oral microbiota maturation during the first 7 years of life in relation to allergy development
Dzidic, M., Abrahamsson, T., Artacho, A., Collado, M. C., Mira, Á., & Jenmalm, M. C. (2018) · Allergy · doi:10.1111/all.13449 · Cited by 120 · see citing works
Bacterial and viral pathogens in saliva: disease relationship and infectious risk
Slots, J., & Slots, H. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00361.x · Cited by 119 · see citing works
“adolescents (1, 42) and to root caries in elderly pa-”
BackgroundThe Predominant Oral Microbiota Is Acquired Early in an Organized Pattern
Sulyanto, R. M., Thompson, Z. A., Beall, C. J., Leys, E. J., & Griffen, A. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-46923-0 · Cited by 114 · see citing works
Self-citationKhor, B., Snow, M., Herrman, E., Ray, N., Mansukhani, K., Patel, K. A., Said-Al-Naief, N. A. H., Maier, T., & Machida, C. A. (2021) · Microorganisms · doi:10.3390/microorganisms9030496 · Cited by 117 · see citing works
Microbial Risk Markers for Childhood Caries in Pediatricians’ Offices
Kanasi, E., Johansson, I., Lu, S. C., Kressin, N. R., Nunn, M. E., Kent, R., & Tanner, A. C. R. (2010) · Journal of Dental Research · doi:10.1177/0022034509360010 · Cited by 116 · see citing works
“Studies of early childhood caries (ECC) microbiota using cultural (Marchant et al., 2001) and molecular approaches (Corby et al., 2005; Aas et al., 2008) further expanded the range of species detected in caries.”
BackgroundInfluentialThe use of propolis in dentistry, oral health, and medicine: A review
Zulhendri, F., Felitti, R., Fearnley, J., & Ravalia, M. (2021) · Journal of Oral Biosciences · doi:10.1016/j.job.2021.01.001 · Cited by 115 · see citing works
White-spot Lesions and Gingivitis Microbiotas in Orthodontic Patients
Tanner, A. C. R., Sonis, A. L., Holgerson, P. L., Starr, J. R., Nuñez, Y., Kressirer, C. A., Paster, B. J., & Johansson, I. (2012) · Journal of Dental Research · doi:10.1177/0022034512455031 · Cited by 114 · see citing works
“Prevotella, Capnocytophaga, Selenomonas, and Fusobacterium species have also been detected in childhood caries (Aas et al., 2008; Gross et al., 2010; Tanner et al., 2011b).”
BackgroundSelf-citationThe pathogenic persona of community‐associated oral streptococci
Whitmore, S. E., & Lamont, R. J. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07707.x · Cited by 112 · see citing works
“In vivo, P. gingivalis can be isolated in areas rich in MGS that possess functional co-adhesins, but rarely in association with mutans streptococci (Slots and Gibbons, 1978; Aas et al., 2008).”
BackgroundCommunity Interactions of Oral Streptococci
Jakubovics, N. S., Yassin, S. A., & Rickard, A. H. (2014) · Advances in Applied Microbiology · doi:10.1016/b978-0-12-800261-2.00002-5 · Cited by 107 · see citing works
Utility of Photodynamic Therapy in Dentistry: Current Concepts
Stájer, A., Kajári, S., Gajdács, M., Musah-Eroje, A., & Baráth, Z. (2020) · Dental journal · doi:10.3390/dj8020043 · Cited by 96 · see citing works
“It is the result of an imbalance between tooth demineralization and remineralization [101,102].”
Background
- Authors
- Aas, J. A., Griffen, A. L., Dardis, S. R., Lee, A. M., Olsen, I., Dewhirst, F. E., Leys, E. J., & Paster, B. J.
- Affiliations
- University of Oslo (NO)
- Department of Pediatric Dentistry
- The Forsyth Institute (US)
- Harvard University (US)
- The Ohio State University (US)
- Corresponding author
- Aas, Jørn A.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2008-04
- Volume
- 46
- Issue
- 4
- Pages
- 1407-1417
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC2292933
- OpenAlex
- W2104771379
- Cited by
- 952
- References
- 42
- Citations by year
- 2026: 22 · 2025: 36 · 2024: 61 · 2023: 62 · 2022: 87 · 2021: 80 · 2020: 84 · 2019: 64 · 2018: 63 · 2017: 46 · 2016: 50 · 2015: 42 · 2014: 53 · 2013: 43 · 2012: 46
- FWCI
- 42.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universitetet i Oslo
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (U01DE016937, DE016125, R01DE016125, DE11443, R01DE011443)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
- Keywords
- dental caries, Streptococcus mutans, primary teeth, permanent teeth, bacterial species composition, 16S rRNA gene sequencing, white spot lesions, dentin lesions, Lactobacillus, Bifidobacterium dentium, Atopobium, Propionibacterium, Actinomyces, Veillonella, caries progression, caries etiology, children and young adults
- MeSH terms
- Adolescent, Adult, Child, Child, Preschool, Dental Caries, Gram-Positive Bacteria, Humans, Molecular Sequence Data, RNA, Ribosomal, 16S, Tooth, Tooth, Deciduous, Gram-Positive Bacterial Infections, Sequence Analysis, DNA
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