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The repeated open application test (ROAT)

Hannuksela, Matti, Salo, Heikki·1986·Contact Dermatitis

Abstract

Repeated open application tests (ROATs) were performed with common ingredients of vehicles in 86 patients with contact dermatitis. The substances were applied twice daily for 7 days to the flexor aspect of the forearm near the cubital fossa, unless dermatitis appeared earlier. Of the patients with a questionable (?+) patch test result, 44% were positive in ROATs. The corresponding figure was 80% in the patients with B positive (+ or ++) response in the patch lest, when the results of ROAT with propylene glycol were excluded. Only 5 of 14 patients reacting lo 30% or to 10% propylene glycol but not in 15 in water in patch testing, showed a positive result to a cream containing 5% propylene glycol in ROAT. All 5 patients with a positive patch test reaction to 1% propylene glycol reacted to 5% propylene glycol in ROAT. The results suggest that ROATs should be performed more often, especially in patients in whom little known or new allergens are suspected as being the cause of allergic contact dermatitis.

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Metadata

Authors
Hannuksela, M., & Salo, H.
Venue
Contact Dermatitis
Publisher
Wiley
Published
1986-04
Volume
14
Issue
4
Pages
221-227
ISSN
  • 0105-1873 (ISSN-L)
  • 1600-0536
OpenAlex
W2000577812
Cited by
281
References
0
FWCI
9.11
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The repeated open application test (ROAT). https://app.cochat.ai/papers/10.1111/j.1600-0536.1986.tb01229.x
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Hannuksela, M., & Salo, H. (1986). The repeated open application test (ROAT). Contact Dermatitis. https://doi.org/10.1111/j.1600-0536.1986.tb01229.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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