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The repeated open application test (ROAT)
Abstract
Repeated open application tests (ROATs) were performed with common ingredients of vehicles in 86 patients with contact dermatitis. The substances were applied twice daily for 7 days to the flexor aspect of the forearm near the cubital fossa, unless dermatitis appeared earlier. Of the patients with a questionable (?+) patch test result, 44% were positive in ROATs. The corresponding figure was 80% in the patients with B positive (+ or ++) response in the patch lest, when the results of ROAT with propylene glycol were excluded. Only 5 of 14 patients reacting lo 30% or to 10% propylene glycol but not in 15 in water in patch testing, showed a positive result to a cream containing 5% propylene glycol in ROAT. All 5 patients with a positive patch test reaction to 1% propylene glycol reacted to 5% propylene glycol in ROAT. The results suggest that ROATs should be performed more often, especially in patients in whom little known or new allergens are suspected as being the cause of allergic contact dermatitis.
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Cited by
Johansen, J. D., Aalto‐Korte, K., Agner, T., Andersen, K. E., Bircher, A., Bruze, M., Cannavó, A., Giménez‐Arnau, A., Gonçalo, M., Goossens, A., et al. (2015) · Contact Dermatitis · doi:10.1111/cod.12432 · Cited by 1,453
Adverse reactions to fragrances: A clinical review
de Groot, A. C., & Frosch, P. J. (1997) · Contact Dermatitis · doi:10.1111/j.1600-0536.1997.tb00418.x · Cited by 274
Investigation of the threshold for allergic reactivity to chromium
Basketter, D., Horev, L., Slodovnik, D., Merimes, S., Trattner, A., & Ingber, A. (2001) · Contact Dermatitis · doi:10.1034/j.1600-0536.2001.440202.x · Cited by 102
Copper Hypersensitivity: Dermatologie Aspects
Hostynek, J. J., & Maibach, H. I. (2003) · Reviews on Environmental Health · doi:10.1515/reveh.2003.18.3.153 · Cited by 95
Fragrance Allergic Contact Dermatitis
Cheng, J., & Zug, K. A. (2014) · Dermatitis® · doi:10.1097/der.0000000000000067 · Cited by 59
Metadata
- Authors
- Hannuksela, M., & Salo, H.
- Venue
- Contact Dermatitis
- Publisher
- Wiley
- Published
- 1986-04
- Volume
- 14
- Issue
- 4
- Pages
- 221-227
- ISSN
- 0105-1873 (ISSN-L)
- 1600-0536
- OpenAlex
- W2000577812
- Cited by
- 281
- References
- 0
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hannuksela, M., & Salo, H. (1986). The repeated open application test (ROAT). Contact Dermatitis. https://doi.org/10.1111/j.1600-0536.1986.tb01229.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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