The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Neuroendocrine regulation of sebocytes – a pathogenetic link between stress and acne
Abstract
Abstract: A causative link between emotional stress and acne has long been postulated. There is mounting evidence that the molecular mechanism underlying this observation is related to the expression of receptors for several neuroendocrine mediators by the sebaceous gland. Recent and ongoing studies have indicated that human sebocytes express functional receptors for corticotropin‐releasing hormone, melanocortins, β‐endorphin, vasoactive intestinal polypeptide, neuropeptide Y and calcitonin gene‐related peptide. After ligand binding, these receptors modulate the production of inflammatory cytokines, proliferation, differentiation, lipogenesis and androgen metabolism in sebocytes. By means of their autocrine, paracrine and endocrine actions, these neuroendocrine factors appear to mediate centrally and topically induced stress towards the sebaceous gland, ultimately affecting the clinical course of acne.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The cloning of a family of genes that encode the melanocortin receptors
Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635
Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776
Neuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727
Sebocytes are the key regulators of androgen homeostasis in human skin
Fritsch, M., Orfanos, C. E., & Zouboulis, C. C. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01312.x · Cited by 232
Self-citationThe Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells
Thiboutot, D., Sivarajah, A., Gilliland, K., Cong, Z., & Clawson, G. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00094.x · Cited by 90
Proopiomelanocortin Peptides and Sebogenesis
ZHANG, L., ANTHONAVAGE, M., HUANG, Q., LI, W., & EISINGER, M. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03175.x · Cited by 68
Cited by
Williams, H. C., Dellavalle, R. P., & Garner, S. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60321-8 · Cited by 1,126
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 665
Neuroimmunology of Stress: Skin Takes Center Stage
Arck, P. C., Slominski, A., Theoharides, T. C., Peters, E. M. J., & Paus, R. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700104 · Cited by 472
TFOS DEWS II Sex, Gender, and Hormones Report
Sullivan, D. A., Rocha, E. M., Aragona, P., Clayton, J. A., Ding, J., Golebiowski, B., Hampel, U., McDermott, A. M., Schaumberg, D. A., Srinivasan, S., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.04.001 · Cited by 434
Tuchayi, S. M., Makrantonaki, E., Ganceviciene, R., Dessinioti, C., Feldman, S. R., & Zouboulis, C. C. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.29 · Cited by 432
Self-citation
Metadata
- Authors
- Zouboulis, C. C., & Böhm, M.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2004-10-26
- Volume
- 13
- Issue
- s4
- Pages
- 31-35
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2097262289
- Cited by
- 161
- References
- 6
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neuroendocrine regulation of sebocytes – a pathogenetic link between stress and acne. https://app.cochat.ai/papers/10.1111/j.1600-0625.2004.00254.x
- The paper
- Zouboulis, C. C., & Böhm, M. (2004). Neuroendocrine regulation of sebocytes – a pathogenetic link between stress and acne. Experimental Dermatology. https://doi.org/10.1111/j.1600-0625.2004.00254.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
