Acne vulgaris
Abstract
Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. Although early colonisation with P acnes and family history might have important roles in the disease, exactly what triggers acne and how treatment affects the course of the disease remain unclear. Other factors such as diet have been implicated, but not proven. Facial scarring due to acne affects up to 20% of teenagers. Acne can persist into adulthood, with detrimental effects on self-esteem. There is no ideal treatment for acne, although a suitable regimen for reducing lesions can be found for most patients. Good quality evidence on comparative effectiveness of common topical and systemic acne therapies is scarce. Topical therapies including benzoyl peroxide, retinoids, and antibiotics when used in combination usually improve control of mild to moderate acne. Treatment with combined oral contraceptives can help women with acne. Patients with more severe inflammatory acne usually need oral antibiotics combined with topical benzoyl peroxide to decrease antibiotic-resistant organisms. Oral isotretinoin is the most effective therapy and is used early in severe disease, although its use is limited by teratogenicity and other side-effects. Availability, adverse effects, and cost, limit the use of photodynamic ther…
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Acne vulgaris is a chronic disease of the pilosebaceous unit resulting from androgen-induced increased sebum production.
“Acne vulgaris is a chronic disease of the pilosebaceous unit resulting from androgen-induced increased sebum production40.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [40]
Key features of acne development include disturbed SG activity resulting in excessive sebum, altered sebocyte proliferation and differentiation, dysregulation of the hormonal environment, hyperkeratinization, colonization of C. acnes, and inflammation.
“Some of the key features of acne development include disturbed SG activity resulting in excessive sebum, altered sebocyte proliferation and differentiation, dysregulation of the hormonal environment, hyperkeratinization, colonization of C. acnes and inflammation2, 40.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [40]
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- Authors
- Williams, H. C., Dellavalle, R. P., & Garner, S.
- Affiliations
- Nottingham University Hospitals NHS Trust (GB)
- VA Eastern Colorado Health Care System (US)
- Tufts Medical Center (US)
- Corresponding author
- Williams, Hywel C
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 379
- Issue
- 9813
- Pages
- 361-372
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4211104405
- Cited by
- 1,126
- References
- 3
- Citations by year
- 2026: 82 · 2025: 114 · 2024: 136 · 2023: 107 · 2022: 117 · 2021: 111 · 2020: 75 · 2019: 68 · 2018: 64 · 2017: 55 · 2016: 66 · 2015: 35 · 2014: 42 · 2013: 35 · 2012: 15
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- acne, pilosebaceous unit, Propionibacterium acnes, sebum production, keratinization, facial scars, acne treatment, benzoyl peroxide, retinoids, topical antibiotics, oral contraceptives, oral isotretinoin, photodynamic therapy, antibiotic resistance, teratogenicity, comparative effectiveness
- MeSH terms
- Acne Vulgaris, Humans
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