The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Pattern recognition receptors and control of adaptive immunity
Abstract
Summary: The mammalian immune system effectively fights infection through the cooperation of two connected systems, innate and adaptive immunity. Germ‐line encoded pattern recognition receptors (PRRs) of the innate immune system sense the presence of infection and activate innate immunity. Some PRRs also induce signals that lead to the activation of adaptive immunity. Adaptive immunity is controlled by PRR‐induced signals at multiple checkpoints dictating the initiation of a response, the type of response, the magnitude and duration of the response, and the production of long‐term memory. PRRs thus instruct the adaptive immune system on when and how to best respond to a particular infection. In this review, we discuss the roles of various PRRs in control of adaptive immunity.
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Cites
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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759
Innate Immune Pattern Recognition: A Cell Biological Perspective
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Metadata
- Authors
- Palm, N. W., & Medzhitov, R.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2008-12-19
- Volume
- 227
- Issue
- 1
- Pages
- 221-233
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2025633900
- Cited by
- 729
- References
- 16
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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