The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
The tyrosine kinase network regulating mast cell activation
Open accessAbstract
Summary: Mast cell mediator release represents a pivotal event in the initiation of inflammatory reactions associated with allergic disorders. These responses follow antigen‐mediated aggregation of immunoglobulin E (IgE)‐occupied high‐affinity receptors for IgE (FcεRI) on the mast cell surface, a response which can be further enhanced following stem cell factor‐induced ligation of the mast cell growth factor receptor KIT (CD117). Activation of tyrosine kinases is central to the ability of both FcεRI and KIT to transmit downstream signaling events required for the regulation of mast cell activation. Whereas KIT possesses inherent tyrosine kinase activity, FcεRI requires the recruitment of Src family tyrosine kinases and Syk to control the early receptor‐proximal signaling events. The signaling pathways propagated by these tyrosine kinases can be further upregulated by the Tec kinase Bruton’s tyrosine kinase and downregulated by the actions of the tyrosine Src homology 2 domain‐containing phosphatase 1 (SHP‐1) and SHP‐2. In this review, we discuss the regulation and role of specific members of this tyrosine kinase network in KIT and FcεRI‐mediated mast cell activation.
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Cites
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T-Cell Signaling Regulated by the Tec Family Kinase, Itk
Andreotti, A. H., Schwartzberg, P. L., Joseph, R. E., & Berg, L. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002287 · Cited by 593
Local immune response to food antigens drives meal-induced abdominal pain
Aguilera-Lizarraga, J., Florens, M. V., Viola, M. F., Jain, P., Decraecker, L., Appeltans, I., Cuende-Estevez, M., Fabre, N., Van Beek, K., Perna, E., et al. (2021) · Nature · doi:10.1038/s41586-020-03118-2 · Cited by 311
Mechanisms of mast cell signaling in anaphylaxis
Metcalfe, D. D., Peavy, R. D., & Gilfillan, A. M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.08.035 · Cited by 283
Self-citationRegulation of Mast Cell Responses in Health and Disease
Gilfillan, A. M., & Beaven, M. A. (2011) · Critical Reviews™ in Immunology · doi:10.1615/critrevimmunol.v31.i6.30 · Cited by 259
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O'Shea, J. J., Laurence, A., & McInnes, I. B. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.7 · Cited by 115
Metadata
- Authors
- Gilfillan, A. M., & Rivera, J.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2009-03
- Volume
- 228
- Issue
- 1
- Pages
- 149-169
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2019064446
- Cited by
- 428
- References
- 165
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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